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Impact of the Normalized Copy Number of BCR-ABL Transcript upon Diagnosis on Prognosis in CML Patients Treated with Imatinib-Mesylate

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DOI: 10.4236/ojbd.2011.12004    5,090 Downloads   10,699 Views  

ABSTRACT

Quantification of the BCR-ABL transcript is recommended to follow-up CML patients treated by imatinib mesylate (IM). Results are expressed as a normalized copy number (NCN) of BCR-ABL. We studied a cohort of 98 CML patients under IM as a first treatment and monitored by RQ-PCR after 12, 18 and 24 months according to the European LeukemiaNet recommendations. Our results support the hypothesis of an independent correlation between BCR-ABL NCN at diagnosis and major molecular response at 18 and 24 months in an inverse relationship. We also highlighted the possibility to use the NCN at diagnosis as a warning at diagnosis, and may be useful to identify patients who could benefit of a more rigorous follow-up.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

C. Martinaud, A. Mayet, S. Bousquet, N. Beaufils, J. Gabert, S. Raynaud and M. Mozziconacci, "Impact of the Normalized Copy Number of BCR-ABL Transcript upon Diagnosis on Prognosis in CML Patients Treated with Imatinib-Mesylate," Open Journal of Blood Diseases, Vol. 1 No. 2, 2011, pp. 12-14. doi: 10.4236/ojbd.2011.12004.

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