Centrosome Functions as a Molecular Dynamo in the Living Cell


Recent development in the field of quantum biology highlights that the intracellular electromagnetic field (EMF) of microtubules plays an important role in many fundamental cellular processes such as mitosis. Here I propose an intriguing hypothesis that centrosome functions as molecular dynamo to generate electric flow over the microtubules, leading to the electric excitation of microtubule EMF that is required for spindle body microtubule self-assembly. With the help of motors proteins within the centrosome, centrosome transforms the energy from ATP into intracellular EMF in the living cell that shapes the functions of microtubules. There will be a general impact for the cell biology field to understand the mechanistic function of centrosome for the first time in correlation with its structural features. This hypothesis can be tested with technics such as super resolution live cell microscope.

Share and Cite:

Zhao, Y. (2015) Centrosome Functions as a Molecular Dynamo in the Living Cell. Advances in Bioscience and Biotechnology, 6, 452-455. doi: 10.4236/abb.2015.67045.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Doxsey, S. (2001) Re-Evaluating Centrosome Function. Nature Review Molecular Cellular Biology, 2, 688-698.
[2] Bornens, M. and Azimzadeh, J. (2007) Origin and Evolution of the Centrosome. Advances in Experimental Medicine and Biology, 607, 119-129.
[3] Bettencourt-Dias, M. and Glover, D. (2007) Centrosome Biogenesis and Function: Centrosomics Brings New Understanding. Nature Review Molecular Cellular Biology, 8, 451-463.
[4] Mogensen, M.M. (1999) Microtubule Release and Capture in Epithelial Cells. Biology of the Cell, 91, 331-341.
[5] Chretien, D., Buendia, B., Fuller, S.D. and Karsenti, E. (1997) Reconstruction of the Centrosome Cycle from Cryoelectron Micrographs. Journal of Structural Biology, 120, 117-133.
[6] Lawo, S., Hasegan, M., Gupta, G.D. and Pelletier, L. (2012) Subdiffraction Imaging of Centrosomes Reveals Higher-Order Organizational Features of Pericentriolar Material. Nature Cell Biology, 14, 1148-1158.
[7] Paintrand, M., Moudjou, M., Delacroix, H. and Bornens, M.J. (1992) Centrosome Organization and Centriole Architecture: Their Sensitivity to Divalent Cations. Journal of Structural Biology, 108, 107-128.
[8] Bornens, M. (2002) Centrosome Composition and Microtubule Anchoring Mechanisms. Current Opinion in Cell Biology, 14, 25-34.
[9] Zhao, Y. and Zhan, Q. (2012) Electric Fields Generated by Synchronized Oscillations of Microtubules, Centrosomes and Chromosomes Regulate the Dynamics of Mitosis and Meiosis. Theoretical Biology and Medical Modelling, 9, 26.
[10] Zhao, Y. and Zhan, Q. (2012) Electric Oscillation and Coupling of Chromatin Regulate Chromosome Packaging and Transcription In Eukaryotic Cells. Theoretical Biology and Medical Modelling, 9, 27.
[11] Havelka, D., Kucera O., Deriu M.A. and Cifra M. (2014) Electro-Acoustic Behavior of the Mitotic Spindle: A Semi-Classical Coarse-Grained Model. PLoS ONE, 9, Article ID: e86501.
[12] Havelka, D., Cifra, M. and Kucera, O. (2014) Insilico Demonstration of Electric Pulse Moving along a Microtubule. Applied Physics Letters, 104, Article ID: 243702.
[13] Sahu S., Ghosh S., Fujita D. and Bandyopadhyay A. (2014) Live Visualizations of Single Isolated Tubulin Protein Self-Assembly via Tunneling Current: Effect of Electromagnetic Pumping during Spontaneous Growth of Microtubule. Scientific Reports, 4, 7303.
[14] Zimmerman, J.W., Pennison, M.J., Brezovich, I., et al. (2012) Cancer Cell Proliferation Is Inhibited by Specific Modulation Frequencies. British Journal of Cancer, 106, 307-313.
[15] Hutson, R.L. (2015) Using the Electromagnetics of Cancer’s Centrosome Clusters to Attract Therapeutic Nanoparticles. Advances in Bioscience and Biotechnology, 6, 172-181.
[16] Van Oosten, A.S. and Janmey, P.A. (2013) Extremely Charged and Incredibly Soft: Physical Characterization of the Pericellular Matrix. Biophysical Journal, 104, 961-963.
[17] Jelínek, F., Cifra, M., Pokorny, J., et al. (2009) Measurement of Electrical Oscillations and Mechanical Vibrations of Yeast Cells Membrane around 1 kHz. Electromagnetic Biology and Medicine, 28, 223-232.
[18] Pohl, H.A., Braden, T., Robinson, S., et al. (1981) Life Cycle Alternations of the Micro-Dielectrophoretic Effects in Cells. Journal of Biological Physics, 9, 133-154.
[19] Adams, M. (2010) The Primary Cilium: An Orphan Organelle Finds a Home. Nature Education, 3, 54.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.