Synthesis of Fluorinated Heterobicyclic Nitrogen Systems Containing 1,2,4-Triazine Moiety as CDK2 Inhibition Agents

Mohammed Saleh Tawfik Makki^*, Reda Mohammdy Abdel-Rahman, Faisal Mohammed Aqlan

Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

DOI: 10.4236/ijoc.2015.53020                

Abstract

New fluorine substituted heterobicyclic nitrogen system as imidozolopyrimidines (2,3), pyrimido- 1,2,4-triazinones (4-7), 1,2,4-triazinyl-1,2,4-triazine (12-16), 1,2,4-triazinyl-1,2,4-triazinones (14-17) and substituted thiobarbituric acids (19-20), have been synthesized using the reaction of 3- amino-5,6-di (4'-fluorophenyl)-1,2,4-triazine (1) with α,β–bifunctional compounds. Structures of the title compounds were characterized by UV, IR, ¹H/¹³C-NMR and mass spectrometric method. The studied compounds were tested for CDK2 inhibiting activity in DNA damage, as well as in vitro anti-tumor activity.

Keywords

Synthesis, Fluoroheterobicyclic Nitrogen, CDK2 Inhibition, Anti-Tumor Activity

Conflicts of Interest

The authors declare no conflicts of interest.

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