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A Greener Way to Screen Toothpaste for Diethylene Glycol

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DOI: 10.4236/ajac.2011.28109    4,561 Downloads   7,706 Views   Citations

ABSTRACT

A method developed for the screening of diethylene glycol (DEG) in toothpaste was released by the FDA in 2007. This method could not only quantify the DEG but also confirm if any potential interfering peak is pre- sent. However, disadvantages of this method such as intermittent shortages of the key reagent acetonitrile and the shorter than expected column-life issues have prompted a search for alternative solutions. An im- provement with an alternate “greener” extraction solvent is presented, and the method comparison and vali- dation are described in this article. The greener extraction solvent, ethanol with limited water, provided a better efficiency for the toothpaste sampling procedures. The limit of detection (LOD) and limit of quantita- tion (LOQ) are 0.0025% and 0.0084% in (w/w) unit, respectively. The sample recovery is 101.2%.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Y. Fu, Z. Hao, B. Parker and M. Knapp, "A Greener Way to Screen Toothpaste for Diethylene Glycol," American Journal of Analytical Chemistry, Vol. 2 No. 8, 2011, pp. 938-943. doi: 10.4236/ajac.2011.28109.

References

[1] R. J. Lewis and S. Hawley, “Condensed Chemical Dic- tionary,” Van Nostrand Reinhold Company, New York, 1993.
[2] J. M. Marraffa, M. G. Holland, C. M. Stork, C. D. Hoy and M. J. Hodgman, “Diethylene Glycol: Widely Used Solvent Present Serious Poisoning Potential,” The Journal of Emergency Medicine, Vol. 35, No. 4, 2008, pp. 401-406. doi:10.1016/j.jemermed.2007.06.025
[3] A. Ghaffara, P. G. Verschuren, J. A. J. Geenevasen, T. Handels, J. Berard, B. Plum, A. A. Dias, P. J. Schoen- makers and Sj. van der Wal, “Fast in vitro Hydrolytic Degradation of Polyester Urethane Acrylate Biomaterials: Structure Elucidation, Separation and Quantification of Degradation Products,” Journal of Chromatography A, Vol. 1218, No. 3, 2011, pp. 449-458. doi:10.1016/j.chroma.2010.11.053
[4] G. Stefania, B. Maura, V. L. Claudia, P. Barbara, M. Ginevra and R. Francesco, “Biological Effects of Diethyl- ene Glycol (DEG) and Produced Waters (PWs) Released from Offshore Activities: A Multi-Biomarker Approach with the Sea Bass Dicentrarchus labrax,” Environmental Pollution, Vol. 157, No. 11, 2009, pp. 3166-3173. doi:10.1016/j.envpol.2009.05.021
[5] C. M. Gryniewicz, J. A. Spencer, M. Hankins and J. F. Kauffman, “Spectroscopic Methods for Rapid Determina- tion of Diethylene Glycol in Glycerin,” American Pharmaceutical Review, Vol. 10, 2007, pp. 1-4.
[6] G. Holloway, R. Maheswaran, A. Leeks, S. Bradby and S. Wahab, “Screening Method for Ethylene Glycol and Di- ethylene Glycol in Glycerin-Containing Products,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 51, No. 3, 2010, pp. 507-511. doi:10.1016/j.jpba.2009.08.025
[7] X. Li, S. Arzhantsev, J. F. Kauffman and J. A. Spencer, “Detection of Diethylene Glycol Adulteration in Propylene Glycol—Method Validation through a Multi-Instrument Collaborative Study,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 54, No. 5, 2011, pp. 1001- 1006. doi:10.1016/j.jpba.2010.11.042
[8] ASTM E611-08 in ASTM, “American Society for Testing and Matericals, Standard Test Methods for Low Concentrations of Diethlyene Glycol in Ethylene Glycol by Gas Chromatography,” Annual book of ASTM standard, Philadelphia.
[9] K. Molever, “Simplfied Assay of Diethylene Glycol and Ethylene Glycol in Various Raw Materials by Capillary Gas Chromatography,” Society of Cosmetic Chemists, Vol. 61, 2010, pp. 225-234.
[10] A. Kenyon, X. Shi, Y. Wang, W. H. Ng, “Simple on-Site Detection of Diethylene Glycol/Ethylene Glycol Contamination of Glycerin and Glycerin-Based Raw Materials by Thin-Layer Chromatography,” Journal of AOAC International, Vol. 81, 1998, pp. 44-50.
[11] J. Ding, H. Gu, S. Yang, M. Li, J. Li and H. Chen, “Se- lective Detection of Diethylene Glycol in Toothpaste Prod- ucts Using Neutral Desorption Reactive Extractive Electros- pray Ionization Tandem Mass Spectrometry,” Analytical Chemistry, Vol. 81, No. 20, 2009, pp. 8632- 8638. doi:10.1021/ac9013594
[12] F. Hernandez, M. Ibanez and J. V. Sancho, “Fast Deter- mination of Toxic Diethylene Glycol in Toothpaste by Ultra-Performance Liquid Chromatography-Time of Flight Mass Spectrometry,” Analytical and Bioanalytical Chemistry, Vol. 391, No. 3, 2008, pp. 1021-1027. doi:10.1007/s00216-008-2082-0
[13] M. Lopez-Sanchez, A. Dominguez-Vidal, M. J. Ayora- Canada and A. Molina-Diaz, “Assessment of Dentifrice Adulteration with Diethylene Glycol by Means of ATR- FTIR Spectroscopy and Chemometrics,” Analytica Chimica Acta, Vol. 620, No. 1-2, 2008, pp. 113-119. doi:10.1016/j.aca.2008.05.032
[14] X. Xing, X. Shi, H. Zhang, W. Wang and J. Ye, “Deter- mination of Diethylene Glycol in Toothpaste by Capillary Electrophoresis with Electrochemical Detection,” Microchimica Acta, Vol. 167, 2009, pp. 297-302.
[15] A. A. Rahim, B. Saad, H. Osman, N. Hashim, S. Yahya and K. M. Talib, “Simultaneous Determination of Diethylene Glycol, Diethylene Glycol Monoethyl Ether, Coumarin and Caffeine in Food Items by Gas Chromatography,” Food Chemistry, Vol. 126, No. 3, 2011, pp. 1412-1416. doi:10.1016/j.foodchem.2010.11.121
[16] T. Zhou, H. Zhang and G. Duan, “Simultaneous Determi- nation of Diethylene Glycol and Propylene Glycol in Pharmaceutical Products by HPLC after Precolumn Deri- vatization with P-Toluenesulfonyl Isocyanate,” Journal of Separation Science, Vol. 30, No. 16, 2007, pp. 2620- 2627. doi:10.1002/jssc.200700097
[17] A. Cappiello, G. Famiglinia, P. Palma, V. Termopolia, H. Trufelli , R. Di Mentob and M. Mannozzi, “LC-ESI-MS Determination of Diethylene Glycol Pollution in Sea Water Samples Collected around Gas Extraction Platform Plants,” Talanta, Vol. 80, No. 1, 2009, pp. 257-262. doi:10.1016/j.talanta.2009.06.067
[18] P. Teamkao and P. Thiravetyan. “Phytoremediation of Ethylene Glycol and Its Derivatives by the Burhead Plant (Echinodorus cordifolius (L.): Effect of Molecular Size,” Chemosphere, Vol. 81, No. 9, 2010, pp. 1069-1074. doi:10.1016/j.chemosphere.2010.09.049
[19] http://www.fda.gov/Food/ScienceResearch/LaboratoryMethods/DrugChemicalResiduesMethodology/ucm113209. htm
[20] E. Kuhn, “Water Injections in GC―How Wet Can You Get?” LCGC North America, Vol. 20, 2002, pp. 474-478.
[21] F. J. Schenck, P. Callery, P. M. Gannett, J. R. Daft and S. J. Lehotay, “Comparison of Magnesium Sulfate and Sodium Sulfate for Removal of Water from Pesticide Extracts of Foods,” Journal of AOAC International, Vol. 85, 2002, pp. 1177-1180.

  
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