Baseline Laboratory Profile of HIV Positive Patients on Antiretroviral Therapy in Jos North Central Nigeria: Implications for Pre-vention, Treatment, Care and Support
Christian Ogoegbunem Isichei1,2, Mercy Wakili Isichei2,3, Jean Emile Njab4, Johnson Ibidun Rotimi2, Tinuade Abimbola Oyebode5,6, Charles Ujunwa Anyaka2,5, Kenneth Emeka Enwerem2, Ayuba Ishiaku Affi1, Lucius Chidiebere Imoh1, Alexander Ogielu Abu1, Solomon Abiola Asorose1, Noel Omuya Amadu1, Propser Ihenacho Okonkwo6, Ngozi Ijeoma Okoro4
1Department of Chemical Pathology, Faculty of Medical Sciences, University of Jos, Jos University Teaching Hospital, Jos, Nigeria.
2Faith Alive Foundation, Jos, Nigeria.
3Department of Surgery, Faculty of Medical Sciences, University of Jos, Jos University Teaching Hospital, Jos, Nigeria.
4Department of Chemical Pathology, Bingham University, Jos Campus, Jos, Nigeria.
5Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Jos, Jos, Nigeria.
6AIDS Prevention Initiative in Nigeria (APIN), Abuja, Nigeria.
DOI: 10.4236/wja.2015.54036   PDF   HTML   XML   4,572 Downloads   5,541 Views   Citations


Background: We characterized baseline laboratory data of patients to identify priority treatment areas, most affected populations, anticipated clinical complications and assessed the potential burden of retention in care in Jos, Plateau State—North Central Nigeria. Methods: This study was a cross-sectional design from January 2004 to December 2005 at Faith Alive Foundation (FAF). All participants were HIV-positive and underwent pre-antiretroviral therapy counseling based on the national antiretroviral therapy (ART) guidelines and baseline laboratory testing. Data were captured on Microsoft Excel, validated on Epi Info and analyzed on SPSS version 21 at P < .05 level of significance. Results: Total of 1499 (463 men and 1036 women) participants were evaluated in this study. The age and sex related distribution of participants showed that majority (80.3% for males and 92.5% for females) were 16 - 45 years old. Amylase and creatinine were significantly higher in males than females (P = .02). Anaemia was the most common baseline abnormality (63% for females and 58% for males), while baseline CD4 count was significantly lower in males than females (P < .02) and at one-third had elevated liver enzymes (AST and ALT). Conclusion: The baseline laboratory profile of most HIV positive patients in Jos and environs of North Central–Nigeria was characterized by anaemia, elevated creatinine, and abnormal liver transaminase levels (AST and ALT). This pre-ART laboratory result suggests that HIV-positive individuals have multiple clinical abnormalities which may require more extensive care than just treating the HIV disease.

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Isichei, C. , Isichei, M. , Njab, J. , Rotimi, J. , Oyebode, T. , Anyaka, C. , Enwerem, K. , Affi, A. , Imoh, L. , Abu, A. , Asorose, S. , Amadu, N. , Okonkwo, P. and Okoro, N. (2015) Baseline Laboratory Profile of HIV Positive Patients on Antiretroviral Therapy in Jos North Central Nigeria: Implications for Pre-vention, Treatment, Care and Support. World Journal of AIDS, 5, 328-334. doi: 10.4236/wja.2015.54036.

Conflicts of Interest

The authors declare no conflicts of interest.


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