Sleep in the Work of Marcos José Salgado, Author of the First Book of Physiology in the Americas, Published in 1727


Sleep and wakefulness are functions of the central nervous system (CNS) that are altered in numerous psychiatric disorders. Interestingly, Marcos José Salgado published in 1727 his book which is considered the first book of Physiology in the American continent and entitled “Cursus Medicus Mexicanus” (Figure 1) that suggests the use of drugs to regulate brain functions and their therapeutic action on sleep. In the work of Salgado, the concepts of sleep and wakefulness are offered using Hippocratic and Galenic knowledge to explain the pathophysiology of both functions. Today those concepts might be considered wrong. However, taking into account the historical moment and the intrinsic value of the text written in Latin, this manuscript is unique. Considered by art critics as valuable, there are only eight original copies of this book. In the present report, we discussed paragraph by paragraph the chapter “Sleep and wakefulness”, the work of this Medical Doctor of the New Spain.

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Flores, G., Fernández-Sánchez, C. M., Valdes-Cruz, A., & Morales-Medina, J. C. (2015) Sleep in the Work of Marcos José Salgado, Author of the First Book of Physiology in the Americas, Published in 1727. Advances in Historical Studies, 4, 368-379. doi: 10.4236/ahs.2015.45026.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Aréchiga, H. (1988). Physiology in Health in Mexico: Testimonies Medical Specialties in Mexico. Compilers Soberón G, Kumate J and Laguna. Biblioteca de la Salud, Pp. 79-107.
[2] De Michali, A. (2004). The Long Way toward Mexican Cardiology. Gaceta Medica de Mexico, 140, 340-352.
[3] De Micheli Serra, A. (1983). Sesquicentennial of the Medical School of the National University of Mexico (Part 2: 1859-1945). Archivos de Cardiologia de Mexico, 53, 379-384.
[4] De Micheli Serra, A., & Izaquirre-Avila, R. (2010). European Science of the New Spain. Ciencia, 61, 22-29.
[5] Finch, S. (2005). Rare Books Catalogue No. 62. From the Source to the Severn Bore. Wales and England, 32/1727.
[6] Hess, W. R. (1944). Das schlafsyndrom als folge dienzephaler reizung. Helvetica Physiologica et Pharmacologica Acta, 2, 305-344.
[7] Izquierdo, J. J. (1934). Quadricentennial Balance of the Mexican Physiology. México: Ediciones Ciencia, 358.
[8] Izquierdo, J. J. (1965). William Harvey in the Motion of the Heart and Blood in Animals. México: UNAM.
[9] Jouvet, M. (1988) The Regulation of Paradoxical Sleep by the Hypothalamo-Hypophysis. Archives Italiennes de Biologie, 126, 259-274.
[10] Pieron, H. (1913). Le probleme physiologique du sommeil. Paris: Masson, 1-520.
[11] Salgado, M. J. (1727). Cursus Medicus Mexicanus. México: Impr. Her. Vda de Miguel de Rivera.

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