Biologic Agents in Behçet’s Disease: Our Experience and Review of the Literature
Nesibe Karahan Yeşil1, Hatice Şahin2, Hatice Işık3, Zuhal Örnek4, Serpil Yazgan5, Adem Tok6, Yunus Emre Yandı7, Metin Işık8*, İsmail Doğan9
1Department of Rheumatology, Ankara Research and Education Hospital, Ankara, Turkey.
2Department of Internal Medicine, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey.
3Department of Obstetrics and Gynecology, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey.
4Department of Pediatric Disaease, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey.
5Department of Ophtalmology, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey.
6Department of Urology, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey.
7Division of Biochemistry, Department of Medical Services and Techniques, Health Sciences, Vocational School, Bülent Ecevit University, Zonguldak, Turkey.
8Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey.
9Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Hitit University, Çorum, Turkey.
DOI: 10.4236/ojra.2015.54016   PDF   HTML   XML   3,453 Downloads   4,330 Views  


Behcet’s disease (BD) is a large vessel vasculitis with a wide range of clinical manifestations. Some of these manifestation may be life threatening and rapid suppression of the inflammation with effective immunosuppressive agent is crucial. There are traditional drugs with different response rates and all have efficacy on different manifestations of the disease. The most frightening manifestations of the disease are ocular, neurologic, intestinal and vascular types of involvement. Besides benign and easily treated manifestations there are also refractory cases with complicated involvement. The novel biologic agents have been used for these resistant patients and favorable response rates have been reported. In this review, we have shared our experience with biologic agents in BD and also reviewed the literature for the efficacy and safety for these novel agents for refractory patients.

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Yeşil, N. , Şahin, H. , Işık, H. , Örnek, Z. , Yazgan, S. , Tok, A. , Yandı, Y. , Işık, M. and Doğan, İ. (2015) Biologic Agents in Behçet’s Disease: Our Experience and Review of the Literature. Open Journal of Rheumatology and Autoimmune Diseases, 5, 97-103. doi: 10.4236/ojra.2015.54016.

Conflicts of Interest

The authors declare no conflicts of interest.


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