Liponeurocytoma of the Cerebellum with Myoid Features


We report an extremely rare tumor presenting with myoid features in the left cerebellum lobe in a 62-year-old man. This tumor consisted of medium to large round cells with focal lipomatous and myoid differentiation. Immunohistochemically, the tumor cells expressed synaptophysin, GFAP (glial fibrillary acidic protein) and focally desmin. From these findings, we concluded that this tumor was a liponeurocytoma with myoid features. To our knowledge, this is the second report of liponeurocytoma with myoid differentiation in the cerebellum.

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C. Laila, B. Ikram, Z. Kaoutar, B. Mohamed, M. Mustapha and A. Afaf, "Liponeurocytoma of the Cerebellum with Myoid Features," Open Journal of Pathology, Vol. 2 No. 2, 2012, pp. 21-23. doi: 10.4236/ojpathology.2012.22004.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] J. T.Bechtel, J. M. Patton and Y. Takei, “Mixed Mesenchymal and Neuroectodermal Tumor of the Cerebellum,” Acta Neuropathologica, Vol. 41, No. 3, 1978, pp. 261263. doi:10.1007/BF00690447
[2] D. N. Louis, H. Ohgaki, O. D. Wiestler and W. K. Cavenee, “Pathology and Genetics of Tumours of the Nervous System,” In: World Health Organization Classification of Tumours, International Agency for Research on Cancer, Lyon, 2007, p. 110.
[3] C. H. Alleyne Jr., S. Hunter, J. J. Olson and D. L. Barrow, “Lipomatous Glioneurocytoma of the Posterior Fossa with Divergent Differentiation: Case Report,” Neurosurgery, Vol. 42, No. 3, 1998, pp. 639-643. doi:10.1097/00006123-199803000-00035
[4] R. Gonzalez-Campora and R. O. Weller, “Lipidized Mature Neuroectodermal Tumor of the Cerebellum with Myoid Differentiation,” Neuropathology and Applied Neurobiology, Vol. 24, No. 5, 1998, pp. 397-402. doi:10.1046/j.1365-2990.1998.00139.x
[5] N. Montagna, L. C. Vaz and M. A. Astro, “Meduloblastoma Cerebelar Em Adulto com Areas Lipomatosas,” Journal Brasileiro de Patologia e Medicina Laboratorial, Vol. 35, No. 49, 1999.
[6] B. K. Owler, J. M. Makeham, M. Shingde and M. Besser, “Cerebellar Liponeurocytoma,” Journal of Clinical Neuroscience, Vol. 12, No. 3, 2005, pp. 326-329. doi:10.1016/j.jocn.2004.05.017
[7] J. Buhren, A. H. Christoph, R. Buslei, S. Albrecht, O. D. Wiestler and T. Pietsch, “Expression of the Neurotrophin Receptor p75NTR in Medulloblastomas Is Correlated with Distinct Histological and Clinical Features: Evidence for a Medulloblastoma Subtype Derived from the External Granule Cell Layer,” Journal of Neuropathology Experimental Neurology, Vol. 59, No. 3, 2000, pp. 229240.
[8] S. Horstmann, A. Perry and G. Reifenberger, et al., “Genetic and Expression Profiles of Cerebellar Liponeurocytomas,” Brain Pathology, Vol. 14, No. 3, pp. 281-289.

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