Are mean platelet volume and splenomegaly subclinical inflammatory marker in children with familial mediterranean fever?

Ismail Dursun, Faysal Gok, Oguzhan Babacan, Erkan Sarı, Onur Sakallıoglu
DOI: 10.4236/health.2010.27105                

Abstract

The present study aimed to investigate the correlation of MPV and splenomegaly as inflammation activity of FMF patients at the attacks free period. We retrospectively reviewed the medical records of 43 patients with FMF. This study was performed at the attack free period as clinical and laboratory. For this study, patients were divided into two groups. Patients with splenomegaly is called group 1 (n = 12) and patients with no splenomegaly is called group 2 (n = 31). Groups were compared respect to age, gender, platelet counts, acute phase reactants and MPV. The mean MPV (fl) were significantly higher in group 1 (8.9 ± 0.8) than in group 2 (8.4 ± 0.5, p < 0.05). This study suggested that increased MPV and splenomegaly without amyloidosis could be a sign of chronic inflammation in children with FMF even in attack free period.

Keywords

Familial Mediterranean Fever; Mean Platelet Volume; Subclinical Inflammation

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Woo, P., Laxer, R.M. and Sherry, D.D. (2007) Autoinflammatory syndromes. In: Woo, P., Laxer, R.M. and Sherry, D.D. Pediatric Rheumatology in Clinical Practice. Springer, London, 123-136.
[2]	Direskeneli, H., Ozdogan, H., Korkmaz, C., Akoglu, T. and Yazici, H. (1999). Serum soluble intercellular adhesion molecule-1 and interleukin-8 levels in familial Mediterranean fever. The Journal of Rheumatology, 26(9), 1983-1986.
[3]	Notarnicola, C., Didelot, M.N., Seguret, F., Demaille, J. and Touitou, I. (2002). Enhanced cytokine mRNA levels in attack-free patients with familial Mediterranean fever. Genes & Immunity, 3(1), 43-45.
[4]	Yalc?nkaya, F., Cakar, N., Acar, B., Tutar, E., Güriz, H., Elhan, A.H., et al. (2007). The value of the levels of acute phase reactants for the prediction of familial Mediterranean fever associated amyloidosis: A case control study. Rheumatology International, 27, 517-522.
[5]	Kerr, R., Stirling, D. and Ludlam, C.A. (2001) Interleukin 6 and haemostasis. British Journal of Haematology, 115(1), 3-12.
[6]	Manukyan, G.P., Ghazaryan, K.A., Ktsoyan, Z.h.A., Tatyan, M.V., Khachatryan, Z.A., Hakobyan, G.S., et al. (2008). Cytokine profile of Armenian patients with Familial Mediterranean fever. Clinical Biochemistry, 41 (10-11), 920-922.
[7]	Akcan, Y., Bayraktar, Y., Arslan, S., Van Thiel, D.H., Zerrin B.C. and Yildiz, O. (2003). The importance of serial measurements of cytokine levels for the evaluation of their role in pathogenesis in familial Mediterraean fever. European Journal of Medical Research, 8, 304-306.
[8]	Baykal, Y., Saglam, K., Yilmaz, M.I., Taslipinar, A., Akinci, S.B. and Inal, A (2003) Serum sIL-2r, IL-6, IL-10 and TNF-alpha level in familial Mediterranean fever patients. Clinical Rheumatology, 22(2), 99-101.
[9]	Heath, H.W. and Pearson, H.A. (1989) Thrombocytosis in pediatric outpatients. Journal of Pediatrics, 114(5), 805-807.
[10]	Rimon, D., Meir, Y. and Cohen, L. (1989) Retroperitoneal lymphadenopathy in familial Mediterranian fever. Postgraduate Medical Journal, 65(768), 776-778.
[11]	Schwabe, A.D. and Peters, R.S. (1974). Familial Mediterranean fever in Armenians. Analysis of 100 cases. Medicine, 53(6), 453-462.
[12]	Castle, V., Coates, G., Kelton, J.G. and Andrew, M. (1987) 111 In-oxine platelet survivals in thrombocytopenic infants. Blood, 70(3), 652-656.
[13]	Savolainen, S. (1992). SPECT versus planar scintigraphy for quantification of splenic sequestration of 111In-labelled platelets. Nuclear Medicine Communications, 13 (10), 757-763.
[14]	Livneh, A., Langevitz, P., Zemer, D., Kees, S. and Lidav, T. (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis & Rheumatism, 40(10), 1879- 1885.
[15]	Du?unsel, R., Dursun, I., Gündüz, Z., Poyrazo?lu, M.H., Gürg?ze, M.K. and Dundar, M. (2008). Genotype-ph- enotype correlation in children with familial Mediterranean fever in a Turkish population. Pediatrics International, 50(2), 208-212.
[16]	Konu?, O.L., Ozdemir, A., Akkaya, A., Erba?, G., Celik, H. and I?ik, S. (1998) Normal liver, spleen, and kidney dimensions in neonates, infants, and children: Evaluation with sonography. American Journal of Roentgenology, 171(6), 1693-1698.
[17]	Aharoni, D., Hiller, N. and Hadas H.I. (2000). Familial Mediterranean fever: Abdominal imaging findings in 139 patients and review of the literature. Abdom Imaging, 25(3), 297-300.
[18]	Odabas, A.R., Cetinkaya, R., Selcuk, Y. and Bilen, H. (2002) Familial Mediterranean fever. Southern Medical Journal, 95(12), 1400-1403.
[19]	Milovanovic, M., Nilsson, E. and J?remo, P. (2004). Relationships between platelets and inflammatory markers in rheumatoid arthritis. Clinica Chimica Acta, 343(1-2), 237-240.
[20]	Ertenli, I., Kiraz, S., Oztürk, M.A., Haznedaro?lu, I., Celik, I. and Calgüneri, M. (2003) Pathologic thrombopoiesis of rheumatoid arthritis. Rheumatology International, 23(2), 49-60.
[21]	Kisacik, B., Tufan, A., Kalyoncu, U., Karadag, O., Akdogan, A., Ozturk, M.A., et al. (2008) Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 75(3), 291-294.
[22]	Koné, P.I., Dubuc, M., Sportouch, J., Minodier, P., Garnier, J.M. and Touitou, I. (2000). Phenotype-genotype correlation in 91 patients with familial Mediterranean fever reveals a high frequency of cutaneomucous features. Rheumatology, Oxford, 39, 1275-1279.
[23]	Inal, A., Yilmaz, M., Kendirli, S.G., Altintas, D.U. and Karakoc, G.B. (2008) The clinical and genetical features of 124 children with Familial Mediterranean fever: Experience of a single tertiary center. Rheumatology International, 29 (11), 1279-1285.