Nitrogen Nutrition, Its Regulation and Biotechnological Approaches to Improve Crop Productivity

DOI: 10.4236/ajps.2015.618275   PDF   HTML   XML   2,667 Downloads   3,523 Views   Citations


Nitrogen is the most important macronutrient needed for plant growth and development. The availability of nitrogen in the soil fluctuates greatly in both time and space. Crop plants, except leguminous plants, depend on supply of nitrogen as fertilizers. Large quantities of nitrogen fertilizers are applied to crop plants, but only 33% of it is utilized by the plant. Plants have developed efficient mechanisms to sense the varying levels of nitrogen forms and uptake them. They also have well developed mechanisms to assimilate the incoming nitrogen immediately or translocate to different parts of the plant wherever it is needed. Maintenance of nitrogen homeostasis is essential to avoid toxicity. Apart from translocation and assimilation, plants have developed different mechanisms, nitrogen efflux; vacuolar nitrogen storage and downward transport of nitrogen from aerial parts to roots, for maintaining nitrogen homeostasis. In crop plants the “grain yield per unit of available nitrogen in the soil” is referred as the nitrogen use efficiency (NUE) for which remobilization of nitrogen, mediated by various transporters plays a crucial role. All these processes are tightly regulated by proteins and microRNA in response to both external and internal nitrogen levels, carbon status of the plant and hormones. As most crop plants are non-leguminous and depend on soil nitrogen, more production could be achieved if crop plants can be made to utilize the available nitrogen efficiently. The recent explosion of research information and the mechanisms behind nitrogen sensing, signaling, transport and utilization enables biotechnological interventions for better nitrogen nutrition of crop plants. This review discusses such possibilities in the context of recent understanding of nitrogen nutrition and the genomic revolution sweeping the crop science.

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Reddy, M. and Ulaganathan, K. (2015) Nitrogen Nutrition, Its Regulation and Biotechnological Approaches to Improve Crop Productivity. American Journal of Plant Sciences, 6, 2745-2798. doi: 10.4236/ajps.2015.618275.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Marschner, H. (2012) Mineral Nutrition of Higher Plants. 5th Edition, Academic Press, London.
[2] Mengel, K., Kirkby, E.A., Kosegarten, H.A. and Appel, T. (2001) Principles of Plant Nutrition. 5th Edition. Kluwer Academic, Dordrecht.
[3] Sanhueza, E. (1982) The Role of the Atmosphere in Nitrogen Cycling. Plant and Soil, 67, 61-71.
[4] Bluementhal, J., Baltensperger, D., Cassman, K.G., Mason, S. and Pavlista, A. (2008) Importance and Effect of Nitrogen on Crop Quality and Ealth. In: Hatfield, J.L. and Follett, R.F., Eds., Nitrogen in the Environment: Sources, Problems, and Management, Elsevier, Amsterdam, 51-70.
[5] Kraiser, T., Gras, D.E., Gutierrez, A.G., Gonzalez, B. and Gutierrez, R.A. (2011) A Holistic View of Nitrogen Acquisition in Plants. Journal of Experimental Botany, 62, 1455-1466.
[6] Cassman, K.G. (1999) Ecological Intensification of Cereal Production Systems: Yield Potential, Soil Quality, and Precision Agriculture. Proceedings of the National Academy of Sciences of the United States of America, 96, 5952-5959.
[7] Delmer, D. (2005) Agriculture in the Developing World: Connecting Innovations in Plant Research to Downstream Applications. Proceedings of the National Academy of Sciences of the United States of America, 102, 15739-15746.
[8] International Fertilizer Industry (2013) Assessment of Fertilizer Use by Crop at the Global Level 2010-2010/11.
[9] Camarguo, J.A. and Alonso, A. (2006) Ecological and Toxicological Effects of Inorganic Nitrogen Pollution in Aquatic Ecosystems: A Global Assessment. Environment International, 32, 831-849.
[10] Choudhury, A.T.M.A. and Kennedy, I.R. (2005) Nitrogen Fertilizer Losses from Rice Soils and Control of Environmental Pollution Problems. Communications in Soil Science and Plant Analysis, 36, 1625-1639.
[11] Gruber, N. and Galloway, J.N. (2008) An Earth System Perspective of the Global Nitrogen Cycle. Nature, 451, 293-296.
[12] Ladha, J.K., Pathak, H., Krupnik, T.J., Six, J. and Vankessel, C. (2005) Efficiency of Fertilizer Nitrogen in Cereal Production: Retrospects and Prospects. Advances in Agronomy, 87, 85-156.
[13] Schlesinger, W.H. (2009) On the Fate of Anthropogenic Nitrogen. Proceedings of the National Academy of Sciences of the United States of America, 106, 203-208.
[14] Sylvester-Bradley, R. and Kindred, D.R. (2009) Analysin Nitrogen Responses of Cereals to Prioritize Routes to the Improvement of Nitrogen Use Efficiency. Journal of Experimental Botany, 60, 1939-1951.
[15] Tilman, D., Cassman, K.G., Matson, P.A., Naylor, R. and Polasky, S. (2002) Agricultural Sustainability and Intensive Production Practices. Nature, 418, 671-677.
[16] Vitousek, P.M., Naylor, R., Crews, T., David, M.B., Drinkwater, L.E. and Holland, E. (2009) Agriculture: Nutrient Imbalances in Agricultural Development. Science, 324, 1519-1520.
[17] Ahlgren, S., Baky, A., Bernesson, S., Nodberg, A., Noren, O. and Hansson, P.A. (2008) Ammonium Nitrate FertilizerProduction Based on Biomass—Environmental Effects from a Life Cycle Perspective. Bioresource Technology, 99, 8034-8041.
[18] Conley, D.J., Paerl, H.W. and Howarth, R.W. (2009) Controlling Eutrophication: Nitrogen and Phosphorus. Science, 323, 1014-1015.
[19] Engstrom, R., Wadeskog, A. and Finnveden, G. (2007) Environmental Assessment of Swedish Agriculture. Ecological Economics, 60, 550-563.
[20] Giles, J. (2005) Nitrogen Study Fertilizes Fears of Pollution. Nature, 433, 791.
[21] Smith, P., Martino, D. and Cai, Z. (2008) Greenhouse Gas Mitigation in Agriculture. Philosophical Transactions of the Royal Society, B363, 789-813.
[22] Zhang, W.F., Zheng, X.D., Pan, H., Ju, X.T., Davidpowlson, D. and Chadwick, D (2013) New Technologies Reduce Greenhouse Gas Emissions from Nitrogenous Fertilizer In China. Proceedings of the National Academy of Sciences of the United States of America, 110, 8375-8380.
[23] Beatty, P.H., Anbessa, Y., Juskiw, P., Carroll, R.T., Wang, J. and Good, A.G. (2010) Nitrogen Use Efficiencies of Spring Barley Grown Under Varying Nitrogen Conditions in the Field and Growth Chamber. Annals of Botany, 105, 1171-1182.
[24] Mcallister, C.H., Beatty, P.H. and Good, A.G. (2012) Engineering Nitrogen Use Efficient Crop Plants: The Current Status. Plant Biotechnology Journal, 10, 1011-1025.
[25] White, P.J. and Brown, P.H. (2010) Plant Nutrition for Sustainable Development and Global Health. Annals of Botany, 105, 1073-1080.
[26] De Macale, M.A.R. and Velk, P.L.G. (2004) The Role of Azolla Cover in Improving the Nitrogen Use Efficiency of Lowland Rice. Plant Soil, 263, 311-321.
[27] Hirel, B., Le Gouis, J., Ney, B. and Gallais, A. (2007) The Challenge Of Improving Nitrogen Use Efficiency in Crop Plants: Towards a More Central Role for Genetic Variability and Quantitative Genetics within Integrated Approaches. Journal of Experimental Botany, 58, 2369-2387.
[28] Lea, P.J. and Azevedo, R.A. (2006) Nitrogen Use Efficiency. 1. Uptake of Nitrogen from the Soil. Annals of Applied Biology, 149, 243-247.
[29] Lea, P.J. and Azevedo, R.A. (2007) Nitrogen Use Efficiency. 2. Amino Acid Metabolism. Annals of Applied Biology, 151, 269-275.
[30] Von Wiren, N., Gazzarrini, S., Gojon, A. and Frommer, W.B. (2000) The Molecular Physiology Of Ammonium Uptake And Retrieval. Current Opinion in Plant Biology, 3, 254-261.
[31] De Willigen, P. (1986) Supply of Soil Nitrogen to the Plant during the Growing Season. In: Lambers, H., Neeteson, J.J. and Stulen, I., Eds., Fundamental, Ecological and Agricultural Aspects of Nitrogen Metabolism in Higher Plants, Martinusnijhoff, Dordrecht, 417-432.
[32] Miller, A.J. and Cramer, M.D. (2004) Root Nitrogen Acquisition and Assimilation. Plant Soil, 274, 1-36.
[33] Barber, S.A. (1995) Soil Nutrient Bioavailability: A Mechanistic Approach. 2nd Ed. John Wiley, New York.
[34] Crawford, N.M. and Glass, A.D.M. (1998) Molecular and Physiological Aspects of Nitrate Uptake in Plants. Trends in Plant Science, 3, 389-395.
[35] Owen, A.G. and Jones, D.L. (2001) Competition for Amino Acids between Wheat Roots and Rhizosphere Microorganisms and the Role of Amino Acids in Plant N Acquisition. Soil Biology & Biochemistry, 33, 651-657.
[36] Wang, W.H., Kohler, B., Cao, F.Q. and Liu, L.H. (2008a) Molecular and Physiological Aspects of Urea Transport in Higher Plants. Plant Science, 175, 467-477.
[37] Gaudin, R., Dupuy, J. and Bournat, P. (1987) Suivi Du Contenue En Azote De La Solution Du Sol D’unerizière Après Placement D’urée. Agron. Trop, 42, 13-19.
[38] Polacco, J.C. and Holland, M.A. (1993) Roles of Urease in Plant Cells. International Review of Cytology, 145, 65-103.
[39] Krogmeier, M.J., Mccarty, G.W. and Bremner, J.M. (1989) Phytotoxicity of Foliar-Applied Urea. Proceedings of the National Academy of Sciences of the United States of America, 86, 8189-8191.
[40] Colmer, T.D. and Bloom, A.J. (1998) A Comparison of and Net fluxes along Roots of Rice and Maize. Plant Cell Environ, 21, 240-246.
[41] Lee, R. and Rudge, K. (1986) Effects of Nitrogen Deficiency on the Absorption of Nitrate and Ammonium by Barley Plants. Annals of Botany, 57, 471-486.
[42] Drew, M.C. and Saker, L.R. (1975) Nutrient Supply and the Growth of the Seminal Root System in Barley. II. Localized, Compensatory Increases in Lateral Root Growth and Rates of Nitrate Uptake When Nitrate Supply Is Restricted to Only Part of the Root System. Journal of Experimental Botany, 26, 79-90.
[43] Glass, A.D.M. (2003) Nitrogen Use Efficiency of Crop Plants: Physiological Constraints upon Nitrogen Absorption. Critical Reviews in Plant Sciences, 22, 453-470.
[44] Gruber, B.D., Giehl, R.F.H., Friedel, S. and Von Wirén, N. (2013) Plasticity of the Arabidopsis Root System under Nutrient Deficiencies. Plant Physiology, 163, 161-179.
[45] Kant, S., Bi, Y.M. and Rothstein, S.J. (2011) Understanding Plant Response to Nitrogen Limitation for the Improvement of Crop Nitrogen Use Efficiency. Journal of Experimental Botany, 62, 1499-1509.
[46] Krapp, A., Berthomé, R., Orsel, M., Mercey-Boutet, S., Yu, A. and Castaings, L. (2011) Arabidopsis Roots and Shoots Show Distinct Temporal Adaptation Patterns Toward Nitrogen Starvation. Plant Physiology, 157, 1255-1282.
[47] Krouk, G., Crawford, N.M., Coruzzi, G.M. and Tsay, Y.F. (2010a) Nitrate Signaling: Adaptation to Fluctuating Environments. Current Opinion in Plant Biology, 13, 266-273.
[48] Remans, T., Nacry, P., Pervent, M., Filleur, S., Diatloff, E. and Mounier, E. (2006) The Arabidopsis NRT1.1 Transporter Participates in the Signaling Pathway Triggering Root Colonization Of Nitrate-Rich Patches. Proceedings of the National Academy of Sciences of the United States of America, 103, 19206-19211.
[49] Remans, T., Nacry, P., Pervent, M., Girin, T., Tillard, P., Lepetit, M. and Gojon, A. (2006) A Central Role for the Nitrate Transporter NRT2.1 in the Integrated Morphological and Physiological Responses of the Root System to Nitrogen Limitation in Arabidopsis. Plant Physiology, 140, 909-921.
[50] Zhang, H. and Forde, B.G. (2000) Regulation of Arabidopsis Root Development by Nitrate Availability. Journal of Experimental Botany, 51, 51-59.
[51] Ho, C.H. and Tsay, Y.F. (2010) Nitrate, Ammonium, and Potassium Sensing and Signaling. Current Opinion in Plant Biology, 13, 604-610.
[52] Glass, A.D.M., Brito, D.T., Kaiser, B.N., Kronzucker, H.J., Kumar, A. and Okamoto, M. (2001) Nitrogen Transport in Plants, with an Emphasis on the Regulation Of Fluxes to Match Plant Demand. Journal of Plant Nutrition and Soil Science, 164, 199-207.<199::AID-JPLN199>3.0.CO;2-K
[53] Hoffmann, A., Milde, S., Desel, C., Hümpel, A., Kaiser, H. and Hammes, E. (2007) N Form-Dependent Growth Retardation of Arabidopsis thaliana Seedlings as Revealed from Physiological and Microarray Studies. Journal of Plant Nutrition and Soil Science, 170, 87-97.
[54] Schjoerring, J.K., Husted, S., Mäck, G. and Mattsson, M. (2002) The Regulation of Ammonium Translocation in Plants. Journal of Experimental Botany, 53, 883-890.
[55] Loque, D., Lalonde, S., Looger, L.L., Von Wiren, N. and Frommer, W.B. (2007) A Cytosolic Trans-Activation Domain Essential for Ammonium Uptake. Nature, 446, 195-198.
[56] Neuhäuser, B., Dynowski, M., Mayer, M. and Ludewig, U. (2007) Regulation of NH4 + Transport by Essential Cross Talk between AMT Monomers through the Carboxyl Tails. Plant Physiology, 143, 1651-1659.
[57] Rogato, A., Apuzzo, E.D. and Chiurazzi, M. (2010) The Multiple Plant Response to High Ammonium Conditions: The Lotus japonicas AMT1; 3 Protein Acts as a Putative Transceptor. Plant Signaling & Behavior, 5, 1594-1596.
[58] Lima, J.E., Kojima, S., Takahashi, H. and Von Wiren, N. (2010) Ammonium Triggers Lateral Root Branching in Arabidopsis in an Ammonium Transporter1; 3-Dependent Manner. Plant Cell, 22, 3621-3633.
[59] Loqué, D., Yuan, L., Kojima, S., Gojon, A., Wirth, J., Gazzarrini, S., Ishiyama, K., Takahashi, H. and Von Wirén, N. (2006) Additive Contribution Of AMT1; 1 and AMT1; 3 to High-Affinity Ammonium Uptake across the Plasma Membrane of Nitrogen-Deficient Arabidopsis Roots. The Plant Journal, 48, 522-534.
[60] Khademi, S., O’Connell 3rd, J., Remis, J., Robles-Colmenares, Y., Miercke, L.J. and Stroud R.M. (2004) Mechanism of Ammonia Transport by Amt/MEP/Rh: Structure of Amtb at 1.35 &ARING. Science, 305, 1587-1594.
[61] Ludewig, U., Von Wirén, N. and Frommer, W.B. (2002) Uniport Of by the Root Hair Plasma Membrane Ammonium Transporter Leamt1-1. Journal of Biological Chemistry, 277, 13548-13555.
[62] Ludewig, U., Wilken, S., Wu, B., Jost, W., Obrdlik, P. and El Bakkoury, M. (2003) Homo- and Hetero-Oligomerization of Ammonium Transporter-1 NH4 Uniporters. Journal of Biological Chemistry, 278, 45603-45610.
[63] Benschop, J.J., Mohammed, S., O’Flaherty, M., Heck, A.J., Slijper, M. and Menke, F.L. (2007) Quantitative Phosphoproteomics Of Early Elicitor Signaling in Arabidopsis. Molecular & Cellular Proteomics, 6, 1198-1214.
[64] Hem, S., Rofidal, V., Sommerer, N. and Rossignol, M. (2007) Novel Subsets of the Arabidopsis Plasmalemma Phosphoproteome Identify Phosphorylation Sites in Secondary Active Transporters. Biochemical and Biophysical Research Communications, 363, 375-380.
[65] Lanquar, V., Loqué, D., Hörmann, F., Yuan, L., Bohner, A., Engelsberger, W.R., Lalonde, S. and Schulze, W.X. (2009) Feedback Inhibition of Ammonium Uptake by a Phospho-Dependent Allosteric Mechanism in Arabidopsis. Plant Cell, 21, 3610-3622.
[66] Severi, A., Javelle, M. and Merrick, M. (2007) The Conserved Carboxyterminal Region of the Ammonia Channel Amtb Plays a Critical Role in Channel Function. Molecular Membrane Biology, 24, 161-171.
[67] Yuan, L., Loque, D., Ye, F., Frommer, W.B. and Von Wiren, N. (2007a) Nitrogen-Dependent Posttranscriptional Regulation of the Ammonium Transporter Atamt1; 1. Plant Physiology, 143, 732-744.
[68] Lanquar, V. And Frommer, W.B. (2010) Adjusting Ammonium Uptake via Phosphorylation. Plant Signaling & Behavior, 5, 736-738.
[69] Yuan, L., Gu, R., Xuan, Y., Smith-Valle, E., Loqué, D., Frommer, W.B. and Von Wirén, N. (2013) Allosteric Regulation of Transport Activity by Hetero-Trimerization of Ammonium Transporter Complexes in Vivo. Plant Cell, 25, 974-984.
[70] Wang, Q., Zhao, Y., Luo, W., Li, R., He, Q., Fang, X., Michele, R.D., Ast, C., Von Wirén, N. and Lin, J. (2013a) Single-Particle Analysis Reveals Shutoff Control of the Arabidopsis Ammonium Transporter AMT1; 3 by Clustering and Internalization. Proceedings of the National Academy of Sciences of the United States of America, 110, 13204-13209.
[71] Gojon, A., Krouk, G., Perrine-Walker, F. and Laugier, E. (2011) Nitrate Transceptor(S) in Plants. Journal of Experimental Botany, 62, 2299-2308.
[72] Guo, F.Q., Wang, R., Chen, M. and Crawford, N.M. (2001) The Arabidopsis Dual-Affinity Nitrate Transporter Gene Atnrt1.1 (CHL1) Is Activated And Functions in Nascent Organ Development During Vegetative and Reproductive Growth. Plant Cell, 13, 1761-1777.
[73] Ho, C.H., Lin, S.H., Hu, H.C. and Tsay, Y.F. (2009) CHL1functions as a Nitrate Sensor in Plants. Cell, 138, 1184-1194.
[74] Krouk, G., Lacombe, B., Bielach, A., Perrine-Walker, F., Malinska, K. and Mounier, E. (2010b) Nitrate-Regulated Auxin Transport by NRT1.1 Defines a Mechanism for Nutrient Sensing in Plants. Developmental Cell, 18, 927-937.
[75] Liu, K.H., Huang, C.Y. and Tsay, Y.F. (1999) CHL1 Is a Dual-Affinity Nitrate Transporter of Arabidopsis Involved in Multiple Phases of Nitrate Uptake. Plant Cell. 11, 865-874.
[76] Munos, S., Cazettes, C., Fizames, C., Gaymard, F., Tillard, P., Lepetit, M., Lejay, L. and Gojon, A.(2004) Transcript Profiling in Thechl1-5 Mutant of Arabidopsis Reveals a Role of the Nitrate Transporter NRT1.1 in the Regulation of Another Nitrate Transporter, NRT2.1. Plant Cell, 16, 2433-2447.
[77] Wang, R., Xing, X., Wang, Y., Tran, A. and Crawford, N.M. (2009) A Genetic Screen for Nitrate Regulatory Mutants Captures the Nitrate Transporter Gene NRT1.1. Plant Physiology, 151, 472-478.
[78] Hu, H.C., Wang, Y.Y. and Tsay, Y.F. (2009) Atcipk8, a CBL-Interacting Protein Kinase, Regulates the Low-Affinity Phase of the Primary Nitrate Response. The Plant Journal, 57, 264-278.
[79] Liu, K.H. and Tsay, Y.F. (2003a) Switching Between the Two Actions Modes of the Dual-Affinity Nitrate Transporter CHL1 by Phosphorylation. The EMBO Journal, 22, 1005-1013.
[80] Batistic, O. and Kulda, J. (2009) Plant Calcineurin B-Like Proteins and Their Interacting Protein Kinases. Biochimica et Biophysica Acta, 1793, 985-992.
[81] Xu, J., Li, H.D., Chen, L.Q., Wang, Y., Liu, L.L., He, L. and Wu, W.H. (2006) A Protein Kinase, Interacting with Two Calcineurin B-Like Proteins, Regulates K+ Transporter AKT1 in Arabidopsis. Cell, 125, 1347-1360.
[82] Bouguyon, E., Gojon, A. and Narcy, P. (2012) Nitrate Sensing and Signaling in Plants. Seminars in Cell & Developmental Biology, 23, 648-654.
[83] Little, Y.D., Rao, H., Oliva, S., Daniel-Vedel, F., Krapp, A. and Malamy, J.E. (2005) The Putative High-Affinity Nitrate Transporter NRT2.1 Represses Lateral Root Initiation in Response to Nutritional Cues. Proceedings of the National Academy of Sciences of the United States of America, 102, 13693-13698.
[84] Lam, H.M., Chiao, Y.A., Li, M.W., Yung, Y.K. and Sang, J.I. (2006) Putative Nitrogen Sensing Systems in Higher Plants. Journal of Integrative Plant Biology, 48, 873-888.
[85] Castaings, L., Camargo, A., Pocholle, D., Gaudon, V., Texier, Y., Boutet-Mercey, S., Taconnat, L., Renou, J.P., Daniel-Vedele, F. and Fernandez, E. (2009) The Nodule Inception-Like Protein 7 Modulates Nitrate Sensing and Metabolism in Arabidopsis. The Plant Journal, 57, 426-435.
[86] Rubin, G., Tohge, T., Matsuda, F., Saito, K. and Scheible, W.R. (2009) Members of the LBD Family of Transcription Factors Repress Anthocyanin Synthesis and Affect Additional Nitrogen Responses in Arabidopsis. Plant Cell, 21, 3567-3584.
[87] Zhang, H. and Forde, B.G. (1998) An Arabidopsis MADS Box Gene That Controls Nutrient-Induced Changes in Root Architecture. Science, 279, 407-409.
[88] Gan, Y., Bernreiter, A., Filleur, S., Abram, B. and Forde, B.G. (2012) Over Expressing the ANR1 MADS-Box Gene in Transgenic Plants Provides New Insights into Its Role in the Nitrate Regulation of Root Development. Plant & Cell Physiology, 53, 1003-1016.
[89] Marchive, C., Roudier, F., Castaings, L., Bréhaut, V., Blondet, E., Colot, V., Meyer, C. and Krapp, A. (2013) Nuclear Retention of the Transcription Factor NLP7 Orchestrates the Early Response to Nitrate in Plants. Nature Communications, 4, 1713.
[90] Rueda-Lopez, M., Crespillo, R., Canovas, F.M. and Avila, C. (2008) Differential Regulation of Two Glutamine Synthetase Genes by a Single Dof Transcription Factor. The Plant Journal, 56, 73-85.
[91] Yanagisawa, S., Akiyama, A., Kisaka, H., Uchimiya, H. and Miwa, T. (2004) Metabolic Engineering with Dof1 Transcription Factor in Plants: Improved Nitrogen Assimilation and Growth under Low-Nitrogen Conditions. Proceedings of the National Academy of Sciences of the United States of America, 101, 7833-7838.
[92] Archondeguy, T., Jack, R. and Merrick, M. (2001) PII Signal Transduction Proteins: Privotal Players in Microbial Nitrogen Control. Microbiology and Molecular Biology Reviews, 65, 80-105.
[93] Hsieh, M.H., Lam, H.M., Van De Loo, F.J. and Coruzzi, G.A. (1998) PII-Like Protein in Arabidopsis: Putative Role in Nitrogen Sensing. Proceedings of the National Academy of Sciences of the United States of America, 95, 13965-13970.
[94] Ninfa, A.J. and Atkinson, M.R. (2000) PII Signal Transduction Protein. Trends in Microbiology, 8, 172-179.
[95] Nunes-Nesi, A., Fernie, A.R. and Stitt. M. (2010) Metabolic and Signaling Aspects Underpinning the Regulation of Plant Carbon Nitrogen Interactions. Molecular Plant, 3, 973-996.
[96] Schachtman, D. and Shin, R. (2007) Nutrient Sensing and Signaling: NPKS. Annual Review of Plant Biology, 58, 47-69.
[97] Sugiyama, K., Hayakawa, T., Kudo, T., Ito, T. and Yamaya, T. (2004) Interaction of N-Acetylglutamate Kinase with a PII-Like Protein in Rice. Plant & Cell Physiology, 45, 1768-1778.
[98] Smith, C.S., Weljie, A.M. and Moorhead, G.B.G. (2003) Molecular Properties of the Putative Nitrogen Sensor PII from Arabidopsis thaliana. The Plant Journal, 33, 353-360.
[99] Uhrig, R.G., Ng, K.K. and Greg, B.G.M. (2009) PII in Higher Plants: A Modern Role for an Ancient Protein. Trends in Plant Science, 14, 501-511.
[100] De Marsac, N.T., Lee, H.M., Hisbergues, M., Castets, A.M. and Bedu, S. (2001) Control of Nitrogen and Carbon Metabolism in Cyanobacteria. Journal of Applied Phycology, 13, 287-292.
[101] Kobayashi, M., Takatani, N., Tanigawa, M. and Omata, T. (2005) Posttranslational Regulation of Nitrate Assimilation in the Cyanobacterium Synechocystis sp. Strain PCC 6803. Journal of Bacteriology, 187, 498-506.
[102] Stitt, M. and Krapp, A. (1999) The Interaction between Elevated Carbon Dioxide and Nitrogen Nutrition: The Physiological and Molecular Background. Plant Cell and Environment, 22, 583-621.
[103] Li, M.W. and Lam, H.M. (2008) Searching for Nitrogen Sensing Systems in Higher Plants. Dynamic Soil, Dynamic Plant, 2, 13-22.
[104] Smith, C.S., Morrice, N.A. and Moorhead, G.B.G. (2004) Lack of Evidence for Phosphorylation of Arabidopsis thaliana PII: Implications for Plastid Carbon and Nitrogen Signaling. Biochimica et Biophysica Acta, 1699, 145-154.
[105] Burillo, S., Luque, I., Fuentes, I. and Contreras, A. (2004) Interactions between the Nitrogen Signal Transduction Protein PII and N-Acetyl Glutamate Kinase in Organisms That Perform Oxygenic Photosynthesis. Journal of Bacteriology, 186, 3346-3354.
[106] Chen, Y.M., Ferrar, T.S., Lohmeir-Vogel, E.M., Morrice, N., Mizuno, Y., Berenger, B., Ng, K.K., Muench, D.G. and Moorhead, G.B. (2006) The PII Signal Transduction Protein of Arabidopsis thaliana Forms an Arginine-Regulated Complex with Plastid N-Acetyl Glutamate Kinase. Journal of Biological Chemistry, 281, 5726-5733.
[107] Ferrario-Mery, S., Besin, E., Pichon, O., Meyer, C. and Hodges, M. (2006) The Regulatory PII Protein Controls Arginine Biosynthesis in Arabidopsis. FEBS Letters, 580, 2015-2020.
[108] Ferrario-Mery, S., Bouvet, M., Leleu, O., Savino, G., Hodges, M. and Meyer, C. (2015) Physiological Characterization of Arabidopsis Mutants Affected in the Expression of the Putative Regulatory Protein PII. Planta, 1, 28-39.
[109] Mizuno, Y., Moorhead, G.B.G. and Ng, K.K.S. (2007) Structural Basis for the Regulation of N-Acetylgutamate Kinase by PII in Arabidopsis thaliana. The Journal of Biological Chemistry, 282, 35733-35740.
[110] Hinnebusch, A.G. (2005) Translational Regulation of GCN4 and the General Amino Acid Control of Yeast. Annual Review of Microbiology, 59, 407-450.
[111] Marton, M.J., Crouch, D. and Hinnebusch, A.G. (1993) GCN1, a Translational Activator of GCN4 in Saccharomyces cerevisiae, Is Required for Phosphorylation of Eukaryotic Translation Initiation Factor 2 by Protein Kinase GCN2. Molecular and Cellular Biology, 13, 3541-3556.
[112] Chang, Y., Yang, W.Y., Browning, K. and Roth, D. (1999) Specific in Vitro Phosphorylation of Plant Eif2 Alpha by Eukaryotic Eif2 Alpha Kinases. Plant Molecular Biology, 41, 363-370.
[113] Chang, L.Y., Yang, W.Y. and Roth, D. (2000) Functional Complementation by Wheat Eif2 Alpha in the Yeast GCN2-Mediated Pathway. Biochemical and Biophysical Research Communications, 279, 468-474.
[114] Guyer, D., Patton, D. and Ward, E. (1995) Evidence for Cross Pathway Regulation of Metabolic Gene Expression in Plants. Proceedings of the National Academy of Sciences of the United States of America, 92, 4997-5000.
[115] Kato, T., Sato, S. and Tabata, S. (2004) A Soluble ABC Protein, GCN, Regulate Root Development in Arabidopsis. Plant and Cell Physiology, 45, S2.
[116] Bhat, R.A., Riehl, M., Santandrea, G., Velasco, R., Slocombe, S., Donn, G., Steinbiss, H.H., Thompson, R.D. and Becker, H.A. (2003) Alteration of GCN5 Levels in Maize Reveals Dynamic Responses to Manipulating Histone Acetylation. The Plant Journal, 33, 455-469.
[117] Kawaguchi, R. and Bailey-Serres, J. (2005) Mrna Sequence Features That Contribute to Translational Regulation in Arabidopsis. Nucleic Acids Research, 33, 955-965.
[118] Rogozin, I.B., Kochetov, A.V., Kondrashov, F.A., Koonin, E.V. and Milanesi, L. (2001) Presence of ATG Triplets in 5’Untranslated Regions of Eukaryotic Cdnas Correlates with “Weak” Context of the Start Codon. Bioinformatics, 17, 890-900.
[119] Stockinger, E.J., Mao, Y., Regier, M.K., Triezenberg, S.J. and Thomashow, M.F. (2001) Transcriptional Adaptor and Histone Acetyltransferase Proteins in Arabidopsis and Their Interactions with CBF1, a Transcriptional Activator Involved in Cold-Regulated Gene Expression. Nucleic Acids Research, 29, 1524-1533.
[120] Tsuda, K., Tsuji, T., Hirose, S. and Yamazaki, K. (2005) Three Arabidopsis MBF1 Homologs with Distinct Expression Profiles Plays Roles as Transcriptional Co-Activators. Plant and Cell Physiology, 45, 225-231.
[121] Langland, J.O., Langland, L.A., Browning, K.S. and Roth, D.A. (1996) Phosphorylation of Plant Eukaryotic Initiation Factor-2 by the Plant-Encoded Double-Stranded RNA-Dependent Protein Kinase, Ppkr, and Inhibition of Protein Synthesis in Vitro. Journal of Biological Chemistry, 271, 4539-4544.
[122] Kakimoto, T. (2003) Perception and Signal Transduction of Cytokinins. Annual Review of Plant Physiology, 54, 605-627.
[123] Sakakibara, H., Suzuki, M., Takei, K., Deji, A., Taniguchi, M. and Sugiyama, T. (1998) A Response-Regulator Homologue Possibly Involved in Nitrogen Signal Transduction Mediated by Cytokinin in Maize. The Plant Journal, 14, 337-344.
[124] Sakakibara, H., Takei, K. and Hirose, N. (2006) Interactions between Nitrogen and Cytokinin in the Regulation of Metabolism and Development. Trends in Plant Science, 11, 440-448.
[125] Takei, K., Sakakibara, H., Taniguchi, M. and Sugiyama, T. (2001) Nitrogen-Dependent Accumulation of Cytokinins in Root and the Translocation to Leaf: Implication of Cytokinin Species That Induces Gene Expression of Maize Response Regulator. Plant and Cell Physiology, 42, 85-93.
[126] Takei, K., Ueda, N., Aoki, K., Kuromori, T., Hirayama, T., Shinozaki, K., Yamaya, T. and Sakakibara, H. (2005) Atipt3 Is a Key Determinant of Nitrate-Dependent Cytokinin Biosynthesis in Arabidopsis. Plant and Cell Physiology, 45, 1053-1062.
[127] Collier, M.D., Fotelli, M.N., Nahm, M., Kopriva, S., Rennenberg, H., Hanke, D.E. and Geßler, A. (2003) Regulation of Nitrogen Uptake by Fagussyl Vatica on a Whole Plant Level-Interaction between Cytokinins and Soluble N Compounds. Plant, Cell & Environment, 26, 1549-1560.
[128] Takei, K., Takahashi, T., Sugiyama, T., Yamaya, T. and Sakakibara, H. (2002) Multiple Routes Communicating Nitrogen Availability from Roots to Shoots: A Signal Transduction Pathway Mediated by Cytokinin. Journal of Experimental Botany, 53, 971-977.
[129] Miyawaki, K., Matsumoto-Kitano, M. and Kakimoto, T. (2004) Expression of Cytokinin Biosynthetic Isopentenyltransferase Genes in Arabidopsis: Tissue Specificity and Regulation by Auxin, Cytokinin, and Nitrate. The Plant Journal, 37, 128-138.
[130] Imamura, A., Hanaki, N., Nakamura, A., Suzuki, T., Taniguchi, M., Kiba, T., Ueguchi, C., Sugiyama, T. and Mizuno, T. (1999) Compilation and Characterization of Arabidopsis thaliana Response Regulators Implicated in His-Asp Phosphorelay Signal Transduction. Plant and Cell Physiology, 40, 733-742.
[131] Kiba, T., Naitou, T., Koizumi, N., Yamashino, T., Sakakibara, H. and Mizuno, T. (2005) Combinatorial Microarray Analysis Revealing Arabidopsis Genes Implicated in Cytokinin Responses through the His->Asp Phosphorelay Circuitry. Plant and Cell Physiology, 466, 339-355.
[132] Appleby, J.L., Parkinson, J.S. and Bourret, R.B. (1996) Signal Transduction via the Multi-Step Phosphorelay: Not Necessarily a Road Less Travelled. Cell, 86, 845-848.
[133] Mizuno, T. (1998) His-Asp Phosphotransfer Signal Transduction. Journal of Biological Chemistry, 123, 555-563.
[134] Sakakibara, H., Hayakawa, A., Deji, A., Gawronska, S.W. and Sugiyama, T. (1999) His-Asp Phosphotransfer Possibly Involved in a Nitrogen Signal Transduction Mediated by Cytokinin in Maize: Molecular Cloning of Cdnas for Two-Component Regulatory Factors and Demonstration of Phosphotransfer Activity in Vitro. Plant Molecular Biology, 41, 563-573.
[135] Anantharaman, V. and Aravnd, L. (2001) The CHASE Domain: A Predicted Ligand-Binding Module in Plant Cytokinin Receptors and Other Eukaryotic and Bacterial Receptors. Trends in Biochemical Sciences, 26, 579-582.
[136] Wang, R., Tischner, R., Gutierrez, R.A., Hoffman, M., Xing, X. and Chen, M. (2004) Genomic Analysis of the Nitrate Response Using a Nitrate Reductase-Null Mutant of Arabidopsis. Plant Physiology, 136, 2512-2522.
[137] Chiu, J., Desalle, R., Lam, H.M., Meisel, L. and Coruzzi, G. (1996) Molecular Evolution of Glutamate Receptors: A Primitive Signaling Mechanism That Existed before Plants and Animals Diverged. Molecular Biology and Evolution, 16, 826-838.
[138] Dingledine, R., Borges, K., Bowie, D. and Traynelis, S.F. (1999) The Glutamate Receptor Ion Channels. Pharmacological Reviews, 51, 7-61.
[139] Lacombe, B., Becker, D., Hedrich, R., Desalle, R., Hollmann, M., Kwak, J.M., Schroeder, J.I., Le Novère, N., Nam, H.G., Spalding, E.P., Tester, M., Turano, F.J., Chiu, J. and Coruzzi, G. (2002) The Identity of Plant Glutamate Receptors. Science, 292, 1486-1487.
[140] Kang, J.M. and Turano, F.J. (2003) The Putative Glutamate Receptor 1.1 (Atglr1.1) Functions as a Regulator of Carbon and Nitrogen Metabolism in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America, 100, 6872-6877.
[141] Filleur, S., Walch-Liu, P., Gan, Y. and Forde, B.G. (2005) Nitrate and Glutamate Sensing by Plant Roots. Biochemical Society Transactions, 33, 283-286.
[142] Qi, Z., Stephens, N.R. and Spalding, E.P. (2006) Calcium Entry Mediated by GLR3.3, an Arabidopsis Glutamate Receptor with a Broad Agonist Profile. Plant Physiology, 142, 963-971.
[143] Chiang, T.Y. and Marzluf, G.A. (1992) DNA Recognition by the NIT2 Nitrogen Regulatory Protein—Importance of the Number, Spacing, and Orientation of GATA Core Elements and Their Flanking Sequences upon NIT2 Binding. Biochemistry, 33, 576-582.
[144] Danielvedele, F. and Caboche, M.A. (1993) Tobacco Cdna Clone Encoding a GATA-1 Zinc-Finger Protein Homologous to Regulators of Nitrogen-Metabolism in Fungi. Molecular and General Genetics, 240, 365-373.
[145] Fu, Y.H. and Marzluf, G.A. (1990) Site-Directed Mutagenesis of the Zinc Finger DNA Binding Domain of the Nitrogen-Regulatory Protein NIT2 of Neurospora. Molecular Microbiology, 4, 1847-1852.
[146] Rastogi, R., Bate, N.J., Sivasankar, S. and Rothstein, S.J. (1997) Foot Printing of the Spinach Nitrite Reductase Gene Promoter Reveals the Preservation of Nitrate Regulatory Elements between Fungi and Higher Plants. Plant Molecular Biology, 34, 465-476.
[147] Bi, Y.M., Zhang, Y., Signorelli, T., Zhao, R., Zhu, T. and Rothstein, S. (2005) Genetic Analysis of Arabidopsis GATA Transcription Factor Gene Family Reveals a Nitrate-Inducible Member Important for Chlorophyll Synthesis and Glucose Sensitivity. The Plant Journal, 44, 680-692.
[148] Filleur, S., Dorbe, M.F., Cerezo, M., Orsel, M., Granier, F., Gojon, A. and Daniel-Vedele, F. (2001) An Arabidopsis T-DNA Mutant Affected in Nrt2 Genes Is Impaired in Nitrate Uptake. FEBS Letters, 489, 220-224.
[149] Forde, G. and Clarkson, D.T. (1990) Nitrate and Ammonium Nutrition of Plants: Physiological and Molecular Perspectives. Advances in Botanical Research, 30, 1-90.
[150] Ludewig, U., Neuhauser, B. and Dynowski, M. (2007) Molecular Mechanisms of Ammonium Transport and Accumulation in Plants. FEBS Letters, 581, 2301-2308.
[151] Mack, G. and Tischner, R. (1994) Constitutive and Inducible Net NH4+ Uptake of Barley (Hordeum vulgare L.) Seedlings. Journal of Plant Physiology, 144, 351-357.
[152] Miller, A.J., Fan, X., Orsel, M., Smith, S.J. and Wells, D.M. (2007) Nitrate Transport and Signaling. Journal of Experimental Botany, 58, 2297-2306.
[153] Orsel, M., Filleur, S., Fraisier, V. and Daniel-Vedele, F. (2002) Nitrate Transport in Plants: Which Gene and Which Control? Journal of Experimental Botany, 53, 825-833.
[154] Orsel, M., Krapp, A. and Daniel-Vedele, F. (2002) Analysis of the NRT2 Nitrate Transporter Family in Arabidopsis. Structure and Gene Expression. Plant Physiology, 129, 886-896.
[155] Wang, M.Y., Siddiqi, M.Y., Ruth, T.J. and Glass, A.D.M. (1993) Ammonium Uptake by Rice Roots. I. Fluxes and Subcellular Distribution of 13 . Plant Physiology, 103, 1249-1258.
[156] Witte, C.P. (2011) Urea Metabolism in Plants. Plant Science, 180,431-438.
[157] Huang, N.C., Liu, K.H., Lo, H.J. and Tsay, Y.F. (1999) Cloning and Functional Characterization of an Arabidopsis Nitrate Transporter Gene That Encodes a Constitutive Component of Low-Affinity Uptake. Plant Cell, 11, 381-1392.
[158] Kojima, S. Bohner, A., Gassert, B., Yuan, L. and Von Wiren, N. (2007) AtDUR3 Represents the Major Transporter for High-Affinity Urea Transport across the Plasma Membrane of Nitrogen-Deficient Arabidopsis Roots. The Plant Journal, 52, 30-40.
[159] Li, W., Wang, Y., Okamoto, M., Crawford, N.M., Siddiqi, M.Y. and Glass, A.D. (2007) Dissection of the AtNRT2.1: AtNRT2.2 Inducible High-Affinity Nitrate Transporter Gene Cluster. Plant Physiology, 143, 425-433.
[160] Ninnemann, O., Jauniaux, J.C. and Frommer, W.B. (1994) Identification of a High Affinity Transporter from Plants. EMBO Journal, 1, 3464-3471.
[161] Tsay, Y.F., Schroeder, J.I., Feldmann, K.A. and Crawford, N.M. (1993) The Herbicide Sensitivity Gene CHL1 of Arabidopsis Encodes a Nitrate-Inducible Nitrate Transporter. Cell, 72, 705-713.
[162] Yuan, L., Loque, E.D., Kojima, S., Rauch, S., Ishiyama, K. and Finoue, E. (2007) The Organization of High-Affinity Ammonium Uptake in Arabidopsis Roots Depends on the Spatial Arrangement and Biochemical Properties of AMT1- Type Transporters. Plant Cell, 19, 2636-2652.
[163] Mayer, M. and Ludewig, U. (2006) Role of AMT1; 1 in Acquisition in Arabidopsis thaliana. Plant Biology, 8, 522-528.
[164] Tsay, Y.F. (2007) Nitrate Transporters and Peptide Transporters. FEBS Letters, 581, 2290-2300.
[165] Kojima, S., Bohner, A. and Von Wiren, N. (2006) Molecular Mechanisms of Urea Transport in Plants. Journal of Membrane Biology, 212, 83-91.
[166] Liu, L.H., Ludewig, U., Frommer, W.B. and Von Wiren, N. (2003) AtDUR3 Encodes a New Type of High Affinity Urea H+Symporter in Arabidopsis. Plant Cell, 15, 790-800.
[167] Deng, R.L., Gu, J.T., Lu, W.J., Xu, H.R., Cao, Y.F. and Xiao, K. (2007) Characterization, Function and Expression Analysis of Ammonium Transporter Gene OsAMT1.4 and OsAMT5 in Rice (Oryza sativa). Scientia Agricultura Sinica, 40, 2395-2402.
[168] Gazzarini, S., Lejay, L., Gojon, A., Ninnemann, O. and Frommer, W.B. (1999) Three Functional Transporters for Constitutive, Diurnally Regulated and Starvation-Induced Uptake of Ammonium into Arabidopsis Roots. Plant Cell, 11, 937-948.
[169] Li, B.Z., Merrick, M., Li, S.M., Li, H.Y., Zhu, S.U., Shi, W.M. and Su, Y.H. (2009) Molecular Basis and Regulation of Ammonium Transporter in Rice. Rice Science, 16, 314-322.
[170] Sohlenkamp, C., Wood, C.C., Roeb, G.W. and Udvardi, M.K. (2002) Characterization of Arabidopsis Atamt2, a High-Affinity Ammonium Transporter of the Plasma Membrane. Plant Physiology, 130, 1788-1796.
[171] Suenaga, A., Moriya, K., Sonoda, Y., Ikeda, A., Von Wirén, N., Hayakawa, T., Yamaguchi, J. and Yamaya, T. (2003) Constitutive Expression of a Novel-Type Ammonium Transporter OsAMT2 in Rice Plants. Plant and Cell Physiology, 44, 206-211.
[172] Barbier-Brygoo, H., De Angeli, A., Filleur, S., Frachisse, J.M., Gambale, F., Thomine, S. and Wege, S. (2011) Anion Channels/Transporters in Plants: From Molecular Bases to Regulatory Networks. Annual Review of Plant Biology, 62, 25-51.
[173] Dechorgnat, J., Nguyen, C.T., Armengaud, P., Jossier, M., Diatloff, E., Filleur, S. and Daniel-Vedele, F. (2011) From the Soil to the Seeds: The Long Journey of Nitrate in Plants. Journal of Experimental Botany, 62, 1349-1359.
[174] Negi, J. (2008) CO2 Regulator SLAC1 and Its Homologues Are Essential for Anion Homeostasis in Plant Cells. Nature, 452, 483-486.
[175] Sasaki, T., Mori, I.C., Furuichi, T., Munemasa, S., Toyooka, K., Matsuoka, K., Murata, Y. and Yamamoto, Y. (2010) Closing Plant Stomata Requires a Homologue of an Aluminium-Activated Malate Transporter. Plant and Cell Physiology, 51, 354-365.
[176] Wang, Y.Y., Hsu, P.K. and Tsay, Y.F. (2012) Uptake, Allocation and Signaling of Nitrate. Trends in Plant Sciences, 17, 458-467.
[177] Morère-Le Paven, M.C., Vlau, L., Hamon, A., Vandecasteele, C., Pellizzaro, C.B., Laffont, C. and Lapied, B. (2011) Characterization of a Dual-Affinity Nitrate Transporter MtNRT1.3 in the Model Legume Medicago truncatula. Journal of Experimental Botany, 62, 5595-5605.
[178] Okamoto, M., Kumar, A., Li, W., Wang, Y., Siddiqi, M.Y., Crawford, N.M. and Glass, A.D. (2006) High-Affinity Nitrate Transport in Roots of Arabidopsis Depends on Expression of the NAR2-Like Gene AtNRT3.1. Plant Physiology, 140, 1036-1046.
[179] Yong, Z., Kotur, Z. and Glass, A.D. (2010) Characterization of an Intact Two-Component High-Affinity Nitrate Transporter from Arabidopsis Roots. The Plant Journal, 63, 739-748.
[180] De Angeli, A., Monachello, D., Ephritikhine, G., Frachisse, J.M., Thomine, S., Gambale, F. and Barbier-Brygoo, H. (2006) The Nitrate/Proton Antiporter Atclca Mediates Nitrate Accumulation in Plant Vacuoles. Nature, 442, 939-942.
[181] Von Der Fecht-Bartenbach, J., Bogner, M., Dynowski, M. and Ludewig, U. (2010) CLC-B-Mediated /H+ Exchange across the Tonoplast of Arabidopsis Vacuoles. Plant and Cell Physiology, 51, 960-968.
[182] Geiger, D., Maierhofer, T., Al-Rasheid, K.A., Scherzer, S., Mumm, P., Liese, A. and Ache, P. (2011) Stomatal Closure by Fast Abscisic Acid Signaling Is Mediated by the Guard Cell Anion Channel SLAH3 and the Receptor RCAR1. Science Signaling, 4, Ra32.
[183] Lee, S.C., Lan, W., Buchanan, B.B. and Luan, S.A. (2009) Protein Kinase-Phosphatase Pair Interacts with an Ion Channel to Regulate ABA Signaling in Plant Guard Cells. Proceedings of the National Academy of Sciences of the United States of America, 106, 21419-21424.
[184] Andrade, S.L., Dickmanns, A., Ficner, R. and Einsle, O. (2005) Crystal Structure of the Archaeal Ammonium Transporter Amt-1 from Archaeoglobus fulgidus. Proceedings of the National Academy of Sciences of the United States of America, 102, 14994-14999.
[185] Loque, D. and Von Wiren, N. (2004) Regulatory Levels for the Transport of Ammonium in Plant Roots. Journal of Experimental Botany, 55, 1293-1305.
[186] Forrest, L.R. (2013) Structural Biology. (Pseudo-) Symmetrical Transport. Science, 339, 399-401.
[187] Shi, Y. (2013) Common Folds and Transport Mechanisms of Secondary Active Transporters. Annual Review of Biophysics, 42, 51-72.
[188] De Michele, R., Ast, C., Loqué, D., Ho, C.H., Andrade, S.L., Lanquar, V., Grossmann, G. and Gehne, S. (2013) Fluorescent Sensors Reporting the Activity of Ammonium Transceptors in Live Cells. Elife, 2, Article ID: E00800.
[189] Pantoja, O. (2013) High Affinity Ammonium Transporters and Mechanism of Action. Frontiers in Plant Science, 3, 34.
[190] Dynowski, M., Schaaf, G., Loque, D., Moran, O. and Ludewig, U. (2008) Plant Plasma Membrane Water Channels Conduct the Signaling Molecule H2O2. Biochemical Journal, 414, 53-61.
[191] Jahn, T.P., Moller, A.L., Zeuthen, T., Holm, L.M., Klærke, D.A., Mohsin, B., Kühlbrandt, W. and Schjoerring, J.K. (2004) Aquaporin Homologues in Plants and Mammals Transport Ammonia. FEBS Letters, 574, 31-36.
[192] Loqué, D., Ludewig, U., Yuan, L. and Von Wirén, N. (2005) Tonoplast Intrinsic Proteins AtTIP2; 1 and AtTIP2; 3 Facilitate NH3 Transport into the Vacuole. Plant Physiology, 137, 671-680.
[193] Léran, S., Varala, K., Boyer, J.C., Chiurazzi, M., Crawford, N., Daniel-Vedele, F., David, L. and Dickstein, R. (2014) A Unified Nomenclature of Nitrate Transporter1/Peptide Transporter Family Members in Plants. Trends in Plant Science, 19, 5-9.
[194] Boursiac, Y. (2013) ABA Transport and Transporters. Trends in Plant Science, 18, 325-333.
[195] Criscuolo, G., Valkov, V.T., Parlati, A., Alves, L.M. and Chiurazzi, M. (2012) Molecular Characterization of the Lotus japonicus NRT1 (PTR) and NRT2 Families. Plant, Cell & Environment, 35, 1567-1581.
[196] Nour-Eldin, H.H. (2012) NRT/PTR Transporters Are Essential for Translocation of Glucosinolate Defence Compounds to Seeds. Nature, 488, 531-534.
[197] Tegeder, M. and Rentsch, D. (2010) Uptake and Partitioning of Aminoacids and Peptides. Molecular Plant, 3, 997-1011.
[198] Sun, J., Bankston, J.R., Payandeh, J., Hinds, T.R., Zagotta, W.N. and Zheng, N. (2014) Crystal Structure of the Plant Dual-Affinity Nitrate Transporter NRT1.1. Nature, 507, 73-77.
[199] Pao, S.S., Paulsen, I.T. and Saier, M.H. (1998) Major Facilitator Super Family. Microbiology and Molecular Biology Reviews, 62, 1-34.
[200] Bergsdorf, E.Y., Zdebik, A.A. and Jentsch, T.J. (2009) Residues Important for Nitrate/Proton Coupling in Plant and Mammalian CLC Transporters. Journal of Biological Chemistry, 284, 11184-11193.
[201] Nguitragool, W. and Miller, C. (2006) Uncoupling of a CLC Cl-/H+ Exchange Transporter by Polyatomic Anions. Journal of Molecular Biology, 362, 682-690.
[202] Zifarelli, G. and Pusch, M. (2009) Conversion of the 2 Cl-/1 H+ Antiporter Clc-5in A /H+ Antiporter by a Single Point Mutation. EMBO Journal, 28, 175-182.
[203] Dutzler, R., Campbell, E.B., Cadene, M., Chait, B.T. and Mackinnon, R. (2002) X-Ray Structure of a Clc Chloride Channel at 3.0 a Reveals the Molecular Basis of Anion Selectivity. Nature, 415, 287-294.
[204] Picollo, A., Malvezzi, M., Houtman, J.C. and Accardi, A. (2009) Basis of Substrate Binding and Conservation of Selectivity in the CLC Family of Channels and Transporters. Nature Structural & Molecular Biology, 16, 1294-1301.
[205] De Angeli, A., Moran, O., Wege, S., Filleur, S., Ephritikhine, G. and Thomine, S. (2009) ATP Binding to the C Terminus of the Arabidopsis thaliana Nitrate/Proton Antiporter, Atclca, Regulates Nitrate Transport into Plant Vacuoles. Journal of Biological Chemistry, 284, 26526-26532.
[206] Geelen, D., Lurin, C., Bouchez, D., Frachisse, J.M., Lelièvre, F. and Courtial, B. (2000) Disruption of Putative Anion Channel Gene Atclc-A in Arabidopsis Suggests a Role in the Regulation of Nitrate Content. The Plant Journal, 21, 259-267.
[207] Harada, H., Kuromori, T., Hirayama, T., Shinozaki, K. and Leigh, R.A. (2004) Quantitative Trait Loci Analysis of Nitrate Storage in Arabidopsis Leading to an Investigation of the Contribution of the Anion Channel Gene, Atclc-C, to Variation in Nitrate Levels. Journal of Experimental Botany, 405, 2005-2014.
[208] Zifarell, G. and Pusch, M. (2010) CLC Transport Proteins in Plants. FEBS Letters, 584, 2122-2127.
[209] Kollist, H., Jossier, M., Laanemets, K. and Thomine, S. (2011) Anion Channels in Plant Cells. FEBS Journal, 278, 4277-4292.
[210] Schwacke, R., Schneider, A., Van Der Graaff, E., Fischer, K., Catoni E. and Desimone, M. (2003) ARAMEMNON, a Novel Database for Arabidopsis Integral Membrane Proteins. Plant Physiology, 131, 16-26.
[211] Saraste, M., Shibbald, P.R. and Wittinghofer, A. (1999) The P-Loop—A Common Motif in ATP- and GTP-Binding Proteins. Trends in Biochemical Sciences, 15, 430-434.
[212] Forrest, K.L. and Bhave, M. (2007) Major Intrinsic Proteins (Mips) in Plants: A Complex Gene Family with Major Impacts on Plant Phenotype. Functional & Integrative Genomics, 7, 263-289.
[213] Maurel, C., Verdoucq, L., Luu, D.T. and Santoni, V. (2008) Plant Aquaporins: Membrane Channels with Multiple Integrated Functions. Annual Review of Plant Physiology, 59, 595-624.
[214] Fujiyoshi, Y., Mitsuoka, K., De Groot, B.L., Philippsen, A., Grubmüller, H. and Agre, P. (2002) Structure and Function of Water Channels. Current Opinion in Structural Biology, 12, 509-515.
[215] Wudick, M., Luu, D.T. and Maurel, C. (2009) A Look Inside: Localization Patterns and Functions of Intracellular Plant Aquaporins. New Phytologist, 184, 289-302.
[216] Hoque, M.S., Masle, J., Udvardi, M.K., Ryan, P.R. and Upadhyaya, N.M. (2006) Over-Expression of the Rice Osamt1-1gene Increases Ammonium Uptake and Content, but Impairs Growth and Development of Plants under High Ammonium Nutrition. Functional Plant Biology, 33, 153-163.
[217] Sonoda, Y., Ikeda, A., Saiki, S., Von Wirén, N., Yamaya, T. and Yamaguchi, J. (2003) Distinct Expression and Function of Three Ammonium Transporter Genes (Osamt1; 1-1; 3) in Rice. Plant and Cell Physiology, 44, 726-734.
[218] Gu, R., Duan, F., An, X., Zhang, F., Von Wirén, N. and Yuan, L. (2013) Characterization of AMT-Mediated High-Affinity Ammonium Uptake in Roots of Maize (Zea mays L.). Plant and Cell Physiology, 54, 515-524.
[219] Li, S.M., Li, B.Z. and Shi, W.M. (2012) Expression Patterns of Nine Ammonium Transporters in Rice in Response to N Status. Pedosphere, 22, 860-869.
[220] Yao, S.G. and Sonada, Y. (2009) Promoter Analysis of OsAMT1; 2 and OsAMT1; 3 Implies Their Distinct Roles in Nitrogen Utilization. Breeding Science, 58, 201-207.
[221] Lauter, F.R., Ninnemann, O., Bucher, M., Riesmeier, J. and Frommer, W.B. (1996) Preferential Expression of an Ammonium Transporter and Two Putative Nitrate Transporters in Root Hairs of Tomato. Proceedings of the National Academy of Sciences of the United States of America, 93, 8139-8144.
[222] Tabuchi, M., Abiko, T. and Yamaya, T. (2007) Assimilation of Ammonium Ions and Reutilization of Nitrogen in Rice (Oryza sativa L.). Journal of Experimental Botany, 8, 2319-2327.
[223] Lin, C.M., Koh, S., Stacey, G., Yu, S.M., Lin, T.Y. and Tsay, Y.F. (2000) Cloning and Functional Characterization of a Constitutively Expressed Nitrate Transporter Gene Osnrt1 from Rice. Plant Physiology, 122, 379-388.
[224] Cerezo, M., Tillard, P., Filleur, S., Munos, S., Daniel-Vedele, F. and Gojon, A. (2001) Major Alterations of the Regulation of Root Uptake Are Associated with the Mutation of Nrt2.1 and Nrt2.2 Genes in Arabidopsis. Plant Physiology, 127, 262-271.
[225] Orsel, M., Eulenburg, K., Krapp, A. and Daniel-Vedele, F. (2004) Disruption of the Nitrate Transporter Genes Atnrt2.1 and Atnrt2.2 Restrict Growth at Low External Nitrate Concentration. Planta, 219, 714-721.
[226] Kiba, T., Feria-Bourrellier, A.B., Lafouge, F., Lezhneva, L., Boutet-Mercey, S., Orsel, M. and Bréhaut, V. (2012) The Arabidopsis Nitrate Transporter NRT2.4 Plays a Double Role in Roots and Shoots of Nitrogen-Starved Plants. Plant Cell, 24, 245-258.
[227] Masclaux-Daubresse, C., Daniel-Vedele, F., Dechorgnat, J., Chardon, F, Gaufichon, L. and Suzuki, A. (2010) Nitrogen Uptake, Assimilation and Remobilization in Plants: Challenges for Sustainable and Productive Agriculture. Annals of Botany, 105, 1141-1157.
[228] Araki, R. and Hasegawa, H. (2006) Expression of Rice (Oryza Sativa L.) Genes Involved in High-Affinity Nitrate Transport during the Period of Nitrate Induction. Breeding Science, 56, 295-302.
[229] Krapp, A., Fraisier, V., Scheible, W.-R., Quesada, A., Gojon, A., Stitt, M. and Caboche, M. (1998) Expression Studies of Nrt2: 1Np, a Putative High-Affinity Nitrate Transporter: Evidence for Its Role in Nitrate Uptake. The Plant Journal, 14, 723-731.
[230] Zhuo, D., Okamoto, M., Vidmar, J.J. and Glass, A.D. (1999) Regulation of a Putative High-Affinity Nitrate Transporter (Nrt2; 1At) in Roots of Arabidopsis thaliana. The Plant Journal, 17, 563-568.
[231] Nazoa, P., Videmar, J., Tranbarger, T.J., Mouline, K., Damiani, I., Tillard, P. and Glass, A.D.M. (2003) Regulation of the Nitrate Transporter Gene Atnrt2.1 in Arabidopsis thaliana, Responses to Nitrate, Amino Acids, and Developmental Stage. Plant Molecular Biology, 52, 689-703.
[232] Okamoto, M., Vidmar, J.J. and Glass, A.D. (2003) Regulation of NRT1 and NRT2 Gene Families of Arabidopsis thaliana: Responses to Nitrate Provision. Plant and Cell Physiology, 44, 4-17.
[233] Vidmar, J.J., Zhuo, D., Siddiqi, M.Y., Schoerring, J.K., Touraine, B. and Glass, A.D.M. (2000) Regulation of High Affinity Nitrate Transporter Genes and High Affinity Nitrate Influx by Nitrogen Pools in Plant Roots. Plant Physiology, 123, 307-318.
[234] Santi, G., Locci, R., Monte, R., Pinton, Z. and Varanini, Z. (2003) Induction of Nitrate Uptake in Maize Roots: Expression of a Putative High-Affinity Nitrate Transporter and Plasma Membrane H+-Atpase Isoforms. Journal of Experimental Botany, 54, 1851-1864.
[235] Ullrich, W.R. (1992) Transport of Nitrate and Ammonium through Plant Membranes. In: Mengel, K. and Pilbeam, D.J., Eds., Nitrogen Metabolism of Plants, Clarendon Press, Oxford, 121-137.
[236] Parker, J.L. and Newstead, S. (2014) Molecular Basis of Nitrate Uptake by the Plant Nitrate Transporter NRT1.1. Nature, 507, 68-72.
[237] Elberry, H.M., Majumdar, M.L., Cunningham, T.S., Sumrada, R.A. and Cooper, T.G. (1993) Regulation of the Urea Active Transporter Gene (DUR3) in Saccharomyces cerevisiae. Journal of Bacteriology, 175, 4688-4698.
[238] Wang, W.H., Köhler, B., Cao, F.Q., Liu, G.W., Gong, Y.Y. and Sheng, S. (2012b) Rice DUR3 Mediates High-Affinity Urea Transport and Plays an Effective Role in Improvement af Urea Acquisition and Utilization When Expressed in Arabidopsis. New Phytologist, 193, 432-444.
[239] Wu, Q., Chen, F., Chen, Y., Yuan, L., Zhang, F. and Mi, G. (2011) Root Growth in Response to Nitrogen Supply in Chinese Maize Hybrids Released between 1973 and 2009. Science China Life Sciences, 54, 642-650.
[240] Gu, R., Chen, X., Zhou, Y. and Yuan, L. (2012) Isolation and Characterization of Three Maize Aquaporin Genes, Zmnip2; 1, Zmnip2; 4 and Zmtip4; 4 Involved in Urea Transport. Biochemistry and Molecular Biology Reports, 4, 96-101.
[241] Liu, L.H., Ludewig, U., Gassert, B., Frommer, W.B. and Von Wiren, N. (2003) Urea Transport by Nirogen-Regulated Tonoplast Intrinsic Proteins in Arabidopsis. Plant Physiology, 133, 1220-1228.
[242] Wallace, I.S. and Roberts, D.M. (2005) Distinct Transport Selectivity of Two Structural Subclasses of the Nodulin-Like Intrinsic Protein Family of Plant Aquaglyceroporin Channels. Biochemistry, 44, 16826-16834.
[243] Wallace, I.S., Choi, W.G. and Roberts, D.M. (2006) The Structure, Function and Regulation of the Nodulin 26-Like Intrinsic Protein Family of Plant Aquaglyceroporins. Biochimica et Biophysica Acta, 1758, 1165-1175.
[244] Lin, S.H., Kuo, H.F. and Canivenc, G. (2008) Mutation of the Arabidopsis NRT1.5 Nitrate Transporter Causes Defective Root-to-Shoot Nitrate Transport. The Plant Cell, 20, 2514-2528.
[245] Segonzac, C., Boyer, J.C., Ipotesi, E., Szponarski, W., Tillard, P. and Touraine, B. (2007) Nitrate Efflux at the Root Plasma Membrane: Identification of an Arabidopsis Excretion Transporter. Plant Cell, 19, 3760-3777.
[246] Britto, D.T., Glass, A.D.M., Kronzucker, H.J. and Siddiqi, M.Y. (2001) Cytosolic Concentrations and Transmembrane Fluxes of NH4+/NH3. An Evaluation of Recent Proposals. Plant Physiology, 125, 523-526.
[247] Chen, G., Guo, S., Kronzucker, H.J. and Shi, W. (2013) Nitrogen Use Efficiency (NUE) in Rice Links to Toxicity and Futile Cycling in Roots. Plant Soil, 369, 351-363.
[248] Li, B., Li, G., Kronzucker, H.J., Baluska, F. and Shi, W. (2014) Ammonium Stress in Arabidopsis: Signaling, Genetic Loci, and Physiological Targets. Trends in PlantScience, 19, 107-114.
[249] Britto, D.T. and Kronzucker, H.J. (2002) Toxicity in Plants: A Critical Review. Journal of Plant Physiology, 159, 567-584.
[250] Crawford, N.M. and Forde, B.G. (2002) Molecular and Developmental Biology of Inorganic Nitrogen Nutrition. The Arabidopsis Book: American Society of Plant Biologists, 1, Article ID: E0011.
[251] Hirel, B. and Lea, P. (2001) Ammonia Assimilation. In: Lea, P.J. and Morot-Gaudry, J.F., Eds., Plant Nitrogen, Springer-Verlag, Berlin, 79-100.
[252] Terce-Laforgue, T., Mäck, G. and Hirel, B. (2004) New Insights towards the Function of Glutamate Dehydrogenase Revealed during Source-Sink Transition of Tobacco (Nicotiana tabacum) Plants Grown under Different Nitrogen Regimes. Physiologia Plantarum, 120, 220-228.
[253] Linka, M. and Weber, A.P. (2005) Shuffling Ammonia between Mitochondria and Plastids during Photorespiration. Trends in Plant Sciences, 10, 461-465.
[254] Forde, B.G. and Lea, P.J. (2007) Glutamate in Plants: Metabolism, Regulation, and Signaling. Journal of Experimental Botany, 58, 2339-2358.
[255] Oliveira, I.C., Brenner, E., Chiu, J., Hsieh, M.H., Kouranov, A., Lam, H.M., Shin, M.J. and Coruzzi, G.J. (2001) Metabolite and Light Regulation of Metabolism in Plants Lessons from the Study of a Single Biochemical Pathway. Brazilian Journal of Medical and Biological Research, 34, 567-575.
[256] Dluzniewka, P., Gessler, A., Kopriva, S., Strnad, M., Novák, O., Rennenberg, H. and Dietrich, H. (2006) Exogenous Supply of Glutamine and Active Cytokinin to the Roots Reduces Uptake Rates in Poplar. Plant, Cell & Environment, 29, 1284-1297.
[257] Wingler, A., Lea, P.J., Quick, W.P. and Leegood, R.C. (2000) Photorespiration: Metabolic Pathways and Their Role in Stress Protection. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 355, 1517- 1529.
[258] Kichey, T., Heumez, E., Pocholle, D., Pageau, K., Vanacker, H., Dubois, F.D.R., Le Gouis, J. and Hirel, B. (2006) Combined Agronomic and Physiological Aspects of Nitrogen Management in Wheat Highlight a Central Role for Glutamine Synthetase. The New Phytologist, 169, 265-278.
[259] Suzuki, A. and Knaff, D.B. (2005) Glutamate Synthase: Structural, Mechanistic and Regulatory Properties, and Role in the Amino Acid Metabolism. Photosynthesis Research, 85, 191-217.
[260] Andrews, M., Lea, P.J., Raven, J.A. and Lindsey, K. (2004) Can Genetic Manipulation of Plant Nitrogen Assimilation Enzymes Result in Increased Crop Yield and Greater N-Use Efficiency? An Assessment. Annals of Applied Biology, 145, 25-40.
[261] Raven, J.A. (1985) Regulation of Ph and Generation of Osmolarity in Vascular Plants: A Cost and Benefit Analysis in Relation to Efficiency of Use of Energy, Nitrogen and Water. New Phytologist, 101, 25-77.
[262] Hecht, U. and Mohr, H. (1990) Factors Controlling Nitrate and Ammonium Accumulation in Mustard (Sinapis alba) Seedlings. Physiologia Plantarum, 78, 379-387.
[263] Yuan, L., Graff, L., Loque, D., Kojima, S., Tsuchiya, Y.N., Takahashi, H. and Von Wiren, N. (2009) Atamt1.4, a Pollen-Specific High-Affinity Ammonium Transporter of the Plasma Membrane in Arabidopsis. Plant and Cell Physiology, 50, 13-25.
[264] Bu, Y., Takano, T., Nemoto, K. and Liu, S. (2011) Research Progress of Ammonium Transporter in Rice Plants. Genomics and Applied Biology, 2, 19-23.
[265] Li, S.M. and Shi, W.M. (2006) Quantitative Characterization of Nitrogen Regulation of Osamt1;1, Osamt1;2, and Osamt2;2 Expression in Rice Seedlings. Russian Journal of Plant Physiology, 6, 837-843.
[266] Gaur, V.S., Singh, U.S., Gupta, A.K. and Kumar, A. (2012) Understanding the Differential Nitrogen Sensing Mechanism in Rice Genotypes through Expression Analysis of High and Low Affinity Ammonium Transporter Genes. Molecular Biology Reports, 39, 2233-2241.
[267] Morgan, M.A. and Jackson, W.A. (1998) Inward and Outward Movement of Ammonium in Root Systems: Transient Responses during Recovery from Nitrogen Deprivation in Presence of Ammonium. Journal of Experimental Botany, 39, 179-191.
[268] Shelden, M.C., Dong, B., De Bruxelles, G.L., Trevaskis, B., Whelan, J., Ryan, P.R. and Howitt, S.M. (2001) Arabidopsis Ammonium Transporter, Atamt1;1 and Atamt1;2, Have Different Biochemical Properties and Functional Roles. Plant Soil, 231, 151-160.
[269] Pearson, J.N., Finnemann, J. and Schjoerring, J.K. (2005) Regulation of the High-Affinity Ammonium Transporter (Bnamt1; 2) in the Leaves of Brassica napus by Nitrogen Status. Plant Molecular Biology, 4, 483-490.
[270] Bussell, J.D., Keech, O., Fenske, R. and Smith, S.M. (2013) Requirement for the Plastidial Oxidative Pentose Phosphate Pathway for Nitrate Assimilation in Arabidopsis. The Plant Journal, 75, 578-591.
[271] Murphy, A.T. and Lewis, O.A.M. (1987) Effect of Nitrogen Feeding Source on the Supply of Nitrogen from Root to Shoot and the Site of Nitrogen Assimilaton in Maize (Zea maize). New Phytologist, 107, 327-333.
[272] Scheurwater, I., Koren, M., Lambers, H. and Atkin, O.K. (2002) The Contribution of Roots and Shoots to Whole Plant Nitrate Reduction in Fast and Slow Growing Grass. Journal of Experimental Botany, 53, 1635-1642.
[273] Cookson, S.J., Williams, L.E. and Miller, A.J. (2005) Light-Dark Changes in Cytosolic Nitrate Pools Depend on Nitrate Reductase Activity in Arabidopsis Leaf Cells. Plant Physiology, 138, 1097-1105.
[274] Fedorova, E., Greenwood, J.S. and Oaks, A. (2005) In-Situ Lotalization of Nitrate Reductase in Maize Roots. Planta, 194, 279-2815.
[275] Meyer, C. and Stitt, M. (2001) Nitrate Reduction and Signaling. In: Lea, P.J. and Morot-Gaudry, J.F., Eds., Plant Nitrogen, Springer-Verlag, Berlin, 61-78.
[276] Kaiser, W.M. and Huber, S.C. (2001) Post-Translational Regulation of Nitrate Reductase: Mechanism, Physiological Relevance and Environmental Triggers. Journal of Experimental Botany, 52, 1981-1989.
[277] Fan, X., Gordon-Weeks, R., Shen, Q. and Miller, A.J. (2006) Glutamine Transport and Feedback Regulation of Nitrate Reductase Activity in Barley Roots Leads to Changes in Cytosolic Nitrate Pools. Journal of Experimental Botany, 57, 1333-1340.
[278] Fritz, C., Mueller, C., Matt, P., Feil, R. and Stitt, M. (2006) Impact of the C-N Status on the Amino Acid Profile in Tobacco Source Leaves. Plant, Cell & Environment, 29, 2055-2076.
[279] Lemaitre, T., Gaufichon, L., Boutet-Mercey, S., Christ, A. and Masclaux Daubresse, C. (2008) Enzymatic and Metabolic Diagnostic of Nitrogen Deficiency in Arabidopsis thaliana Wassileskija Accession. Plant and Cell Physiology, 49, 1056-1065.
[280] Redinbaugh, M.G. and Campbell, W.H. (1998) Nitrate Regulation of the Oxidative Pentose Phosphate Pathway in Maize (Zea mays L. Root Plastids Induction of 6-Phosphogluconate Dehydrogenase Activity Protein and Transcript Levels. Plant Science, 134, 129-140.
[281] Wang, R., Tischner, R., Gutiérrez, R.A., Hoffman, M., Xing, X., Chen, M. and Coruzzi, G. (2004) Genomic Analysis of the Nitrate Response Using a Nitrate Reductase-Null Mutant of Arabidopsis. Plant Physiology, 136, 2512-2522.
[282] Wang, R., Xing, X. and Crawford, N. (2007) Nitrite Acts as a Transcriptome Signal at Micromolar Concentrations in Arabidopsis Roots. Plant Physiology, 145, 1735-1745.
[283] Peuke, A.D. (2010) Correlations in Concentrations, Xylem and Phloem Flows, and Partitioning of Elements and Ions in Intact Plants: A Summary and Statistical Re-Evaluation of Modelling Experiments in Ricinus communis. Journal of Experimental Botany, 61, 635-655.
[284] Chen, C.Z., Lv, X.F., Li, J.Y., Yi, H.Y. and Gong, J.M. (2012) Arabidopsis NRT1.5 Is Another Essential Component in the Regulation of Nitrate Reallocation and Stress Tolerance. Plant Physiology, 159, 1582-1590.
[285] Li, J.Y., Fu, Y.L., Pike, S.M., Bao, J., Tian, W. and Zhang, Y. (2010) The Arabidopsis Nitrate Transporter NRT1.8 Functions in Nitrate Removal from the Xylem Sap and Mediates Cadmium Tolerance. The Plant Cell, 22, 1633-1646.
[286] Tang, Z., Fan, X., Li, Q., Feng, H., Miller, A.J. and Shen, Q. (2012) Knockdown of a Rice Stelar Nitrate Transporter Alters Long-Distance Translocation but Not Root Influx. Plant Physiology, 160, 2052-2063.
[287] Feng, H., Yan, M., Fan, X., Li, B., Shen, Q., Miller, A.J. and Xu, G. (2011) Spatial Expression and Regulation of Rice High-Affinity Nitrate Transporters by Nitrogen and Carbon Status. Journal of Experimental Botany, 62, 2319-2332.
[288] Chiu, C.C., Lin, C.S., Hsia, A.P., Su, R.C., Lin, H.L. and Tsay, Y.F. (2004) Mutation of a Nitrate Transporter, Atnrt1:4, Results in a Reduced Petiole Nitrate Content and Altered Leaf Development. Plant & Cell Physiology, 45, 1139-1148.
[289] Hayashi, H. and Chino, M. (1985) Nitrate and Other Anions in the Rice Phloem Sap. Plant and Cell Physiology, 26, 325-330.
[290] Hayashi, H. and Chino, M. (1986) Collection of Pure Phloem Sap from Wheat and Its Chemical Composition. Plant & Cell Physiology, 27, 1387-1393.
[291] Wang, Y.Y. and Tsay, Y.F. (2011) Arabidopsis Nitrate Transporter NRT1. 9 Is Important in Phloem Nitrate Transport. The Plant Cell, 23, 1945-1957.
[292] Hine, J.C. and Sprent, J.I. (1988) Growth of Phaseolus Vulgaris on Various Nitrogen Sources: The Importance of Urease. Journal of Experimental Botany, 39, 1505-1512.
[293] Witte, C.P., Tiller, S., Isidore, E., Davies, H.V. and Taylor, M.A. (2005) Analysis of Two Alleles of the Urease Gene from Potato: Polymorphisms, Expression, and Extensive Alternative Splicing of the Corresponding Mrna. Journal of Experimental Botany, 56, 91-99.
[294] Werner, A.K., Romeis, T. and Witte, C.P. (2010) Ureide Catabolism in Arabidopsis thaliana and Escherichia Coli. Nature Chemical Biology, 6, 19-21.
[295] Merigout, M., Lelandais, F., Bitton, X., Briand, C. and Meyer, C. (2008) Physiological and Transcriptomic Aspects of Urea Uptake and Assimilation in Arabidopsis Plants. Plant Physiology, 147, 1225-1238.
[296] Kluge, C., Lahr, J., Hanitzsch, M., Bolte, S., Golldack, D. and Dietz, K.J. (2003) New Insight into the Structure and Regulation of the Plant Vacuolar H+-Atpase. Journal of Bioenergetics and Biomembranes, 35, 377-388.
[297] Maeshima, M. (2000) Vacuolar H+-Pyrophosphatase. Biochimica et Biophysica Acta, 1465, 37-51.
[298] Chen, J.K., Luo, X.M., Yin, J.L., Zhan, P.W. and Shen, Q.R. (2004) Distribution and Remobilization of Nitrate in Two Cultivars of Pakchoi Plant. Scientia Agricultura Sinica, 38, 2277-2282.
[299] Martinoia, U., Heck, A. and Wiemken, A. (1981) Vacuoles as Storage Compartments of Nitrate in Barley Leaves. Nature, 289, 292-294.
[300] Wang, T., Jia, J.L. and Shen, Q.R. (2008b) Relationship between Nitrate Remobilization in Root Vacuoles and Plant Growth of Two Genotypes of Lettuce. Acta Pedologica Sinica, 45, 555-560.
[301] Zhao, S.P., Ye, X.Z., Zhang, Y.Z. and Zheng, J.C. (2010) The Contribution of Bnnrt1 and Bnnrt2 to Nitrate Accumulation Varied According to Genotypes in Chinese Cabbage. African Journal of Biotechnology, 9, 4910-4917.
[302] Chopin, F., Orsel, M., Dorbe, M.F., Chardon, F., Truong, H.N., Miller, A.J. and Krapp, A. (2007) The Arabidopsis ATNRT2.7 Nitrate Transporter Controls Nitrate Content in Seeds. The Plant Cell, 19, 1590-1602.
[303] Kotur, Z., Mackenzie, N., Ramesh, S., Tyerman, S.D., Kaiser, B.N. and Glass, A.A.M. (2012) Nitrate Transport Capacity of the Arabidopsis thaliana NRT2 Family Members and Their Interactions with Atnar2.1. New Phytologist, 194, 724-731.
[304] Plett, D., Toubia, J., Garnett, T., Tester, M., Kaiser, B.N. and Baumann, U. (2010) Dichotomy in the NRT Gene Families of Dicots and Grass Species. PLoS ONE, 5, e15289.
[305] Miller, A.J., Cookson, S.J., Smith, S.J. and Wells, D.M. (2001) The Use of Microelectrodes to Investigate Compartmentation and the Transport of Metabolized Inorganic Ions in Plants. Journal of Experimental Botany, 52, 541-549.
[306] Bertl, R. and Kaldenhoff, R. (2007) Function of a Separate NH3-Pore in Aquaporin TIP2; 2 from Wheat. FEBS Letters, 581, 5413-5417.
[307] Holm, L.M., Jahn, T.P., Moller, A.L., Schjoerring, J.K., Ferri, D. and Klaerke, D.A. (2005) NH3 and Permeability in Aquaporin-Expressing Xenopus Oocytes. Pflügers Archiv, 450, 415-428.
[308] Klebl, F., Wolf, M. and Sauer, N. (2003) A Defect in the Yeast Plasma Membrane Urea Transporter Dur3p Is Complemented by Cpnip1, a Nod26-Like Protein from Zucchini (Cucurbita pepo L.), and by Arabidopsis thaliana Delta- TIP or Gamma-TIP. FEBS Letters, 547, 69-74.
[309] Uehlein, N., Lovisolo, C., Siefritz, F. and Kaldenhoff, R. (2003) The Tobacco Aquaporin Ntaqp1 Is a Membrane CO2 Pore with Physiological Functions. Nature, 425, 734-737.
[310] Howitt, S.M. and Udvardi, M.K. (2005) Structure, Function and Regulation of Ammonium Transporters in Plants. Biochimica et Biophysica Acta, 1465, 152-170.
[311] Wood, C.C., Poree, F., Dreyer, I., Koehler, G.J. and Udvardi, M.K. (2006) Mechanisms of Ammonium Transport, Accumulation, and Retention in Ooyctes and Yeast Cells Expressing Arabidopsis Atamt1; 1. FEBS Letters, 580, 3931- 3936.
[312] Gaspar, M., Sissoëff, I., Bousser, A., Roche, O., Hoarau, J. and Mahé, A. (2003) Cloning and Characterization of Zmpip1-5, an Aquaporin Transporting Water and Urea. Plant Science, 165, 21-31.
[313] Kim, S.H., Kim, K., Ju, H.W., Lee, H. and Hong, S.W. (2008) Over Expression of Gene Encoding Tonoplast Intrinsic Aquaporin Promotes Urea Transport in Arabidopsis. Journal of Applied Biological Chemistry, 51, 102-110.
[314] Malagoli, P., Laine, P., Rossato, L. and Ourry, A. (2005) Dynamics of Nitrogen Uptake and Mobilization in Field-Grown Winter Oilseed Rape (Brassica napus) from Stem Extension to Harvest. Annals of Botany, 95, 853-861.
[315] Rossato, L., Laine, P. and Ourry, A. (2001) Nitrogen Storage and Remobilization in Brassica napus L. during the Growth Cycle: Nitrogen Fluxes within the Plant and Changes in Soluble Protein Patterns. Journal of Experimental Botany, 52, 1655-1663.
[316] Schiltz, S., Munier-Jolain, N., Jeudy, C., Burstin, J. and Salon, C. (2005) Dynamics of Exogenous Nitrogen Partitioning and Nitrogen Remobilization from Vegetative Organs in Pea Revealed by 15N in Vivo Labelling throughout Seed Filling. Plant Physiology, 137, 1463-1473.
[317] Simpson, R.J., Lambers, H. and Dalling, M.J. (1993) Nitrogen Redistribution during Grain Growth in Wheat (Triticum aestivum L.): IV. Development of a Quantitative Model of the Translocation of Nitrogen to the Grain. Plant Physiology, 71, 7-14.
[318] Wendler, R., Carvalho, P., Pereira, J. and Millard, P. (1995) Role of Nitrogen Remobilization from Old Leaves for New Leaf Growth of Eucalyptus Globulus Seedlings. Tree Physiology, 15, 679-683.
[319] Izumi, M., Wada, S., Makino, A. and Ishida, H. (2010) The Autophagic Degradation of Chloroplasts via Rubisco-Containing Bodies Is Specifically Linked to Leaf Carbon Status but Not Nitrogen Status in Arabidopsis. Plant Physiology, 154, 1196-1209.
[320] Mae, T., Makino, A. and Ohira, K. (1984) Changes in the Amounts of Ribulose Biphosphate Carboxylase Synthesized and Degraded during the Life Span of Rice Leaf (Oryza sativa L.). Plant and Cell Physiology, 24, 1079-1086.
[321] Feller, U. and Keist, M. (1986) Senescence and Nitrogen Metabolism in Annual Plants. In: Lambers, H., Neetson, J.J. and Stulen, I., Eds., Fundamental, Ecological and Agricultural Aspects of Nitrogen Metabolism, Martinus Nijhoff Publishers, Dordrecht, 219-234.
[322] Gallais, A., Coque, M., Quilléré, I., Le Gouis, J., Prioul, J.L. and Hirel, B. (2007) Estimating the Proportion of Nitrogen Remobilization and of Postsilking Nitrogen Uptake Allocated to Maize Kernels by Nitrogen-15 Labeling. Crop Science, 47, 685-691.
[323] Kichey, T., Hirel, B., Heumez, E., Dubois, F. and Le Gouis, J. (2007) In Winter Wheat (Triticum aestivum L.), Post-Anthesis Nitrogen Uptake and Remobilisation to the Grain Correlates with Agronomic Traits and Nitrogen Physiological Markers. Field Crops Research, 102, 22-32.
[324] Masclaux-Daubresse, C., Quilleré, I., Gallais, A. and Hirel, B. (2001) The Challenge of Remobilisation in Plant Nitrogen Economy. A Survey of Physio-Agronomic and Molecular Approaches. Annals of Applied Biology, 138, 68-81.
[325] Ono, Y., Wada, S., Izumi, M., Makino, A. and Ishida, H. (2013) Evidence for Contribution of Autophagy to Rubisco Degradation during Leaf Senescence in Arabidopsis thaliana. Plant Cell Environment, 36, 1147-1159.
[326] Almagro, A., Lin, S.H. and Tsay, Y.F. (2008) Characterization of the Arabidopsis Nitrate Transporter NRT1.6 Reveals a Role of Nitrate in Early Embryo Development. The Plant Cell, 20, 3289-3299.
[327] Fan, S.C., Lin, C.S., Hsu, P.K., Lin, S.H. and Tsay, Y.F. (2009) The Arabidopsis Nitrate Transporter NRT1.7, Expressed in Phloem, Is Responsible for Source-to-Sink Remobilization of Nitrate. The Plant Cell, 21, 2750-2761.
[328] Hsu, P.K. and Tsay, Y.F. (2013) Two Phloem Nitrate Transporters, NRT1.11 and NRT1.12, Are Important for Redistributing Xylem-Borne Nitrate to Enhance Plant Growth. Plant Physiology, 163, 844-856.
[329] Soto, G., Alleva, K., Mazzella, M.A., Amodeo, G. and Muschietti, J.P. (2008) Attip1;3 and Attip5;1, the Only Highly Expressed Arabidopsis Pollen-Specific Aquaporins, Transport Water and Urea. FEBS Letters, 582, 4077-4082.
[330] Soto, G., Fox, R., Ayub, N., Alleva, K., Guaimas, F., Erijman, E.J., Mazzella, A. and Amodeo, G. (2010) TIP5; 1 Is an Aquaporin Specifically Targeted to Pollen Mitochondria and Is Probably Involved in Nitrogen Remobilization in Arabidopsis thaliana. The Plant Journal, 64, 1038-1047.
[331] Masclaux-Daubresse, C., Reisdorf-Cren, M. and Pageau, K. (2006) Glutamine Synthetase-Glutamate Synthase Pathway and Glutamate Dehydrogenase Play Distinct Roles in the Sink-Source Nitrogen Cycle in Tobacco. Plant Physiology, 140, 444-456.
[332] Patrick, J.W. and Offler, C.E. (2001) Compartmentation of Transport and Transfer Events in Developing Seeds. Journal of Experimental Botany, 52, 551-564.
[333] Rochat, C. and Boutin, J.P. (1991) Metabolism of Phloem-Borne Amino Acids in Maternal Tissues of Fruit of Nodulated or Nitrate-Fed Pea Plants (Pisum sativum L.). Journal of Experimental Botany, 42, 207-214.
[334] Bailey, C.J. and Boulter, D. (1971) Urease, a Typical Seed Protein of the Leguminosae. In: Harborne, J., Boulter, D. and Turner, B., Eds., Chemotaxonomy of the Leguminosae, Academic Press, New York, 485-502.
[335] Stebbins, N.E. and Polacco, J.C. (1995) Urease Is Not Essential for Ureide Degradation in Soybean. Plant Physiology, 109, 169-175.
[336] Zonia, L.E., Stebbins, N.E. and Polacco, J.C. (1995) Essential Role of Urease in Germination of Nitrogen-Limited Arabidopsis thaliana Seeds. Plant Physiology, 107, 1097-1103.
[337] Suryapriya, P., Snehalatha, A., Kayalvili, U., Krishna, R., Singh, S. and Ulaganathan, K. (2009) Genome-Wide Analyses of Rice Root Development Qtls and Development of an Online Resource, Rootbrowse. Bioinformation, 3, 279-281.
[338] Rani, S. (2010) Rnai Mediated Functional Validation of Root Development QTL Associated Candidate Genes in Rice. PhD Thesis, Osmania University, Hyderabad.
[339] Forde, B.G. and Lorenzo, H. (2011) The Nutritional Control of Root Development. Plant Soil, 232, 51-68.
[340] Roycewicz, P. and Malamy, J.E. (2012) Dissecting the Effects of Nitrate, Sucrose and Osmotic Potential on Arabidopsis Root and Shoot System Growth in Laboratory Assays. Philosophical Transactions of the Royal Society B, 367, 1489-1500.
[341] Vidal, E.A., Araus, V., Lu, C., Parry, G. and Green, P.J. (2010) Nitrate-Responsive Mir393/AFB3 Regulatory Module Controls Root System Architecture in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America, 107, 4477-4482.
[342] Walch-Liu, P., Ivanov, I.I., Filleur, S., Gan, Y., Remans, T. and Forde, B. (2006) Nitrogen Regulation of Root Branching. Annals of Botany, 97, 875-881.
[343] Walch-Liu, P. and Forde, B.G. (2008) Nitrate Signaling Mediated by the NRT1.1 Nitrate Transporter Antagonises L-Glutamate-Induced Changes in Root Architecture. The Plant Journal, 54, 820-828.
[344] Zhang, H., Jennings, A., Barlow, P.W. and Forde, B.G. (1999) Dual Pathways for Regulation of Root Branching by Nitrate. Proceedings of the National Academy of Sciences of the United States of America, 96, 6529-6534.
[345] Zhang, H., Rong, H. and Pilbeam, D. (2007) Signaling Mechanisms Underlying the Morphological Responses of the Root System to Nitrogen in Arabidopsis thaliana. Journal of Experimental Biology, 58, 2329-2338.
[346] De Smet, I., Tetsumura, T., De Rybel, B., Frey, N.F., Laplaze, L., Casimiro, I. and Swarup, R. (2007) Auxin-Dependent Regulation of Lateral Root Positioning in the Basal Meristem of Arabidopsis. Development, 134, 681-690.
[347] Laskowski, M., Grieneisen, V.A., Hofhuis, H., Hove, C.A., Hogeweg, P., Maree, A.F. and Scheres, B. (2008) Root System Architecture from Coupling Cell Shape to Auxin Transport. PLoS Biology, 6, E307.
[348] Mounier, E., Pervent, M., Ljung, K., Gojon, A. and Nacry, P. (2014) Auxin-Mediated Nitrate Signaling by NRT1.1 Participates in the Adaptive Response of Arabidopsis Root Architecture to the Spatial Heterogeneity of Nitrate Availability. Plant Cell And Environment, 37, 162-174.
[349] Péret, B., Larrieu, A. and Bennet, M.J. (2009) Lateral Root Emergence: A Difficult Birth. Journal of Experimental Biology, 60, 3637-3643.
[350] Bloom, A.J., Paul, A., Meyerhoff, P.A., Taylor, A.R. and Rost, T.L. (2002) Root Development and Absorption of Ammonium and Nitrate from the Rhizosphere. Journal of Plant Growth Regulation, 21, 416-431.
[351] Gifford, M.L., Dean, A., Gutierrez, R.A., Coruzzi, G.M. and Birnbaum, K.D. (2008) Cell-Specific Nitrogen Responses Mediate Developmental Plasticity. Proceedings of the National Academy of Sciences of the United States of America, 105, 803-808.
[352] De Smet, I., Signora, L., Beeckman, T., Inze, D., Foyer, C.H. and Zhang, H. (2003) An Abscisic Acid-Sensitive Checkpoint in Lateral Root Development of Arabidopsis. The Plant Journal, 33, 543-555.
[353] Ivanchenko, M.G., Muday, G.K. and Dubrovsky, J.G. (2008) Ethylene-Auxin Interactions Regulate Lateral Root Initiation and Emergence in Arabidopsis thaliana. The Plant Journal, 55, 335-347.
[354] Tian, Q.Y., Sun, P. and Zhang, W.H. (2009) Ethylene Is Involved in Nitrate-Dependent Root Growth and Branching in Arabidopsis thaliana. New Phytologist, 184, 918-931.
[355] Mantelin, S., Desbrosses, G., Larcher, M., Tranbarger, T.J., Cleyet-Marel, J.C. and Touraine, B. (2006) Nitrate-Dependent Control of Root Architecture and N Nutrition Are Altered by a Plant Growth-Promoting Phyllobacterium sp. Planta, 223, 591-603.
[356] Barth, C., Gouzd, Z.A., Steelt, H.P. and Imperio, R.M. (2010) A Mutation in GDP-Mannose Pyrophosphorylase Causes Conditional Hypersensitivity to Ammonium, Resulting in Arabidopsis Root Growth Inhibition, Altered Ammonium Metabolism, and Hormone Homeostasis. Journal of Experimental Botany, 61, 379-394.
[357] Cao, Y.W., Glass, A.D.M. and Crawford, N.M. (1993) Ammonium Inhibition of Arabidopsis Root Growth Can Be Reversed by Potassium and by Auxin Resistance Mutations Aux1, Axr1, and Axr2. Plant Physiology, 102, 983-989.
[358] Li, Q., Li, B., Kronzucker, H.J. and Shi, W. (2010) Root Growth Inhibition by in Arabidopsisis Mediated by the Root Tip and Is Linked to Efflux and Gmpase Activity. Plant Cell and Environment, 33, 1529-1542.
[359] Qin, C., Qian, W., Wang, Y., Wu, C., Yu, X., Jiang, D., Wang, P. and Wu, P. (2008) GDP-Mannose Pyrophosphorylase Is a Genetic Determinant of Ammonium Sensitivity in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America, 105, 18308-18313.
[360] Lejay, L., Tillard, P., Lepetit, M., Olife, F., Filleur, S., Daniel-Vedele, F. and Gojon, A. (1999) Molecular and Functional Regulation of Two Uptake Systems by N- and C-Status of Arabidopsis Plants. The Plant Journal, 18, 509-519.
[361] Malamy, J. and Ryan, K. (2001) Environmental Regulation of Lateral Root Initiation in Arabidopsis. Plant Physiology, 127, 899-909.
[362] Walch-Liu, P., Liu, L.H., Remans, T., Tester, M. and Forde, B.G. (2006) Evidence That L-Glutamate Can Act as an Exogenous Signal to Modulate Root Growth and Branching in Arabidopsis thaliana. Plant and Cell Physiology, 47, 1045-1057.
[363] Tian, Q., Chen, F., Liu, J., Zhang, F. and Mi, G. (2008) Inhibition of Maize Root Growth by High Nitrate Supply Is Correlated with Reduced IAA Levels in Roots. Journal of Plant Physiology, 165, 942-951.
[364] Ma, W., Li, J., Qu, B., He, X., Zhao, X., Li, B., Fu, X. and Tong, Y. (2014) Auxin Biosynthetic Gene TAR2 Is Involved in Low Nitrogen Mediated Reprogramming of Root Architecture in Arabidopsis. The Plant Journal, 78, 70-79.
[365] Barber, M.J. and Kay, C.J. (1996) Superoxide Production during Reduction of Molecular Oxygen by Assimilatory Nitrate Reductase. Archives of Biochemistry and Biophysics, 326, 227-232.
[366] Meyer, C., Lea, U.S., Provan, F., Kaiser, W.M. and Lillo, C. (2005) Is Nitrate Reductase a Major Player in the Plant NO (Nitric Oxide) Game? Photosynthesis Research, 83, 181-189.
[367] Yamasaki, H. and Sakihama, Y. (2000) Simultaneous Production of Nitric Oxide and Peroxynitrite by Plant Nitrate Reductase: In Vitro Evidence for the NR-Dependent Formation of Active Nitrogen Species. FEBS Letters, 468, 89-92.
[368] Von Wirén, N., Gazzarrini, S. and Frommer, W.B. (1997) Regulation of Mineral Nitrogen Uptake in Plants. Plant and Soil, 196, 191-199.
[369] Filleur, S. and Daniel-Vedele, F. (1997) Expression Analysis of a High-Affinity Nitrate Transporter Isolated from Arabidopsis thaliana by Differential Display. Planta, 207, 461-469.
[370] Santi, S., Locci, G., Pinton, R. and Varanini, Z. (2003)Induction of Nitrate Uptake in Maize Roots: Expression of a Putative High-Affinity Nitrate Transporter and Plasma Membrane H+-Atpase Isoforms. Journal of Experimental Botany, 54, 1851-1864.
[371] Yan, M., Fan, X.R., Feng, H.M., Miller, A.J., Shen, Q. and Xu, G.H. (2011) Rice OsNAR2.1 Interacts with OsNRT2.1, OsNRTt2.2 and OsNRT2.3a Nitrate Transporters to Provide Uptake over High and Low Concentration Ranges. Plant, Cell & Environment, 34, 1360-1372.
[372] Dluzniewska, P., Gessler, A., Kopriva, S., Strand, M., Novak, O., Dietrich, H. and Rennenberg, H. (2006) Supply of Glutamine and Active Cytokinin to the Roots Reduces NO3 Uptake Rates in Poplar. Plant Cell and Environment, 29, 1284-1297.
[373] Muller, B., Tilliard, P. and Touraine, V. (1995) Nitrate Fluxes in Soybean Seedling Roots and Their Response to Amino Acids: An Approach Using 15N. Plant Cell and Environment, 18, 1267-1279.
[374] Gansel, X., Muños, S., Tillard, P. and Gojon, A. (2001) Differential Regulation of The NO3- and Transporter Genes Atnrt2.1 and Atamt1;1 in Arabidopsis: Relation with Long-Distance and Local Controls by N Status of the Plant. The Plant Journal, 26, 143-155.
[375] Widiez, T., Kafafiel, E.L., Girin, T., Berr, A., Ruffel, S., Krouk, G. and Vayssières, A. (2011) High Nitrogen Insensitive 9 (HNI9)-Mediated Systemic Repression of Root Uptake Is Associated with Changes in Histone Methylation. Proceedings of the National Academy of Sciences of the United States of America, 108, 13329-13334.
[376] Engelsberger, W.R. and Schulze, W.X. (2012) Nitrate and Ammonium Lead to Distinct Global Dynamic Phosphorylation Patterns When Resupplied to Nitrogen-Starved Arabidopsis Seedlings. The Plant Journal, 69, 978-995.
[377] Vialaret, J., Pietro, M.D., Hem, S., Maurel, C., Rossignol, M. and Santoni, V. (2014) Phosphorylation Dynamics of Membrane Proteins from Arabidopsis Roots Submitted to Salt Stress. Proteomics, 14, 1058-1070.
[378] De Jong, F., Thodey, K., Lejay, L.V. and Bevan, M.V. (2013) Glucose Elevates NRT2.1 Protein Levels and Nitrate Transport Activity Independently of Its HXK1-Mediated Stimulation of NRT2.1 Expression. Plant Physiology, 164, 308-320.
[379] Kruger, N.J. and Von Schaewen, A. (2003) The Oxidative Pentose Phosphate Pathway: Structure and Organisation. Current Opinion in Plant Biology, 16, 236-246.
[380] Lejay, L., Wirth, V., Pervent, M., Cross, J.M.F., Tillard, P. and Gojon, A. (2008) Oxidative Pentose Phosphate Pathway-Dependent Sugar Sensing as a Mechanism for Regulation of Root Ion Transporters by Photosynthesis. Plant Physiology, 146, 2036-2053.
[381] Lejay, L., Gansel, X., Cerezo, M., Tillard, P., Muller, C., Krapp, A. And Von Wiren, N. (2003) Regulation of Root Ion Transporters by Photosynthesis: Functional Importance and Relation with Hexokinase. The Plant Cell, 5, 2218-2232.
[382] Kronzucker, H.J., Siddiqi, M.Y. and Glass, A.D.M. (1995) Compartmentation and Flux Characteristics of Ammonium in Spruce. Planta, 196, 691-698.
[383] Rawat, S.R., Silim, S.N., Kronzucker, H.J., Siddiqi, M.Y. and Glass, A.D.M. (1999) Atamt1 Gene Expression and Uptake in Roots of Arabidopsis thaliana: Evidence for Regulation by Root Glutamine Levels. The Plant Journal, 19, 143-152.
[384] Loque, D. and Wiren, N. (2004) Regulatory Levels for the Transport of Ammonium in Plant Roots. Journal of Experimental Botany, 55, 1293-1305.
[385] Loque, D., Ludewig, U., Yuan, L. and Von Wiren, N. (2005) Tonoplast Intrinsic Proteins AtTIP2; 1 and AtTIP2; 3 Faciliate NH3 Transport into the Vacuole. Plant Physiology, 137, 671-680.
[386] Ortiz-Ramirez, C., Mora, S.I., Trejo, J. and Pantoja, O. (2011) PvAMT1; 1, a Highly Selective Ammonium Transporter That Functions as H+/ Symporter. Journal of Biological Chemistry, 286, 31113-31122.
[387] Sogaard, R., Alsterfjord, M., Macaulay, N. and Thomas, Z. (2009) Ammonium Ion Transport by the AMT/Rh Homolog TaAMT1; 1 Is Stimulated by Acidic pH. Pflügers Archiv—European Journal of Physiology, 458, 733-743.
[388] Zhao, M., Ding, H., Zhu, J.K., Zhang, F. and Li, W.X. (2011) Involvement of miR169 in the Nitrogen-Starvation Responses in Arabidopsis. New Phytologist, 190, 906-915.
[389] Li, W.X., Oono, Y., Zhu, J., He, X.J., Wu, J.M., Iida, K., Lu, X.Y., Cui, X., Jin, H. and Zhu, J.K. (2008) The Arabidopsis NFYA5 Transcription Factor Is Regulated Transcriptionally and Post transcriptionally to Promote Drought Resistance. Plant Cell, 20, 2238-2251.
[390] Mantovani, R. (1999) The Molecular Biology of the CCAAT-Binding Factor NF-Y. Gene, 239, 15-27.
[391] Nelson, D.E. (2007) Plant Nuclear Factor Y (NF-Y) B Subunits Confer Drought Tolerance and Lead to Improved Corn Yields on Water-Limited Acres. Proceedings of the National Academy of Sciences of the United States of America, 104, 16450-16455.
[392] Zanetti, M.E., Blanco, F.A., Beker, M.P., Battaglia, M. and Aguilar, O.M. (2010) A C Subunit of the Plant Nuclear Factor NF-Y Required for Rhizobial Infection and Nodule Development Affects Partner Selection in the Common Bean-Rhizobium Etli Symbiosis. Plant Cell, 22, 4142-4157.
[393] .Hsieh, L.C., Lin, S.I., Shih, A.C., Chen, J.W., Lin, W.Y., Tseng, C.Y., Li, W.H. and Chiou, T.J. (2009) Uncovering Small RNA-Mediated Responses to Phosphate Deficiency in Arabidopsis by Deep Sequencing. Plant Physiology, 151, 2120-2132.
[394] Pant, B.D., Musialak-Lange, M., Nuc, P., May, P., Buhtz, A., Kehr, J. and Walther, D. (2009) Identification of Nutrient-Responsive Arabidopsis and Rapeseed Micrornas by Comprehensive Real-Time Polymerase Chain Reaction Profiling and Small RNA Sequencing. Plant Physiology, 150, 1541-1555.
[395] Kiba, T., Kudo, T., Kojima, M. and Sakakibara, H. (2011) Hormonal Control of Nitrogen Acquisition: Roles of Auxin, Abscisic Acid, and Cytokinin. Journal of Experimental Botany, 62, 1399-1409.
[396] Argyros, R.D., Mathews, D.E., Chiang, Y.H., Palmer, C.M., Thibault, D.M., Etheridge, N. and Argyros, D.A. (2008) Type B Response Regulators of Arabidopsis Play Key Roles in Cytokinin Signaling and Plant Development. Plant Cell, 20, 2102-2116.
[397] Séguéla, M., Briat, J.F., Vert, G. and Curie, C. (2008) Cytokinins Negatively Regulate the Root Iron Uptake Machinery in Arabidopsis through a Growth Dependent Pathway. The Plant Journal, 55, 289-300.
[398] Aslam, M., Travis, R.L. and Rains, D.W. (1996) Evidence for Substrate Lnduction of a Nitrate Efflux System in Barley Roots. Plant Physiology, 112, 1167-1175.
[399] Leran, S., Muños, S., Brachet, C., Tillard, P., Gojon, A. and Lacombe, B. (2013) The Arabidopsis NRT1.1 Is a Bidirectional Transporter Involved in Root-to-Shoot Nitrate Translocation. Molecular Plant, 6, 1984-1987.
[400] Mattsson, M. and Schjoerring, J.K. (2002) Dynamic and Steady-State Responses of Inorganic Nitrogen Pools and NH3 Exchange in Leaves of Lolium perenne and Bromus erectus to Changes in Root Nitrogen Supply. Plant Physiology, 128, 742-750.
[401] Gutierrez, R.A., Stokes, T.L., Thum, K., Xu, X., Obertello, M. and Katari, M.S. (2008) Systems Approach Identifies an Organic Nitrogen-Responsive Gene Network That Is Regulated by the Master Clock Control Gene CCA1. Proceedings of the National Academy of Sciences of the United States of America, 105, 4939-4944.
[402] Lam, H.M., Coschigano, K.T., Oliveira, I.C., Melo-Oliveira, R. and Coruzzi, G.M. (1996) The Molecular-Genetics of Nitrogen Assimilation into Amino Acids in Higher Plants. Annual Review of Plant Physiology and Plant Molecular Biology, 47, 569-593.
[403] Ranathunge, K., El-Kereamy, A., Gidda, S., Bi, Y.M. and Rothstein, S.J. (2014) Osamt1;1 Transgenic Rice Plants with Enhanced Permeability Show Superior Growth and Higher Yield under Optimal and Suboptimal Conditions. Journal of Experimental Botany, 65, 965-979.
[404] Ishiyama, K., Inoue, E., Watanabe-Takahashi, A., Obara, M., Yamaya, T. and Takahashi, H. (2004) Kinetic Properties and Ammonium-Dependent Regulation of Cytosolic Isoenzymes of Glutamine Synthetase in Arabidopsis. Journal of Biological Chemistry, 27916, 598-605.
[405] Lima, L., Seabra, A., Melo, P., Cullimore, J. and Carvalho, H. (2006) Post-Translational Regulation of Cytosolic Glutamine Synthetase of Medicago truncatula. Journal of Experimental Botany, 57, 2751-2761.
[406] Lothier, J., Gaufichon, L., Sormani, R., Lemaitre, T., Azzopardi, M. and Morin, H. (2011) The Cytosolic Glutamine Synthetase GLN1;2 Plays a Role in the Control of Plant Growth and Ammonium Homeostasis in Arabidopsis Rosettes When Nitrate Supply Is Not Limiting. Journal of Experimental Botany, 62, 1375-1390.
[407] Li, J.Y., Fu, Y.L., Pike, S.M., Bao, J., Tian, W. and Zhang, Y. (2010) The Arabidopsis Nitrate Transporter NRT1.8 Functions in Nitrate Removal from the Xylem Sap and Mediates Cadmium Tolerance. Plant Cell, 22, 1633-1646.
[408] Krapp, A. (2015) Plant Nitrogen Assimilation and Its Regulation: A Complex Puzzle with Missing Pieces. Current Opinion in Plant Biology, 25, 115-122.
[409] Brenner, W.G., Romanov, G.A., Kollmer, I., Burkle, L. and Schmülling, T. (2005) Immediate-Early and Delayed Cytokinin Response Genes of Arabidopsis thaliana Identified by Genome-Wide Expression Profiling Reveal Novel Cytokinin-Sensitive Processes and Suggest Cytokinin Action through Transcriptional Cascades. The Plant Journal, 44, 314- 333.
[410] Good, A.G., Shrawat, A.K. and Muench, D.G. (2004) Can Less Yield More? Is Reducing Nutrient Input into the Environment Compatible with Maintaining Crop Production? Trends in Plant Science, 9, 597-605.
[411] Fraisier, V., Dorbe, M.F. and Daniel-Vedele, F. (2001) Identification and Expression Analyses of Two Genes Encoding Putative Low-Affinity Nitrate Transporters from Nicotiana plumbaginifolia. Plant Molecular Biology, 45, 181-190.
[412] Katayama, H., Mori, M., Kawamura, Y., Tanaka, T., Mori, M. and Hasegawa, H. (2009) Production and Characterization of Transgenic Rice Plants Carrying a High-Affinity Nitrate Transporter Gene (Osnrt2.1). Breeding Science, 59, 237-243.
[413] Djennane, S., Chauvin, J.E. and Meyer, C. (2002) Glasshouse Behaviour of Eight Transgenic Potato Clones with a Modified Nitrate Reductase Expression under Two Fertilization Regimes. Journal of Experimental Botany, 53, 1037-1045.
[414] Djennane, S., Chauvin, J.E., Quillere, I., Meyer, C. and Chupeau, Y. (2002) Introduction and Expression of a Deregulated Tobacco Nitrate Reductase Gene in Potato Lead to Highly Reduced Nitrate Levels in Transgenic Tubers. Transgenic Research, 11, 175-184.
[415] Lea, U.S., Hoopen, F., Provan, F., Kaiser, W.M. and Meyer, C. (2009) Mutation of the Regulatory Phosphorylation Site of Tobacco Nitrate Reductase Results in High Nitrite Excretion and No Emission from Leaf and Root Tissue. Planta, 219, 59-65.
[416] Lillo, C. (2008) Signaling Cascades Integrating Light-Enhanced Nitrate Metabolism. Biochemical Journal, 415, 11-19.
[417] Schofield, R.A., Bi, Y.M., Kant, S. and Rothstein, S.J. (2009) Over-Expression Ofstp13, a Hexose Transporter, Improves Plant Growth and Nitrogen Use in Arabidopsis thaliana Seedlings. Plant, Cell & Environment, 32, 271-285.
[418] Brauer, E.K., Rochon, A., Bi, Y.M., Bozzo, G.G., Rothstein, S.J. and Shelp, B.J. (2011) Reappraisal of Nitrogen Use Efficiency in Rice over Expressing Glutamine Synthetase1. Physiologia Plantarum, 141, 361-372.
[419] Gallardo, F., Fu, J., Cantón, F., Gutierrez, A., Cánovas, F.M. and Kirby, E.G. (1999) Expression of a Conifer Glutamine Synthetase Gene in Transgenic Poplar. Planta, 210, 19-26.
[420] Habash, D.Z., Massiah, A.J., Rong, H.L., Wallsgrove, R.M. and Leigh, R.A. (2001) The Role of Cytosolic Glutamine Synthetase in Wheat. Annals of Applied Biology, 138, 83-89.
[421] Migge, A., Bork, C., Hell, R. and Becker, T.W. (2000) Negative Regulation of Nitrate Reductase Gene Expression by Gluta Mate or Asparagine Accumulation in Leaves of Sulfur Deprived Tobacco. Planta, 211, 587-595.
[422] Suerez, R.V., Marquez, J., Shishkova, S. and Hernandez, G. (2003) Over Expression of Alfalfa Cytosolic Glutamine Synthetase in Nodules and Flowers of Transgenic Lotus japonicus Plants. Physiologia Plantarum, 117, 326-336.
[423] Good, A.G., Johnson, S.J., De Pauw, M., Carroll, R.T. and Savidov, N. (2007) Engineering Nitrogen Use Efficiency with Alanine Aminotransferase. Canadian Journal of Botany, 85, 252-262.
[424] Good, A. and Beatty, P. (2011) Biotechnological Approaches to Improving Nitrogen Use Efficiency in Plants: Alanine Aminotransferase as a Case Study. In: Hawkesford, M.J. and Barraclough, P., Eds., The Molecular and Physiological Basis of Nutrient Use Efficiency in Crops, Wiley-Blackwell, Oxford, 165-192.
[425] Strange, S., Park, J., Bennett, R. and Phipps, R. (2008) The Use of Life-Cycle Assessment to Evaluate the Environmental Impacts Ogrowing Genetically Modified Nitrogen Use-Efficient Canola. Plant Biotechnology Journal, 6, 337- 345.
[426] Shrawat, A.K., Carroll, R.T., Depauw, M., Taylor, G.J. and Good, A.G. (2008) Genetic Engineering of Improved Nitrogen Use Efficiency in Rice by the Tissue-Specific Expression of Alanine Amino Transferase. Plant Biotechnology Journal, 6, 722-732.
[427] Okumoto, S. and Pilot, G. (2011) Amino Acid Export in Plants: A Missing Link in Nitrogen Cycling. Molecular Plant, 4, 453-463.
[428] Li, X., Guo, C., Gu, J., Duan, W., Zhao, M., Ma, C., Du, X., Lu, W. and Xiao, K. (2014) Overexpression of VP, a Vacuolar H+-Pyrophosphatase Gene in Wheat (Triticum aestivum L.), Improves Tobacco Plant Growth under Pi and N Deprivation, High Salinity, and Drought. Journal of Experimental Botany, 65, 683-696.
[429] Bally, J., Nadai, M., Vitel, M., Rolland, A., Dumain, R. and Dubald, M. (2009) Plant Physiological Adaptations to the Massive Foreign Protein Synthesis Occurring in Recombinant Chloroplasts. Plant Physiology, 150, 1474-1481.
[430] Vincent, R., Fraisier, V., Chaillou, S., Limami, M.A. and Deleens, E. (1997) Overexpression of a Soybean Gene Encoding Cytosolic Glutamine Synthetase in Shoots of Transgenic Lotus corniculatus L. Plants Triggers Changes in Ammonium and Plant Development. Planta, 201, 424-433.
[431] Hodges, M. (2002) Enzyme Redundancy and the Importance of 2-Oxoglutarate in Plant Ammonium Assimilation. Journal of Experimental Botany, 53, 905-916.
[432] Cai, C., Wang, J.Y., Zhu, Y.G., Shen, Q.R., Li, B. and Tong, Y.P. (2008) Gene Structure and Expression of the High-Affinity Nitrate Transport System in Rice Roots. Journal of Integrative Plant Biology, 50, 443-451.
[433] Bai, H., Euring, D., Volmerz, K., Janz, D. and Polle, A. (2013) The Nitrate Transporter (NRT) Gene Family in Poplar. PLoS ONE, 8, E72126.
[434] Migocka, M., Warzybok, A. and Klobus, G. (2013) The Genomic Organization and Transcriptional Pattern of Genes Encoding Nitrate Transporters 1 (NRT1) in Cucumber. Plant Soil, 364, 245-260.
[435] Couturier, J., Montanini, B., Martin, F., Brun, A., Blaudez, D. and Chalot, M. (2007) The Expanded Family of Ammonium Transporters in the Perennial Poplar Plant. New Phytologist, 174, 137-150.
[436] D’Apuzzo, E., Rogato, A., Simon-Rosin, U., El Alaoui, H., Barbulova, A. and Betti, M. (2004) Characterisation of Three Functional High Affinity Ammonium Transporters in Lotus japonicus with Differential Transcriptional Regulation and Spatial Expression. Plant Physiology, 134, 1763-1774.
[437] Alvarezj, M., Vidal, E.A. and Gutiérrez, R.A. (2012) Integration of Local and Systemic Signaling Pathways for Plant N Responses. Current Opinion in Plant Biology, 15, 185-191.
[438] Vidal, E.A. and Gutiérrez, R.A. (2008) A Systems View of Nitrogen Nutrient and Metabolite Responses in Arabidopsis. Current Opinion in Plant Biology, 11, 521-529.
[439] Wang, R., Okamoto, M., Xing, X. and Crawford, N.M. (2003) Microarray Analysis of the Nitrate Response in Arabidopsis Roots and Shoots Reveals over 1,000 Rapidly Responding Genes and New Linkages to Glucose, Trehalose-6-Phosphate, Iron, and Sulfate Metabolism. Plant Physiology, 132, 556-567.
[440] Cai, H., Lui, Y., Xie, W., Zhu, T. and Lian, X. (2012) Transcriptome Response to Nitrogen Starvation in Rice. Journal of Biosciences, 37, 731-747.
[441] Zhao, W., Yang, X., Yu, H., Jiang, W., Sun, N. and Liu, X.X. (2014) RNA-Seq-Based Transcriptome Profiling of Early Nitrogen Deficiency Response in Cucumber Seedlings Provides New Insight into the Putative Nitrogen Regulatory Network. Plant and Cell Physiology, 56, 455-467.
[442] O’Rourke, J.A., Iniguez, L.P., Fu, F., Bucciarelli, B., Miller, S.S. and Jackson S.A. (2014) An RNA-Seq Based Gene Expression Atlas of the Common Bean. BMC Genomics, 15, 866.
[443] Peng, M., Bi, Y.M., Zhu, T. and Rothstein, S.J. (2007) Genome-Wide Analysis of Arabidopsis Responsive Transcriptome Response to Nitrogen Limitation and Its Regulation by the Ubiquitin Ligas Gene NLA. Plant Molecular Biology, 65, 775-797.
[444] Lian, X., Wang, S., Zhang, J., Feng, Q., Zhang, L. and Fan, D. (2006) Expression Profiles of 10,422 Genes at Early Stage of Low Nitrogen Stress in Rice Assayed Using a cDNA Microarray. Plant Molecular Biology, 60, 617-631.
[445] Wang, R., Guegler, K., Labrie, S.T. and Crawford, N.M. (2000) Genomic Analysis of a Nutrient Response in Arabidopsis Reveals Diverse Expression Patterns and Novel Metabolic and Potential Regulatory Genes That Are Induced by Nitrate. Plant Cell, 12, 1491-510.
[446] Wang, Y.H., Garvin, D.F. and Kochian, L.V. (2001) Nitrate-Induced Genes in Tomato Roots. Array Analysis Reveals Novel Genes That May Play a Role in Nitrogen Nutrition. Plant Physiology, 127, 345-359.
[447] Bi, Y.M., Meyer, A., Downs, G.S., Shi, X., El-Kereamy, A. and Lukens, L. (2014) High Throughput RNA Sequencing of Hybrid Maize and Its Parents Shows Different Mechanisms Responsive to Nitrogen Limitation. BMC Genomics, 15, 77.
[448] Cabeza, R., Koester, B., Liese, R., Lingner, A., Baumgarten, V. and Dirks, J. (2014) An RNA Sequencing Transcriptome Analysis Reveals Novel Insights into Molecular Aspects of the Nitrate Impact on the Nodule Activity of Medicago truncatula. Plant Physiology, 164, 400-411.
[449] Vidal, E.A., Moyano, T.C., Krouk, G., Katari, M.S., Tanurdzic, M. and Mccombie, W.R. (2013) Integrated RNA-Seq and Srna-Seq Analysis Identifies Novel Nitrate-Responsive Genes in Arabidopsis thaliana Roots. BMC Genomics, 14, 701.
[450] Lei, B., Lu, K., Ding, F., Zhang, K., Chen, Y. and Zhao, H. (2014) RNA Sequencing Analysis Reveals Transcriptomic Variations in Tobacco (Nicotiana tabacum) Leaves Affected by Climate, Soil, and Tillage Factors. International Journal of Molecular Sciences, 15, 6137-6160.
[451] Boussadia, O., Steppeb, K., Zgallaid, H., Hadjc, S.B.E., Brahama, M. and Lemeurb, R. (2010) Effects of Nitrogen Deficiency on Leaf Photosynthesis, Carbohydrate Status and Biomass Production in Two Olive Cultivars “Meski” and “Koroneiki”. Scientia Horticulturae, 123, 336-342.
[452] Foyer, C.H., Noctor, G. and Verrier, P. (2006) Photosynthetic Carbon-Nitrogen Interactions: Modelling Inter-Pathway Control and Signaling. In: Plaxton, W. and Mcmanus, M.T., Eds., Annual Plant Reviews: Control of Primary Metabolism in Plants, Blackwell, Oxford, 325-347.
[453] Taylor, L., Nunesnesi, A., Parsley, K., Leiss, A., Leach, G. and Coates, S. (2010) Cytosolic Pyruvate, Orthophosphate Dikinase Functions in Nitrogen Remobilization during Leaf Senescence and Limits Individual Seed Growth and Nitrogen Content. The Plant Journal, 62, 641-652.
[454] Wingler, A., Purdy, S., Maclean, A. and Pourtau, N. (2006) The Role of Sugars in Integrating Environmental Signals during the Regulation of Leaf Senescence. Journal of Experimental Botany, 57, 391-399.
[455] Gutierrez, R.A., Lejay, L.V., Dean, A., Chiaromonte, F., Shasha, D.E. and Coruzzi, G.M. (2007) Qualitative Network Models and Genome-Wide Expression Data Define Carbon/Nitrogen-Responsive Molecular Machines in Arabidopsis. Genome Biology, 8, R7.
[456] Diaz-Troya, S., Perez-Perez, M.E., Florencio, F.J. and Crespo, J.L. (2008) TOR in Autophagy Regulation from Yeast to Plants and Mammals. Autophagy, 4, 851-865.
[457] Kapahi, P., Chen, D., Rogers, A.N., Katewa, S.D., Li, P.W.L. and Thomas, E.L. (2010) With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging. Cell Metabolism, 11, 453-465.
[458] Maekawa, S., Sato, T., Asada, Y., Yasuda, S., Yoshida, M., Chiba, Y. and Yamaguchi, J. (2012) The Arabidopsis Ubiquitin Ligases ATL31 and ATL6 Control the Defense Response as Well as the Carbon/Nitrogen Response. Plant Molecular Biology, 79, 217-227.
[459] Malamy, J.E. (2005) Intrinsic and Environmental Response Pathways That Regulate Root System Architecture. Plant, Cell & Environment, 28, 67-77.
[460] Fait, A., Nesi, A.N., Angelovici, R., Lehmann, M., Pham, P.A., Song, L. and Haslam, R.P. (2011) Targeted Enhancement of Glutamate-to-Γ-Aminobutyrate Conversion in Arabidopsis Seeds Affects Carbon-Nitrogen Balance and Storage Reserves in a Development-Dependent Manner. Plant Physiology, 157, 1026-1042.
[461] Kurai, T., Wakayama, M., Abiko, T., Yanagisawa, S., Aoki, N. and Ohsugi, R. (2011) Introduction of the Zmdof1 Gene into Rice Enhances Carbon and Nitrogen Assimilation under Low-Nitrogen Conditions. Plant Biotechnology Journal, 9, 826-837.
[462] Nero, D., Krouk, G., Tranchina, D. and Coruzzi, G.M. (2009) A System Biology Approach Highlights a Hormonal Enhancer Effect on Regulation of Genes in a Nitrate Responsive “Biomodule”. BMC Systems Biology, 3, 59.
[463] Gao, P., Xin, Z. and Zheng, Z.L. (2008) The OSU1/QUA2/TSD2-Encoded Putative Methyltransferase Is a Critical Modulator of Carbon and Nitrogen Nutrient Balance Response in Arabidopsis. PLoS ONE, 3, E1387.
[464] Price, J., Laxmi, A., St Martin, S.K. and Jang, J.C. (2004) Global Transcription Profiling Reveals Multiple Sugar Signal Transduction Mechanisms in Arabidopsis. Plant Cell, 16, 2128-2150.
[465] Bi, Y.M., Zhang, Y., Signorelli, T., Zhao, R., Zhu, T. and Rothstein, S. (2005) Genetic Analysis of Arabidopsis GATA Transcription Factor Gene Family Reveals a Nitrate-Inducible Member Important for Chlorophyll Synthesis and Glucose Sensitivity. The Plant Journal, 44, 680-692.
[466] Chiang, Y.H., Zubo, Y.O., Tapken, W., Kim, H.J., Lavanway, A.M. and Howard, L. (2012) Functional Characterization of the GATA Transcription Factors GNC and CGA1 Reveals Their Key Role in Chloroplast Development, Growth, and Division in Arabidopsis. Plant Physiology, 160, 332-348.
[467] Naito, T., Kiba, T., Koizumi, N., Yamashino, T. and Mizuno, T. (2007) Characterization of a Unique GATA Family Gene That Responds to Both Light and Cytokinin in Arabidopsis thaliana. Bioscience, Biotechnology, and Biochemistry, 71, 1557-1560.
[468] Zheng, Z.L. (2009) Carbon and Nitrogen Nutrient Balance Signaling in Plants. Plant Signaling & Behavior, 4, 584-591.
[469] Palenchar, P.M., Kouranov, A., Lejay, L.V. and Coruzzi, G.M. (2004) Genome-Wide Patterns of Carbon and Nitrogen Regulation of Gene Expression Validate the Combined Carbon and Nitrogen (CN)-Signaling Hypothesis in Plants. Genome Biology, 5, R91.
[470] Egli, D.B., Leggett, J.E. and Duncan, W.G. (1976) Influence of N Stress on Leaf Senescence and N Redistribution in Soybeans. Agronomy Journal, 70, 43-47.
[471] Schildhauer, J., Wiedemuth, K. and Humbeck, K. (2008) Supply of Nitrogen Can Reverse Senescence Processes and Affect Expression of Genes Coding for Plastidic Glutamine Synthetase and Lysine-Ketoglutarate Reductase/Saccharopine Dehydrogenase. Plant Biology, 10, 76-84.
[472] Castaings, L., Marchive, C., Meyer, C. and Krapp, A. (2011) Nitrogen Signaling in Arabidopsis: How to Obtain Insights into a Complex Signaling Network. Journal of Experimental Botany, 62, 1391-1397.
[473] Gutiérrez, R.A. (2012) Systems Biology for Enhanced Plant Nitrogen Nutrition. Science, 336, 1673-1675.
[474] Balazadeh, S., Schildhauer, J., Araújo, W.L., Munné-Bosch, S., Fernie, A.R. and Proost, S. (2014) Reversal of Senescence by N Resupply to N-Starved Arabidopsis thaliana: Transcriptomic and Metabolomic Consequences. Journal of Experimental Botany, 65, 3975-3992.
[475] Breeze, E., Harrison, E., Mchattie, S., Hughes, L., Hickman, R. and Hill, C. (2011) High-Resolution Temporal Profiling of Transcripts during Arabidopsis Leaf Senescence Reveals a Distinct Chronology of Processes and Regulation. The Plant Cell, 23, 873-894.
[476] Monfils, L.S., Bi, Y.M., Downs, G., Wu, W., Signorelli, T. and Lu, G. (2013) Nitrogen Transporter and Assimilation Genes Exhibit Developmental Stage-Selective Expression in Maize (Zea mays L.) Associated with Distinct Cis-Acting Promoter Motifs. Plant Signaling and Behavior Biosience, 8, Article ID: e26056.
[477] Kechid, M., Desbrosses, G., Rokhsi, W., Varoquaux, F., Djekoun, A. and Touraine, B. (2013) The NRT2.5 and NRT2.6 Genes Are Involved in Growth Promotion of Arabidopsis by the Plant Growth-Promoting Rhizobacterium (PGPR) Strain Phyllobacterium brassicacearum STM196. New Phytologist, 198, 514-524.
[478] Dechorgnat, J., Patrit, O., Krapp, A., Fagard, M. and Daniel-Vedele, F. (2012) Characterization of the Nrt2.6 Gene in Arabidopsis thaliana: A Link with Plant Response to Bioti and Abiotic Stress. PLoS ONE, 7, E42491.
[479] David, L.C., Dechorgnat, J., Berquin, P., Routaboul, J.M., Debeaujon, I. and Daniel-Vedele, F. (2014) Proanthocyanidin Oxidation of Arabidopsis Seeds Is Altered in Mutant of the High-Affinity Nitrate Transporter NRT2.7. Journal of Experimental Botany, 65, 885-893.
[480] Reddy, M.M. and Ulaganthan, K. (2015) RNA-Seq Analysis of Urea Nutrition Responsive Transcriptome of Oryza sativa Elite Indica Cultivar RP Bio 226. Genomics Data, 6, 112-113.

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