Human cancer is transmitted via genome


Recent discredit of “somatic mutation” hypotheses forced the need of new paradigms about the nature of human cancer. The present article is devoted to further development of one such paradigm: the hypothesis of invasive parasitic nature, origin, evolution, pathogenesis and transmission of human cancer. Development was performed by supplementing and supporting the hypothesis by data which could not be applied before. The supplementation included integrative reconsidering, and reinterpretation of the make-ups, traits and processes existing not only in human cancer but also in animal cancers. Special attention has been focused on xenogamous intrusion of carcinogenic traits in the genome of a host. It was evidenced that human cancer possesses the same set of traits characteristic of transmissible animal cancer. In contrast to animal cancer formed of solitary cell lineage, human cancer consists of a couple of lineages constructed under different genetic regulations and performed different structural and physiological functions. The diversity of cancer composition remains stable over sequential propagation. The subsistence of human cancer regularly includes obligetory rotation alternation of its successive forms including genomic, gametic, zygotic, micro-population and tumorous ones. Human cancer possesses its own biological watch and the ability to gobble its victim, transmit via the intrusion of the genome, perform intercommunications within the tumor components and between the dispersed subunits of cancer.

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Rumyantsev, S. (2013) Human cancer is transmitted via genome. Open Journal of Genetics, 3, 6-11. doi: 10.4236/ojgen.2013.31002.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Bauer, K.H. (1928) Mutationstheorie der geschswulst-Entstehung. Springer, Berlin. doi:10.1007/978-3-642-99670-2
[2] Rumyantsev, S.N. (2008) Hereditary Immunity: Fundamental Principles and Exploitation in Life Study and Health Care. New York, Nova Biomedical Books.
[3] Rumyantsev, S.N. (2009) The discredit of cancer metastasis. Science Advisory Board.
[4] Rumyantsev, S.N. (2009) The uniqueness and ordinaryness of cancer origin and pathogenesis: New epidemiological, clinical and preventive perspectives. Journal of Clinical Medicine Research, 1, 32-36.
[5] Rumyantsev, S.N. (2012) Toward the genomic roots of cancer. Journal of Medicine and Medical Sciences, 3, 638-659.
[6] Mardis, E.R. (2012) Genome sequencing and cancer. Current Opinion in Genetics & Development, 22, 245-250. doi:10.1016/j.gde.2012.03.005
[7] Kharazmi, E., Fallah, M., Sundquist, K. and Hemminki, K. (2012) Familial risk of early and late onset cancer: Nationwide prospective cohort study. BMJ, 345, e8076. doi:10.1136/bmj.e8076
[8] Rebbeck, C.A., Thomas, R., Breen, M., Leroi, A.M. and Burt, A. (2009) Origins and evolution of a transmissible cancer. Evolution, 63, 2340-2349. doi:10.1111/j.1558-5646.2009.00724.x
[9] Murchison, E.P. (2008) Clonally transmissible cancers in dogs and Tasmanian devils. Oncogene, 27, S19-S30. doi:10.1038/onc.2009.350
[10] Banfield, W.G., Woke, P.A., Mackay, C.M. and Cooper, H.L. (1965) Mosquito transmission of a reticulum cell sarcoma of hamsters. Science, 148, 1239-1240. doi:10.1126/science.148.3674.1239
[11] Cooper, H.L., Mackay, C.M. and Banfield, W.G. (1964) Chromosome studies of a contagious reticulum cell sarcoma of the Syrian hamster. Journal of the National Cancer Institute, 33, 691-706.
[12] McAloose, D. and Newton, A.L. (2009) Wildlife cancer: A conservation perspective. Nature Reviews Cancer, 9, 517-526. doi:10.1038/nrc2665
[13] Welsh, J.S. (2011) Contagious cancer. Oncologist, 16, 14. doi:10.1634/theoncologist.2010-0301
[14] Mello Martins, M.I., de Souza, F.F. and Gobello, C. (2005) Canine transmissible venereal tumor: Etiology, pathology, diagnosis and treatment. Recent Advances in Small Animal Reproduction.
[15] Murgia C, Pritchard, J.K., Kim, S.Y., Fassati, A. and Weiss, R.A. (2006) Clonal Origin and evolution of a transmissible cancer. Cell, 126, 477-487. doi:10.1016/j.cell.2006.05.051
[16] Dingli, D. and Nowak, M.A. (2006) Cancer biology: Infectious tumour cells. Nature, 443, 35-36. doi:10.1038/443035a
[17] Hawkins, C.E., Baars, C., Hesterman, H., Hocking, G.J., Jones, M.E., Lazenby, B., Mann, D., Mooney, N., Pemberton, D. and Pyecroft, S. (2006) Emerging disease and population decline of an island endemic, the Tasmanian devil Sarcophilus harrisii. Biological Conservation, 131, 307-324. doi:10.1016/j.biocon.2006.04.010
[18] Pearse, A.M. and Swift, K. (2006) Allograft theory: Transmission of devil facial-tumour disease. Nature, 439, 549. doi:10.1038/439549a
[19] Pour, P., Mohr, U., Althoff, J., Cardesa, A. and Kmoch, N. (1976) Spontaneous tumors and common diseases in two colonies of Syrian hamsters. IV. vascular and lymphatic systems and lesions of other sites. Journal of the National Cancer Institute, 56, 949-961.
[20] Brindley, D.C. and Banfield, W.G. (1961) A contagious tumor of the hamster. Journal of the National Cancer Institute, 26, 949-957.
[21] Kreiss, A., Cheng, Y., Kimble, F., Wells, B., Donovan, S., Belov, K. and Woods, G.M. (2011) Allorecognition in the Tasmanian devil (Sarcophilus harrisii), an endangered marsupial species with limited genetic diversity. PLoS One, 6, e22402. doi:10.1371/journal.pone.0022402
[22] Kreso, A., O’Brien, C.A., van Galen, P., Gan, O., Notta, F., Brown, A.M.K., Ng, K., Ma, J., Wienholds, E., Pollett, A., Gallinger, S., McPherson, J., Mullighan, C.J., Shibata, D. and Dick, J.E. (2012) Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science, 338, 6113.
[23] Rumyantsev, S.N. (2010) Hypothesis: Towards the origin of cancer epidemics and pathogenesis. Journal of Carcinogenesis, 9, 1-7.
[24] Rumyantsev, S.N. (2011) Functions of hereditary immunity and xenogamy in cancer origin and pandemic spread. Open Journal of Immunology, 1, 27-40. doi:10.4236/oji.2011.12004
[25] Bonnicksen, A.L. (2009) Chimeras, hybrids, and interspecies research: Politics and policymaking. Georgetown University Press, Washington.
[26] McLaren, A. (1976) Mammalian chimaeras. Cambridge University Press, Cambridge.
[27] Quintana, E., Piskounova, E., Shackleton, M., Weinberg, D., Eskiocak, U., Fullen, D.R., Johnson, T.M. and Morrison, S.J. (2012) Human melanoma metastasis in NSG mice correlates with clinical outcome in patients. Science Translational Medicine, 7, 159.
[28] Patterson, N., Richter, D.J., Gnerre, S., et al. (2006) Genetic evidence for complex speciation of humans and chimpanzees. Nature, 441, 1103-1108. doi:10.1038/nature04789
[29] Sankararaman, S., Patterson, N., Paabo, S. and Reich, D. (2012) The Date of Interbreeding between Neandertals and Modern Humans. PLoS Genetics, 8, e1002947. doi:10.1371/journal.pgen.1002947

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