Unilateral ovarian hypoplasia—A report of two cases


Unilateral ovarian hypoplasia is a rare event with unknown true incidence. Our knowledge about this developmental anomaly is limited and based primarily on case reports. Ovarian hypoplasia is usually asymptomatic; it is most commonly diagnosed from laparoscopy for other indications. Here we report two cases of unilateral ovarian hypoplasia in patients who presented to the Continuum Reproductive Center with primary infertility. After initial infertility workup, both patients underwent diagnostic laparoscopy for suspected tubal disease. In each case, operative findings were consistent with unilateral ovarian hypoplasia. Following the surgery, one patient underwent in vitro fertilization and achieved an ongoing pregnancy. The other conceived spontaneously, but was diagnosed with an ectopic pregnancy.

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K. Breborowicz, A. , E. Stein, D. , A. Lederman, M. and D. Keltz, M. (2012) Unilateral ovarian hypoplasia—A report of two cases. Open Journal of Obstetrics and Gynecology, 2, 69-72. doi: 10.4236/ojog.2012.21013.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Eustace, D.L.S. (1992) Congenital absence of fallopian tube and ovary. European Journal of Obstetrics & Gynecology and Reproductive Biology, 46, 157-159. doi:10.1016/0028-2243(92)90263-X
[2] Dare, F.O., Makinde, O.O., Makinde, O.N. and Odutayo, R. (1989) Congenital absence of an ovary in a Nigerian woman. International Journal of Gynecology & Obstetrics, 29, 377-378. doi:10.1016/0020-7292(89)90364-0
[3] Sivanesaratnam, V. (1986) Unexplained unilateral absence of ovary and fallopian tube. European Journal of Obstetrics & Gynecology and Reproductive Biology, 22, 103-105. doi:10.1016/0028-2243(86)90096-1
[4] James, D.F., Barber, H.R. and Graber, E.A. (1970) Torsion of normal uterine adnexa in children. Report of three cases. Obstetrics & Gynecology, 35, 226-230.
[5] Sebastian, J.A., Baker, R.L. and Cordray, D. (1973) Asymptomatic infarction and separation of ovary and distal uterine tube. Obstetrics & Gynecology, 41, 531-535.
[6] Silva, P.D., Glasser, K.E. and Virata, R.L. (1995) Spontaneously acquired unilateral absence of the adnexa. A case report. Journal of Reproductive Medicine, 40, 63-64.
[7] Acien, P. (1997) Incidence of Mullerian defects in fertile and infertile women. Human Reproduction, 12, 1372- 1376.
[8] Haydardedeoglu, B., Simsek, E., Kilicdag, E.B., Tarim, E., Aslan, E. and Bagis, T. (2006) A case of unicornuate uterus with ipsilateral ovarian and renal agenesis. Fertility and Sterility, 85, 750.e1-750.e4.
[9] Kives, S.L., Bond, S.J. and Lara-Torre, E. (2005) Mullerian agenesis and ovarian torsion. A case report and review of literature. Journal of Pediatric Surgery, 40, 1326-1328. doi:10.1016/j.jpedsurg.2005.05.022
[10] Mulayim, B., Demirbaoulu, S. and Oral, O. (2003) Unicornuate uterus and unilateral ovarian agenesis associated with pelvic kidney. Surgical Endoscopy, 17, 161.
[11] Demir, B., Guven, S., Guven, E.S.G. and Gunalp, G.S. (2007) An incidental finding of unicornuate uterus with unilateral ovarian agenesis during cesarean delivery. Archives of Gynecology and Obstetrics, 276, 91-93. doi:10.1007/s00404-006-0317-x
[12] Nigam, A., Puri, M., Trivedi, S.S. and Chattopadhyay, B. (2010) Septate uterus with hypoplastic left adnexa with cervical duplication and longitudinal vaginal septum: Rare Mullerian anomaly. Journal of Human Reproductive Sciences 3, 105-107. doi:10.4103/0974-1208.69331
[13] Mylonas, I.., Hansch, S., Markmann, S., Bolz, M. and Friese, K. (2003) Unilateral Ovarian agenesis: Report of three cases and review of the literature. Archives of Gynecology and Obstetrics, 268, 57-60.
[14] Rapisarda, G., Pappalardo, E.M., Arancio, A. and La Grecca, M. (2009) Unilateral ovarian and fallopian tube agenesis. Archives of Gynecology and Obstetrics, 280, 849-850. doi:10.1007/s00404-009-1018-z
[15] Uckuyu, A., Ozcimen, E.E. and Cifici, F.C.S. (2009) Unilateral congenital ovarian and partial tubal absence: Report of four cases with review of the literature. Fertility and Sterility, 91, 936.e5-936.e8.
[16] Dueck, A., Poenaru, D., Jamieson, A. and Kamal, I.K. (2001) Unilateral ovarian agenesis and fallopian tube maldescent. Pediatric Surgery International, 17, 228-229. doi:10.1007/s003830000413
[17] Sirisena, L.A.W. (1978) Unexplained absence of an ovary and uterine tube. Postgraduate Medical Journal, 54, 423-424. doi:10.1136/pgmj.54.632.423
[18] Georgy, F.M. and Viechnicki, M.B. (1974) Absence of an ovary and uterine tube. Obstetrics & Gynecology, 44, 441-442.
[19] World Health Organization (1999) Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th Edition, Cambridge University Press, New York.
[20] Dahan, M.H., Burney, R. and Lathi, R. (2006) Congenital interruption of the ampullary portion of the fallopian tube. Fertility and Sterility, 85, 1820-1821. doi:10.1016/j.fertnstert.2006.01.012
[21] Dresler, S. (1977) Antenatal Torsion of a normal ovary and fallopian tube. American Journal of Diseases of Children, 131, 236.
[22] Jeffcoate, N. (1975) Absence or underdevelopment of the ovary. 4th Edition, Butterworth, 145-146.
[23] Paternoster, D.M., Costantini, W., Uglietti, A., Vasile, C. and Bocconi, L. (1998) Congenital or torsion-induced absence of Fallopian tubes. Two case reports. Minerva Ginecologica, 50, 191-194.

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