Natural Remedies against Multi-Drug Resistant Mycobacterium tuberculosis


Tuberculosis (TB), caused by Mycobacterium tuberculosis is an infectious deadly disease and the treatment of which is one of the most severe challenges at the global level. Currently more than 20 chemical medications are described for the treatment of TB. Regardless of availability of several drugs to treat TB, the causative agent, M. tuberculosis is nowadays getting resistant toward the conventional drugs and leading to conditions known as Multidrug-resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB). This situation has terrified the global health community and raised a demand for new anti-tuberculosis drugs. Medicinal plants have been used to cure different common as well as lethal diseases by ancient civilizations due to its virtue of variety of chemical compounds which may have some important remedial properties. The aim of the present review is to focus the anti-tubercular medicinal plants native to India as well as the plants effective against MDR or XDR-TB across the globe. In the present review, we have addressed 25 medicinal plants for TB and 16 plants effective against MDR-TB testified from India and 23 herbal plants described for MDR-TB across the world during 2011-2015. These herbal plants can serve as promising candidates for developing novel medications to combat multidrug resistant M. tuberculosis.

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Pandit, R. , Singh, P. and Kumar, V. (2015) Natural Remedies against Multi-Drug Resistant Mycobacterium tuberculosis. Journal of Tuberculosis Research, 3, 171-183. doi: 10.4236/jtr.2015.34024.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Gutierrez, M.C., Brisse, S., Brosch, R., Fabre, M., Omais, B., et al. (2005) Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis. PLoS Pathogens, 1, e5.
[2] (2014) Organization WH Global Tuberculosis Report 2014. World Health Organization, Geneva.
[3] Zager, E.M. and McNerney, R. (2008) Multidrug-Resistant Tuberculosis. BMC Infectious Diseases, 8, 10.
[4] Brothwell, D. and Sandison, A.T. (1967) Diseases in Antiquity. A Survey of the Diseases, Injuries and Surgery of Early Populations. Diseases in Antiquity a Survey of the Diseases, Injuries and Surgery of Early Populations.
[5] Herzog, B. (1998) History of Tuberculosis. Respiration, 65, 5-15.
[6] D’Ambrosio, L., Centis, R., Sotgiu, G., Pontali, E., Spanevello, A., et al. (2015) New Anti-Tuberculosis Drugs and Regimens: 2015 Update. ERJ Open Research, 1, 00010-02015.
[7] WHO (2014) Global Tuberculosis Report 2014. World Health Organization, Geneva.
[8] Zignol, M., Hosseini, M.S., Wright, A., Lambregts-van Weezenbeek, C., Nunn, P., et al. (2006) Global Incidence of Multidrug-Resistant Tuberculosis. Journal of Infectious Diseases, 194, 479-485.
[9] Control, CfD. and Prevention (2006) Emergence of Mycobacterium tuberculosis with Extensive Resistance to Second- Line Drugs—Worldwide, 2000-2004. MMWR Morbidity and Mortality Weekly Report, 55, 301.
[10] Dooley, S.W., Jarvis, W.R., Marione, W.J. and Snider, D.E. (1992) Multidrug-Resistant Tuberculosis. Annals of Internal Medicine, 117, 257-259.
[11] Edlin, B.R., Tokars, J.I., Grieco, M.H., Crawford, J.T., Williams, J., et al. (1992) An Outbreak of Multidrug-Resistant Tuberculosis among Hospitalized Patients with the Acquired Immunodeficiency Syndrome. New England Journal of Medicine, 326, 1514-1521.
[12] Sharma, S. and Mohan, A. (2004) Multidrug-Resistant Tuberculosis. Indian Journal of Medical Research, 120, 354- 376.
[13] India Tuberculosis (2012) Revised National Tuberculosis Control Programme. Annual Status Report.
[14] Ohno, H., Koga, H. and Kohno, S. (1998) Multidrug-Resistant Tuberculosis. 2. Mechanisms of Drug-Resistance in Mycobacterium tuberculosis—Genetic Mechanisms of Drug-Resistance. Kekkaku:
[Tuberculosis], 73, 657-663.
[15] Flandrois, J.P., Lina, G. and Dumitrescu, O. (2014) MUBII-TB-DB: A Database of Mutations Associated with Antibiotic Resistance in Mycobacterium tuberculosis. BMC Bioinformatics, 15, 107.
[16] Diel, R., Rutz, S., Castell, S. and Schaberg, T. (2012) Tuberculosis: Cost of Illness in Germany. European Respiratory Journal, 40, 143-151.
[17] Alsaad, N., van Altena, R., Pranger, A.D., van Soolingen, D., de Lange, W.C., et al. (2013) Evaluation of Co-Trimoxazole in the Treatment of Multidrug-Resistant Tuberculosis. European Respiratory Journal, 42, 504-512.
[18] Skripconoka, V., Danilovits, M., Pehme, L., Tomson, T., Skenders, G., et al. (2013) Delamanid Improves Outcomes and Reduces Mortality in Multidrug-Resistant Tuberculosis. European Respiratory Journal, 41, 1393-1400.
[19] Diacon, A.H., Pym, A., Grobusch, M.P., de los Rios, J.M., Gotuzzo, E., et al. (2014) Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline. New England Journal of Medicine, 371, 723-732.
[20] Migliori, G., De Iaco, G., Besozzi, G., Centis, R. and Cirillo, D. (2007) First Tuberculosis Cases in Italy Resistant to All Tested Drugs. Euro Surveillance, 12, Article ID: E070517.
[21] Udwadia, Z.F., Amale, R.A., Ajbani, K.K. and Rodrigues, C. (2012) Totally Drug-Resistant Tuberculosis in India. Clinical Infectious Diseases, 54, 579-581.
[22] Klopper, M., Warren, R.M., Hayes, C., van Pittius, N.C.G., Streicher, E.M., et al. (2013) Emergence and Spread of Extensively and Totally Drug-Resistant Tuberculosis, South Africa. Emerging Infectious Diseases, 19, 449-455.
[23] Parida, S., Axelsson-Robertson, R., Rao, M., Singh, N., Master, I., et al. (2015) Totally Drug-Resistant Tuberculosis and Adjunct Therapies. Journal of Internal Medicine, 277, 388-405.
[24] Mahajan, G.B. and Balachandran, L. (2011) Antibacterial Agents from Actinomycetes—A Review. Frontiers in Bioscience (Elite Edition), 4, 240-253.
[25] Adegboye, M. and Babalola, O. (2013) Actinomycetes: A Yet Inexhaustive Source of Bioactive Secondary Metabolites. In: Mendez-Vilas, A., Ed., Microbial Pathogens and Strategies for Combating Them: Science, Technology and Education, Formatex, Badajoz, 786-795.
[26] Patel, J.D., Parmar, M., Patel, P., Rohit, P., Taviyad, R., et al. (2014) Dynamism of Antimicrobial Activity of Actinomycetes—A Case Study from Undisturbed Microbial Niche. Advances in Microbiology, 4, 324-334.
[27] Smith, D. and Ryan, M. (2009) Fungal Sources for New Drug Discovery. Access Science, © McGraw-Hill Companies.
[28] Aly, A.H., Debbab, A. and Proksch, P. (2011) Fifty Years of Drug Discovery from Fungi. Fungal Diversity, 50, 3-19.
[29] Singh, R.K., Tiwari, S.P., Rai, A.K. and Mohapatra, T.M. (2011) Cyanobacteria: An Emerging Source for Drug Discovery. The Journal of Antibiotics, 64, 401-412.
[30] Abdallah, E.M. (2011) Plants: An Alternative Source for Antimicrobials. Journal of Applied Pharmaceutilcal Science, 1, 16-20.
[31] Katiyar, C., Gupta, A., Kanjilal, S. and Katiyar, S. (2012) Drug Discovery from Plant Sources: An Integrated Approach. Ayu, 33, 10-19.
[32] Akshata, J., Chakrabarthy, A., Swapna, R., Buggi, S. and Somashekar, M. (2015) Adverse Drug Reactions in Management of Multi Drug Resistant Tuberculosis, in Tertiary Chest Institute. Journal of Tuberculosis Research, 3, 27-33.
[33] Arbex, M.A., Varella Mde, C., Siqueira, H.R. and Mello, F.A. (2010) Antituberculosis Drugs: Drug Interactions, Adverse Effects, and Use in Special Situations-Part 1: First-Line Drugs. Jornal Brasileiro de Pneumologia, 36, 626-640.
[34] Arbex, M.A., Varella Mde, C., Siqueira, H.R. and Mello, F.A. (2010) Antituberculosis Drugs: Drug Interactions, Adverse Effects, and Use in Special Situations-Part 2: Second Line Drugs. Jornal Brasileiro de Pneumologia, 36, 641- 656.
[35] Glesinger, L. (1954) Medicine through Centuries. Zora, Zagreb, 21-38.
[36] Bottcher, H. (1965) Miracle Drugs. Zora, Zagreb, 23-139.
[37] Castiglioni, A., Krumbhaar, E.B. and Alfred, A. (1947) A History of Medicine. Knopf, New York.
[38] Petrovska, B.B. (2012) Historical Review of Medicinal Plants’ Usage. Pharmacognosy Reviews, 6, 1-5.
[39] Cragg, G.M. and Newman, D.J. (2013) Natural Products: A Continuing Source of Novel Drug Leads. Biochimica et Biophysica Acta (BBA)—General Subjects, 1830, 3670-3695.
[40] Santhosh, R.S. and Suriyanarayanan, B. (2014) Plants: A Source for New Antimycobacterial Drugs. Planta Medica, 80, 9-21.
[41] Newton, S.M., Lau, C. and Wright, C.W. (2000) A Review of Antimycobacterial Natural Products. Phytotherapy Research, 14, 303-322.<303::AID-PTR712>3.0.CO;2-N
[42] Mohamad, S., Zin, N.M., Wahab, H.A., Ibrahim, P., Sulaiman, S.F., et al. (2011) Antituberculosis Potential of Some Ethnobotanically Selected Malaysian Plants. Journal of Ethnopharmacology, 133, 1021-1026.
[43] Babalola, I.T., Adelakun, E.A., Wang, Y. and Shode, F.O. (2012) Anti-TB Activity of Sterculia setigera Del., Leaves (Sterculiaceae). Journal of Pharmacognosy and Phytochemistry, 1, 19-26.
[44] Robles-Zepeda, R.E., Coronado-Aceves, E.W., Velázquez-Contreras, C.A., Ruiz-Bustos, E., Navarro-Navarro, M., et al. (2013) In Vitro Anti-Mycobacterial Activity of Nine Medicinal Plants Used by Ethnic Groups in Sonora, Mexico. BMC Complementary and Alternative Medicine, 13, 329.
[45] Balcha, E., Mengiste, B., Gebrelibanos, M., Worku, A. and Ameni, G. (2014) Evaluation of In-Vitro Anti-Mycobacterial Activity of Selected Medicinal Plants in Mekelle, Ethiopia. World Applied Sciences Journal, 31, 1217-1220.
[46] Njeru, S.N., Obonyo, M.A., Ngari, S.M., Nyambati, S., Onsarigo, J.M.N., et al. (2015) Antituberculous, Antimicrobial, Cytotoxicity and Phytochemical Activity Study of Piliostigma thonningii Extract Fractions. Journal of Medicinal Plants Research, 9, 655-663.
[47] Gautam, R., Saklani, A. and Jachak, S.M. (2007) Indian Medicinal Plants as a Source of Antimycobacterial Agents. Journal of Ethnopharmacology, 110, 200-234.
[48] Arya, V. (2011) A Review on Anti-Tubercular Plants. International Journal of PharmaTech Research, 3, 872-880.
[49] Chattopadhyay, D., Arunachalam, G., Mandal, A.B., Sur, T.K., Mandal, S.C., et al. (2002) Antimicrobial and Anti- Inflammatory Activity of Folklore: Mallotus peltatus Leaf Extract. Journal of Ethnopharmacology, 82, 229-237.
[50] Gupta, V., Shukla, C., Bisht, G., Saikia, D., Kumar, S., et al. (2011) Detection of Anti-Tuberculosis Activity in Some Folklore Plants by Radiometric BACTEC Assay. Letters in Applied Microbiology, 52, 33-40.
[51] Saikia, D., Parveen, S., Gupta, V.K. and Luqman, S. (2012) Anti-Tuberculosis Activity of Indian Grass KHUS (Vetiveria zizanioides L. Nash). Complementary Therapies in Medicine, 20, 434-436.
[52] Adaikkappan, P., Kannapiran, M. and Anthonisamy, A. (2012) Anti-Mycobacterial Activity of Withania somnifera and Pueraria tuberosa against Mycobacterium tuberculosis H37Rv. Journal of Academia and Industrial Research, 1, 153- 156.
[53] Birdi, T., D’souza, D., Tolani, M., Daswani, P., Nair, V., et al. (2012) Assessment of the Activity of Selected Indian Medicinal Plants against Mycobacterium tuberculosis: A Preliminary Screening Using the Microplate Alamar Blue Assay. European Journal of Medicinal Plants, 2, 308-323.
[54] Antony, M., James, J., Misra, C.S., Sagadevan, L., Veettil, A.T., et al. (2012) Anti Mycobacterial Activity of the Plant Extracts of Alstonia scholaris. International Journal of Current Pharmaceutical Research, 4, 40-42.
[55] Mishra, P.K., Singh, R.K., Gupta, A., Chaturvedi, A., Pandey, R., et al. (2013) Antibacterial Activity of Andrographis paniculata (Burm. f.) Wall. ex Nees Leaves against Clinical Pathogens. Journal of Pharmacy Research, 7, 459-462.
[56] Tawde, K., Gacche, R. and Pund, M. (2012) Evaluation of Selected Indian Traditional Folk Medicinal Plants against Mycobacterium tuberculosis with Antioxidant and Cytotoxicity Study. Asian Pacific Journal of Tropical Disease, 2, S685-S691.
[57] Tiwari, N., Thakur, J., Saikia, D. and Gupta, M.M. (2013) Antitubercular Diterpenoids from Vitex trifolia. Phytomedicine, 20, 605-610.
[58] Viswanathan, V., Phadatare, A. and Mukne, A. (2014) Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs. Indian Journal of Pharmaceutical Sciences, 76, 256-261.
[59] Rajiniraja, M. and Jayaraman, G. (2014) Bioautography Guided Screening of Selected Indian Medicinal Plants Reveals Potent Antimycobacterial Activity of Allium sativum Extracts-Implication of Non-Sulfur Compounds in Inhibition. International Journal of Pharmacy and Pharmaceutical Sciences, 6, 671-676.
[60] Munna, S., Basha, S.C., Reddy, P.R., Pramod, N., Kumar, Y.P., et al. (2014) Antitubercular Activity of Actiniopteris radiata Linn. Journal of Global Trends in Pharmaceutical Sciences, 5, 1443-1445.
[61] Kaur, R. and Kaur, H. (2015) Antitubercular Activity and Phytochemical Screening of Selected Medicinal Plants. Oriental Journal of Chemistry, 31, 597-600.
[62] Suhitha, S., Devi, S.K., Gunasekaran, K., Carehome Pakyntein, H., Bhattacharjee, A., et al. (2015) Phytochemical Analyses and Activity of Herbal Medicinal Plants of North-East India for Anti-Diabetic, Anti-Cancer and Anti- Tuberculosis and Their Docking Studies. Current Topics in Medicinal Chemistry, 15, 21-36.
[63] Sheeba, D.G., Gomathi, K.S. and Citarasu, D. (2015) Anti-Mycobacterial and Phytochemical Investigation of Methanol Extracts of Few Medicinal Plants. Journal of Chemical and Pharmaceutical Sciences, 8, 480-486.
[64] Gowrish, A., Vagdevi, H. and Rajashekar, H. (2015) In Vitro Antioxidant and Antitubercular Activity of Leucas marrubioides Desf. Root Extracts. Journal of Applied Pharmaceutical Science, 5, 137-142.
[65] Channabasappa, H.S., Shrinivas, J.D. and Venkatrao, K.H. (2015) Evaluation of Antibacterial and Antitubercular Activity of Cassia fistula Linn Root. International Journal of Research in Pharmaceutical Sciences, 6, 82-84.
[66] Gaur, R., Thakur, J.P., Yadav, D.K., Kapkoti, D.S., Verma, R.K., et al. (2015) Synthesis, Antitubercular Activity, and Molecular Modeling Studies of Analogues of Isoliquiritigenin and Liquiritigenin, Bioactive Components from Glycyrrhiza glabra. Medicinal Chemistry Research, 24, 3494-3503.
[67] Sureram, S., Senadeera, S.P., Hongmanee, P., Mahidol, C., Ruchirawat, S., et al. (2012) Antimycobacterial Activity of Bisbenzylisoquinoline Alkaloids from Tiliacora triandra against Multidrug-Resistant Isolates of Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters, 22, 2902-2905.
[68] Leitão, F., Leitão, S.G., de Almeida, M.Z., Cantos, J., Coelho, T., et al. (2013) Medicinal Plants from Open-Air Markets in the State of Rio de Janeiro, Brazil as a Potential Source of New Antimycobacterial Agents. Journal of Ethnopharmacology, 149, 513-521.
[69] Nguta, J.M., Appiah-Opong, R., Nyarko, A.K., Yeboah-Manu, D. and Addo, P.G. (2015) Medicinal Plants Used to Treat TB in Ghana. International Journal of Mycobacteriology, 4, 116-123.
[70] Wang, M., Guan, X., Chi, Y., Robinson, N. and Liu, J.P. (2015) Chinese Herbal Medicine as Adjuvant Treatment to Chemotherapy for Multidrug-Resistant Tuberculosis (MDR-TB): A Systematic Review of Randomized Clinical Trials. Tuberculosis, 95, 364-372.
[71] Lu, J., Qin, R., Ye, S. and Yang, M. (2011) Prunella vulgaris L. Extract Improves Cellular Immunity in MDR-TB Challenged Rats. Journal of Medical Colleges of PLA, 26, 230-237.
[72] Torres-Romero, D., Jimenez, I.A., Rojas, R., Gilman, R.H., Lopez, M., et al. (2011) Dihydro-Beta-Agarofuran Sesquiterpenes Isolated from Celastrus vulcanicola as Potential Anti-Mycobacterium tuberculosis Multidrug-Resistant Agents. Bioorganic & Medicinal Chemistry, 19, 2182-2189.
[73] Molina-Salinas, G.M., Pena-Rodriguez, L.M., Mata-Cardenas, B.D., Escalante-Erosa, F., Gonzalez-Hernandez, S., et al. (2011) Flourensia cernua: Hexane Extracts a Very Active Mycobactericidal Fraction from an Inactive Leaf Decoction against Pansensitive and Panresistant Mycobacterium tuberculosis. Evidence-Based Complementary and Alternative Medicine: eCAM, 2011, Article ID: 782503.
[74] Hannan, A., Ikram Ullah, M., Usman, M., Hussain, S., Absar, M., et al. (2011) Anti-Mycobacterial Activity of Garlic (Allium sativum) against Multi-Drug Resistant and Non-Multi-Drug Resistant Mycobacterium tuberculosis. Pakistan Journal of Pharmaceutical Sciences, 24, 81-85.
[75] Dini, C., Fabbri, A. and Geraci, A. (2011) The Potential Role of Garlic (Allium sativum) against the Multi-Drug Resistant Tuberculosis Pandemic: A Review. Annali dell’Istituto Superiore di Sanita, 47, 465-473.
[76] Navarro-Garcia, V.M., Luna-Herrera, J., Rojas-Bribiesca, M.G., Alvarez-Fitz, P. and Rios, M.Y. (2011) Antibacterial Activity of Aristolochia brevipes against Multidrug-Resistant Mycobacterium tuberculosis. Molecules, 16, 7357-7364.
[77] Patra, A., Ghosh, S. and Mukherjee, B. (2010) Structure Elucidation of Two New Bisbenzylisoquinoline Alkaloids and NMR Assignments of the Alkaloids from the Fruits of Tiliacora racemosa. Magnetic Resonance in Chemistry, 48, 823-828.
[78] Serkani, J.E., Isfahani, B.N., Safaei, H.G., Kermanshahi, R.K. and Asghari, G. (2012) Evaluation of the Effect of Humulus lupulus Alcoholic Extract on Rifampin-Sensitive and Resistant Isolates of Mycobacterium tuberculosis. Research in Pharmaceutical Sciences, 7, 235-242.
[79] Crandall, P.G., Ricke, S.C., O’Bryan, C.A. and Parrish, N.M. (2012) In Vitro Effects of Citrus Oils against Mycobacterium tuberculosis and Non-Tuberculous Mycobacteria of Clinical Importance. Journal of Environmental Science and Health Part B, Pesticides, Food Contaminants, and Agricultural Wastes, 47, 736-741.
[80] Leon-Diaz, R., Meckes-Fischer, M., Valdovinos-Martinez, L., Campos, M.G., Hernandez-Pando, R., et al. (2013) Antitubercular Activity and the Subacute Toxicity of (-)-Licarin A in BALB/c Mice: A Neolignan Isolated from Aristolochia taliscana. Archives of Medical Research, 44, 99-104.
[81] Nogueira, T., Medeiros, M.A., Marcelo-Curto, M.J., García-Pérez, B., Luna-Herrera, J., et al. (2013) Profile of Antimicrobial Potential of Fifteen Hypericum Species from Portugal. Industrial Crops and Products, 47, 126-131.
[82] Jimenez-Arellanes, A., Luna-Herrera, J., Cornejo-Garrido, J., Lopez-Garcia, S., Castro-Mussot, M.E., et al. (2013) Ursolic and Oleanolic Acids as Antimicrobial and Immunomodulatory Compounds for Tuberculosis Treatment. BMC Complementory and Alternative Medicines, 13, 258.
[83] Uc-Cachon, A.H., Borges-Argaez, R., Said-Fernandez, S., Vargas-Villarreal, J., Gonzalez-Salazar, F., et al. (2014) Naphthoquinones Isolated from Diospyros anisandra Exhibit Potent Activity against Pan-Resistant First-Line Drugs Mycobacterium tuberculosis Strains. Pulmonary Pharmacology and Therapeutics, 27, 114-120.
[84] Zhang, L., Li, R., Li, M., Qi, Z. and Tian, J. (2015) In Vitro and in Vivo Study of Anti-Tuberculosis Effect of Extracts Isolated from Ranunculi Ternati Radix. Sarcoidosis Vasculitis and Diffuse Lung Diseases. Official Journal of WASOG/ World Association of Sarcoidosis and Other Granulomatous Disorders, 31, 336-342.
[85] Radji, M., Kurniati, M. and Kiranasari, A. (2015) Comparative Antimycobacterial Activity of Some Indonesian Medicinal Plants against Multi-Drug Resistant Mycobacterium tuberculosis. Journal of Applied Pharmaceutical Science, 5, 19-22.
[86] Jang, W.S., Jyoti, M.A., Kim, S., Nam, K.W., Ha, T.K., et al. (2015) In Vitro Antituberculosis Activity of Diterpenoids from the Vietnamese Medicinal Plant Croton tonkinensis. Journal of Natural Medicines, 70, 127-132.
[87] Gupta, R., Thakur, B., Singh, P., Singh, H., Sharma, V., et al. (2010) Anti-Tuberculosis Activity of Selected Medicinal Plants against Multi-Drug Resistant Mycobacterium tuberculosis Isolates. Indian Journal of Medical Research, 131, 809-813.
[88] Lakshmanan, D., Werngren, J., Jose, L., Suja, K., Nair, M.S., et al. (2011) Ethyl p-Methoxycinnamate Isolated from a Traditional Anti-Tuberculosis Medicinal Herb Inhibits Drug Resistant Strains of Mycobacterium tuberculosis in Vitro. Fitoterapia, 82, 757-761.
[89] Gupta, S., Dwivedi, G.R., Darokar, M.P. and Srivastava, S.K. (2012) Antimycobacterial Activity of Fractions and Isolated Compounds from Vetiveria zizanioides. Medicinal Chemistry Research, 21, 1283-1289.
[90] Singh, R., Hussain, S., Verma, R. and Sharma, P. (2013) Anti-Mycobacterial Screening of Five Indian Medicinal Plants and Partial Purification of Active Extracts of Cassia sophera and Urtica dioica. Asian Pacific Journal of Tropical Medicine, 6, 366-371.
[91] Kumar, P., Singh, A., Sharma, U., Singh, D., Dobhal, M., et al. (2013) Anti-Mycobacterial Activity of Plumericin and Isoplumericin against MDR Mycobacterium tuberculosis. Pulmonary Pharmacology & Therapeutics, 26, 332-335.
[92] Basu, S., Ghosh, A. and Hazra, B. (2005) Evaluation of the Antibacterial Activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: Isolation of Emodin and Physcion as Active Antibacterial Agents. Phytotherapy Research, 19, 888-894.
[93] Dey, D., Ray, R. and Hazra, B. (2014) Antitubercular and Antibacterial Activity of Quinonoid Natural Products against Multi-Drug Resistant Clinical Isolates. Phytotherapy Research, 28, 1014-1021.
[94] Hazra, B., Sarkar, R., Bhattacharyya, S., Ghosh, P.K., Chel, G., et al. (2002) Synthesis of Plumbagin Derivatives and Their Inhibitory Activities against Ehrlich ascites Carcinoma in Vivo and Leishmania donovani Promastigotes in Vitro. Phytotherapy Research, 16, 133-137.
[95] Prabu, A., Hassan, S., Prabuseenivasan Shainaba, A.S., Hanna, L.E., et al. (2015) Andrographolide: A Potent Antituberculosis Compound That Targets Aminoglycoside 2’-N-Acetyltransferase in Mycobacterium tuberculosis. Journal of Molecular Graphics & Modelling, 61, 133-140.
[96] Dey, D., Ray, R. and Hazra, B. (2015) Antimicrobial Activity of Pomegranate Fruit Constituents against Drug-Resistant Mycobacterium tuberculosis and β-Lactamase Producing Klebsiella pneumoniae. Pharmaceutical Biology, 53, 1474- 1418.

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