Evaluation of the Results of Radical Management of a Cohort of 107 Patients with Hepatocellular Carcinoma in Colombia


Introduction: Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and usually appears as part of liver cirrhosis (LC). Its management in the presence of LC is ideally with orthotopic liver transplantation. Surgical resection is indicated only in the presence of a tumor in a patient with a very good liver function and who for medical reasons cannot be carried to transplantation. Materials and Methods: A descriptive study of a prospective and consecutive series of patients undergoing surgery (resection or liver transplantation) for HCC in a hospital in the city of Medellin was performed, from June 2004 to January 2015. A multivariate analysis was carried out of factors associated with survival during the follow-up. Results: 116 surgical interventions for the management of HCC between June 2004 and January 2015 were performed. The analysis included 107 patients, of which 73% were men. The median age of all patients was 60 years. The factors that showed better survival were: patients undergoing transplantation, the presence of cirrhosis, tumor less than 5 cm in diameter, a unique and well-differentiated tumor; however, none of these factors achieved statistical significance. Conclusion: Both resection and liver transplantation, when well indicated achieve good 5-years of survival in patients with HCC.

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Hoyos, S. , Chávez, J. , Duarte, Á. and Arenas, I. (2015) Evaluation of the Results of Radical Management of a Cohort of 107 Patients with Hepatocellular Carcinoma in Colombia. Journal of Cancer Therapy, 6, 1137-1144. doi: 10.4236/jct.2015.613123.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Parikh, S. and Hyman, D. (2007) Hepatocellular Cancer: A Guide for the Internist. The American Journal of Medicine, 120, 194-202.
[2] GLOBOCAB 2012: Estimated Cáncer Incidence, Mortality and Prevalence Worldwide in 2012.
[3] Parkin, D., Bray, F., Ferlay, J. and Pisani, P. (2005) Global Cancer Statistics, 2002. CA: A Cancer Journal for Clinicians, 55, 74-108.
[4] GLOBOCAB 2012: Estimated Cáncer Incidence, Mortality and Prevalence.
[5] Boyle, P. and Levin, B., Eds. (2008) World Cancer Report. IARC Press, Lyon, 350-357.
[6] El-Serag, H. and Rudolph, K. (2007) Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis. Gastroenterology, 132, 2557-2576.
[7] Kew, M., Dos Santos, H. and Sherlock, S. (1971) Diagnosis of Primary Cancer of the Liver. British Medical Journal, 4, 408-411.
[8] Bruix, J. and Sherman, M. (2005) Management of Hepatocellular Carcinoma. Hepatology, 42, 1208-1236.
[9] Llovet, J. and Beaugrand, M. (2003) Hepatocellular Carcinoma: Present Status and Future Prospects. Journal of Hepatology, 38, S136-S149.
[10] Bruix, J., Sherman, M., Llovet, J., Beaugrand, M., Lencioni, R., Burroughs, A., et al. (2001) Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona 2000 EASL Conference. Journal of Hepatology, 35, 421-430.
[11] Hoyos, S., Escobar, J., Cardona, D., Guzmán, C., Mena, A., Osorio, G., et al. (2015) Factors Associated with Recurrence and Survival in Liver Transplant Patients with HCC—A Single Center Retrospective Study. Annals of Hepatology, 14, 58-63.
[12] Ruiz, E., Sanchez, J., Celis, J., Payet, E., Berrospi, F., Chavez, I., et al. (2007) Resultados a corto y largo plazo de la Resección Hepática por Hepatocarcinoma. Análisis de 232 Resecciones Consecutivas. Rev Gastroenterol Perú, 27, 223-235.
[13] Manterola, C., Munoz, S., Araya, J.C., Calderón, C. and Barroso, M.S. (2000) Clinical Features of 29 Patients with Hepatocellular Carcinoma. Revista Médica de Chile, 128, 896-898.
[14] Arnaoutakis, D., Mavros, M., Shen, F., Alexandrescu, S., Firoozmand, A., Popescu, I., et al. (2014) Recurrence Patterns and Prognostic Factors in Patients with Hepatocellular Carcinoma in Noncirrhotic Liver: A Multi-Institutional Analysis. Annals of Surgical Oncology, 21, 147-154.

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