Three New Compounds Derived from Nitrofurantoin: X-Ray Structures and Hirshfeld Surface Analyses

Hao Wang, Hongping Xiao, Na Liu, Bo Zhang, Qian Shi^*

Nanomaterials & Chemistry Key Laboratory, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, China.

DOI: 10.4236/ojic.2015.53008                

Abstract

The polymorphism of nitrofurantoin (NF), 1), the cocrystals of NF:2,2’-bipyridyl = 2:1, 2) and NF: 1,10-phenanthroline = 1:1, 3) have been prepared and characterized. The crystal structure analyses show that there are various weak forces among the molecules, such as C/N-H···O, N-H···N hydrogen bond interactions and π···π/lone pair stacking interactions, which play a key role in the assembly of supramolecular networks. A thorough analysis of Hirshfeld surfaces and fingerprint plots facilitates a comparison of intermolecular interactions in 1 - 3, which are crucial in building supramolecular architectures.

Keywords

Nitrofurantoin Co-Crystals, Intermolecular Interactions, X-Ray Structures, Hirshfeld Surface

Conflicts of Interest

The authors declare no conflicts of interest.

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