Gain of Chromosomes 1, 2, 7, 10, 13 and 17 in an Acquired Cystic Kidney Disease Associated Renal Cell Carcinoma
Shuting Bai, Dengfeng Cao, Diane Robirds, Julie Branson, Zhanyong Bing
DOI: 10.4236/ojpathology.2012.21001   PDF    HTML     4,677 Downloads   8,409 Views  


The acquired cystic disease of the kidney-associated renal cell carcinoma (ACDK-RCC) in the current study occurred in a kidney with multiple cysts and was composed of cells with eosinophilic cytoplasm and prominent nucleoli. There were extensive calcium oxalate deposits in both non-neoplastic cysts and tumor. The tumor cells were positive for RCC Ma, CD10, and EMA, focally positive for CK7, negative for vimentin. Interphase in situ hybridizations (FISH) were performed for chromosome 1, 2, 7, 10, 13 and 17. No chromosomal abnormality was observed in the non-neoplastic cysts. Polysomies of chromosomes 1, 2, 7, 10, 13, 17 were observed in the tumor. Trisomy 13 was first reported in this type of tumor, which warranted further study.

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S. Bai, D. Cao, D. Robirds, J. Branson and Z. Bing, "Gain of Chromosomes 1, 2, 7, 10, 13 and 17 in an Acquired Cystic Kidney Disease Associated Renal Cell Carcinoma," Open Journal of Pathology, Vol. 2 No. 1, 2012, pp. 1-5. doi: 10.4236/ojpathology.2012.21001.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] P. Cossu-Rocca, J. N. Eble, S. Zhang, G. Martignoni, M. Brunelli and L. Cheng, “Acquired Cystic Disease-Associated Renal Tumors: An Immunohistochemical and Fluorescence in Situ Hybridization Study,” Modern Pathology, Vol. 19, No. 6, 2006, pp. 780-787.
[2] N. Kuroda, T. Shiotsu, O. Hes, M. Michal, T. Shuin, G. H. Lee, “Acquired Cystic Disease-Associated Renal Cell Carcinoma with Gain of Chromosomes 3, 7, and 16, Gain of Chromosome X, and Loss of Chromosome Y,” Medical Molecular Morphology, Vol. 43, No. 4, 2010, pp. 231-234. doi:10.1007/s00795-009-0465-8
[3] N. Kuroda, M. Tamura, N. Hamaguchi, S. Mikami, C. C. Pan, M. Brunelli, G. Martignoni, O. Hes, M. Michal and G. H. Lee, “Acquired Cystic Disease-Associated Renal Cell Carcinoma with Sarcomatoid Change and Rhabdoid Features,” Annals of Diagnostic Pathology, Vol. 15, No. 6, 2011, pp. 462-466. doi:10.1016/j.anndiagpath.2010.07.008
[4] C. C Pan, Y. J. Chen, L. C. Chang, Y. H. Chang and D. M. Ho, “Immunohistochemical and Molecular Genetic Profiling of Acquired Cystic Disease-Associated Renal Cell Carcinoma,” Histopathology, Vol. 55, No. 2, 2009, pp. 145-153. doi:10.1111/j.1365-2559.2009.03361.x
[5] N. Sule, U. Yakupoglu, S. S. Shen, B. Krishnan, G. Yang, S. Lerner, D. Sheikh-Hamad and L. D. Truong, “Calcium Oxalate Deposition in Renal Cell Carcinoma Associated with Acquired Cystic Kidney Disease: A Comprehensive Study,” American Journal of Surgical Pathology, Vol. 29, No. 4, 2005, pp. 443-451. doi:10.1097/01.pas.0000152131.58492.97
[6] Y. Enoki, G. Katoh, H. Okabe and A. Yanagisawa, “Clinicopathological Features and CD57 Expression in Renal Cell Carcinoma in Acquired Cystic Disease of the Kidneys: With Special Emphasis on a Relation to the Duration of Haemodialysis, the Degree of Calcium Oxalate Deposition, Histological Type, and Possible Tumorigenesis,” Histopathology, Vol. 56, No. 3, pp. 384- 394. doi:10.1111/j.1365-2559.2010.03480.x
[7] S. K. Tickoo, M. N. DePeralta-Venturina, L. R. Harik, H. D. Worcester, M. E. Salama, A. N. Young, H. Moch and M. B. Amin, “Spectrum of Epithelial Neoplasms in End-Stage Renal Disease: An Experience from 66 Tumor-Bearing Kidneys with Emphasis on Histologic Patterns Distinct from Those in Sporadic Adult Renal Neoplasia,” American Journal of Surgical Pathology, Vol. 30, No. 2, 2006, pp. 141-153. doi:10.1097/01.pas.0000185382.80844.b1
[8] Y. Allory, F. Commo, L. Boccon-Gibod, M. Sibony, P. Callard, P. Ronco and H. Debiec, “Sulfated HNK-1 Epitope in Developing and Mature Kidney: A New Marker for Thin Ascending Loop of Henle and Tubular Injury in Acute Tubular Necrosis,” Journal of Histochemistry & Cytochemistry, Vol. 54, No. 5, 2006, pp. 575-584. doi:10.1369/jhc.5A6791.2006
[9] I. Ishikawa and G. Kovacs, “High Incidence of Papillary Renal Cell Tumours in Patients on Chronic Haemodialysis,” Histopathology, Vol. 22, No. 2, 1993, pp. 135-139. doi:10.1111/j.1365-2559.1993.tb00091.x
[10] W. Cheuk, E. S. Lo, A. K. Chan and J. K. Chan, “Atypical Epithelial Proliferations in Acquired Renal Cystic Disease Harbor Cytogenetic Aberrations,” Human Pathology, Vol. 33, No. 7, 2002, pp. 761-765. doi:10.1053/hupa.2002.125370
[11] O. Hes, R. Sima, J. Nemcova, M. Hora, S. Bulimbasic, D. V. Kazakov, T. Urge, T. Reischig, M. Dvorak and M. Michal, “End-Stage Kidney Disease: Gains of Chromosomes 7 and 17 and Loss of Y Chromosome in Non- Neoplastic Tissue,” Virchows Arch, Vol. 453, No. 4, 2008, pp. 313-319. doi:10.1007/s00428-008-0661-2
[12] A. Szponar, D. Zubakov, J. Pawlak, A. Jauch and G. Kovacs, “Three Genetic Developmental Stages of Papillary Renal Cell Tumors: Duplication of Chromosome 1q Marks Fatal Progression,” International Journal of Cancer, Vol. 124, No. 9, 2009, pp. 2071-2076. doi:10.1002/ijc.24180
[13] T. W. Corson, A. Huang, M. S. Tsao and B. L. Gallie, “KIF14 is a Candidate Oncogene in the 1q Minimal Region of Genomic Gain in Multiple Cancers,” Oncogene, Vol. 24, No. 30, 2005, pp. 4741-4753. doi:10.1038/sj.onc.1208641
[14] E. Prat, M. Bernues, J. Del Rey, J. Camps, I. Ponsa, F. Algaba, J. Egozcue, M. R. Caballin, A. Gelabert and R. Miro, “Common Pattern of Unusual Chromosome Abnormalities in Hereditary Papillary Renal Carcinoma,” Cancer Genetics and Cytogenetics, Vol. 164, No. 2, 2006, pp. 142-147. doi:10.1016/j.cancergencyto.2005.09.010
[15] H. J. Decker, B. Wullich, J. M. Whaley, G. Herrera, S. M. Klauck, A. A. Sandberg, D. W. Yandell and B. R. Seizinger, “Cytogenetic and Molecular Studies of a Familial Renal Cell Carcinoma,” Cancer Genetics and Cytogenetics, Vol. 63, No. 1, 1992, pp. 25-31. doi:10.1016/0165-4608(92)90059-H

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