Efficacy and Safety of Vortioxetine and Duloxetine 60 mg Compared Placebo for the Treatment of Major Depressive Disorder: A Systematic Review and Meta-Analysis

Masoud Behzadifar¹, Abouzar Keshavarzi², Abed Tofighian¹, Mohammad Rastian¹, Mohammad Zobidi¹, Ali Akbari Sari^3*

¹Department of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
²Shiraz University of Medical Sciences, Shiraz , Iran.
³Department of Health Management and Economics, Tehran University of Medical Sciences, Tehran, Iran.

DOI: 10.4236/jbbs.2015.510041                

Abstract

Background: Major depressive disorder is a serious public health problem affecting the lives of millions in the worldwide and leading causes of disability and disease. This study aimed to evaluate the efficacy and safety of Vortioxetine and Duloxetine 60 mg compared to placebo for the treatment of major depressive disorder. Method: We searched the Cochrane library, Pub Med, CRD, Scopus, and Central Register of Controlled Trials to January 2015. We also searched ClinicalTrials.gov, International depressive disorder Conference and the Anxiety Disorders and Depression Conference. We identified that five randomized clinical trials were ultimately included in a Meta analysis. Data analysis was conducted by Standardized Mean Differences (SMD) for Montgomery-Åsberg Depression Rating Scale (MADRS), and Odds Ratio (OR) for adverse events. The SMD and OR reported by 95% CI. Results: Results showed statistical significance in the MADRS for Vortioxetine (SMD = ﹣3.29; 95% CI ﹣4.47 to ﹣2.10; I² = 99.3%) and for Duloxetine 60 mg (SMD = ﹣6.35; 95% CI ﹣8.84, ﹣3.87; I² = 99.3%). Results showed that the Vortioxetine 2.5, 5, 10, 15, 20 mg and overall compared to placebo showed a significance for Nausea and no significance for diarrhea, dry mouth, dizziness, fatigue and headache. Also results of Duloxetine 60 mg showed a significant effect for dry mouth, dizziness, fatigue and nausea. Conclusion: It is necessary to do more studies so as to better assess and much more powerful than the evidence for the use of this drug in the treatment of depression.

Keywords

Vortioxetine, Duloxetine 60 mg, Placebo, Major Depressive Disorder, Systematic Review, Meta-Analysis

Conflicts of Interest

The authors declare no conflicts of interest.

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