Combination Effect of Miconazole with Polygodial against Candida albicans
Isao Kubo, Sang Hwa Lee, Kuniyoshi Shimizu
DOI: 10.4236/ojmm.2011.11002   PDF    HTML     6,176 Downloads   11,689 Views   Citations


The combination effect of miconazole with polygodial against Candida albicans was investigated by an in vitro checkerboard method. Isobolograms, fractional inhibitory concentration (FIC), and fractional fungicidal concentration (FFC) indices were used for evaluating the interaction between compounds combined. The combination of miconazole with polygodial exhibited strong synergism on both fungistatic and fungicidal action against this opportunistic pathogen.

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I. Kubo, S. Lee and K. Shimizu, "Combination Effect of Miconazole with Polygodial against Candida albicans," Open Journal of Medical Microbiology, Vol. 1 No. 1, 2011, pp. 7-11. doi: 10.4236/ojmm.2011.11002.

Conflicts of Interest

The authors declare no conflicts of interest.


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