Diastolic Dysfunction and Left Ventricle Remodeling in Men with Impaired Fasting Glucose


Background: Early disturbances of carbohydrate metabolism are an independent risk factor of development of cardiovascular diseases. Objective: The diastolic dysfunction and left ventricle remodeling depending on presence of impaired fasting glucose were examined. Methods: The characteristics of heart remodeling and fasting glucose of capillary blood were studied in 85 men aged 30 to 63 years without coronary heart disease. Results: In male patients with impaired fasting glucose in comparison of persons with level of glucose less than 5.6 mM/l, more pronounced diastolic dysfunction and left ventricle remodeling associated with more often presence III degree of peripheral obesity. Conclusion: Impaired fasting glucose in men increases probability of development of heart remodeling.

Share and Cite:

Kratnov, A. and Timganova, E. (2015) Diastolic Dysfunction and Left Ventricle Remodeling in Men with Impaired Fasting Glucose. World Journal of Cardiovascular Diseases, 5, 261-265. doi: 10.4236/wjcd.2015.59029.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Straka, R.J, Liu, L.Z., Girase, P.S., DeLorenzo, A. and Chapman, R.H. (2009) Incremental Cardiovascular Costs and Resource Use Associated with Diabetes: An Assessment of 29,863 Patients in the US Managed-Care Setting. Cardiovascular Diabetology, 8, 53.
[2] The DECODE study group on behalf of the Europe an Diabetes Epidemiology Group (1999) Glucose Tolerance and Mortality: Comparison of WHO and American Diabetes Association Diagnostic Criteria. Lancet, 354, 617-621.
[3] Vakili, B.A., Okin, P.M. and Devereux, R.B. (2001) Prognostic Implications of Left Ventricular Hypertrophy. American Heart Journal, 141, 334-341.
[4] Galderisi, M., Anderson, K.M., Wilson, P.W. and Levy, D. (1991) Echocardiographic Evidence for the Existence of a Distinct Diabetic Cardiomyopathy (the Framingham Heart Study). American Journal Cardiology, 68, 85-89.
[5] Chae, C.U., Glynn, R.J., Manson, J.E., Guralnik, J.M., Taylor, J.O. and Pfeer, M.A. (1998) Diabetes Predicts Congestive Heart Failure Risk in the Elderly. Circulation, 98, 721.
[6] Miyazato, J., Horio, T., Takishita, S. and Kawano, Y. (2002) Fasting Plasma Glucose Is an Independent Determinant of Left Ventricular Diastolic Dysfunction in Nondiabetic Patients with Treated Essential Hypertension. Hypertension Research, 25, 403-439.
[7] D’Souza, A., Howarth, F.C., Yanni, J., Dobryznski, H., Boyett, M.R., Adeghate, E., Bidasee, K.R. and Singh, J. (2011) Left Ventricle Structural Remodelling in the Prediabetic Goto-Kakizaki Rat. Experimental Physiology, 96, 875-888.
[8] Nagueh, S.F., Appleton, C.P., Gillebert, T.C., Marino, P.N., Oh, J.K., Smiseth, O.A., Waggoner, A.D., Flachskampf, F.A., Pellikka, P.A. and Evangelista, A. (2009) Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography. European Journal of Echocardiography, 10, 165-193.
[9] Lang, R. M., Bierig, M., Devereux, R.B., Flachskampf, F.A., Foster, E., Pellikka, P.A., Picard, M.H., Roman, M.J., Seward, J., Shanewise, J., Solomon, S., Spencer, K.T., St John, Sutton, M. and Stewart, W. (2006) Recommendations for Chamber Quantification. European Journal of Echocardiography, 7, 79-108.
[10] Ganau, A., Devereux, R.B., Roman, M.J., de Simone, G., Pickering, T.G., Saba, P.S., Vargiu, P., Simongini, I. and Laragh, J.H. (1992) Patterns of Left Ventricular Hypertrophy and Geometric Remodeling in Essential Hypertension. Journal of the American College of Cardiology, 19, 1550-1558.
[11] Buse, J.B., Ginsberg, H.N., Bakris, G.L., Clark, N.G., Costa, F., Eckel, R., Fonseca, V., Gerstein, H.C., Grundy, S., Nesto, R.W., Pignone, M.P., Plutzky, J., Porte, D., Redberg, R., Stitzel, K.F. and Stone, N.J. (2007) Primary Prevention of Cardiovascular Diseases in People with Diabetes Mellitus: A Scientific Statement from the American Heart Association and the American Diabetes Association. Circulation, 115, 114-126.
[12] Qiao, Q., Lindstrom, J., Valle, T.T. and Tuomilehto, J. (2003) Progression to Clinically Diagnosed and Treated Diabetes from Impaired Glucose Tolerance and Impaired Fasting Glycaemia. Journal of British Diabetic Association, 20, 1027-1033.
[13] De Fronzo, R.A., Ferrannini, E., Keen, H. and Zimmet, P. (2004) International Textbook of Diabetes Mellitus (Third Edition). John Wiley & Sons, Hoboken.
[14] Romero-Corral, A., Montori, V.M., Somers, V.K., Korinek, J., Thomas, R.J., Allison, T.G., Mookadam, F. and Lopez-Jimenez, F. (2006) Association of Body-weight with Total Mortality and with Cardiovascular Events in Coronary Artery Disease: A Systematic Review of Cohort Studies. Lancet, 368, 666-678.
[15] Haslam, D.W. and James, W.P. (2005) Obesity. Lancet, 366, 1197-1209.
[16] Ussher, J.R. and Lopaschuk, G.D. (2006) Clinical Implications of Energetic Problems in Cardiovascular Disease. Heart and Metabolism, 32, 9-17.
[17] Paolisso, G., Gambardella, A., Galzerano, D., D’Amore, A., Rubino, P., Verza, M., Teasuro, P., Varricchio, M. and D’Onofrio, F. (1994) Total-Body and Myocardial Substrate Oxidation in Congestive Heart Failure. Metabolism, 43, 174-178.
[18] Boudina, S., Sena, S., Theobald, H., Sheng, X., Wright, J.J., Hu, X.X., Aziz, S., Johnson, J.I., Bugger, H., Zaha, V.G. and Abel, E.D. (2007) Mitochondrial Energetics in the Heart in Obesity-Related Diabetes: Direct Evidence for Increased Uncoupled Respiration and Activation of Uncoupling Proteins. Diabetes, 56, 2457-2466.
[19] Chen, W.J.Y., Greulich, S., van der Meer, R.W., Rijzewijk, L.J., Lamb, H.J., de Roos, A., Smit, J.W.A., Romijn, J.A, Ruige J.B., Lammertsma, A.A., Lubberink, M., Diamant, M. and Ouwens, D.M. (2013) Activin a Is Associated with Impaired Myocardial Glucose Metabolism and Left Ventricular Remodeling in Patients with Uncomplicated Type 2 Diabetes. Cardiovascular Diabetology, 12, 150.
[20] Blum, W.F., Englaro, P., Hanitsch, S., Juul, A., Hertel, N.T., Muller, J., Skakkebaek, N.E., Heiman, M.L., Birkett, M., Attanasio, A.M., Kiess, W. and Rascher, W. (1997) Plasma Leptin Levels in Healthy Children and Adolescents: Dependence on Body Mass Index, Body Fat Mass, Gender, Pubertal Stage and Testosterone. The Journal of Clinical Endocrinology & Metabolism, 82, 2904-2910.
[21] Matsumura, K., Abe, I., Tsuchihashi, T. and Fujishima, M. (2000) Central Effects of Leptin on Cardiovascular and Neurohormonal Responses in Conscious Rabbits. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 278, R1314-R1320.
[22] Francis, G.S., Goldsmith, S.R., Levine, T.B., Olivari, M.T. and Cohn, J.N. (1984) The Neurohumoral Axis in Congestive Heart Failure. Annals of Internal Medicine, 101, 370-377.

Copyright © 2022 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.