Telomere Length and Parkinson’s Disease Traits: A Mendelian Randomization Study ()
1. Introduction
Aging is the leading risk factor for Parkinson’s Disease (PD), the second most common age-related neurodegenerative disease in the United States after Alzheimer’s Disease [1]. It remains unclear which age-related changes in cell function specifically contribute to risk of PD; the underlying mechanisms of neurodegeneration and biological aging are closely related, and neuronal cell death is influenced by a wide range of interacting genetic, environmental, and behavioral factors [2]. Measuring the effects of aging and the specific biological pathways impacted by aging that in turn contribute to the risk of PD is challenging [3]. There is also a need to understand the role of aging in other PD-related phenotypes like onset age and severity, as their underlying biological mechanisms are not well understood.
Telomeres are comprised of repeat sequences of DNA that cap the ends of chromosomes in the cell nucleus. Their presence helps to maintain the structural integrity of the ends of chromosomes during cell replication. Telomeres shorten with each mitotic cell replication cycle, and with exposure to oxidative stress [4]. As such, telomere length (TL) is considered a biomarker of cellular aging. TL chronologically varies over time, between individuals, and across cell types. TL is also organism-specific. The rate of TL attrition varies by age, by organ, and with respect to behavioral and environmental factors. Risk of PD has demonstrated varying associations with TL [5]. However, the directionality of this relationship is inconsistent across existing observational studies, which may be affected by issues of confounding, reverse causality, and measurement error [4] [5].
Mendelian randomization (MR) is a robust framework for causal analysis that utilizes genetic data for the construction of instrumental variables. Under the foundational assumptions of 1) instrument strength, 2) independence of the instrument and the outcome, and 3) exclusion—that the instrument is only associated with the outcome via its association with the exposure—it is possible to mitigate the effects of unmeasured confounding, and identify directionality of effect between the exposure and the outcome of the study. Prior investigations have demonstrated a null relationship between leukocyte TL and PD risk using an MR approach [6]. However, an updated genome-wide association study (GWAS) for leukocyte TL provides the opportunity to create stronger genetic instruments that capture a broader amount of variation in the exposure phenotype. Stronger genetic instruments in MR-based approaches may expose subtle relationships between exposures and outcomes that were not detectable in analyses with other genetic instruments. In addition, exploring multiple outcomes or characteristics of a single disease using MR approaches may reveal underlying genetic architecture of these complex phenotypes. Here, we conduct bidirectional MR analysis to investigate the effects of leukocyte TL as a measure of cellular aging on PD risk and other PD-related phenotypes.
2. Methods
2.1. Samples
Summary statistics for TL were obtained from the UK Biobank’s 2021 GWAS of leukocyte TL (Table 1) [7]. The four PD-related outcomes of interest included PD risk [8], age at onset (AAO) [9], binary motor subtype (BMS; categorized as either the tremor-dominant (TD) or the postural instability/gait difficulty (PIGD) subtype), and continuous motor subtype (CMS; a ratio of TD and PIGD scores from the Unified Parkinson’s Disease Rating Scale (UPDRS)) [10]. Summary statistics for all four PD-related outcomes were obtained from the International Parkinson Disease Genomics Consortium (IPDGC) (Table 1).
Table 1. Description of summary statistics utilized for genetic instruments in 2-sample Mendelian randomization.
|
Phenotype |
Sample Size |
Authors |
nSNPs (trait)a |
h2 (trait) |
h2 (instrument) |
Exposure |
Telomere Length |
472,147 cases |
Codd et al. 2021 |
197 |
0.08 |
0.05 |
Outcomes |
Risk |
37,700 cases 1,400,000 controls |
Nalls et al. 2019 |
90 |
0.27 |
0.16 |
Age at Onset |
17,415 cases |
Blauwendraat et al. 2016 |
2 |
0.11 |
NA |
Binary Disease Subtype |
3,212 cases |
Alfradique-Dunham et al. 2021 |
31 |
NA |
NA |
Continuous Disease Subtype |
3,212 cases |
Alfradique-Dunham et al. 2021 |
7 |
NA |
NA |
a. nSNP: number of SNPs contained in the genetic instrument after clumping; h2: narrow-sense heritability.
2.2. Mendelian Randomization
2-sample Mendelian randomization (2SMR) was used to investigate the relationship between TL and each PD-related outcome, using the R package TwoSampleMR. The TL genetic instrument was constructed using GWAS independent significant signals (p < 5.0 × 10−8) from Codd et al. 2021, clumped for linkage disequilibrium (LD) at a threshold of r2 < 0.05. Summary statistics for each SNP in the TL instrument were extracted from the four outcome datasets where available. F-statistics were calculated for each genetic instrumental variable (Supplementary Tables A1(a)-(d)). Associations between exposure and outcome were calculated via inverse-variance weighted meta-analysis, weighted median, simple model, weighted mode, and MR-PRESSO approaches. The MR-Egger intercept test and MR-PRESSO global test were used to detect the presence of directional horizontal pleiotropy.
To investigate the possibility of reverse causality, bidirectional MR was employed to investigate the effects of each PD-related phenotype on TL. Instruments for PD Risk and AAO were constructed using significant independent signals from their respective GWAS. Notably, for the BMS and CMS disease outcomes, no individual SNPs cleared a genome-wide significance p-value threshold of 5.0 × 10−8; genetic instruments for these exposures were instead constructed from SNPs with a suggestive association p-value threshold of 1.0 × 10−5. For all instruments, LD clumping was performed at a threshold of r2 < 0.05. F-statistics were calculated for each genetic instrumental variable (Supplementary Tables A2-A5).
2.3. Ethics Statement
This study was approved by the Case Western Reserve ethics board as non-human subjects research. All data are aggregate summary statistics, with patient consent obtained from the original genome-wide association analyses.
3. Results
In 2SMR analysis, TL did not appear to have a significant association with any of the four PD-related outcomes (p > 0.05) (Table 2). Results of the Egger intercept test and MR-PRESSO test did not indicate the presence of horizontal pleiotropy (p > 0.05 for all models).
MR analysis in the reverse direction did not reveal significant causal effects of any of the four PD-related phenotypes on TL (Table 2). Similarly, there were null results for the Egger intercept test and MR-PRESSO for all models, demonstrating a lack of horizontal pleiotropy. Of note, the Egger intercept test could not be performed for the investigation of the effects of PD AAO on TL; only two genetic variants were incorporated into the genetic instrument, which is not sufficient to perform an Egger intercept test.
Table 2. Results for bidirectional Mendelian randomization between Telomere Length and PD traits.
Exposure |
Outcome |
nSNPa |
BETA |
SE |
p |
Egger Test
p-value |
MR-PRESSO p (Global) |
Telomere Length |
PD Risk |
118 |
0.148 |
0.086 |
0.086 |
0.568 |
0.109 |
PD AAO |
108 |
0.746 |
0.528 |
0.158 |
0.590 |
0.213 |
PD Binary Disease Subtype |
118 |
0.355 |
0.262 |
0.175 |
0.187 |
0.244 |
PD Continuous
Disease Subtype |
118 |
−0.109 |
0.096 |
0.259 |
0.162 |
0.485 |
PD Risk |
Telomere Length |
84 |
0.002 |
0.005 |
0.732 |
0.926 |
0.941 |
PD AAO |
2 |
−0.002 |
0.004 |
0.566 |
- |
- |
PD Binary Disease Subtype |
29 |
−0.003 |
0.003 |
0.387 |
0.874 |
0.297 |
PD Continuous Disease Subtype |
6 |
−0.006 |
0.005 |
0.217 |
0.371 |
0.206 |
a. nSNP: number of SNPs contained in the genetic instrument after clumping for LD, extracting from the outcome dataset, and data harmonization.
4. Discussion
In this study, we applied bidirectional Mendelian randomization (MR) to examine the potential causal relationship between telomere length (TL)—a marker of cellular aging—and multiple Parkinson’s disease (PD)-related phenotypes, including disease risk, age at onset (AAO), and two motor subtypes: binary motor subtype (BMS) and continuous motor subtype (CMS). Despite using a large and updated genome-wide association study (GWAS) for TL to create a strong genetic instrument, our findings were null across all outcomes and directions, and MR-Egger intercepts did not suggest directional pleiotropy. These results are consistent with earlier MR studies investigating TL and PD risk, that used a different set of genetic instruments [6]. Our work expands on prior work by being the first to evaluate PD AAO and motor subtypes via MR.
Our findings offer several key implications. First, while previous observational studies have reported conflicting associations between TL and PD risk [5] [11] [12]—ranging from inverse to positive relationships—our MR results suggest that TL, as genetically determined in leukocytes, is unlikely to be a causal driver of PD onset or symptomology. Moreover, the directionality of the beta estimate for CMS hints at a possible trend toward more severe postural instability/gait difficulty (PIGD) motor symptoms in individuals with longer telomeres, though this result was not statistically significant. Future studies with larger sample sizes or more granular phenotype definitions may help clarify whether such trends reflect meaningful biological relationships.
Another key consideration is that telomere length was measured in leukocytes, which are often used as proxies for systemic aging due to their accessibility. However, TL varies by tissue type [13], and the correlations between leukocyte TL and telomere dynamics in neurons or glial cells are only modest. The lack of association observed here may reflect a disconnect between systemic TL and disease-relevant cellular aging in brain tissue. Studies have suggested that TL in substantia nigra neurons may be preserved even in PD [14], while stress responses or telomerase activity in glial populations might differ from those in circulating leukocytes. Thus, as GWAS of brain- or muscle-specific TL becomes available, future MR studies could better capture tissue-specific relevance to PD pathology. Nonetheless, null findings in MR may reflect biological complexity, including tissue- or cell-type–specific compensatory mechanisms. For example, increased telomerase activity in neural stem cells, or stress-adaptive responses, may modulate aging effects in the brain differently than in peripheral tissues. These subtleties, coupled with the lifelong accumulation of oxidative and inflammatory insults, underscore the complexity of teasing apart causal versus correlative signals in neurodegenerative disease.
Our findings contrast with several observational studies reporting associations between shorter TL and PD risk. These discrepancies could stem from key limitations in observational designs, including residual confounding, measurement error, and reverse causation. For instance, observational studies may fail to account for shared environmental exposures (e.g., smoking, inflammation) that influence both TL and neurodegeneration. Additionally, survival bias could distort associations if individuals with shorter TL and more severe PD are underrepresented in aging cohorts due to earlier mortality. Mendelian randomization helps address some of these issues but may miss effects driven by non-genetic or later-life processes. Together, these methodological differences may explain the inconsistent findings across studies.
There are strengths and limitations to acknowledge. Mendelian randomization is a robust framework for causal analysis, capable of circumventing issues of reverse causality and unmeasured confounding when exploring the relationship between exposures and outcomes. A key limitation was the comparatively small sample size of the GWAS cohorts for PD AAO, BMS, and CMS. Smaller sample sizes can lead to weaker GWAS associations, which can hinder the ability of 2SMR to detect exposure-outcome associations. Another concern is the modest heritability explained by the instruments, which is a consistent concern across chronic phenotypes whose genetic architecture is yet to be fully discerned. A final limitation is that we were unable to evaluate horizontal pleiotropy for the AAO analyses.
5. Conclusion
Using two-sample MR and robust genetic instruments, we found no evidence that leukocyte TL causally influences the risk of PD or related clinical features such as AAO or motor subtype. Nor do these PD traits influence leukocyte TL. Our findings highlight several key areas for further investigation. Future MR studies should explore TL in brain or muscle tissues once such data become available. In addition, other biomarkers of cellular aging may offer deeper insight into the biological links between aging and PD. These include epigenetic clocks, mitochondrial DNA copy numbers, cellular senescence markers, oxidative stress biomarkers, and pro-inflammatory cytokines. Integration of transcriptomic or epigenetic data could reveal novel intermediate mechanisms that explain how cellular aging intersects with PD neurodegeneration. Genetic instruments for these biomarkers are emerging and offer exciting opportunities for future research aimed at understanding aging-related vulnerability to PD. Also, to overcome current limitations, future MR studies would benefit from improved genetic instruments for PD-related phenotypes such as age at onset and motor subtype, as well as larger sample sizes that enhance statistical power.
Supplementary Tables
Table A1. (a) Variants used in the genetic instrument for Telomere Length used for PD Risk MR; (b) Variants used in the genetic instrument for Telomere Length used for PD AAO MR; (c) Variants used in the genetic instrument for Telomere Length used for PD Binary Disease Subtype MR; (d) Variants used in the genetic instrument for Telomere Length used for PD Continuous Disease Subtype MR.
(a)
rsID |
CHR |
BP |
A1 |
A2 |
EAF |
BETA |
SE |
pval |
R2 |
F-Statistic |
rs138895564 |
5 |
1.30E+06 |
C |
T |
0.990903 |
−0.835 |
0.010969 |
1.10E−59 |
0.012578 |
50.95611 |
rs183553155 |
16 |
7.40E+07 |
G |
A |
0.989437 |
−0.931 |
0.010204 |
3.10E−12 |
0.018136 |
73.88732 |
rs115451758 |
5 |
1.30E+06 |
G |
A |
0.989626 |
1.088 |
0.009949 |
6.70E−17 |
0.024289 |
99.58028 |
rs139795227 |
1 |
9.30E+07 |
A |
C |
0.985979 |
−0.942 |
0.008673 |
6.70E−12 |
0.024522 |
100.561 |
rs146546514 |
3 |
1.70E+08 |
C |
A |
0.983095 |
−0.923 |
0.008418 |
2.30E−22 |
0.028324 |
116.6052 |
rs144204502 |
17 |
7.60E+07 |
C |
T |
0.987438 |
1.106 |
0.008929 |
3.40E−28 |
0.030362 |
125.257 |
rs33987166 |
5 |
1.30E+06 |
T |
C |
0.975189 |
−0.907 |
0.006633 |
8.00E−50 |
0.039778 |
165.7125 |
rs78491606 |
3 |
7.30E+07 |
A |
C |
0.981567 |
1.079 |
0.007398 |
1.90E−24 |
0.042127 |
175.9286 |
rs79717857 |
5 |
1.30E+06 |
C |
A |
0.973921 |
−0.950 |
0.006633 |
3.80E−15 |
0.045872 |
192.3205 |
rs154979 |
6 |
3.30E+07 |
C |
A |
0.971166 |
−0.957 |
0.006122 |
1.70E−13 |
0.051287 |
216.2527 |
rs138061125 |
7 |
1.60E+08 |
G |
A |
0.969815 |
−0.958 |
0.005867 |
2.60E−13 |
0.053723 |
227.1058 |
rs182059586 |
16 |
1.50E+07 |
T |
C |
0.97489 |
1.059 |
0.006633 |
4.90E−17 |
0.054871 |
232.2397 |
rs141379009 |
11 |
1.10E+08 |
T |
G |
0.974488 |
1.096 |
0.006378 |
8.70E−48 |
0.059767 |
254.2795 |
rs35640778 |
20 |
6.20E+07 |
G |
A |
0.979243 |
1.232 |
0.007143 |
9.60E−195 |
0.061748 |
263.2608 |
rs115251750 |
5 |
1.30E+06 |
G |
A |
0.964935 |
−0.965 |
0.005357 |
4.50E−11 |
0.06297 |
268.822 |
rs61748181 |
5 |
1.30E+06 |
C |
T |
0.971072 |
1.061 |
0.005867 |
2.80E−23 |
0.063219 |
269.9568 |
rs80324517 |
6 |
204031 |
G |
A |
0.951741 |
−0.961 |
0.004592 |
1.80E−17 |
0.084798 |
370.6399 |
rs9952504 |
18 |
657458 |
A |
G |
0.958066 |
1.054 |
0.005357 |
2.40E−24 |
0.089336 |
392.4231 |
rs76219171 |
16 |
5.00E+07 |
G |
A |
0.941567 |
−0.965 |
0.004082 |
7.80E−17 |
0.102393 |
456.3202 |
rs3093888 |
14 |
2.10E+07 |
G |
A |
0.94869 |
1.029 |
0.004592 |
1.50E−10 |
0.103168 |
460.1719 |
rs55765053 |
20 |
6.20E+07 |
C |
T |
0.933938 |
−0.978 |
0.004082 |
3.6E−08 |
0.118084 |
535.6108 |
rs17185038 |
1 |
2.80E+07 |
C |
G |
0.93539 |
1.026 |
0.004082 |
2.10E−10 |
0.127323 |
583.6303 |
rs11769630 |
7 |
5.00E+07 |
T |
A |
0.927773 |
1.026 |
0.003827 |
4.30E−11 |
0.141174 |
657.5597 |
rs111811424 |
18 |
674579 |
C |
T |
0.913521 |
−0.962 |
0.003571 |
1.40E−27 |
0.146145 |
684.6772 |
rs11579626 |
1 |
1.50E+08 |
A |
C |
0.915118 |
−0.973 |
0.003827 |
1.30E−13 |
0.147187 |
690.4035 |
rs34003787 |
16 |
7.30E+07 |
C |
T |
0.912293 |
1.024 |
0.003571 |
1.90E−11 |
0.167898 |
807.1491 |
rs72801474 |
5 |
1.30E+08 |
G |
A |
0.911707 |
1.021 |
0.003571 |
3.90E−09 |
0.1679 |
807.1652 |
rs76666449 |
12 |
1.20E+08 |
T |
C |
0.899375 |
−0.970 |
0.003316 |
8.20E−19 |
0.170459 |
821.9904 |
rs73581419 |
14 |
2.20E+07 |
C |
T |
0.893395 |
−0.977 |
0.003061 |
1.30E−12 |
0.181917 |
889.5328 |
rs5030755 |
17 |
1.80E+06 |
A |
G |
0.886658 |
−0.970 |
0.003316 |
6.20E−22 |
0.189286 |
933.9801 |
rs2259797 |
20 |
6.20E+07 |
T |
C |
0.907332 |
1.084 |
0.003571 |
1.30E−116 |
0.197734 |
985.937 |
rs3761121 |
20 |
6.20E+07 |
T |
C |
0.878032 |
−0.980 |
0.003061 |
7.30E−11 |
0.205785 |
1036.483 |
rs4919611 |
10 |
1.00E+08 |
C |
A |
0.112898 |
1.026 |
0.003316 |
5.10E−16 |
0.210995 |
1069.743 |
rs79824385 |
18 |
4.20E+07 |
T |
A |
0.870276 |
−0.969 |
0.003061 |
7.90E−27 |
0.211793 |
1074.876 |
rs7012816 |
8 |
7.10E+07 |
G |
A |
0.870003 |
−0.982 |
0.002806 |
3E−09 |
0.218197 |
1116.447 |
rs12615793 |
2 |
5.40E+07 |
G |
A |
0.859605 |
−0.956 |
0.002806 |
1.80E−55 |
0.220594 |
1132.182 |
rs28711261 |
16 |
6.80E+07 |
A |
G |
0.867449 |
−0.983 |
0.003061 |
1.6E−08 |
0.222275 |
1143.275 |
rs11866592 |
16 |
7.50E+07 |
G |
A |
0.85802 |
−0.966 |
0.002806 |
1.30E−33 |
0.227172 |
1175.863 |
rs12613375 |
2 |
5.90E+07 |
C |
T |
0.862288 |
−0.982 |
0.002806 |
9.10E−10 |
0.229097 |
1188.791 |
rs4724 |
17 |
7.80E+06 |
G |
A |
0.883402 |
1.057 |
0.003061 |
9.80E−69 |
0.22996 |
1194.605 |
rs9990898 |
4 |
1.60E+08 |
T |
C |
0.857338 |
−0.970 |
0.002806 |
3.00E−26 |
0.230374 |
1197.398 |
rs762679 |
8 |
4.90E+07 |
T |
A |
0.143499 |
−0.969 |
0.003061 |
1.40E−27 |
0.231036 |
1201.878 |
rs1291143 |
20 |
3.60E+07 |
A |
C |
0.150974 |
−0.952 |
0.002806 |
1.80E−69 |
0.23243 |
1211.323 |
rs12572897 |
10 |
9.60E+07 |
G |
A |
0.869908 |
1.033 |
0.003061 |
3.60E−27 |
0.241295 |
1272.218 |
rs11557154 |
9 |
3.40E+07 |
C |
T |
0.86997 |
1.035 |
0.002806 |
1.10E−30 |
0.242164 |
1278.264 |
rs1985369 |
7 |
1.60E+08 |
A |
G |
0.131822 |
1.031 |
0.003061 |
3.60E−25 |
0.24353 |
1287.796 |
rs1609812 |
11 |
5.20E+06 |
G |
A |
0.160214 |
−0.954 |
0.002806 |
3.90E−65 |
0.244949 |
1297.731 |
rs12369950 |
12 |
2.50E+07 |
T |
C |
0.859325 |
1.018 |
0.003061 |
8.00E−10 |
0.250633 |
1337.921 |
rs6030416 |
20 |
3.60E+07 |
T |
G |
0.135696 |
1.035 |
0.003061 |
1.50E−30 |
0.25107 |
1341.036 |
rs429358 |
19 |
4.50E+07 |
T |
C |
0.846031 |
−0.983 |
0.002806 |
3.80E−10 |
0.251816 |
1346.359 |
rs1957937 |
14 |
9.60E+07 |
A |
T |
0.83982 |
−0.979 |
0.002551 |
1.90E−14 |
0.257979 |
1390.765 |
rs932002 |
1 |
2.30E+08 |
C |
T |
0.849157 |
1.041 |
0.002806 |
7.30E−47 |
0.277515 |
1536.539 |
rs1332941 |
13 |
4.20E+07 |
A |
G |
0.179534 |
−0.974 |
0.002806 |
5.90E−21 |
0.279675 |
1553.143 |
rs9419958 |
10 |
1.10E+08 |
T |
C |
0.13861 |
1.084 |
0.003061 |
2.60E−167 |
0.280789 |
1561.743 |
rs12941945 |
17 |
4.10E+07 |
A |
G |
0.832437 |
1.026 |
0.002551 |
3.00E−22 |
0.293862 |
1664.711 |
rs41269079 |
1 |
4.50E+07 |
T |
A |
0.811009 |
−0.985 |
0.002551 |
1.70E−09 |
0.297487 |
1693.945 |
rs61818036 |
1 |
1.50E+08 |
G |
A |
0.176391 |
1.019 |
0.002551 |
2.10E−12 |
0.301808 |
1729.185 |
rs3768321 |
1 |
4.00E+07 |
G |
T |
0.810305 |
1.016 |
0.002551 |
1.10E−09 |
0.317418 |
1860.214 |
rs8088824 |
18 |
4.20E+07 |
C |
T |
0.236812 |
−0.974 |
0.002296 |
8.10E−28 |
0.343148 |
2089.779 |
rs4743037 |
9 |
1.10E+08 |
C |
T |
0.769126 |
−0.985 |
0.002296 |
5.10E−10 |
0.344646 |
2103.7 |
rs1907702 |
12 |
8.90E+07 |
G |
A |
0.233229 |
−0.985 |
0.002551 |
5.90E−10 |
0.347096 |
2126.599 |
rs2056726 |
7 |
1.00E+08 |
G |
A |
0.785624 |
1.023 |
0.002551 |
7.90E−21 |
0.352694 |
2179.59 |
rs1727302 |
12 |
1.20E+08 |
G |
A |
0.259019 |
−0.980 |
0.002296 |
8.40E−18 |
0.368805 |
2337.325 |
rs1023767 |
8 |
9.60E+07 |
G |
A |
0.762405 |
1.018 |
0.002296 |
5.00E−15 |
0.375567 |
2405.956 |
rs7705526 |
5 |
1.30E+06 |
C |
A |
0.673422 |
−0.925 |
0.002296 |
2.40E−282 |
0.376317 |
2413.662 |
rs2303262 |
16 |
8.20E+07 |
C |
T |
0.222887 |
1.048 |
0.002551 |
2.90E−85 |
0.38056 |
2457.586 |
rs2069536 |
17 |
7.40E+07 |
A |
G |
0.249795 |
1.015 |
0.002296 |
1.80E−10 |
0.386209 |
2517.027 |
rs13230646 |
7 |
2.40E+07 |
T |
C |
0.751055 |
1.017 |
0.002296 |
8.90E−14 |
0.386875 |
2524.11 |
rs13129697 |
4 |
9.90E+06 |
T |
G |
0.720832 |
−0.983 |
0.002296 |
1.50E−14 |
0.389013 |
2546.931 |
rs8105767 |
19 |
2.20E+07 |
A |
G |
0.70533 |
−0.968 |
0.002041 |
2.50E−50 |
0.38913 |
2548.19 |
rs75664430 |
17 |
8.10E+06 |
C |
G |
0.751972 |
1.024 |
0.002296 |
3.60E−24 |
0.391362 |
2572.202 |
rs7218033 |
17 |
1.70E+06 |
C |
T |
0.746597 |
1.023 |
0.002296 |
1.00E−22 |
0.396192 |
2624.776 |
rs35671754 |
2 |
2.20E+08 |
G |
T |
0.704253 |
−0.988 |
0.002296 |
1.4E−08 |
0.406683 |
2741.921 |
rs4758644 |
12 |
1.20E+08 |
A |
C |
0.269222 |
1.017 |
0.002296 |
2.70E−13 |
0.407091 |
2746.566 |
rs3891167 |
18 |
658423 |
A |
G |
0.746565 |
1.044 |
0.002296 |
1.20E−70 |
0.412395 |
2807.462 |
rs11190184 |
10 |
1.00E+08 |
G |
C |
0.71576 |
1.017 |
0.002296 |
1.10E−14 |
0.420968 |
2908.248 |
rs939916 |
11 |
202253 |
G |
A |
0.330033 |
−0.976 |
0.002041 |
6.60E−29 |
0.421497 |
2914.573 |
rs35601737 |
19 |
1.30E+07 |
C |
G |
0.704101 |
1.014 |
0.002041 |
1.90E−10 |
0.428518 |
2999.519 |
rs13062095 |
3 |
1.00E+08 |
T |
C |
0.672157 |
−0.986 |
0.002041 |
9.70E−11 |
0.428555 |
2999.975 |
rs17677991 |
15 |
4.20E+07 |
C |
G |
0.657877 |
−0.978 |
0.002041 |
4.40E−26 |
0.430773 |
3027.247 |
rs10840270 |
11 |
9.60E+06 |
C |
G |
0.344316 |
−0.986 |
0.002296 |
1.30E−11 |
0.439058 |
3131.043 |
rs2293607 |
3 |
1.70E+08 |
T |
C |
0.757553 |
1.099 |
0.002296 |
<1.0E−314 |
0.44331 |
3185.512 |
rs111527438 |
17 |
2.90E+07 |
T |
C |
0.648749 |
−0.987 |
0.002296 |
3.10E−09 |
0.444051 |
3195.091 |
rs7790856 |
7 |
1.20E+08 |
C |
T |
0.710861 |
1.045 |
0.002296 |
1.80E−87 |
0.448889 |
3258.263 |
rs66731853 |
1 |
2.10E+07 |
G |
A |
0.682696 |
1.018 |
0.002041 |
1.50E−16 |
0.449125 |
3261.373 |
rs6565924 |
18 |
7.50E+07 |
A |
G |
0.638554 |
−0.987 |
0.002041 |
2.90E−10 |
0.449759 |
3269.729 |
rs869785 |
3 |
2.40E+07 |
T |
C |
0.327529 |
1.015 |
0.002041 |
4.40E−12 |
0.453923 |
3325.171 |
rs11556924 |
7 |
1.30E+08 |
C |
T |
0.624146 |
−0.987 |
0.002041 |
6.80E−10 |
0.457134 |
3368.503 |
rs2276182 |
18 |
5.20E+07 |
C |
G |
0.596773 |
−0.977 |
0.002041 |
2.80E−30 |
0.459633 |
3402.579 |
rs2811491 |
3 |
1.30E+08 |
C |
A |
0.39223 |
−0.985 |
0.002041 |
8.90E−14 |
0.462681 |
3444.565 |
rs4530278 |
19 |
3.40E+07 |
G |
T |
0.40185 |
−0.986 |
0.002041 |
1.50E−11 |
0.467459 |
3511.372 |
rs10845387 |
12 |
1.20E+07 |
G |
A |
0.647334 |
1.014 |
0.002041 |
1.50E−11 |
0.46955 |
3540.984 |
rs1980240 |
15 |
5.70E+07 |
A |
C |
0.594757 |
−0.987 |
0.002041 |
2.20E−10 |
0.469671 |
3542.693 |
rs11646283 |
16 |
9.10E+06 |
T |
C |
0.589297 |
−0.985 |
0.002041 |
5.30E−14 |
0.469746 |
3543.768 |
rs6669563 |
1 |
3.20E+07 |
G |
A |
0.562232 |
−0.982 |
0.002041 |
2.10E−19 |
0.474848 |
3617.063 |
rs762810 |
14 |
6.60E+07 |
C |
A |
0.647514 |
1.020 |
0.002041 |
4.30E−22 |
0.475109 |
3620.837 |
rs5742915 |
15 |
7.40E+07 |
T |
C |
0.554171 |
−0.981 |
0.002041 |
1.60E−21 |
0.475706 |
3629.527 |
rs56178008 |
2 |
2.90E+07 |
T |
A |
0.562503 |
−0.986 |
0.002041 |
9.70E−13 |
0.478597 |
3671.822 |
rs4498805 |
1 |
1.10E+08 |
G |
T |
0.453368 |
−0.985 |
0.002041 |
5.70E−14 |
0.481002 |
3707.382 |
rs8114049 |
20 |
6.20E+07 |
C |
T |
0.330913 |
1.043 |
0.002041 |
1.40E−85 |
0.481623 |
3716.611 |
rs10774625 |
12 |
1.10E+08 |
A |
G |
0.476428 |
−0.984 |
0.002041 |
1.70E−15 |
0.483177 |
3739.816 |
rs4742448 |
9 |
826585 |
C |
G |
0.530842 |
−0.985 |
0.002041 |
6.40E−14 |
0.483377 |
3742.805 |
rs1143697 |
17 |
7.60E+07 |
T |
C |
0.536558 |
−0.986 |
0.002041 |
5.50E−12 |
0.483595 |
3746.081 |
rs4695407 |
4 |
4.90E+07 |
A |
G |
0.492157 |
−0.986 |
0.002041 |
1.50E−12 |
0.486075 |
3783.455 |
rs2293579 |
11 |
4.70E+07 |
G |
A |
0.613726 |
1.013 |
0.002041 |
3.30E−10 |
0.486622 |
3791.753 |
rs6590343 |
11 |
1.30E+08 |
A |
G |
0.483615 |
−0.988 |
0.002041 |
1.50E−09 |
0.487619 |
3806.911 |
rs4731541 |
7 |
1.30E+08 |
C |
G |
0.375099 |
1.021 |
0.002041 |
1.40E−23 |
0.488908 |
3826.613 |
rs28502153 |
22 |
1.70E+07 |
C |
A |
0.622042 |
1.022 |
0.002041 |
1.20E−25 |
0.491363 |
3864.38 |
rs6776756 |
3 |
1.30E+08 |
G |
A |
0.402438 |
1.017 |
0.002041 |
1.10E−17 |
0.497597 |
3961.975 |
rs8102497 |
19 |
5.70E+07 |
G |
A |
0.568172 |
1.015 |
0.002041 |
1.40E−13 |
0.505649 |
4091.665 |
rs871134 |
4 |
7.00E+06 |
C |
T |
0.430968 |
1.018 |
0.002041 |
1.70E−19 |
0.508448 |
4137.732 |
rs8053839 |
16 |
4.80E+07 |
G |
T |
0.458038 |
1.014 |
0.002041 |
1.00E−11 |
0.510576 |
4173.124 |
rs12884911 |
14 |
6.50E+07 |
C |
T |
0.49667 |
1.013 |
0.002041 |
2.90E−11 |
0.513148 |
4216.294 |
rs9398196 |
6 |
1.10E+08 |
A |
G |
0.47995 |
1.014 |
0.002041 |
9.50E−13 |
0.513371 |
4220.065 |
rs41272947 |
3 |
1.60E+08 |
G |
A |
0.458021 |
1.017 |
0.002041 |
5.90E−18 |
0.513646 |
4224.712 |
rs2306646 |
8 |
2.20E+07 |
G |
C |
0.440525 |
1.021 |
0.002041 |
3.30E−25 |
0.514069 |
4231.876 |
rs10112752 |
8 |
7.40E+07 |
G |
A |
0.569631 |
1.029 |
0.002041 |
9.50E−46 |
0.519581 |
4326.331 |
rs611646 |
11 |
1.10E+08 |
T |
A |
0.591315 |
1.038 |
0.002041 |
3.50E−73 |
0.520446 |
4341.335 |
SNP: SNP rsID; CHR: Chromosome of SNP; BP: Base-pair location of SNP (hg19); A1: Effect allele; A2: Other allele; EAF: Effect allele frequency; BETA: SNP effect estimate; SE: SE of SNP effect estimate; pval: P-value for effect allele on Telomere length.
(b)
rsID |
CHR |
BP |
A1 |
A2 |
EAF |
BETA |
SE |
pval |
R2 |
F-Statistic |
rs66731853 |
1 |
2.10E+07 |
G |
A |
0.682696 |
1.018 |
0.002041 |
1.50E−16 |
0.449125281 |
354.0479 |
rs17185038 |
1 |
2.80E+07 |
C |
G |
0.93539 |
1.026 |
0.004082 |
2.10E−10 |
0.12732268 |
63.35771 |
rs6669563 |
1 |
3.20E+07 |
G |
A |
0.562232 |
−0.982 |
0.002041 |
2.10E−19 |
0.474848387 |
392.6609 |
rs3768321 |
1 |
4.00E+07 |
G |
T |
0.810305 |
1.016 |
0.002551 |
1.10E−09 |
0.317418198 |
201.941 |
rs41269079 |
1 |
4.50E+07 |
T |
A |
0.811009 |
−0.985 |
0.002551 |
1.70E−09 |
0.297486977 |
183.8912 |
rs139795227 |
1 |
9.30E+07 |
A |
C |
0.985979 |
−0.942 |
0.008673 |
6.70E−12 |
0.024522306 |
10.9167 |
rs4498805 |
1 |
1.10E+08 |
G |
T |
0.453368 |
−0.985 |
0.002041 |
5.70E−14 |
0.481002215 |
402.4658 |
rs11579626 |
1 |
1.50E+08 |
A |
C |
0.915118 |
−0.973 |
0.003827 |
1.30E−13 |
0.147187455 |
74.94879 |
rs61818036 |
1 |
1.50E+08 |
G |
A |
0.176391 |
1.019 |
0.002551 |
2.10E−12 |
0.301807962 |
187.7168 |
rs932002 |
1 |
2.30E+08 |
C |
T |
0.849157 |
1.041 |
0.002806 |
7.30E−47 |
0.277515158 |
166.8036 |
rs56178008 |
2 |
2.90E+07 |
T |
A |
0.562503 |
−0.986 |
0.002041 |
9.70E−13 |
0.47859667 |
398.6055 |
rs12615793 |
2 |
5.40E+07 |
G |
A |
0.859605 |
−0.956 |
0.002806 |
1.80E−55 |
0.220594188 |
122.9073 |
rs12613375 |
2 |
5.90E+07 |
C |
T |
0.862288 |
−0.982 |
0.002806 |
9.10E−10 |
0.229097063 |
129.0527 |
rs35671754 |
2 |
2.20E+08 |
G |
T |
0.704253 |
−0.988 |
0.002296 |
1.4E−08 |
0.406682965 |
297.6573 |
rs869785 |
3 |
2.40E+07 |
T |
C |
0.327529 |
1.015 |
0.002041 |
4.40E−12 |
0.453922959 |
360.9738 |
rs78491606 |
3 |
7.30E+07 |
A |
C |
0.981567 |
1.079 |
0.007398 |
1.90E−24 |
0.042126825 |
19.09845 |
rs13062095 |
3 |
1.00E+08 |
T |
C |
0.672157 |
−0.986 |
0.002041 |
9.70E−11 |
0.428554827 |
325.6711 |
rs2811491 |
3 |
1.30E+08 |
C |
A |
0.39223 |
−0.985 |
0.002041 |
8.90E−14 |
0.462680534 |
373.935 |
rs6776756 |
3 |
1.30E+08 |
G |
A |
0.402438 |
1.017 |
0.002041 |
1.10E−17 |
0.497597239 |
430.1039 |
rs41272947 |
3 |
1.60E+08 |
G |
A |
0.458021 |
1.017 |
0.002041 |
5.90E−18 |
0.513645938 |
458.6261 |
rs2293607 |
3 |
1.70E+08 |
T |
C |
0.757553 |
1.099 |
0.002296 |
<1.0E−314 |
0.44330966 |
345.8127 |
rs871134 |
4 |
7.00E+06 |
C |
T |
0.430968 |
1.018 |
0.002041 |
1.70E−19 |
0.508447728 |
449.1837 |
rs13129697 |
4 |
9.90E+06 |
T |
G |
0.720832 |
−0.983 |
0.002296 |
1.50E−14 |
0.389012608 |
276.4896 |
rs4695407 |
4 |
4.90E+07 |
A |
G |
0.492157 |
−0.986 |
0.002041 |
1.50E−12 |
0.486074555 |
410.7241 |
rs9990898 |
4 |
1.60E+08 |
T |
C |
0.857338 |
−0.970 |
0.002806 |
3.00E−26 |
0.2303736 |
129.9871 |
rs33987166 |
5 |
1.30E+06 |
T |
C |
0.975189 |
−0.907 |
0.006633 |
8.00E−50 |
0.039777853 |
17.98941 |
rs7705526 |
5 |
1.30E+06 |
C |
A |
0.673422 |
−0.925 |
0.002296 |
2.40E−282 |
0.376317385 |
262.0222 |
rs79717857 |
5 |
1.30E+06 |
C |
A |
0.973921 |
−0.950 |
0.006633 |
3.80E−15 |
0.045871889 |
20.87793 |
rs115251750 |
5 |
1.30E+06 |
G |
A |
0.964935 |
−0.965 |
0.005357 |
4.50E−11 |
0.062969855 |
29.18277 |
rs61748181 |
5 |
1.30E+06 |
C |
T |
0.971072 |
1.061 |
0.005867 |
2.80E−23 |
0.063218849 |
29.30595 |
rs115451758 |
5 |
1.30E+06 |
G |
A |
0.989626 |
1.088 |
0.009949 |
6.70E−17 |
0.024288954 |
10.81023 |
rs72801474 |
5 |
1.30E+08 |
G |
A |
0.911707 |
1.021 |
0.003571 |
3.90E−09 |
0.167900476 |
87.6242 |
rs80324517 |
6 |
204031 |
G |
A |
0.951741 |
−0.961 |
0.004592 |
1.80E−17 |
0.084797595 |
40.23591 |
rs154979 |
6 |
3.30E+07 |
C |
A |
0.971166 |
−0.957 |
0.006122 |
1.70E−13 |
0.051287372 |
23.47595 |
rs9398196 |
6 |
1.10E+08 |
A |
G |
0.47995 |
1.014 |
0.002041 |
9.50E−13 |
0.513371007 |
458.1216 |
rs13230646 |
7 |
2.40E+07 |
T |
C |
0.751055 |
1.017 |
0.002296 |
8.90E−14 |
0.386875438 |
274.0122 |
rs11769630 |
7 |
5.00E+07 |
T |
A |
0.927773 |
1.026 |
0.003827 |
4.30E−11 |
0.141173966 |
71.38333 |
rs2056726 |
7 |
1.00E+08 |
G |
A |
0.785624 |
1.023 |
0.002551 |
7.90E−21 |
0.352694305 |
236.6118 |
rs7790856 |
7 |
1.20E+08 |
C |
T |
0.710861 |
1.045 |
0.002296 |
1.80E−87 |
0.44888932 |
353.7104 |
rs11556924 |
7 |
1.30E+08 |
C |
T |
0.624146 |
−0.987 |
0.002041 |
6.80E−10 |
0.457134193 |
365.6778 |
rs4731541 |
7 |
1.30E+08 |
C |
G |
0.375099 |
1.021 |
0.002041 |
1.40E−23 |
0.48890839 |
415.4092 |
rs1985369 |
7 |
1.60E+08 |
A |
G |
0.131822 |
1.031 |
0.003061 |
3.60E−25 |
0.243530257 |
139.8005 |
rs2306646 |
8 |
2.20E+07 |
G |
C |
0.440525 |
1.021 |
0.002041 |
3.30E−25 |
0.514069229 |
459.4038 |
rs762679 |
8 |
4.90E+07 |
T |
A |
0.143499 |
−0.969 |
0.003061 |
1.40E−27 |
0.231036441 |
130.4734 |
rs7012816 |
8 |
7.10E+07 |
G |
A |
0.870003 |
−0.982 |
0.002806 |
3E−09 |
0.218197351 |
121.1992 |
rs10112752 |
8 |
7.40E+07 |
G |
A |
0.569631 |
1.029 |
0.002041 |
9.50E−46 |
0.519581492 |
469.6576 |
rs1023767 |
8 |
9.60E+07 |
G |
A |
0.762405 |
1.018 |
0.002296 |
5.00E−15 |
0.375567177 |
261.1857 |
rs11557154 |
9 |
3.40E+07 |
C |
T |
0.86997 |
1.035 |
0.002806 |
1.10E−30 |
0.242164155 |
138.7657 |
rs4743037 |
9 |
1.10E+08 |
C |
T |
0.769126 |
−0.985 |
0.002296 |
5.10E−10 |
0.344646348 |
228.3733 |
rs12572897 |
10 |
9.60E+07 |
G |
A |
0.869908 |
1.033 |
0.003061 |
3.60E−27 |
0.241295242 |
138.1094 |
rs11190184 |
10 |
1.00E+08 |
G |
C |
0.71576 |
1.017 |
0.002296 |
1.10E−14 |
0.420967557 |
3177.598 |
rs4919611 |
10 |
1.00E+08 |
C |
A |
0.112898 |
1.026 |
0.003316 |
5.10E−16 |
0.210995462 |
116.1291 |
rs9419958 |
10 |
1.10E+08 |
T |
C |
0.13861 |
1.084 |
0.003061 |
2.60E−167 |
0.280789 |
169.5396 |
rs939916 |
11 |
202253 |
G |
A |
0.330033 |
−0.976 |
0.002041 |
6.60E−29 |
0.421497147 |
316.4001 |
rs1609812 |
11 |
5.20E+06 |
G |
A |
0.160214 |
−0.954 |
0.002806 |
3.90E−65 |
0.244948852 |
140.8791 |
rs10840270 |
11 |
9.60E+06 |
C |
G |
0.344316 |
−0.986 |
0.002296 |
1.30E−11 |
0.439057642 |
339.8997 |
rs2293579 |
11 |
4.70E+07 |
G |
A |
0.613726 |
1.013 |
0.002041 |
3.30E−10 |
0.486621901 |
411.625 |
rs611646 |
11 |
1.10E+08 |
T |
A |
0.591315 |
1.038 |
0.002041 |
3.50E−73 |
0.520445648 |
471.2865 |
rs141379009 |
11 |
1.10E+08 |
T |
G |
0.974488 |
1.096 |
0.006378 |
8.70E−48 |
0.059766962 |
27.60407 |
rs6590343 |
11 |
1.30E+08 |
A |
G |
0.483615 |
−0.988 |
0.002041 |
1.50E−09 |
0.487618651 |
413.2705 |
rs10845387 |
12 |
1.20E+07 |
G |
A |
0.647334 |
1.014 |
0.002041 |
1.50E−11 |
0.469550439 |
384.4019 |
rs12369950 |
12 |
2.50E+07 |
T |
C |
0.859325 |
1.018 |
0.003061 |
8.00E−10 |
0.250633413 |
145.2419 |
rs1907702 |
12 |
8.90E+07 |
G |
A |
0.233229 |
−0.985 |
0.002551 |
5.90E−10 |
0.347095826 |
230.8593 |
rs10774625 |
12 |
1.10E+08 |
A |
G |
0.476428 |
−0.984 |
0.002041 |
1.70E−15 |
0.483177011 |
405.9867 |
rs76666449 |
12 |
1.20E+08 |
T |
C |
0.899375 |
−0.970 |
0.003316 |
8.20E−19 |
0.170458645 |
89.2336 |
rs1727302 |
12 |
1.20E+08 |
G |
A |
0.259019 |
−0.980 |
0.002296 |
8.40E−18 |
0.368805094 |
253.7353 |
rs4758644 |
12 |
1.20E+08 |
A |
C |
0.269222 |
1.017 |
0.002296 |
2.70E−13 |
0.407091485 |
298.1616 |
rs1332941 |
13 |
4.20E+07 |
A |
G |
0.179534 |
−0.974 |
0.002806 |
5.90E−21 |
0.279675214 |
168.606 |
rs3093888 |
14 |
2.10E+07 |
G |
A |
0.94869 |
1.029 |
0.004592 |
1.50E−10 |
0.103168095 |
49.95532 |
rs73581419 |
14 |
2.20E+07 |
C |
T |
0.893395 |
−0.977 |
0.003061 |
1.30E−12 |
0.181917107 |
96.56587 |
rs12884911 |
14 |
6.50E+07 |
C |
T |
0.49667 |
1.013 |
0.002041 |
2.90E−11 |
0.513147712 |
457.7123 |
rs762810 |
14 |
6.60E+07 |
C |
A |
0.647514 |
1.020 |
0.002041 |
4.30E−22 |
0.475108511 |
393.0707 |
rs1957937 |
14 |
9.60E+07 |
A |
T |
0.83982 |
−0.979 |
0.002551 |
1.90E−14 |
0.257978866 |
150.9786 |
rs17677991 |
15 |
4.20E+07 |
C |
G |
0.657877 |
−0.978 |
0.002041 |
4.40E−26 |
0.430772542 |
328.6318 |
rs1980240 |
15 |
5.70E+07 |
A |
C |
0.594757 |
−0.987 |
0.002041 |
2.20E−10 |
0.469670651 |
384.5875 |
rs5742915 |
15 |
7.40E+07 |
T |
C |
0.554171 |
−0.981 |
0.002041 |
1.60E−21 |
0.475706314 |
394.014 |
rs8053839 |
16 |
4.80E+07 |
G |
T |
0.458038 |
1.014 |
0.002041 |
1.00E−11 |
0.510576225 |
453.0258 |
rs76219171 |
16 |
5.00E+07 |
G |
A |
0.941567 |
−0.965 |
0.004082 |
7.80E−17 |
0.102392985 |
49.53719 |
rs28711261 |
16 |
6.80E+07 |
A |
G |
0.867449 |
−0.983 |
0.003061 |
1.6E−08 |
0.222275166 |
124.1116 |
rs183553155 |
16 |
7.40E+07 |
G |
A |
0.989437 |
−0.931 |
0.010204 |
3.10E−12 |
0.018135754 |
8.021057 |
rs11866592 |
16 |
7.50E+07 |
G |
A |
0.85802 |
−0.966 |
0.002806 |
1.30E−33 |
0.227171562 |
127.6493 |
rs2303262 |
16 |
8.20E+07 |
C |
T |
0.222887 |
1.048 |
0.002551 |
2.90E−85 |
0.380559519 |
266.7905 |
rs7218033 |
17 |
1.70E+06 |
C |
T |
0.746597 |
1.023 |
0.002296 |
1.00E−22 |
0.396191847 |
284.9404 |
rs5030755 |
17 |
1.80E+06 |
A |
G |
0.886658 |
−0.970 |
0.003316 |
6.20E−22 |
0.189286367 |
101.391 |
rs4724 |
17 |
7.80E+06 |
G |
A |
0.883402 |
1.057 |
0.003061 |
9.80E−69 |
0.229959771 |
129.6838 |
rs75664430 |
17 |
8.10E+06 |
C |
G |
0.751972 |
1.024 |
0.002296 |
3.60E−24 |
0.391361871 |
279.233 |
rs111527438 |
17 |
2.90E+07 |
T |
C |
0.648749 |
−0.987 |
0.002296 |
3.10E−09 |
0.444050752 |
346.8525 |
rs12941945 |
17 |
4.10E+07 |
A |
G |
0.832437 |
1.026 |
0.002551 |
3.00E−22 |
0.293861581 |
180.7176 |
rs2069536 |
17 |
7.40E+07 |
A |
G |
0.249795 |
1.015 |
0.002296 |
1.80E−10 |
0.38620912 |
273.2433 |
rs1143697 |
17 |
7.60E+07 |
T |
C |
0.536558 |
−0.986 |
0.002041 |
5.50E−12 |
0.483595014 |
406.6669 |
rs9952504 |
18 |
657458 |
A |
G |
0.958066 |
1.054 |
0.005357 |
2.40E−24 |
0.089336088 |
42.60065 |
rs3891167 |
18 |
658423 |
A |
G |
0.746565 |
1.044 |
0.002296 |
1.20E−70 |
0.41239514 |
304.7724 |
rs111811424 |
18 |
674579 |
C |
T |
0.913521 |
−0.962 |
0.003571 |
1.40E−27 |
0.146145087 |
74.32716 |
rs8088824 |
18 |
4.20E+07 |
C |
T |
0.236812 |
−0.974 |
0.002296 |
8.10E−28 |
0.343148355 |
226.8622 |
rs2276182 |
18 |
5.20E+07 |
C |
G |
0.596773 |
−0.977 |
0.002041 |
2.80E−30 |
0.459633019 |
369.377 |
rs6565924 |
18 |
7.50E+07 |
A |
G |
0.638554 |
−0.987 |
0.002041 |
2.90E−10 |
0.449758512 |
354.9551 |
rs35601737 |
19 |
1.30E+07 |
C |
G |
0.704101 |
1.014 |
0.002041 |
1.90E−10 |
0.428517635 |
325.6217 |
rs8105767 |
19 |
2.20E+07 |
A |
G |
0.70533 |
−0.968 |
0.002041 |
2.50E−50 |
0.389130112 |
276.6263 |
rs4530278 |
19 |
3.40E+07 |
G |
T |
0.40185 |
−0.986 |
0.002041 |
1.50E−11 |
0.467459327 |
381.1873 |
rs429358 |
19 |
4.50E+07 |
T |
C |
0.846031 |
−0.983 |
0.002806 |
3.80E−10 |
0.251816132 |
146.158 |
rs8102497 |
19 |
5.70E+07 |
G |
A |
0.568172 |
1.015 |
0.002041 |
1.40E−13 |
0.505649354 |
444.1828 |
rs1291143 |
20 |
3.60E+07 |
A |
C |
0.150974 |
−0.952 |
0.002806 |
1.80E−69 |
0.232430057 |
131.4988 |
rs55765053 |
20 |
6.20E+07 |
C |
T |
0.933938 |
−0.978 |
0.004082 |
3.6E−08 |
0.118083931 |
58.14481 |
rs3761121 |
20 |
6.20E+07 |
T |
C |
0.878032 |
−0.980 |
0.003061 |
7.30E−11 |
0.205785354 |
112.5185 |
rs8114049 |
20 |
6.20E+07 |
C |
T |
0.330913 |
1.043 |
0.002041 |
1.40E−85 |
0.481622927 |
403.4677 |
rs2259797 |
20 |
6.20E+07 |
T |
C |
0.907332 |
1.084 |
0.003571 |
1.30E−116 |
0.197734167 |
107.0313 |
rs35640778 |
20 |
6.20E+07 |
G |
A |
0.979243 |
1.232 |
0.007143 |
9.60E−195 |
0.06174761 |
28.57906 |
rs28502153 |
22 |
1.70E+07 |
C |
A |
0.622042 |
1.022 |
0.002041 |
1.20E−25 |
0.491362721 |
419.5091 |
SNP: SNP rsID; CHR: Chromosome of SNP; BP: Base-pair location of SNP (hg19); A1: Effect allele; A2: Other allele; EAF: Effect allele frequency; BETA: SNP effect estimate; SE: SE of SNP effect estimate; pval: P-value for effect allele on Telomere length.
(c)
rsID |
CHR |
BP |
A1 |
A2 |
EAF |
BETA |
SE |
pval |
R2 |
F-Statistic |
rs138895564 |
5 |
1.30E+06 |
C |
T |
0.990903 |
−0.835 |
0.010969 |
1.10E−59 |
0.012578 |
50.95611 |
rs33987166 |
5 |
1.30E+06 |
T |
C |
0.975189 |
−0.907 |
0.006633 |
8.00E−50 |
0.039778 |
165.7125 |
rs146546514 |
3 |
1.70E+08 |
C |
A |
0.983095 |
−0.923 |
0.008418 |
2.30E−22 |
0.028324 |
116.6052 |
rs7705526 |
5 |
1.30E+06 |
C |
A |
0.673422 |
−0.925 |
0.002296 |
2.40E−282 |
0.376317 |
2413.662 |
rs183553155 |
16 |
7.40E+07 |
G |
A |
0.989437 |
−0.931 |
0.010204 |
3.10E−12 |
0.018136 |
73.88732 |
rs139795227 |
1 |
9.30E+07 |
A |
C |
0.985979 |
−0.942 |
0.008673 |
6.70E−12 |
0.024522 |
100.561 |
rs79717857 |
5 |
1.30E+06 |
C |
A |
0.973921 |
−0.950 |
0.006633 |
3.80E−15 |
0.045872 |
192.3205 |
rs1291143 |
20 |
3.60E+07 |
A |
C |
0.150974 |
−0.952 |
0.002806 |
1.80E−69 |
0.23243 |
1211.323 |
rs1609812 |
11 |
5.20E+06 |
G |
A |
0.160214 |
−0.954 |
0.002806 |
3.90E−65 |
0.244949 |
1297.731 |
rs12615793 |
2 |
5.40E+07 |
G |
A |
0.859605 |
−0.956 |
0.002806 |
1.80E−55 |
0.220594 |
1132.182 |
rs154979 |
6 |
3.30E+07 |
C |
A |
0.971166 |
−0.957 |
0.006122 |
1.70E−13 |
0.051287 |
216.2527 |
rs138061125 |
7 |
1.60E+08 |
G |
A |
0.969815 |
−0.958 |
0.005867 |
2.60E−13 |
0.053723 |
227.1058 |
rs80324517 |
6 |
204031 |
G |
A |
0.951741 |
−0.961 |
0.004592 |
1.80E−17 |
0.084798 |
370.6399 |
rs111811424 |
18 |
674579 |
C |
T |
0.913521 |
−0.962 |
0.003571 |
1.40E−27 |
0.146145 |
684.6772 |
rs76219171 |
16 |
5.00E+07 |
G |
A |
0.941567 |
−0.965 |
0.004082 |
7.80E−17 |
0.102393 |
456.3202 |
rs115251750 |
5 |
1.30E+06 |
G |
A |
0.964935 |
−0.965 |
0.005357 |
4.50E−11 |
0.06297 |
268.822 |
rs11866592 |
16 |
7.50E+07 |
G |
A |
0.85802 |
−0.966 |
0.002806 |
1.30E−33 |
0.227172 |
1175.863 |
rs8105767 |
19 |
2.20E+07 |
A |
G |
0.70533 |
−0.968 |
0.002041 |
2.50E−50 |
0.38913 |
2548.19 |
rs79824385 |
18 |
4.20E+07 |
T |
A |
0.870276 |
−0.969 |
0.003061 |
7.90E−27 |
0.211793 |
1074.876 |
rs762679 |
8 |
4.90E+07 |
T |
A |
0.143499 |
−0.969 |
0.003061 |
1.40E−27 |
0.231036 |
1201.878 |
rs9990898 |
4 |
1.60E+08 |
T |
C |
0.857338 |
−0.970 |
0.002806 |
3.00E−26 |
0.230374 |
1197.398 |
rs5030755 |
17 |
1.80E+06 |
A |
G |
0.886658 |
−0.970 |
0.003316 |
6.20E−22 |
0.189286 |
933.9801 |
rs76666449 |
12 |
1.20E+08 |
T |
C |
0.899375 |
−0.970 |
0.003316 |
8.20E−19 |
0.170459 |
821.9904 |
rs11579626 |
1 |
1.50E+08 |
A |
C |
0.915118 |
−0.973 |
0.003827 |
1.30E−13 |
0.147187 |
690.4035 |
rs8088824 |
18 |
4.20E+07 |
C |
T |
0.236812 |
−0.974 |
0.002296 |
8.10E−28 |
0.343148 |
2089.779 |
rs1332941 |
13 |
4.20E+07 |
A |
G |
0.179534 |
−0.974 |
0.002806 |
5.90E−21 |
0.279675 |
1553.143 |
rs939916 |
11 |
202253 |
G |
A |
0.330033 |
−0.976 |
0.002041 |
6.60E−29 |
0.421497 |
2914.573 |
rs2276182 |
18 |
5.20E+07 |
C |
G |
0.596773 |
−0.977 |
0.002041 |
2.80E−30 |
0.459633 |
3402.579 |
rs73581419 |
14 |
2.20E+07 |
C |
T |
0.893395 |
−0.977 |
0.003061 |
1.30E−12 |
0.181917 |
889.5328 |
rs17677991 |
15 |
4.20E+07 |
C |
G |
0.657877 |
−0.978 |
0.002041 |
4.40E−26 |
0.430773 |
3027.247 |
rs55765053 |
20 |
6.20E+07 |
C |
T |
0.933938 |
−0.978 |
0.004082 |
3.6E−08 |
0.118084 |
535.6108 |
rs1957937 |
14 |
9.60E+07 |
A |
T |
0.83982 |
−0.979 |
0.002551 |
1.90E−14 |
0.257979 |
1390.765 |
rs1727302 |
12 |
1.20E+08 |
G |
A |
0.259019 |
−0.980 |
0.002296 |
8.40E−18 |
0.368805 |
2337.325 |
rs3761121 |
20 |
6.20E+07 |
T |
C |
0.878032 |
−0.980 |
0.003061 |
7.30E−11 |
0.205785 |
1036.483 |
rs5742915 |
15 |
7.40E+07 |
T |
C |
0.554171 |
−0.981 |
0.002041 |
1.60E−21 |
0.475706 |
3629.527 |
rs6669563 |
1 |
3.20E+07 |
G |
A |
0.562232 |
−0.982 |
0.002041 |
2.10E−19 |
0.474848 |
3617.063 |
rs12613375 |
2 |
5.90E+07 |
C |
T |
0.862288 |
−0.982 |
0.002806 |
9.10E−10 |
0.229097 |
1188.791 |
rs7012816 |
8 |
7.10E+07 |
G |
A |
0.870003 |
−0.982 |
0.002806 |
3E−09 |
0.218197 |
1116.447 |
rs13129697 |
4 |
9.90E+06 |
T |
G |
0.720832 |
−0.983 |
0.002296 |
1.50E−14 |
0.389013 |
2546.931 |
rs429358 |
19 |
4.50E+07 |
T |
C |
0.846031 |
−0.983 |
0.002806 |
3.80E−10 |
0.251816 |
1346.359 |
rs28711261 |
16 |
6.80E+07 |
A |
G |
0.867449 |
−0.983 |
0.003061 |
1.6E−08 |
0.222275 |
1143.275 |
rs10774625 |
12 |
1.10E+08 |
A |
G |
0.476428 |
−0.984 |
0.002041 |
1.70E−15 |
0.483177 |
3739.816 |
rs4742448 |
9 |
826585 |
C |
G |
0.530842 |
−0.985 |
0.002041 |
6.40E−14 |
0.483377 |
3742.805 |
rs4498805 |
1 |
1.10E+08 |
G |
T |
0.453368 |
−0.985 |
0.002041 |
5.70E−14 |
0.481002 |
3707.382 |
rs11646283 |
16 |
9.10E+06 |
T |
C |
0.589297 |
−0.985 |
0.002041 |
5.30E−14 |
0.469746 |
3543.768 |
rs2811491 |
3 |
1.30E+08 |
C |
A |
0.39223 |
−0.985 |
0.002041 |
8.90E−14 |
0.462681 |
3444.565 |
rs1907702 |
12 |
8.90E+07 |
G |
A |
0.233229 |
−0.985 |
0.002551 |
5.90E−10 |
0.347096 |
2126.599 |
rs4743037 |
9 |
1.10E+08 |
C |
T |
0.769126 |
−0.985 |
0.002296 |
5.10E−10 |
0.344646 |
2103.7 |
rs41269079 |
1 |
4.50E+07 |
T |
A |
0.811009 |
−0.985 |
0.002551 |
1.70E−09 |
0.297487 |
1693.945 |
rs4695407 |
4 |
4.90E+07 |
A |
G |
0.492157 |
−0.986 |
0.002041 |
1.50E−12 |
0.486075 |
3783.455 |
rs1143697 |
17 |
7.60E+07 |
T |
C |
0.536558 |
−0.986 |
0.002041 |
5.50E−12 |
0.483595 |
3746.081 |
rs56178008 |
2 |
2.90E+07 |
T |
A |
0.562503 |
−0.986 |
0.002041 |
9.70E−13 |
0.478597 |
3671.822 |
rs4530278 |
19 |
3.40E+07 |
G |
T |
0.40185 |
−0.986 |
0.002041 |
1.50E−11 |
0.467459 |
3511.372 |
rs10840270 |
11 |
9.60E+06 |
C |
G |
0.344316 |
−0.986 |
0.002296 |
1.30E−11 |
0.439058 |
3131.043 |
rs13062095 |
3 |
1.00E+08 |
T |
C |
0.672157 |
−0.986 |
0.002041 |
9.70E−11 |
0.428555 |
2999.975 |
rs1980240 |
15 |
5.70E+07 |
A |
C |
0.594757 |
−0.987 |
0.002041 |
2.20E−10 |
0.469671 |
3542.693 |
rs11556924 |
7 |
1.30E+08 |
C |
T |
0.624146 |
−0.987 |
0.002041 |
6.80E−10 |
0.457134 |
3368.503 |
rs6565924 |
18 |
7.50E+07 |
A |
G |
0.638554 |
−0.987 |
0.002041 |
2.90E−10 |
0.449759 |
3269.729 |
rs111527438 |
17 |
2.90E+07 |
T |
C |
0.648749 |
−0.987 |
0.002296 |
3.10E−09 |
0.444051 |
3195.091 |
rs6590343 |
11 |
1.30E+08 |
A |
G |
0.483615 |
−0.988 |
0.002041 |
1.50E−09 |
0.487619 |
3806.911 |
rs35671754 |
2 |
2.20E+08 |
G |
T |
0.704253 |
−0.988 |
0.002296 |
1.4E−08 |
0.406683 |
2741.921 |
rs12884911 |
14 |
6.50E+07 |
C |
T |
0.49667 |
1.013 |
0.002041 |
2.90E−11 |
0.513148 |
4216.294 |
rs2293579 |
11 |
4.70E+07 |
G |
A |
0.613726 |
1.013 |
0.002041 |
3.30E−10 |
0.486622 |
3791.753 |
rs9398196 |
6 |
1.10E+08 |
A |
G |
0.47995 |
1.014 |
0.002041 |
9.50E−13 |
0.513371 |
4220.065 |
rs8053839 |
16 |
4.80E+07 |
G |
T |
0.458038 |
1.014 |
0.002041 |
1.00E−11 |
0.510576 |
4173.124 |
rs10845387 |
12 |
1.20E+07 |
G |
A |
0.647334 |
1.014 |
0.002041 |
1.50E−11 |
0.46955 |
3540.984 |
rs35601737 |
19 |
1.30E+07 |
C |
G |
0.704101 |
1.014 |
0.002041 |
1.90E−10 |
0.428518 |
2999.519 |
rs8102497 |
19 |
5.70E+07 |
G |
A |
0.568172 |
1.015 |
0.002041 |
1.40E−13 |
0.505649 |
4091.665 |
rs869785 |
3 |
2.40E+07 |
T |
C |
0.327529 |
1.015 |
0.002041 |
4.40E−12 |
0.453923 |
3325.171 |
rs2069536 |
17 |
7.40E+07 |
A |
G |
0.249795 |
1.015 |
0.002296 |
1.80E−10 |
0.386209 |
2517.027 |
rs3768321 |
1 |
4.00E+07 |
G |
T |
0.810305 |
1.016 |
0.002551 |
1.10E−09 |
0.317418 |
1860.214 |
rs41272947 |
3 |
1.60E+08 |
G |
A |
0.458021 |
1.017 |
0.002041 |
5.90E−18 |
0.513646 |
4224.712 |
rs6776756 |
3 |
1.30E+08 |
G |
A |
0.402438 |
1.017 |
0.002041 |
1.10E−17 |
0.497597 |
3961.975 |
rs11190184 |
10 |
1.00E+08 |
G |
C |
0.71576 |
1.017 |
0.002296 |
1.10E−14 |
0.420968 |
2908.248 |
rs4758644 |
12 |
1.20E+08 |
A |
C |
0.269222 |
1.017 |
0.002296 |
2.70E−13 |
0.407091 |
2746.566 |
rs13230646 |
7 |
2.40E+07 |
T |
C |
0.751055 |
1.017 |
0.002296 |
8.90E−14 |
0.386875 |
2524.11 |
rs871134 |
4 |
7.00E+06 |
C |
T |
0.430968 |
1.018 |
0.002041 |
1.70E−19 |
0.508448 |
4137.732 |
rs66731853 |
1 |
2.10E+07 |
G |
A |
0.682696 |
1.018 |
0.002041 |
1.50E−16 |
0.449125 |
3261.373 |
rs1023767 |
8 |
9.60E+07 |
G |
A |
0.762405 |
1.018 |
0.002296 |
5.00E−15 |
0.375567 |
2405.956 |
rs12369950 |
12 |
2.50E+07 |
T |
C |
0.859325 |
1.018 |
0.003061 |
8.00E−10 |
0.250633 |
1337.921 |
rs61818036 |
1 |
1.50E+08 |
G |
A |
0.176391 |
1.019 |
0.002551 |
2.10E−12 |
0.301808 |
1729.185 |
rs762810 |
14 |
6.60E+07 |
C |
A |
0.647514 |
1.020 |
0.002041 |
4.30E−22 |
0.475109 |
3620.837 |
rs2306646 |
8 |
2.20E+07 |
G |
C |
0.440525 |
1.021 |
0.002041 |
3.30E−25 |
0.514069 |
4231.876 |
rs4731541 |
7 |
1.30E+08 |
C |
G |
0.375099 |
1.021 |
0.002041 |
1.40E−23 |
0.488908 |
3826.613 |
rs72801474 |
5 |
1.30E+08 |
G |
A |
0.911707 |
1.021 |
0.003571 |
3.90E−09 |
0.1679 |
807.1652 |
rs28502153 |
22 |
1.70E+07 |
C |
A |
0.622042 |
1.022 |
0.002041 |
1.20E−25 |
0.491363 |
3864.38 |
rs7218033 |
17 |
1.70E+06 |
C |
T |
0.746597 |
1.023 |
0.002296 |
1.00E−22 |
0.396192 |
2624.776 |
rs2056726 |
7 |
1.00E+08 |
G |
A |
0.785624 |
1.023 |
0.002551 |
7.90E−21 |
0.352694 |
2179.59 |
rs75664430 |
17 |
8.10E+06 |
C |
G |
0.751972 |
1.024 |
0.002296 |
3.60E−24 |
0.391362 |
2572.202 |
rs34003787 |
16 |
7.30E+07 |
C |
T |
0.912293 |
1.024 |
0.003571 |
1.90E−11 |
0.167898 |
807.1491 |
rs12941945 |
17 |
4.10E+07 |
A |
G |
0.832437 |
1.026 |
0.002551 |
3.00E−22 |
0.293862 |
1664.711 |
rs4919611 |
10 |
1.00E+08 |
C |
A |
0.112898 |
1.026 |
0.003316 |
5.10E−16 |
0.210995 |
1069.743 |
rs11769630 |
7 |
5.00E+07 |
T |
A |
0.927773 |
1.026 |
0.003827 |
4.30E−11 |
0.141174 |
657.5597 |
rs17185038 |
1 |
2.80E+07 |
C |
G |
0.93539 |
1.026 |
0.004082 |
2.10E−10 |
0.127323 |
583.6303 |
rs10112752 |
8 |
7.40E+07 |
G |
A |
0.569631 |
1.029 |
0.002041 |
9.50E−46 |
0.519581 |
4326.331 |
rs3093888 |
14 |
2.10E+07 |
G |
A |
0.94869 |
1.029 |
0.004592 |
1.50E−10 |
0.103168 |
460.1719 |
rs1985369 |
7 |
1.60E+08 |
A |
G |
0.131822 |
1.031 |
0.003061 |
3.60E−25 |
0.24353 |
1287.796 |
rs12572897 |
10 |
9.60E+07 |
G |
A |
0.869908 |
1.033 |
0.003061 |
3.60E−27 |
0.241295 |
1272.218 |
rs6030416 |
20 |
3.60E+07 |
T |
G |
0.135696 |
1.035 |
0.003061 |
1.50E−30 |
0.25107 |
1341.036 |
rs11557154 |
9 |
3.40E+07 |
C |
T |
0.86997 |
1.035 |
0.002806 |
1.10E−30 |
0.242164 |
1278.264 |
rs611646 |
11 |
1.10E+08 |
T |
A |
0.591315 |
1.038 |
0.002041 |
3.50E−73 |
0.520446 |
4341.335 |
rs932002 |
1 |
2.30E+08 |
C |
T |
0.849157 |
1.041 |
0.002806 |
7.30E−47 |
0.277515 |
1536.539 |
rs8114049 |
20 |
6.20E+07 |
C |
T |
0.330913 |
1.043 |
0.002041 |
1.40E−85 |
0.481623 |
3716.611 |
rs3891167 |
18 |
658423 |
A |
G |
0.746565 |
1.044 |
0.002296 |
1.20E−70 |
0.412395 |
2807.462 |
rs7790856 |
7 |
1.20E+08 |
C |
T |
0.710861 |
1.045 |
0.002296 |
1.80E−87 |
0.448889 |
3258.263 |
rs2303262 |
16 |
8.20E+07 |
C |
T |
0.222887 |
1.048 |
0.002551 |
2.90E−85 |
0.38056 |
2457.586 |
rs9952504 |
18 |
657458 |
A |
G |
0.958066 |
1.054 |
0.005357 |
2.40E−24 |
0.089336 |
392.4231 |
rs4724 |
17 |
7.80E+06 |
G |
A |
0.883402 |
1.057 |
0.003061 |
9.80E−69 |
0.22996 |
1194.605 |
rs182059586 |
16 |
1.50E+07 |
T |
C |
0.97489 |
1.059 |
0.006633 |
4.90E−17 |
0.054871 |
232.2397 |
rs61748181 |
5 |
1.30E+06 |
C |
T |
0.971072 |
1.061 |
0.005867 |
2.80E−23 |
0.063219 |
269.9568 |
rs78491606 |
3 |
7.30E+07 |
A |
C |
0.981567 |
1.079 |
0.007398 |
1.90E−24 |
0.042127 |
175.9286 |
rs9419958 |
10 |
1.10E+08 |
T |
C |
0.13861 |
1.084 |
0.003061 |
2.60E−167 |
0.280789 |
1561.743 |
rs2259797 |
20 |
6.20E+07 |
T |
C |
0.907332 |
1.084 |
0.003571 |
1.30E−116 |
0.197734 |
985.937 |
rs115451758 |
5 |
1.30E+06 |
G |
A |
0.989626 |
1.088 |
0.009949 |
6.70E−17 |
0.024289 |
99.58028 |
rs141379009 |
11 |
1.10E+08 |
T |
G |
0.974488 |
1.096 |
0.006378 |
8.70E−48 |
0.059767 |
254.2795 |
rs2293607 |
3 |
1.70E+08 |
T |
C |
0.757553 |
1.099 |
0.002296 |
<1.0E−314 |
0.44331 |
3185.512 |
rs144204502 |
17 |
7.60E+07 |
C |
T |
0.987438 |
1.106 |
0.008929 |
3.40E−28 |
0.030362 |
125.257 |
rs35640778 |
20 |
6.20E+07 |
G |
A |
0.979243 |
1.232 |
0.007143 |
9.60E−195 |
0.061748 |
263.2608 |
SNP: SNP rsID; CHR: Chromosome of SNP; BP: Base−pair location of SNP (hg19); A1: Effect allele; A2: Other allele; EAF: Effect allele frequency; BETA: SNP effect estimate; SE: SE of SNP effect estimate; pval: P-value for effect allele on Telomere length.
(d)
rsID |
CHR |
BP |
A1 |
A2 |
EAF |
BETA |
SE |
pval |
R2 |
F-Statistic |
rs138895564 |
5 |
1.30E+06 |
C |
T |
0.990903 |
−0.835 |
0.010969 |
1.10E−59 |
0.012578 |
50.95611 |
rs33987166 |
5 |
1.30E+06 |
T |
C |
0.975189 |
−0.907 |
0.006633 |
8.00E−50 |
0.039778 |
165.7125 |
rs146546514 |
3 |
1.70E+08 |
C |
A |
0.983095 |
−0.923 |
0.008418 |
2.30E−22 |
0.028324 |
116.6052 |
rs7705526 |
5 |
1.30E+06 |
C |
A |
0.673422 |
−0.925 |
0.002296 |
2.40E−282 |
0.376317 |
2413.662 |
rs183553155 |
16 |
7.40E+07 |
G |
A |
0.989437 |
−0.931 |
0.010204 |
3.10E−12 |
0.018136 |
73.88732 |
rs139795227 |
1 |
9.30E+07 |
A |
C |
0.985979 |
−0.942 |
0.008673 |
6.70E−12 |
0.024522 |
100.561 |
rs79717857 |
5 |
1.30E+06 |
C |
A |
0.973921 |
−0.950 |
0.006633 |
3.80E−15 |
0.045872 |
192.3205 |
rs1291143 |
20 |
3.60E+07 |
A |
C |
0.150974 |
−0.952 |
0.002806 |
1.80E−69 |
0.23243 |
1211.323 |
rs1609812 |
11 |
5.20E+06 |
G |
A |
0.160214 |
−0.954 |
0.002806 |
3.90E−65 |
0.244949 |
1297.731 |
rs12615793 |
2 |
5.40E+07 |
G |
A |
0.859605 |
−0.956 |
0.002806 |
1.80E−55 |
0.220594 |
1132.182 |
rs154979 |
6 |
3.30E+07 |
C |
A |
0.971166 |
−0.957 |
0.006122 |
1.70E−13 |
0.051287 |
216.2527 |
rs138061125 |
7 |
1.60E+08 |
G |
A |
0.969815 |
−0.958 |
0.005867 |
2.60E−13 |
0.053723 |
227.1058 |
rs80324517 |
6 |
204031 |
G |
A |
0.951741 |
−0.961 |
0.004592 |
1.80E−17 |
0.084798 |
370.6399 |
rs111811424 |
18 |
674579 |
C |
T |
0.913521 |
−0.962 |
0.003571 |
1.40E−27 |
0.146145 |
684.6772 |
rs76219171 |
16 |
5.00E+07 |
G |
A |
0.941567 |
−0.965 |
0.004082 |
7.80E−17 |
0.102393 |
456.3202 |
rs115251750 |
5 |
1.30E+06 |
G |
A |
0.964935 |
−0.965 |
0.005357 |
4.50E−11 |
0.06297 |
268.822 |
rs11866592 |
16 |
7.50E+07 |
G |
A |
0.85802 |
−0.966 |
0.002806 |
1.30E−33 |
0.227172 |
1175.863 |
rs8105767 |
19 |
2.20E+07 |
A |
G |
0.70533 |
−0.968 |
0.002041 |
2.50E−50 |
0.38913 |
2548.19 |
rs79824385 |
18 |
4.20E+07 |
T |
A |
0.870276 |
−0.969 |
0.003061 |
7.90E−27 |
0.211793 |
1074.876 |
rs762679 |
8 |
4.90E+07 |
T |
A |
0.143499 |
−0.969 |
0.003061 |
1.40E−27 |
0.231036 |
1201.878 |
rs9990898 |
4 |
1.60E+08 |
T |
C |
0.857338 |
−0.970 |
0.002806 |
3.00E−26 |
0.230374 |
1197.398 |
rs5030755 |
17 |
1.80E+06 |
A |
G |
0.886658 |
−0.970 |
0.003316 |
6.20E−22 |
0.189286 |
933.9801 |
rs76666449 |
12 |
1.20E+08 |
T |
C |
0.899375 |
−0.970 |
0.003316 |
8.20E−19 |
0.170459 |
821.9904 |
rs11579626 |
1 |
1.50E+08 |
A |
C |
0.915118 |
−0.973 |
0.003827 |
1.30E−13 |
0.147187 |
690.4035 |
rs8088824 |
18 |
4.20E+07 |
C |
T |
0.236812 |
−0.974 |
0.002296 |
8.10E−28 |
0.343148 |
2089.779 |
rs1332941 |
13 |
4.20E+07 |
A |
G |
0.179534 |
−0.974 |
0.002806 |
5.90E−21 |
0.279675 |
1553.143 |
rs939916 |
11 |
202253 |
G |
A |
0.330033 |
−0.976 |
0.002041 |
6.60E−29 |
0.421497 |
2914.573 |
rs2276182 |
18 |
5.20E+07 |
C |
G |
0.596773 |
−0.977 |
0.002041 |
2.80E−30 |
0.459633 |
3402.579 |
rs73581419 |
14 |
2.20E+07 |
C |
T |
0.893395 |
−0.977 |
0.003061 |
1.30E−12 |
0.181917 |
889.5328 |
rs17677991 |
15 |
4.20E+07 |
C |
G |
0.657877 |
−0.978 |
0.002041 |
4.40E−26 |
0.430773 |
3027.247 |
rs55765053 |
20 |
6.20E+07 |
C |
T |
0.933938 |
−0.978 |
0.004082 |
3.6E−08 |
0.118084 |
535.6108 |
rs1957937 |
14 |
9.60E+07 |
A |
T |
0.83982 |
−0.979 |
0.002551 |
1.90E−14 |
0.257979 |
1390.765 |
rs1727302 |
12 |
1.20E+08 |
G |
A |
0.259019 |
−0.980 |
0.002296 |
8.40E−18 |
0.368805 |
2337.325 |
rs3761121 |
20 |
6.20E+07 |
T |
C |
0.878032 |
−0.980 |
0.003061 |
7.30E−11 |
0.205785 |
1036.483 |
rs5742915 |
15 |
7.40E+07 |
T |
C |
0.554171 |
−0.981 |
0.002041 |
1.60E−21 |
0.475706 |
3629.527 |
rs6669563 |
1 |
3.20E+07 |
G |
A |
0.562232 |
−0.982 |
0.002041 |
2.10E−19 |
0.474848 |
3617.063 |
rs12613375 |
2 |
5.90E+07 |
C |
T |
0.862288 |
−0.982 |
0.002806 |
9.10E−10 |
0.229097 |
1188.791 |
rs7012816 |
8 |
7.10E+07 |
G |
A |
0.870003 |
−0.982 |
0.002806 |
3E−09 |
0.218197 |
1116.447 |
rs13129697 |
4 |
9.90E+06 |
T |
G |
0.720832 |
−0.983 |
0.002296 |
1.50E−14 |
0.389013 |
2546.931 |
rs429358 |
19 |
4.50E+07 |
T |
C |
0.846031 |
−0.983 |
0.002806 |
3.80E−10 |
0.251816 |
1346.359 |
rs28711261 |
16 |
6.80E+07 |
A |
G |
0.867449 |
−0.983 |
0.003061 |
1.6E−08 |
0.222275 |
1143.275 |
rs10774625 |
12 |
1.10E+08 |
A |
G |
0.476428 |
−0.984 |
0.002041 |
1.70E−15 |
0.483177 |
3739.816 |
rs4498805 |
1 |
1.10E+08 |
G |
T |
0.453368 |
−0.985 |
0.002041 |
5.70E−14 |
0.481002 |
3707.382 |
rs4742448 |
9 |
826585 |
C |
G |
0.530842 |
−0.985 |
0.002041 |
6.40E−14 |
0.483377 |
3742.805 |
rs11646283 |
16 |
9.10E+06 |
T |
C |
0.589297 |
−0.985 |
0.002041 |
5.30E−14 |
0.469746 |
3543.768 |
rs2811491 |
3 |
1.30E+08 |
C |
A |
0.39223 |
−0.985 |
0.002041 |
8.90E−14 |
0.462681 |
3444.565 |
rs1907702 |
12 |
8.90E+07 |
G |
A |
0.233229 |
−0.985 |
0.002551 |
5.90E−10 |
0.347096 |
2126.599 |
rs4743037 |
9 |
1.10E+08 |
C |
T |
0.769126 |
−0.985 |
0.002296 |
5.10E−10 |
0.344646 |
2103.7 |
rs41269079 |
1 |
4.50E+07 |
T |
A |
0.811009 |
−0.985 |
0.002551 |
1.70E−09 |
0.297487 |
1693.945 |
rs4695407 |
4 |
4.90E+07 |
A |
G |
0.492157 |
−0.986 |
0.002041 |
1.50E−12 |
0.486075 |
3783.455 |
rs1143697 |
17 |
7.60E+07 |
T |
C |
0.536558 |
−0.986 |
0.002041 |
5.50E−12 |
0.483595 |
3746.081 |
rs56178008 |
2 |
2.90E+07 |
T |
A |
0.562503 |
−0.986 |
0.002041 |
9.70E−13 |
0.478597 |
3671.822 |
rs4530278 |
19 |
3.40E+07 |
G |
T |
0.40185 |
−0.986 |
0.002041 |
1.50E−11 |
0.467459 |
3511.372 |
rs10840270 |
11 |
9.60E+06 |
C |
G |
0.344316 |
−0.986 |
0.002296 |
1.30E−11 |
0.439058 |
3131.043 |
rs13062095 |
3 |
1.00E+08 |
T |
C |
0.672157 |
−0.986 |
0.002041 |
9.70E−11 |
0.428555 |
2999.975 |
rs1980240 |
15 |
5.70E+07 |
A |
C |
0.594757 |
−0.987 |
0.002041 |
2.20E−10 |
0.469671 |
3542.693 |
rs11556924 |
7 |
1.30E+08 |
C |
T |
0.624146 |
−0.987 |
0.002041 |
6.80E−10 |
0.457134 |
3368.503 |
rs6565924 |
18 |
7.50E+07 |
A |
G |
0.638554 |
−0.987 |
0.002041 |
2.90E−10 |
0.449759 |
3269.729 |
rs111527438 |
17 |
2.90E+07 |
T |
C |
0.648749 |
−0.987 |
0.002296 |
3.10E−09 |
0.444051 |
3195.091 |
rs6590343 |
11 |
1.30E+08 |
A |
G |
0.483615 |
−0.988 |
0.002041 |
1.50E−09 |
0.487619 |
3806.911 |
rs35671754 |
2 |
2.20E+08 |
G |
T |
0.704253 |
−0.988 |
0.002296 |
1.4E−08 |
0.406683 |
2741.921 |
rs12884911 |
14 |
6.50E+07 |
C |
T |
0.49667 |
1.013 |
0.002041 |
2.90E−11 |
0.513148 |
4216.294 |
rs2293579 |
11 |
4.70E+07 |
G |
A |
0.613726 |
1.013 |
0.002041 |
3.30E−10 |
0.486622 |
3791.753 |
rs9398196 |
6 |
1.10E+08 |
A |
G |
0.47995 |
1.014 |
0.002041 |
9.50E−13 |
0.513371 |
4220.065 |
rs8053839 |
16 |
4.80E+07 |
G |
T |
0.458038 |
1.014 |
0.002041 |
1.00E−11 |
0.510576 |
4173.124 |
rs10845387 |
12 |
1.20E+07 |
G |
A |
0.647334 |
1.014 |
0.002041 |
1.50E−11 |
0.46955 |
3540.984 |
rs35601737 |
19 |
1.30E+07 |
C |
G |
0.704101 |
1.014 |
0.002041 |
1.90E−10 |
0.428518 |
2999.519 |
rs8102497 |
19 |
5.70E+07 |
G |
A |
0.568172 |
1.015 |
0.002041 |
1.40E−13 |
0.505649 |
4091.665 |
rs869785 |
3 |
2.40E+07 |
T |
C |
0.327529 |
1.015 |
0.002041 |
4.40E−12 |
0.453923 |
3325.171 |
rs2069536 |
17 |
7.40E+07 |
A |
G |
0.249795 |
1.015 |
0.002296 |
1.80E−10 |
0.386209 |
2517.027 |
rs3768321 |
1 |
4.00E+07 |
G |
T |
0.810305 |
1.016 |
0.002551 |
1.10E−09 |
0.317418 |
1860.214 |
rs41272947 |
3 |
1.60E+08 |
G |
A |
0.458021 |
1.017 |
0.002041 |
5.90E−18 |
0.513646 |
4224.712 |
rs6776756 |
3 |
1.30E+08 |
G |
A |
0.402438 |
1.017 |
0.002041 |
1.10E−17 |
0.497597 |
3961.975 |
rs11190184 |
10 |
1.00E+08 |
G |
C |
0.71576 |
1.017 |
0.002296 |
1.10E−14 |
0.420968 |
2908.248 |
rs4758644 |
12 |
1.20E+08 |
A |
C |
0.269222 |
1.017 |
0.002296 |
2.70E−13 |
0.407091 |
2746.566 |
rs13230646 |
7 |
2.40E+07 |
T |
C |
0.751055 |
1.017 |
0.002296 |
8.90E−14 |
0.386875 |
2524.11 |
rs871134 |
4 |
7.00E+06 |
C |
T |
0.430968 |
1.018 |
0.002041 |
1.70E−19 |
0.508448 |
4137.732 |
rs66731853 |
1 |
2.10E+07 |
G |
A |
0.682696 |
1.018 |
0.002041 |
1.50E−16 |
0.449125 |
3261.373 |
rs1023767 |
8 |
9.60E+07 |
G |
A |
0.762405 |
1.018 |
0.002296 |
5.00E−15 |
0.375567 |
2405.956 |
rs12369950 |
12 |
2.50E+07 |
T |
C |
0.859325 |
1.018 |
0.003061 |
8.00E−10 |
0.250633 |
1337.921 |
rs61818036 |
1 |
1.50E+08 |
G |
A |
0.176391 |
1.019 |
0.002551 |
2.10E−12 |
0.301808 |
1729.185 |
rs762810 |
14 |
6.60E+07 |
C |
A |
0.647514 |
1.020 |
0.002041 |
4.30E−22 |
0.475109 |
3620.837 |
rs2306646 |
8 |
2.20E+07 |
G |
C |
0.440525 |
1.021 |
0.002041 |
3.30E−25 |
0.514069 |
4231.876 |
rs4731541 |
7 |
1.30E+08 |
C |
G |
0.375099 |
1.021 |
0.002041 |
1.40E−23 |
0.488908 |
3826.613 |
rs72801474 |
5 |
1.30E+08 |
G |
A |
0.911707 |
1.021 |
0.003571 |
3.90E−09 |
0.1679 |
807.1652 |
rs28502153 |
22 |
1.70E+07 |
C |
A |
0.622042 |
1.022 |
0.002041 |
1.20E−25 |
0.491363 |
3864.38 |
rs7218033 |
17 |
1.70E+06 |
C |
T |
0.746597 |
1.023 |
0.002296 |
1.00E−22 |
0.396192 |
2624.776 |
rs2056726 |
7 |
1.00E+08 |
G |
A |
0.785624 |
1.023 |
0.002551 |
7.90E−21 |
0.352694 |
2179.59 |
rs75664430 |
17 |
8.10E+06 |
C |
G |
0.751972 |
1.024 |
0.002296 |
3.60E−24 |
0.391362 |
2572.202 |
rs34003787 |
16 |
7.30E+07 |
C |
T |
0.912293 |
1.024 |
0.003571 |
1.90E−11 |
0.167898 |
807.1491 |
rs12941945 |
17 |
4.10E+07 |
A |
G |
0.832437 |
1.026 |
0.002551 |
3.00E−22 |
0.293862 |
1664.711 |
rs4919611 |
10 |
1.00E+08 |
C |
A |
0.112898 |
1.026 |
0.003316 |
5.10E−16 |
0.210995 |
1069.743 |
rs11769630 |
7 |
5.00E+07 |
T |
A |
0.927773 |
1.026 |
0.003827 |
4.30E−11 |
0.141174 |
657.5597 |
rs17185038 |
1 |
2.80E+07 |
C |
G |
0.93539 |
1.026 |
0.004082 |
2.10E−10 |
0.127323 |
583.6303 |
rs10112752 |
8 |
7.40E+07 |
G |
A |
0.569631 |
1.029 |
0.002041 |
9.50E−46 |
0.519581 |
4326.331 |
rs3093888 |
14 |
2.10E+07 |
G |
A |
0.94869 |
1.029 |
0.004592 |
1.50E−10 |
0.103168 |
460.1719 |
rs1985369 |
7 |
1.60E+08 |
A |
G |
0.131822 |
1.031 |
0.003061 |
3.60E−25 |
0.24353 |
1287.796 |
rs12572897 |
10 |
9.60E+07 |
G |
A |
0.869908 |
1.033 |
0.003061 |
3.60E−27 |
0.241295 |
1272.218 |
rs6030416 |
20 |
3.60E+07 |
T |
G |
0.135696 |
1.035 |
0.003061 |
1.50E−30 |
0.25107 |
1341.036 |
rs11557154 |
9 |
3.40E+07 |
C |
T |
0.86997 |
1.035 |
0.002806 |
1.10E−30 |
0.242164 |
1278.264 |
rs611646 |
11 |
1.10E+08 |
T |
A |
0.591315 |
1.038 |
0.002041 |
3.50E−73 |
0.520446 |
4341.335 |
rs932002 |
1 |
2.30E+08 |
C |
T |
0.849157 |
1.041 |
0.002806 |
7.30E−47 |
0.277515 |
1536.539 |
rs8114049 |
20 |
6.20E+07 |
C |
T |
0.330913 |
1.043 |
0.002041 |
1.40E−85 |
0.481623 |
3716.611 |
rs3891167 |
18 |
658423 |
A |
G |
0.746565 |
1.044 |
0.002296 |
1.20E−70 |
0.412395 |
2807.462 |
rs7790856 |
7 |
1.20E+08 |
C |
T |
0.710861 |
1.045 |
0.002296 |
1.80E−87 |
0.448889 |
3258.263 |
rs2303262 |
16 |
8.20E+07 |
C |
T |
0.222887 |
1.048 |
0.002551 |
2.90E−85 |
0.38056 |
2457.586 |
rs9952504 |
18 |
657458 |
A |
G |
0.958066 |
1.054 |
0.005357 |
2.40E−24 |
0.089336 |
392.4231 |
rs4724 |
17 |
7.80E+06 |
G |
A |
0.883402 |
1.057 |
0.003061 |
9.80E−69 |
0.22996 |
1194.605 |
rs182059586 |
16 |
1.50E+07 |
T |
C |
0.97489 |
1.059 |
0.006633 |
4.90E−17 |
0.054871 |
232.2397 |
rs61748181 |
5 |
1.30E+06 |
C |
T |
0.971072 |
1.061 |
0.005867 |
2.80E−23 |
0.063219 |
269.9568 |
rs78491606 |
3 |
7.30E+07 |
A |
C |
0.981567 |
1.079 |
0.007398 |
1.90E−24 |
0.042127 |
175.9286 |
rs9419958 |
10 |
1.10E+08 |
T |
C |
0.13861 |
1.084 |
0.003061 |
2.60E−167 |
0.280789 |
1561.743 |
rs2259797 |
20 |
6.20E+07 |
T |
C |
0.907332 |
1.084 |
0.003571 |
1.30E−116 |
0.197734 |
985.937 |
rs115451758 |
5 |
1.30E+06 |
G |
A |
0.989626 |
1.088 |
0.009949 |
6.70E−17 |
0.024289 |
99.58028 |
rs141379009 |
11 |
1.10E+08 |
T |
G |
0.974488 |
1.096 |
0.006378 |
8.70E−48 |
0.059767 |
254.2795 |
rs2293607 |
3 |
1.70E+08 |
T |
C |
0.757553 |
1.099 |
0.002296 |
<1.0E−314 |
0.44331 |
3185.512 |
rs144204502 |
17 |
7.60E+07 |
C |
T |
0.987438 |
1.106 |
0.008929 |
3.40E−28 |
0.030362 |
125.257 |
rs35640778 |
20 |
6.20E+07 |
G |
A |
0.979243 |
1.232 |
0.007143 |
9.60E−195 |
0.061748 |
263.2608 |
SNP: SNP rsID; CHR: Chromosome of SNP; BP: Base-pair location of SNP (hg19); A1: Effect allele; A2: Other allele; EAF: Effect allele frequency; BETA: SNP effect estimate; SE: SE of SNP effect estimate; pval: P-value for effect allele on Telomere length.
Table A2. Variants used in the genetic instrument for Parkinson’s disease risk
SNP |
CHR |
BP |
A1 |
A2 |
EAF |
BETA |
SE |
P |
R2 |
F-Statistic |
rs11578699 |
1 |
171719769 |
T |
C |
0.1949 |
−0.0704 |
0.012 |
4.47E−09 |
0.001555 |
24.88349 |
rs114138760 |
1 |
154898185 |
C |
G |
0.0112 |
0.2812 |
0.0478 |
4.19E−09 |
0.001751 |
28.02507 |
rs6658353 |
1 |
161469054 |
C |
G |
0.5011 |
0.065 |
0.0094 |
6.1E−12 |
0.002112 |
33.81515 |
rs4653767 |
1 |
226916078 |
T |
C |
0.7196 |
0.0833 |
0.0104 |
1.38E−15 |
0.0028 |
44.85442 |
rs10797576 |
1 |
232664611 |
T |
C |
0.1403 |
0.1114 |
0.0133 |
6.84E−17 |
0.002994 |
47.96289 |
rs11557080 |
1 |
205737739 |
A |
G |
0.1389 |
0.1315 |
0.0135 |
2.5E−22 |
0.004137 |
66.34922 |
rs76763715 |
1 |
155205634 |
T |
C |
0.9953 |
−0.7467 |
0.0765 |
1.59E−22 |
0.005216 |
83.76138 |
rs823118 |
1 |
205723572 |
T |
C |
0.566 |
0.1066 |
0.0094 |
1.11E−29 |
0.005583 |
89.67682 |
rs35749011 |
1 |
155135036 |
A |
G |
0.0169 |
0.6068 |
0.0342 |
1.72E−70 |
0.012235 |
197.8564 |
rs2042477 |
2 |
96000943 |
A |
T |
0.2422 |
−0.0657 |
0.0116 |
1.38E−08 |
0.001584 |
25.34991 |
rs76116224 |
2 |
18147848 |
A |
T |
0.9042 |
0.1104 |
0.0194 |
1.27E−08 |
0.002112 |
33.79982 |
rs11683001 |
2 |
102396963 |
A |
T |
0.337 |
0.0705 |
0.0098 |
8.04E−13 |
0.002221 |
35.55622 |
rs57891859 |
2 |
135464616 |
A |
G |
0.7185 |
0.0807 |
0.0107 |
4.55E−14 |
0.002634 |
42.19161 |
rs1474055 |
2 |
169110394 |
T |
C |
0.1312 |
0.1796 |
0.0137 |
2.54E−39 |
0.007354 |
118.3314 |
rs1450522 |
3 |
161077630 |
A |
G |
0.6742 |
−0.0616 |
0.0099 |
5.01E−10 |
0.001667 |
26.67191 |
rs11707416 |
3 |
151108965 |
A |
T |
0.3672 |
−0.0627 |
0.0097 |
1.13E−10 |
0.001827 |
29.23659 |
rs12497850 |
3 |
48748989 |
T |
G |
0.6476 |
0.0636 |
0.0099 |
1.36E−10 |
0.001846 |
29.54526 |
rs6808178 |
3 |
28705690 |
T |
C |
0.3794 |
0.0658 |
0.0096 |
8.09E−12 |
0.002039 |
32.63439 |
rs55961674 |
3 |
122196892 |
T |
C |
0.1722 |
0.0861 |
0.0126 |
9.98E−12 |
0.002113 |
33.83078 |
rs73038319 |
3 |
18361759 |
A |
C |
0.9592 |
−0.1693 |
0.0235 |
5.94E−13 |
0.002243 |
35.91591 |
rs10513789 |
3 |
182760073 |
T |
G |
0.8112 |
0.1485 |
0.0121 |
1.22E−34 |
0.006755 |
108.6312 |
rs6825004 |
4 |
77110365 |
C |
G |
0.6912 |
0.0622 |
0.0102 |
1.17E−09 |
0.001652 |
26.42457 |
rs62333164 |
4 |
170583157 |
A |
G |
0.3264 |
−0.0638 |
0.01 |
2E−10 |
0.00179 |
28.64177 |
rs34025766 |
4 |
17968811 |
A |
T |
0.1589 |
−0.0839 |
0.0133 |
2.87E−10 |
0.001882 |
30.11214 |
rs13117519 |
4 |
114369065 |
T |
C |
0.1744 |
0.0875 |
0.0123 |
9.82E−13 |
0.002205 |
35.29548 |
rs4101061 |
4 |
77147969 |
A |
G |
0.7107 |
−0.0912 |
0.0102 |
4.97E−19 |
0.00342 |
54.8202 |
rs6854006 |
4 |
77198054 |
T |
C |
0.3632 |
−0.0912 |
0.0097 |
5.82E−21 |
0.003847 |
61.69372 |
rs4698412 |
4 |
15737348 |
A |
G |
0.5529 |
0.1035 |
0.0094 |
2.06E−28 |
0.005296 |
85.04846 |
rs873786 |
4 |
925376 |
T |
C |
0.0988 |
−0.1731 |
0.0182 |
1.79E−21 |
0.005336 |
85.6888 |
rs5019538 |
4 |
90636630 |
A |
G |
0.6792 |
−0.1565 |
0.0124 |
1.13E−36 |
0.010673 |
172.3254 |
rs34311866 |
4 |
951947 |
T |
C |
0.8065 |
−0.2126 |
0.012 |
9.98E−70 |
0.014107 |
228.5654 |
rs356182 |
4 |
90626111 |
A |
G |
0.6278 |
−0.2774 |
0.0105 |
3.89E−154 |
0.035962 |
595.8605 |
rs11950533 |
5 |
134199105 |
A |
C |
0.102 |
−0.0916 |
0.0158 |
7.16E−09 |
0.001537 |
24.5903 |
rs26431 |
5 |
102365794 |
C |
G |
0.7025 |
0.0621 |
0.0103 |
1.57E−09 |
0.001612 |
25.78965 |
rs1867598 |
5 |
60137959 |
A |
G |
0.9019 |
−0.1554 |
0.0156 |
2.52E−23 |
0.004273 |
68.55159 |
rs9261484 |
6 |
30108683 |
T |
C |
0.2451 |
−0.0635 |
0.0112 |
1.62E−08 |
0.001492 |
23.87025 |
rs997368 |
6 |
112243291 |
A |
G |
0.8049 |
0.0714 |
0.0119 |
1.84E−09 |
0.001601 |
25.6165 |
rs12528068 |
6 |
72487762 |
T |
C |
0.2844 |
0.0657 |
0.0103 |
1.63E−10 |
0.001757 |
28.114 |
rs4140646 |
6 |
27738801 |
A |
G |
0.2081 |
0.0833 |
0.0121 |
5.62E−12 |
0.002287 |
36.61466 |
rs75859381 |
6 |
133210361 |
T |
C |
0.9673 |
−0.2207 |
0.0341 |
1.04E−10 |
0.003081 |
49.37216 |
rs112485576 |
6 |
32578772 |
A |
C |
0.163 |
−0.1676 |
0.0153 |
6.96E−28 |
0.007665 |
123.3761 |
rs76949143 |
7 |
66009851 |
A |
T |
0.0507 |
−0.1432 |
0.0253 |
1.43E−08 |
0.001974 |
31.59249 |
rs199351 |
7 |
23300049 |
A |
C |
0.5939 |
0.1016 |
0.0096 |
5.25E−26 |
0.004979 |
79.93369 |
rs2280104 |
8 |
22525980 |
T |
C |
0.3604 |
0.0556 |
0.0098 |
1.16E−08 |
0.001425 |
22.79767 |
rs2086641 |
8 |
130901909 |
T |
C |
0.7225 |
−0.0605 |
0.0107 |
1.81E−08 |
0.001468 |
23.4789 |
rs620513 |
8 |
16697593 |
T |
G |
0.2682 |
−0.0856 |
0.0108 |
2.72E−15 |
0.002876 |
46.07633 |
rs1293298 |
8 |
11712443 |
A |
C |
0.7444 |
0.093 |
0.0114 |
3.99E−16 |
0.003291 |
52.74644 |
rs6476434 |
9 |
34046391 |
T |
C |
0.7336 |
−0.0615 |
0.0106 |
6.58E−09 |
0.001478 |
23.6491 |
rs10756907 |
9 |
17727065 |
A |
G |
0.7666 |
−0.0926 |
0.011 |
5.06E−17 |
0.003068 |
49.16483 |
rs13294100 |
9 |
17579690 |
T |
G |
0.3422 |
−0.0859 |
0.01 |
8.72E−18 |
0.003322 |
53.23945 |
rs10748818 |
10 |
104015279 |
A |
G |
0.8514 |
−0.079 |
0.013 |
1.05E−09 |
0.001579 |
25.26512 |
rs72840788 |
10 |
121415685 |
A |
G |
0.2155 |
0.0763 |
0.0113 |
1.57E−11 |
0.001968 |
31.50455 |
rs896435 |
10 |
15557406 |
T |
C |
0.6892 |
0.0735 |
0.0101 |
3.41E−13 |
0.002314 |
37.05403 |
rs117896735 |
10 |
121536327 |
A |
G |
0.0166 |
0.4354 |
0.0394 |
2.36E−28 |
0.006189 |
99.48091 |
rs7938782 |
11 |
10558777 |
A |
G |
0.8776 |
0.087 |
0.0145 |
2.12E−09 |
0.001626 |
26.01666 |
rs12283611 |
11 |
83487277 |
A |
C |
0.4148 |
−0.0645 |
0.0102 |
2.61E−10 |
0.00202 |
32.32725 |
rs3802920 |
11 |
133787001 |
T |
G |
0.2054 |
0.1073 |
0.0117 |
6.26E−20 |
0.003758 |
60.25762 |
rs7134559 |
12 |
46419086 |
T |
C |
0.404 |
−0.0539 |
0.0098 |
3.96E−08 |
0.001399 |
22.37904 |
rs11610045 |
12 |
133063768 |
A |
G |
0.4896 |
0.0601 |
0.0094 |
1.77E−10 |
0.001805 |
28.88777 |
rs76904798 |
12 |
40614434 |
T |
C |
0.1444 |
0.1439 |
0.013 |
1.52E−28 |
0.005117 |
82.15154 |
rs10847864 |
12 |
123326598 |
T |
G |
0.364 |
0.1478 |
0.0115 |
1.47E−37 |
0.010114 |
163.2114 |
rs34637584 |
12 |
40734202 |
A |
G |
0.0015 |
2.4289 |
0.0937 |
3.61E−148 |
0.017672 |
287.3627 |
rs9568188 |
13 |
49927732 |
T |
C |
0.7397 |
0.0617 |
0.0108 |
1.15E−08 |
0.001466 |
23.45122 |
rs4771268 |
13 |
97865021 |
T |
C |
0.2295 |
0.0675 |
0.0112 |
1.45E−09 |
0.001611 |
25.78051 |
rs12147950 |
14 |
37989270 |
T |
C |
0.4376 |
−0.0529 |
0.0096 |
3.54E−08 |
0.001377 |
22.03235 |
rs3742785 |
14 |
75373034 |
A |
C |
0.7866 |
0.0707 |
0.0118 |
1.92E−09 |
0.001678 |
26.85003 |
rs979812 |
14 |
88464264 |
T |
G |
0.4421 |
0.061 |
0.0093 |
6.19E−11 |
0.001836 |
29.37397 |
rs11158026 |
14 |
55348869 |
T |
C |
0.3245 |
−0.0842 |
0.0102 |
1.66E−16 |
0.003108 |
49.80173 |
rs2251086 |
15 |
61997385 |
T |
C |
0.1417 |
−0.1186 |
0.0137 |
6.08E−18 |
0.003421 |
54.8397 |
rs6500328 |
16 |
50736656 |
A |
G |
0.5985 |
0.0586 |
0.0097 |
1.82E−09 |
0.00165 |
26.40527 |
rs2904880 |
16 |
28944396 |
C |
G |
0.3094 |
−0.065 |
0.0106 |
7.87E−10 |
0.001806 |
28.89261 |
rs6497339 |
16 |
19277493 |
A |
T |
0.4536 |
0.063 |
0.0095 |
2.76E−11 |
0.001967 |
31.48824 |
rs3104783 |
16 |
52636242 |
A |
C |
0.4343 |
0.0668 |
0.0094 |
1.29E−12 |
0.002193 |
35.10027 |
rs10221156 |
16 |
52969426 |
A |
G |
0.0932 |
−0.1156 |
0.0179 |
1.08E−10 |
0.002259 |
36.16208 |
rs11150601 |
16 |
30977799 |
A |
G |
0.6442 |
0.0907 |
0.0099 |
5.12E−20 |
0.003771 |
60.46588 |
rs12600861 |
17 |
7355621 |
A |
C |
0.6484 |
−0.0565 |
0.0099 |
1.01E−08 |
0.001456 |
23.28357 |
rs12951632 |
17 |
40741013 |
T |
C |
0.7349 |
0.0642 |
0.0106 |
1.4E−09 |
0.001606 |
25.69415 |
rs666463 |
17 |
76425480 |
A |
T |
0.8328 |
0.076 |
0.0128 |
3.2E−09 |
0.001609 |
25.73544 |
rs2269906 |
17 |
42294337 |
A |
C |
0.6531 |
0.0631 |
0.0102 |
6.24E−10 |
0.001804 |
28.87056 |
rs61169879 |
17 |
59917366 |
T |
C |
0.1641 |
0.082 |
0.0134 |
9.28E−10 |
0.001845 |
29.5203 |
rs11658976 |
17 |
44866805 |
A |
G |
0.5802 |
−0.0624 |
0.0113 |
3.52E−08 |
0.001897 |
30.35583 |
rs850738 |
17 |
42434630 |
A |
G |
0.6056 |
−0.071 |
0.0105 |
1.29E−11 |
0.002408 |
38.55803 |
rs117615688 |
17 |
43798308 |
A |
G |
0.067 |
−0.2324 |
0.0288 |
6.71E−16 |
0.006752 |
108.5924 |
rs62053943 |
17 |
43744203 |
T |
C |
0.1552 |
−0.27 |
0.0155 |
3.58E−68 |
0.019116 |
311.3034 |
rs1941685 |
18 |
31304318 |
T |
G |
0.4983 |
0.0531 |
0.0094 |
1.69E−08 |
0.00141 |
22.55096 |
rs8087969 |
18 |
48683589 |
T |
G |
0.5496 |
−0.0578 |
0.0102 |
1.41E−08 |
0.001654 |
26.46354 |
rs12456492 |
18 |
40673380 |
A |
G |
0.6816 |
−0.0983 |
0.0099 |
3.8E−23 |
0.004194 |
67.27648 |
rs55818311 |
19 |
2341047 |
T |
C |
0.6937 |
−0.0696 |
0.0111 |
4.18E−10 |
0.002059 |
32.95038 |
rs77351827 |
20 |
6006041 |
T |
C |
0.1275 |
0.0802 |
0.0139 |
8.87E−09 |
0.001431 |
22.89152 |
rs2248244 |
21 |
38852361 |
A |
G |
0.2828 |
0.0714 |
0.0107 |
2.74E−11 |
0.002068 |
33.10118 |
SNP: SNP rsID; CHR: Chromosome of SNP; BP: Base-pair location of SNP (hg19); A1: Effect allele; A2: Other allele; EAF: Effect allele frequency; BETA: SNP effect estimate; SE: SE of SNP effect estimate; pval: P-value for effect allele on Telomere length.
Table A3. Variants used in the genetic instrument for Parkinson’s disease age at onset.
SNP |
CHR |
BP |
A1 |
A2 |
EAF |
BETA |
SE |
P |
R2 |
F-Statistic |
rs356203 |
4 |
90666041 |
G |
A |
0.37 |
−0.626 |
0.089 |
1.90E−12 |
0.182693 |
1946.051 |
rs34311866 |
4 |
951947 |
C |
T |
0.26 |
−0.613 |
0.107 |
9.62E−09 |
0.143361 |
1456.971 |
SNP: SNP rsID; CHR: Chromosome of SNP; BP: Base-pair location of SNP (hg19); A1: Effect allele; A2: Other allele; EAF: Effect allele frequency; BETA: SNP effect estimate; SE: SE of SNP effect estimate; pval: P-value for effect allele on Telomere length.
Table A4. Variants used in the genetic instrument for Parkinson’s disease continuous motor subtype.
SNP |
CHR |
BP |
A1 |
A2 |
EAF |
BETA |
SE |
P |
R2 |
F-Statistic |
rs113942635 |
3 |
75446661 |
T |
C |
0.01 |
0.81 |
0.18 |
8.00E−06 |
0.012991 |
1.350142 |
rs2913614 |
5 |
5224692 |
A |
T |
0.54 |
0.15 |
0.03 |
6.33E−06 |
0.011178 |
1.159609 |
rs77942836 |
11 |
103916643 |
A |
G |
0.02 |
−0.53 |
0.12 |
8.11E−06 |
0.011011 |
1.14212 |
rs80164227 |
18 |
5197857 |
A |
G |
0.97 |
−0.43 |
0.1 |
9.15E−06 |
0.010761 |
1.115897 |
rs79890063 |
21 |
20786475 |
A |
C |
0.12 |
−0.22 |
0.04 |
6.96E−07 |
0.010222 |
1.059417 |
rs17488950 |
13 |
110127965 |
T |
C |
0.07 |
−0.27 |
0.06 |
1.46E−06 |
0.009492 |
0.982982 |
rs9626407 |
22 |
46008464 |
A |
G |
0.04 |
−0.35 |
0.07 |
1.97E−06 |
0.009408 |
0.974244 |
rs116917617 |
12 |
62440045 |
T |
C |
0.98 |
−0.46 |
0.1 |
2.11E−06 |
0.008295 |
0.857995 |
rs11644635 |
16 |
15972631 |
T |
C |
0.39 |
−0.13 |
0.03 |
3.14E−06 |
0.008041 |
0.831539 |
rs10109703 |
8 |
8387903 |
A |
C |
0.64 |
−0.13 |
0.03 |
1.44E−06 |
0.007788 |
0.805119 |
rs2301857 |
4 |
5418485 |
T |
C |
0.12 |
−0.19 |
0.04 |
6.60E−07 |
0.007624 |
0.788117 |
rs117238693 |
10 |
56421400 |
T |
C |
0.98 |
0.43 |
0.1 |
8.04E−06 |
0.007248 |
0.748941 |
rs12242050 |
10 |
103048995 |
T |
G |
0.76 |
−0.14 |
0.03 |
8.44E−07 |
0.00715 |
0.738742 |
rs6958272 |
7 |
5794044 |
T |
C |
0.92 |
−0.22 |
0.05 |
3.01E−06 |
0.007124 |
0.736078 |
rs66792854 |
7 |
132040533 |
A |
G |
0.06 |
0.25 |
0.06 |
9.96E−06 |
0.00705 |
0.728328 |
rs118076379 |
17 |
72542970 |
A |
G |
0.01 |
0.59 |
0.13 |
9.49E−06 |
0.006892 |
0.711932 |
rs2336592 |
11 |
132873644 |
C |
G |
0.63 |
−0.12 |
0.03 |
7.82E−06 |
0.006713 |
0.693307 |
rs2717804 |
7 |
148211886 |
A |
G |
0.36 |
−0.12 |
0.03 |
2.67E−06 |
0.006636 |
0.685223 |
rs538015403 |
19 |
14878196 |
A |
G |
0.02 |
−0.41 |
0.09 |
2.56E−06 |
0.00659 |
0.680441 |
rs7834008 |
8 |
22906180 |
T |
C |
0.79 |
0.14 |
0.03 |
5.98E−06 |
0.006503 |
0.671477 |
rs9483680 |
6 |
134657949 |
A |
C |
0.9 |
−0.19 |
0.04 |
7.02E−06 |
0.006498 |
0.670929 |
rs56242312 |
2 |
57141732 |
A |
G |
0.9 |
−0.19 |
0.04 |
8.18E−06 |
0.006498 |
0.670929 |
rs72636490 |
13 |
87927123 |
A |
C |
0.08 |
−0.21 |
0.05 |
8.59E−06 |
0.006492 |
0.670255 |
rs143548133 |
2 |
72300987 |
T |
C |
0.01 |
0.57 |
0.13 |
7.02E−06 |
0.006433 |
0.664176 |
rs76377494 |
4 |
86019236 |
T |
C |
0.07 |
−0.22 |
0.05 |
1.89E−06 |
0.006302 |
0.65053 |
rs17015314 |
1 |
105497011 |
A |
G |
0.88 |
−0.17 |
0.04 |
7.90E−06 |
0.006104 |
0.629965 |
rs75477320 |
14 |
47229012 |
T |
C |
0.13 |
0.16 |
0.04 |
9.07E−06 |
0.005791 |
0.597476 |
rs6535273 |
4 |
82616045 |
T |
C |
0.39 |
0.11 |
0.02 |
1.37E−06 |
0.005757 |
0.593995 |
rs7257687 |
19 |
45887928 |
T |
C |
0.03 |
−0.3 |
0.07 |
8.30E−06 |
0.005238 |
0.540147 |
rs2892663 |
4 |
116121350 |
T |
C |
0.5 |
0.1 |
0.02 |
5.73E−06 |
0.005 |
0.515481 |
rs1552340 |
3 |
142015590 |
A |
G |
0.42 |
0.1 |
0.02 |
9.73E−06 |
0.004872 |
0.50222 |
SNP: SNP rsID; CHR: Chromosome of SNP; BP: Base-pair location of SNP (hg19); A1: Effect allele; A2: Other allele; EAF: Effect allele frequency; BETA: SNP effect estimate; SE: SE of SNP effect estimate; pval: P-value for effect allele on Telomere length.
Table A5. Variants used in the genetic instrument for Parkinson’s disease binary motor subtype.
rsID |
CHR |
BP |
A1 |
A2 |
EAF |
BETA |
SE |
P |
R2 |
F-Statistic |
rs116504637 |
1 |
47557933 |
T |
G |
0.74 |
0.35 |
0.07 |
9.83E−07 |
0.047138 |
22.64309 |
rs11949046 |
5 |
161678799 |
T |
C |
0.89 |
0.54 |
0.11 |
1.57E−06 |
0.057095 |
27.71576 |
rs78926797 |
16 |
19502663 |
A |
C |
0.6 |
−0.3 |
0.06 |
2.08E−06 |
0.0432 |
20.66603 |
rs6932127 |
6 |
125107499 |
T |
C |
0.89 |
−0.46 |
0.1 |
3.01E−06 |
0.041431 |
19.78334 |
rs55971529 |
11 |
22583068 |
A |
G |
0.97 |
−1.08 |
0.23 |
3.95E−06 |
0.067884 |
33.3346 |
rs988295487 |
1 |
77190938 |
C |
G |
0.96 |
−0.84 |
0.18 |
4.98E−06 |
0.05419 |
26.22469 |
rs13330839 |
16 |
82279626 |
A |
G |
0.87 |
−0.47 |
0.1 |
7.00E−06 |
0.049968 |
24.07378 |
SNP: SNP rsID; CHR: Chromosome of SNP; BP: Base-pair location of SNP (hg19); A1: Effect allele; A2: Other allele; EAF: Effect allele frequency; BETA: SNP effect estimate; SE: SE of SNP effect estimate; pval: P-value for effect allele on Telomere length.