Primary Pure Squamous Cell Carcinoma of the Gallbladder: Case Report


Squamous cell carcinoma of the gallbladder is rare and accounts for about 12.7% of all cases of gallbladder cancer. Pure squamous cell carcinoma is even less common with a reported incidence of 3.3%. We present a case of 72 year-old African-American woman with decreased appetite, fatigue, and weight loss associated with intermittent right upper quadrant pain for two months. Computed tomography of the abdomen revealed a mass in the gallbladder and the hepatic flexure of the colon with involvement of adjacent small bowel. On exploratory laparotomy, a mass at the dome of the gallbladder was found with local invasion of the hepatic flexure, and the proximal transverse colon. There was no obvious involvement of the duodenum, common bile duct, or the extra-hepatic biliary tree. An extended right hemicolectomy, distal small bowel resection, cholecystectomy, a wedge resection of the liver and a feeding jejunostomy, were performed. Pathologic evaluation demonstrated well to moderately differentiated squamous cell carcinoma of gallbladder without evidence of distant metastasis. The patient improved clinically and was discharged home in good condition.

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S. Nazir, M. Rauf, I. Jabbour, J. Duperval, A. Asarian, F. Shaikh, P. Xiao and P. Pappas, "Primary Pure Squamous Cell Carcinoma of the Gallbladder: Case Report," Surgical Science, Vol. 3 No. 8, 2012, pp. 418-420. doi: 10.4236/ss.2012.38083.

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The authors declare no conflicts of interest.


[1] W. Rekik, C. Ben Fadhel, A. L. Boufaroua, H. Mestiri, M. T. Khalfallah, S. Bouraoui and S. Mzabi-Rgaya, “Case Report: Primary Pure Squamous Cell Carcinoma of the Gallbladder,” Journal of Visceral Surgery, Vol. 148, No. 2, 2011, pp. e149-e151. doi:10.1016/j.jviscsurg.2011.03.004
[2] A. Soyama, Y. Tajima, T. Kuroki, N. Tsuneoka, S. Ohno, T. Adachi, S. Eguchi and T. Kanematsu, “Radical Surgery for Advanced Pure Squamous Cell Carcinoma of the Gallbladder: Report of a Case,” Hepatogastroenterology, Vol. 58, No. 112, pp. 2118-2120. doi:10.5754/hge10140
[3] J. C. Roa, O. Tapia, A. Cakir, O. Basturk, N. Dursun, D. Akdemir, B. Saka, H. Losada, P. Bagci and N. V. Adsay, “Squamous Cell and Adenosquamous Carcinomas of the Gallbladder: Clinicopathological Analysis of 34 Cases Identified in 606 Carcinomas,” Modern Pathology, Vol. 24, No. 8, pp. 1069-1078.
[4] J. Waisberg, S. H. Bromberg, M. I. F. Franco, et al., “Squamous Cell Carcinoma of the Gallbladder,” Sao Paulo Medical Journal, Vol. 119, No. 1, 2001, p. 43. doi:10.1590/S1516-31802001000100010
[5] M. D’Angelica and W. Jarnagin, “Tumors of the Gallbladder,” In B. L. Saunders, Ed., Surgery of the Liver, Biliary Tract, and Pancreas, 4th Edition, Elsevier, Amsterdam, 2006, pp. 764-781.
[6] T. Roppongi, I. Takeyoshi, S. Ohwada, et al., “Minute Squamous Cell Carcinoma of the Gallbladder: A Case Report,” Japanese Journal of Clinical Oncology, Vol. 30, No. 1, 2000, pp. 43-45. doi:10.1093/jjco/hyd010
[7] D. Henson, J. Albores-Saavedra and D. Corle, “Carcinoma of the Gallbladder. Histologic Types, Stage of Disease, Grade, and Survival Rates,” Cancer, Vol. 70, No. 6, 1992, pp. 1493-1497. doi:10.1002/1097-0142(19920915)70:6<1493::AID-CNCR2820700608>3.0.CO;2-U
[8] K. Moore, “The Developing Human,” W.B. Saunders Company, Philadelphia, 1982.
[9] M. A. Memon, S. Anwar, M. H. Shiwani and B. Memon, “Gallbladder Carcinoma: A Retrospective Analysis of Twenty-Two Years Experience of a Single Teaching Hospital,” International Seminars in Surgical Oncology, Vol. 2, 2005, p. 6. doi:10.1186/1477-7800-2-6
[10] Y. Oohashi, Y. Shirai, T. Wakai, et al., “Adenosquamous Carcinoma of the Gallbladder Warrants Resection Only If Curative Resection Is Feasible,” Cancer, Vol. 94, No. 11, 2002, pp. 3000-3005. doi:10.1002/cncr.10578

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