Nine Months of Memory Training Increases Cognistat Measured Memory in 79 - 89 Year-Old Mild Cognitively Impaired Individuals

Peter A. Magaro, Bruce Brotter, Mariyam Jalees

Memory Training Centers of America, New York, NY, USA.

DOI: 10.4236/aar.2015.43010                

Abstract

The effects of a memory training paradigm on performance across multiple cognitive domains, measured via the Cognistat, in 70 - 89 year-old individuals with mild cognitive impairment (MCI), were examined. Memory training sessions were conducted on average twice weekly, for 55 minutes each session, for 9 months. Across the testing period, Cognistat-measured memory increased relative to performance in other cognitive domains. Additionally, performance on non-memory measures remained stable or declined. Thus, memory training in older adult, MCI individuals may result in improved memory, but not in improvement in other, non-memory, cognitive domains. Results replicate previous work examining “oldest-old” individuals ranging in age from 90 to 99 years old at the time of study start.

Keywords

Older Adult, Mild Cognitive Impairment, MCI, Cognistat, Cognitive Training, Memory

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Wolinsky, F.D., Vander Weg, M.W., Martin, R., Unverzagt, F.W., Willis, S.L., Marsiske, M., Tennstedt, S.L., et al. (2010) Does Cognitive Training Improve Internal Locus of Control Among Older Adults? The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 65B, 591-598. http://dx.doi.org/10.1093/geronb/gbp117
[2]	Wolinsky, F.D., Unverzagt, F.W., Smith, D.M., Jones, R., Stoddard, A. and Tennstedt, S.L. (2006) The ACTIVE Cognitive Training Trial and Health-Related Quality of Life: Protection that Lasts for 5 Years. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61, 1324-1329. http://dx.doi.org/10.1093/gerona/61.12.1324
[3]	Rebok, G.W., Ball, K., Guey, L.T., Jones, R.N., Kim, H.-Y., King, J.W., Willis, S.L., et al. (2014) Ten-Year Effects of the Advanced Cognitive Training for Independent and Vital Elderly Cognitive Training Trial on Cognition and Everyday Functioning in Older Adults. Journal of the American Geriatrics Society, 62, 16-24. http://dx.doi.org/10.1111/jgs.12607
[4]	Ball, K., Berch, D.B., Helmers, K.F., Jobe, J.B., Leveck, M.D., Marsiske, M., et al. (2002) Effects of Cognitive Training Interventions with Older Adults: A Randomized Controlled Trial. JAMA: The Journal of the American Medical Association, 288, 2271-2281. http://dx.doi.org/10.1001/jama.288.18.2271
[5]	Willis, S.L., Tennstedt, S.L., Marsiske, M., Ball, K., Elias, J., Koepke, K.M., et al. (2006) Long-Term Effects of Cognitive Training on Everyday Functional Outcomes in Older Adults. JAMA: The Journal of the American Medical Association, 296, 2805-2814. http://dx.doi.org/10.1001/jama.296.23.2805
[6]	Smith, G., Housen, P., Yaffe, K., Ruff, R., Kennison, R.F., Mahncke, H.W. and Zelinski, E.M. (2009) A Cognitive Training Program Based on Principles of Brain Plasticity: Re-sults from the Improvement in Memory with Plasticity-Based Adaptive Cognitive Training (IMPACT) study. Journal of the American Geriatrics Society, 57, 594-603. http://dx.doi.org/10.1111/j.1532-5415.2008.02167.x
[7]	Brehmer, Y., Rieckmann, A., Bellander, M., Westerberg, H., Fischer, H. and Backman, L. (2011) Neural Correlates of Training-Related Working-Memory Gains in Old Age. NeuroImage, 58, 1110-1120. http://dx.doi.org/10.1016/j.neuroimage.2011.06.079
[8]	Richmond, L.L., Morrison, A.B., Chein, J.M. and Olson, I.R. (2011) Working Memory Training and Transfer in Older Adults. Psychology and Aging, 26, 813-822. http://dx.doi.org/10.1037/a0023631
[9]	Magaro, P.A., Brotter, B. and Jalees, M. (2015) Memory Training and Task Specificity in 90-99-Year-Old Seniors with Mild Cognitive Impairment. Advances in Aging Research, 4, 1-12. http://dx.doi.org/10.4236/aar.2015.41001
[10]	Kita, Y., Dodge, H.H., Ganguli, M., Takechi, H., Ueshima, H. and Hayakawa, T. (2008) Healthy Cognitive Aging and Leisure Activities among the Oldest Old in Japan: Takashima Study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 63, 1193-1200. http://dx.doi.org/10.1093/gerona/63.11.1193
[11]	Yang, L. and Krampe, R.T. (2009) Long-Term Maintenance of Retest Learning in Young Old and Oldest Old Adults. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 64B, 608-611. http://dx.doi.org/10.1093/geronb/gbp063
[12]	Troyer, A.K., Murphy, K.J., Anderson, N.D., Moscovitch, M. and Craik, F.I.M. (2008) Changing Everyday Memory Behaviour in Amnestic Mild Cognitive Impairment: A Randomised Controlled Trial. Neuropsychological Rehabilitation, 18, 65-88. http://dx.doi.org/10.1080/09602010701409684
[13]	Corrada, M.M., Berlau, D.J. and Kawas, C.H. (2012) A Pop-ulation-Based Clinicopathological Study in the Oldest-Old: The 90+ Study. Current Alzheimer Research, 9, 709-717. http://dx.doi.org/10.2174/156720512801322537
[14]	Prohovnik, I., Perl, D.P., Davis, K.L., Libow, L., Lesser, G. and Haroutunian, V. (2006) Dissociation of Neuropathology from Severity of Dementia in Late-Onset Alzheimer Disease. Neurology, 66, 49-55. http://dx.doi.org/10.1212/01.wnl.0000191298.68045.50
[15]	Savva, G.M., Wharton, S.B., Ince, P.G., Forster, G., Matthews, F.E. and Brayne, C. (2009) Age, Neuropathology, and Dementia. The New England Journal of Medicine, 360, 2302-2309. http://dx.doi.org/10.1056/NEJMoa0806142
[16]	Kwok, T.C.Y., Chau, W.W., Yuen, K.S.L., Wong, A.Y.M., Li, J.C.Y., Shiu, R.Y.Y. and Ho, F.K.Y. (2011) Who Would Benefit from Memory Training? A Pilot Study Examining the Ceiling Effect of Concurrent Cognitive Stimulation. Clinical Interventions in Aging, 6, 83-88.
[17]	Moser, D.V. (1992) Does Memory Affect Judgment? Self-Generated versus Recall Memory Measures. Journal of Personality and Social Psychology, 62, 555-563. http://dx.doi.org/10.1037/0022-3514.62.4.555
[18]	Kiernan, R.J., Mueller, J., Langston, J.W. and Van Dyke, C. (1997) The Neurobehavioral Cognitive Status Examination: A Brief But Differentiated Approach to Cognitive Assessment. Annals of Internal Medicine, 107, 481-485. http://dx.doi.org/10.7326/0003-4819-107-4-481