Analysis of 1246 Cases of Orbital Lesions: A Study of 17 Years

Asad Aslam Khan, Suhail Sarwar, M. Ali Ayaz Sadiq, Munib Ur Rehman, Asad Ullah, Imran Ahmad

Institute of Ophthalmology, King Edward Medical University, Mayo Hospital, Lahore, Pakistan.

DOI: 10.4236/ns.2015.76036                

Abstract

Purpose: The aim of this study is to present an analysis of orbital lesions by classifying them according to the site of origin in patients of all ages presenting at a tertiary care eye hospital from 1996 till 2012. Methods: 1637 patients were initially enrolled in this descriptive case series. Clinical data of 1246 patients who completed the study during 17 years were analyzed. Orbital lesions of the patients were examined and managed medically or surgically as per requirement. The histopathological reports of these patients were used to classify the lesions. Results: Out of all cases 54.57% (n = 680) were neoplastic and 45.42% (n = 566) were nonneoplastic lesions. Amongst the neoplastic lesions 86.17% (n = 586) were malignant and 13.82% (n = 94) were benign. Primary orbital lesions were the most common orbital lesions being 963 (77.29%) followed by secondary orbital lesions being 232 (18.62%), hematopoietic reticuloendothelial being 47 (3.77%) and metastatic lesions being 04 (0.32%). Conclusion: Orbital lesions are more common in adults as compared to children. Neoplastic lesions are more common than nonneoplastic lesions, and amongst the neoplastic lesions malignant lesions are more common than benign ones. Primary orbital lesions are the most common orbital lesions followed by secondary orbital lesions, lesions of the hematopoietic reticuloendothelial system and metastatic lesions.

Keywords

Neoplastic Lesions, Primary Orbital Lesions, Secondary Orbital Lesions, Hematopoietic Orbital Lesions, Metastatic Orbital Lesions, Case Study

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Lemke, B.N. and Lucarelli, M.J. (2012) Anatomy of the ocular Adnexa, Orbit and Related Facial Structures. In: Black, E.H., Nesi, F.A., Gladstone, G.J. and Levine, M.R., Eds., Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery, 3rd Edition, Springer Science + Business Media, LLC, New York, 3-58. http://dx.doi.org/10.1007/978-1-4614-0971-7_1
[2]	Costin, B.R., Perry, J.D. and Foster, J.A. (2014) Classification of Orbital Tumors. In: Perry, J.D. and Singh, A.D., Eds., Clinical Ophthalmic Oncology, Springer-Verlag, Berlin Heidelberg, 9-14. http://dx.doi.org/10.1007/978-3-642-40492-4_2
[3]	Rootman, J. and Nugent, R.A. (2003) Structure of the Orbit: Anatomic and Imaging Features. In: Rootman, J., Ed., Diseases of the Orbit: A Multidisciplinary Approach, 2nd Edition, Lippincott, Williams and Wilkins, Philadelphia, 1-15.
[4]	Khan, A.A., Amjad, M., Azher, A.N. and Sarwar, M.S. (1998) Orbital Lesions in Children. Pakistan Journal of Ophthalmology, 14, 86-89.
[5]	Parashkevova, B. and Balabanov, C. (2007) Orbital Tumors—Clinical Cases Presentation. Journal of IMAB—Annual Proceeding (Scientific Papers), 13, Book 1.
[6]	Demirci, H., Shields, C.L., Shields, J.A., Honavar, S.G., Mercado, G.J. and Tovilla, J.C. (2002) Orbital Tumors in the Older Adult Population. Ophthalmology, 109, 243-248. http://dx.doi.org/10.1016/S0161-6420(01)00932-0
[7]	Bonavolontà, G., Strianese, D., Grassi, P., Comune, C., Tranfa, F., Uccello, G. and Iuliano, A. (2013) An Analysis of 2,480 Space-Occupying Lesions of the Orbit from 1976 to 2011. Ophthalmic Plastic and Reconstructive Surgery, 29, 79-86. http://dx.doi.org/10.1097/IOP.0b013e31827a7622
[8]	Ohtsuka, K., Hashimoto, M. and Suzuki, Y. (2005) A Review of 244 Orbital Tumors in Japanese Patients during a 21-Year Period: Origins and Locations. Japanese Journal of Ophthalmology, 49, 49-55. http://dx.doi.org/10.1007/s10384-004-0147-y
[9]	Angotti Neto, H., Cunha, L.P., Gasparin, F., Santo, R.M. and Monteiro, M.L. (2008) Orbital Space-Occupying Lesions: an 11-Year Study of Cases with Histopathologic Analysis Seen at Hospital das Clínicas of FMUSP. Arquivos Brasileiros de Oftalmologia, 71, 809-812. http://dx.doi.org/10.1590/S0004-27492008000600008