Clinicopathological Correlation of Primary Malignant Bone Tumors—An Observational Study


Background: Primary malignant tumors arising from bone are uncommon but important malignant neoplasms which account for 0.2% of all primary cancers in adults and approximately 5% of all childhood malignancies. Aim: No comprehensive surveillance data about primary malignant bone tumors is available from this region of West Bengal in the literature. An attempt is undertaken to correlate clinicopathological findings, both histological & cytological features of primary bone tumours. Method: This observational study of clinical presentation was corroborated with cytology and histopathology of 67 cases of primary malignant bone tumors in 2005-2007 in a tertiary health care centre. Results: Among the primary malignant tumors, 39 cases (58.20%) were male and 28 (41.80%) were female. Sixty one lesions (91%) were located in the long bones and 6 (9%) involving flat and short bones. Osteosarcomas are found to be the predominant primary malignant bone tumors (44.77%), followed by Ewing’s sarcomas (20.89%), chondrosarcomas (13.43%), high grade giant cell tumor, and plasmacytoma (5.97%). Predilection for male (M: F 2:1) found in both osteosarcoma and chondrosarcoma, but it was reverse in cases of Ewing’s sarcomas. Conclusion: Osteosarcoma is the most common around knee joint and chondrosarcoma is frequent in long bones in this region. We made an attempt to correlate FNAC findings with the histopathology and it was seen that overall sensitivity of FNAC of primary malignant bone tumors was 56.71%.

Share and Cite:

Bhattacharya, P. , Chowdhury, A. , Mitra, B. and Paul, B. (2015) Clinicopathological Correlation of Primary Malignant Bone Tumors—An Observational Study. Open Journal of Orthopedics, 5, 100-108. doi: 10.4236/ojo.2015.54013.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Patel, S.R. and Benjamin, R.S. (2004) Soft Tissue and Bone Sarcomas and Bone Metastases. In: Kasper, D.L., Braunwald, E., Hauser, S., Longo, D., Jameson, J.L., Fauci, A.S., Eds., Harrison’s Principles of Internal Medicine, 16th Edition, McGraw-Hill, 560-562.
[2] Wingo, P.A., Tong, T. and Bolden, S. (1995) Cancer Statistics, 1995. CA: A Cancer Journal of Clinicians, 45, 8-30.
[3] Ackerman, L.V. and Del Regato, J.A. (1954) Cancer—Diagnosis, Treatment, and Prognosis. CV Mosby Co., St. Louis, 1028.
[4] Heck Jr, R.K., Peabody, T.D. and Simon, M.A. (2006) Staging of Primary Malignancies of Bone. CA: A Cancer Journal of Clinicians, 56, 366-375.
[5] Nakajima, T., Kameya, T., Watanabe, S., et al. (1984) S100 Protein Distribution in Normal and Neoplastic Tissues. In: De Lellis, R., Ed., Advances in Immunohistochemistry, Mason, New York, 141-158.
[6] Susnerwala, S.S., Shanks, J.H., Banerjee, S.S., Scarffe, J.H., Farrington, W.T. and Slevin, N.J. (1997) Extramedullary Plasmacytoma of the Head and Neck Region: Clinicopathological Correlation in 25 Cases. British Journal of Cancer, 75, 921-927.
[7] Sim, J. and Wright, C.C. (2005) The Kappa Statistic in Reliability Studies: Use, Interpretation, and Sample Size Requirements. Physical Therapy, 85, 257-268.
[8] Nakamura, Y., Becker, L.E. and Marks, A. (1983) S-100 Protein in Tumors of Cartilage and Bone: An Immunohistochemical Study. Cancer, 52, 1820-1824.
[9] Zhon, H., Randall, R.L., Brothman, A.R., Maxwell, T., Coffin, C.M., Goldsby, R.E., et al. (2003) Her2/Neu Expression in Osteosarcoma Increases Risk of Lung Metastasis and Can Be Associated with Gene Amplification. Journal of Pediatric Hematology/Oncology, 25, 27-32.
[10] Anninga, J.K., van de Vijver, M.J., Cleton-Jansen, A.M., Kristel, P.M., Taminiau, A.H., Nooij, M., et al. (2004) Overexpression of the HER-2 Oncogene Does Not Play a Role in High-Grade Osteosarcomas. European Journal of Cancer, 40, 963-970.
[11] Pritchard, D.J., Dahlin, D.C., Dauphine, R.T., Taylor, W.F. and Beabout, J.W. (1975) Ewing’s Sarcoma. A Clinicopathological and Statistical Analysis of Patient Surviving 5 Years or Long. Journal of Bone and Joint Surgery, 57, 10-16.
[12] Dahlin, D.C. and Unni, K.K. (1986) Bone Tumors: General Aspects and Data on 8542 Cases. Charles C Thomas Pub Ltd., Springfield.
[13] Ahmad, I., Ul Haq, Z. and Faruq, A. (2003) Ewing’s Sarcoma—A Clinico Pathological Study of 11 Cases. Biomedica, 19, 3-7.

Copyright © 2021 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.