Concurrent Acute Rheumatic Fever and Infective Endocarditis: Case Report (Short Report)


Acute rheumatic fever (ARF) is an inflammatory disease that occurs following an infection with certain strains of group A beta-hemolytic streptococci. Despite dramatic falls in the incidence, Acute Rheumatic Fever remains a major cause of morbidity and mortality associated with acquired heart disease in developing countries. Infective endocarditis (IE) is defined as a microbial infection of the endothelial surface of the heart. IE occurs most frequently in patients with chronic rheumatic heart disease. As far as we know, the simultaneous occurrence of both conditions has not been previously reported. References to our outpatient clinic with complaints of fever and joint pain, clinical and laboratory findings suggestive of infective endocarditis fits both with both the ARF and remitted entirely with appropriate treatment, as far as we know, we think that this is not a case of our similar event in the literature. Here we present a case of a fifteen-year-old girl with concurrent acute rheumatic fever and infective endocarditis.

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Çetin, M. , Yilmaz, M. , Ceylan, Y. , Alkan, F. , Özdemir, M. , Gözkeser, E. and Coşkun, Ş. (2015) Concurrent Acute Rheumatic Fever and Infective Endocarditis: Case Report. Case Reports in Clinical Medicine, 4, 197-201. doi: 10.4236/crcm.2015.45040.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Cilliers, A.M. (2006) Rheumatic Fever and Its Management. BMJ, 333, 1153-1156.
[2] Beg, A. and Sadiq, M. (2008) Subclinical Valvulitis in Children with Acute Rheumatic Fever. Pediatric Cardiology, 29, 619-623.
[3] Brusch, J.L. (2007) Infective Endocarditis and Its Mimics in the Critical Care Unit. In: Cunha, B.A., Ed., Infectious Diseases in Critical Care Medicine, 2nd Edition, Informa Healthcare, New York, 261-262.
[4] Karchmer, A.W. (2005) Infective Endocarditis. In: Zipes, D.P., Libby, P., Bonow, R.O. and Braunwald, E., Eds., Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, 7th Edition, WB Saunders Co., Philadelphia, 1633-1658.
[5] Saxena, A. (2002) Rheumatic Fever and Long-Term Sequelae in Children. Current Treatment Options in Cardiovascular Medicine, 4, 309-319.
[6] (1992) Guidelines for the Diagnosis of Rheumatic Fever. Jones Criteria, 1992 Update. Special Writing Group of the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovasvular Disease in the Young of the American Heart Association. JAMA, 268, 2069-2073.
[7] Habib, G., Hoen, B., Tornos, P., Thuny, F., Prendergast, B., Vilacosta, I., Moreillon, P., de JesusAntunes, M., Thilen, U., Lekakis, J., Lengyel, M., Müller, L., Naber, C.K., Nihoyannopoulos, P., Moritz, A., Zamorano, J.L. and ESC Committee for Practice Guidelines (2009) Guidelines on the Prevention, Diagnosis, and Treatment of Infective Endocarditis (New Version 2009): The Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). European Heart Journal, 30, 2369-2413.
[8] Carapetis, J.R., McDonald, M.and Wilson, N.J. (2005) Acuterheumatic Fever. The Lancet, 366, 155-168.
[9] Carapetis, J.R., Steer, A.C., Mulholland, E.K. and Martin Weber, M. (2005) The Global Burden of Group A Streptococcal Diseases. The Lancet Infectious Disease, 5, 685-694.
[10] Irlam, J.H., Mayosi, B.M., Engel, M.E. and Gaziano, T.A. (2013) A Cost-Effective Strategy for Primary Prevention of Acute Rheumatic Fever and Rheumatic Heart Disease in Children with Pharyngitis. South African Medical Journal, 103, 894-895.
[11] Fink, A.M. (2006) Endocarditis after Valve Replacement Surgery. Early Recognition and Treatment Are Essential to Averting Deadly Complications. AJN, American Journal of Nursing, 106, 40-51.
[12] Hickey, E.J., Jung, G., Manlhiot, C., Sakopoulos, A.G., Caldarone, C.A.A, Coles, J.G., et al. (2009) Infective Endocarditis in Children: Native Valvepreservation Is Frequently Possible Despite Advanced Clinical Disease. European Journal of Cardiothoracic Surgery, 35, 130-135.
[13] Tornos, P., Iung, B., Permanyer-Miralda, G., Baron, G., Delahaye, F., Gohlke-Barwolf, C., et al. (2005) Infective Endocarditis in EUROPE: Lessons from the Euro Heart Survey. Heart, 91 571-575.
[14] Netzer, R.O.M., Zollinger, E., Seiler, C. and Cerny, A. (2000) Infective Endocarditis: Clinical Spectrum Presentation and Outcome. An Analysis of 212 Cases 1980-1995. Heart, 84, 25-30.
[15] Hoen, B., Alla, F., Selton-Suty, C., Béguinot, I., Bouvet, A., Briancon, S., et al. (2002) Changing Profile of Infective Endocarditis. Results of a 1-Year Survey in France. JAMA, 288, 75-81.
[16] Cecchi, E., Forno, D., Imazio, M., Migliardi, A., Gnavi, R., Dal Conte, I., et al. (2004) New Trends in the Epidemiological and Clinical Features of Infective Endocarditis: Results of a Multicenter Prospective Study. Italian Heart Journal, 5, 249-256.

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