Rosai-Dorfman Disease: Two Cases Report and Literature Review

Atoumane Faye^*, Nafissatou Diagne Sakho, Fatou Samba D. Ndiaye, Seynabou Fall, Awa Cheikh Ndao Mbengue, Boundia Djiba, Baidy Sy Kane, Souhaibou Ndongo, Abdoulaye Pouye

Medical Clinic 1 University Teaching Hospital Aristide Le Dantec/Cheikh Anta Diop University of Dakar, Dakar, Sénégal.

DOI: 10.4236/ojim.2015.52004                

Abstract

The lymph node is the revelation mode of several pathology. In tropical area, their etiology are dominated by tuberculosis and hemopathy. Some etiology such as histiocytosis are rarely mentioned. We report two cases of Rosai-Dorfman-Destombes disease. The first observation concerned a patient of 45 years without pathological antecedent, who had a inguinal and cervical tumoral lymph nodes. This evolved in a feverish poor general condition. Infection research was negative. Morphological explorations found deep lymph nodes. The excision biopsy examination concluded to Rosai-Dorfman-Destombes disease. The second observation concerned a patient of 40 years without pathological antecedent, who had a chronic non-inflammatory left supra-collarbone lymph node, associated with poor general condition and fever. X-ray showed mediastinal lymph nodes and ultra-sonography showed mesenteric lymph nodes, and latero-aortic lymph nodes. The examination of the excision biopsy was for Rosai Dorfman Destombes disease. The difficulty of diagnosis in our regions based on technical tray lack and our patients financial limits. Also this disease is rarely mentioned first. This is often the source of considerable diagnostic delay noted in our two patients and therefore the initiation of an untimely anti-tuberculosis treatment.

Keywords

Histiocytosis, Rosai-Dorfman-Destombes Disease, Sub-Saharan Africa

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Bernard, F., Sarran, N., Serre, I., Baldet, P., Callamand, P., Margueritte, G. and Astruc, J. (1999) Histiocytose Sinusale (Maladie de Destombes-Rosai-Dorfman) Révélée par une atteinte extra-ganglionnaire rachidienne. Archives of Pediatrics, 6, 173-177. http://dx.doi.org/10.1016/S0929-693X(99)80205-X
[2]	Sanchez, R., Rosai, J. and Dorfman, R.J. (1977) Sinus Histiocytosis with Massive Lymphadenopathy: An Analysis of 113 Cases with Special Reference on Its Extranodal Manifestations. Labinvest, 36, 349-350.
[3]	Galicier, L., Fieschi, C., Meignin, V., et al. (2007) Histiocytose Sinusale de Rosai Dorfman. Presse Médicale, 36, 1669-1675. http://dx.doi.org/10.1016/j.lpm.2007.06.008
[4]	Belembaogo, E., Sanou, S., Girinski, J.R. and Nguemby Mbina, C. (1999) Maladie de Rosai Dorfman. Médecine d’Afrique Noire, 46, 123-124.
[5]	Essalki, I. (2007) La maladie de Rosai-Dorfman à localisation ganglionnaire cervicale à propos de deux observations colligées au service d’ORL du CHU de Dakar. Mémoire de Certificat d’Etudes Spécialisées.
[6]	Khayat, O., El Mezni, F., Zermani, R., Meddeb, B., et al. (1998) Le syndrome de Destombes Rosai Dorfman (à propos d’un cas). La Tunisie Médicale, 76.
[7]	Foucar, E., Rosai, J. and Dorfman, R.F. (1988) Sinus Histiocytosis with Massive Lymphadenopathy (Rosai Dorfman Disease): Review of the Entity. Seminars in Diagnostic Pathology, 7, 19-73.
[8]	Boman Ferrand, F. and Floquet, J. (1990) Histiocytose sinusale avec lymphadénopathie massive. Ann Pathol., 10, 152- 160.
[9]	Diebold, J., Tixier, P., Baufine-Ducroq, H., Tricot, G., Verger, J.P. and Wierzbicki, N. Lymphadénopathie par histiocytose sinusale hémophagocytaire (Syndrome de Destombes Rosai Dorfman). Etude immunologique et histopathologique d’un nouveau cas. Ann Anat Pathol, 21, 347-356.
[10]	Destombes, P. (1965) Adénites avec surcharge lipidique de l’enfant ou de l’adulte jeune observées aux Antilles et au Mali (quatre observations). Bulletin Société Pathologie Exotique, 58, 1169-1175.
[11]	Rosai, J. and Dorfman, R.F. (1969) Sinus Histiocytoses with Massive Lymphadenopathy: A Newly Recognized Benign Clinicopathological Entity. Archives of Pathology, 87, 67-70.
[12]	Sacchi, S., Artusi, T., Torelli, U. and Emilia, G. (1992) Sinus Histiocytosis with Massive Lymphadenopathy. Leukemia and Lymphoma, 7, 189-194. http://dx.doi.org/10.3109/10428199209053622
[13]	Rosai, J. and Dorfman, R.F. (1972) Sinus Histiocytoses with Massive Lymphadenopathy: A Pseudolymphomatous Benign Disorder. Analysis of 34 Cases. Cancer, 30, 1174-1188. http://dx.doi.org/10.1002/1097-0142(197211)30:5<1174::AID-CNCR2820300507>3.0.CO;2-S
[14]	Foucar, E., Rosai, J. and Dorfman, R.F. (1988) Sinus Histiocytosis with Massive Lymphadenopathy. Current Status and Future Directions. Archives of Dermatology, 124, 1211-1214. http://dx.doi.org/10.1001/archderm.1988.01670080023011
[15]	Slaoui, B., Chami, R., Rifki, A., Iraqi, A. and Bougrine, M. (1997) Histiocytose sinusale bénigne ou maladie de Destombes Rosai Dorfman: à propos d’un cas. Annales Pédiatrie, 44, 423-425.
[16]	Natkunam, Y. (2004) Sinus Histiocytosis with Massive Lymphadenopathy (Rosai Dorfman Disease). An Update. ASH Education Program, 287-291.
[17]	Pulsoni, A., Anghel, G., Falcucci, P., et al. (2002) Treatment of Sinus Histocytosis with Massive Lymphadenopathy (Rosai Dorfman Disease); Report of a Case and Literature review. American Journal of Hematology, 69, 67-71. http://dx.doi.org/10.1002/ajh.10008
[18]	Lampert, F. and Lennert, K. (1976) Sinus Histiocytosis with Massive Lymphadenopathy. Cancer, 37, 783-789. http://dx.doi.org/10.1002/1097-0142(197602)37:2<783::AID-CNCR2820370226>3.0.CO;2-L