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A Facile Synthesis of 2-Amino-5-Cyano-4, 6-Disubstitutedpyrimidines under MWI

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DOI: 10.4236/ijoc.2011.12009    4,749 Downloads   10,635 Views   Citations


Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput synthesis of mononuclear 2-amino-5-cyano-4,6-disubstituted pyrimidines, adaptable to parallel synthesis for compound libraries. The overall reaction time in hrs has been reduced to 25 - 50 minutes with improved yields.

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K. Jain, S. Chaudhari, N. More, K. More, S. Wakedkar and M. Kathiravan, "A Facile Synthesis of 2-Amino-5-Cyano-4, 6-Disubstitutedpyrimidines under MWI," International Journal of Organic Chemistry, Vol. 1 No. 2, 2011, pp. 47-52. doi: 10.4236/ijoc.2011.12009.

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The authors declare no conflicts of interest.


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