5. Conclusion

In this study, we focused on the fast delivery of the PS by HVJ-E and have demonstrated highly selective cytotoxicity of in vitro PDT using PE against drug-resistant prostate cancer cells with a short drug-light interval. This result suggests that PE-mediated PDT can shorten drug-light interval and reduce PDT-mediated side effects, and gives the possibility to apply PDT to a novel treatment modality for drug-resistant prostate cancer in clinical.

Acknowledgements

We are deeply grateful to Erica Miyake Lin for technical assistance with the experiments. This work was supported by JSPS KAKENHI Grant Number JP15K16322 and JGC-S SCHOLARSHIP FOUNDATION Grant Number 1605.

Conflicts of Interest

The authors declare no conflicts of interest.

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