of chondrocytes that may be affected by the age and stage of maturation of an animal. Further investigations are required to ascertain the stage of musculoskeletal maturation in different species and compare the [Ca2+]i of chondrocytes in mature and immature animals, and also [Ca2+]i from diseased or damaged tissue to those of normal, healthy tissue. The behaviour of Fura-2 could also account for these differences and further studies are required to elucidate this before ovids are used as a large animal model for investigating the physiology or pathophysiology of chondrocytes when access to human tissue is limited.

Acknowledgements

RW helped plan the experiments, carried them out, analysed the data and prepared the manuscript. JSG planned the experiments and helped write the manuscript. All authors have read and approved the final manuscript. This work was supported by a BBSRC Studentship held by RW. RW received financial support from University Centre Myerscough for the publication of this article.

Declaration of Conflicting Interests

The Author(s) declare that there are no conflicts of interests.

Conflicts of Interest

The authors declare no conflicts of interest.

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