Two Spontaneous Pregnancies after Treatment with OvocyplusTM among an Infertile Patient with Two Failed IVF: A Case Report

DOI: 10.4236/arsci.2015.32003   PDF   HTML   XML   3,717 Downloads   4,597 Views  

Abstract

The role of oxidative stress in female reproduction is becoming increasingly important, as recent evidence suggests that it has been implicated in the pathology of infertility of both known and idiopathic origin. Although its efficacy has yet to be well established, supplementation with antioxidants is a new tool being developed in the therapeutic armamentarium for female-factor infertility. We present a case of a spontaneous viable pregnancy in a 37-year-old patient with a history of two consequent In Vitro Fertilization (IVF) failures, occurring after a 5-month antioxidant treatment. This report suggests that oral antioxidants supplementation in female patients may provide an alternative or adjunct to conventional fertility therapies and improve their chances of becoming pregnant.

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Kacem, O. , Mustapha, H. , Sallem, A. , Harzallah, M. , Zidi, I. , Hachani, F. , Chachia, S. , Khélifi, A. , Saad, A. and Ajina, M. (2015) Two Spontaneous Pregnancies after Treatment with OvocyplusTM among an Infertile Patient with Two Failed IVF: A Case Report. Advances in Reproductive Sciences, 3, 27-33. doi: 10.4236/arsci.2015.32003.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Bhattacharya, S., Johnson, N., Tijani, H.A., Hart, R., Pandey, S. and Gibreel, A.F. (2010) Female Infertility. Clinical Evidence, 11, 819-871.
[2] Ruder, E.H., Hartman, T.J., Blumberg, J. and Goldman, M.B. (2008) Oxidative Stress and Antioxidants: Exposure and Impact on Female Fertility. Human Reproduction Update, 14, 345-357.
http://dx.doi.org/10.1093/humupd/dmn011
[3] Agarwal, A., Gupta, S., Sekhon, L. and Shah, R. (2008) Redox Considerations in Female Reproductive Function and Assisted Reproduction: From Molecular Mechanisms to Health Implications. Antioxidiants and Redox Signaling, 10, 1376-1388. http://dx.doi.org/10.1089/ars.2007.1964
[4] Agarwal, A., Aponte-Mellado, A., Premkumar, B.J., Shaman, A. and Gupta, S. (2012) The Effects of Oxidative Stress on Female Reproduction: A Review. Reproductive Biology and Endocrinology, 10, 49-80.
http://dx.doi.org/10.1186/1477-7827-10-49
[5] Tsunoda, S., Kimura, N. and Fujii, J. (2014) Oxidative Stress and Redox Regulation of Gametogenesis, Fertilization, and Embryonic Development. Reproductive Medicine and Biology, 13, 71-79.
http://dx.doi.org/10.1007/s12522-013-0170-0
[6] Rizzo, A., Roscino, M.T., Binetti, F. and Sciorsci, R.L. (2012) Roles of Reactive Oxygen Species in Female Reproduction. Reproduction in Domestic Animals, 47, 344-352.
http://dx.doi.org/10.1111/j.1439-0531.2011.01891.x
[7] du Plessis, S.S., Makker, K., Desai, N.R. and Agarwal, A. (2008) Impact of Oxidative Stress on IVF. Expert Review of Obstetrics and Gynecolog, 3, 539-554. http://dx.doi.org/10.1586/17474108.3.4.539
[8] Guérin, P., El Mouatassim, S. and Ménézo, Y. (2001) Oxidative Stress and Protection against Reactive Oxygen Species in the Pre-Implantation Embryo and Its Surroundings. Human Reproduction Update, 7, 175-189. http://dx.doi.org/10.1093/humupd/7.2.175
[9] Sekhon, L.H., Gupta, S., Kim, Y. and Agarwal, A. (2010) Female Infertility and Antioxidants. Current Women’s Health Reviews, 6, 84-95. http://dx.doi.org/10.2174/157340410791321381
[10] Ebisch, I., Thomas, C., Peters, W., Braat, D. and Steegers-Theunissen, R. (2007) The Importance of Folate, Zinc and Antioxidants in the Pathogenesis and Prevention of Subfertility. Human Reproduction Update, 13, 163-174. http://dx.doi.org/10.1093/humupd/dml054
[11] Showell, M.G., Brown, J., Clarke, J. and Hart, R.J. (2013) Antioxidants for Female Subfertility. Cochrane Database System Review, 8, Article ID: CD007807.
http://dx.doi.org/10.1002/14651858.CD007807.pub2
[12] Macer, M.L. and Taylor, H.S. (2012) Endometriosis and Infertility: A Review of the Pathogenesis and Treatment of Endometriosis-Associated Infertility. Obstetrics and Gynecology Clinics of North America, 39, 535-549. http://dx.doi.org/10.1016/j.ogc.2012.10.002
[13] Lin, X., Wei, M., Tong, X., Xu, W.H., Zhou, F., Huang, Q.X., Wen, G.F. and Zhang, S.Y. (2012) Outcome of in Vitro Fertilization in Endometriosis-Associated Infertility: A 5-Year Database Cohort Study. Chinese Medical Journal, 125, 2688-2693.
[14] Augoulea, A., Mastorakos, G., Lambrinoudaki, I., Christodoulakos, G. and Creatsas, G. (2009) The Role of the Oxidative- Stress in the Endometriosis-Related Infertility. Gynecological Endocrinology, 25, 75-81.
http://dx.doi.org/10.1080/09513590802485012
[15] Prieto, L., Quesada, J.F., Cambero, O., Pacheco, A., Pellicer, A., Codoceo, R. and Garcia-Velasco, J.A. (2012) Analysis of Follicular Fluid and Serum Markers of Oxidative Stress in Women with Infertility Related to Endometriosis. Fertility and Sterility, 98, 126-130. http://dx.doi.org/10.1016/j.fertnstert.2012.03.052
[16] Huang, B., Li, Z., Ai, J., Zhu, L., Li, Y., Jin, L. and Zhang, H. (2014) Antioxidant Capacity of Follicular Fluid from Patients Undergoing in Vitro Fertilization. International Journal of Clinical and Experimental Pathology, 7, 2273- 2282.
[17] Özkaya, M.O., Naziroglu, M., Barak, C. and Berkkanoglu, M. (2011) Effects of Multivitamin/Mineral Supplementation on Trace Element Levels in Serum and Follicular Fluid of Women Undergoing in Vitro Fertilization (IVF). Biological Trace Element Research, 139, 1-9.
http://dx.doi.org/10.1007/s12011-010-8637-x
[18] Mier-Cabrera, J., Aburto-Soto, T., Burrola-Mendez, S., Jiménez-Zamudio, L., Tolentino, M.C., Casanueva, E. and Hernández-Guerrero, C. (2009) Women with Endometriosis Improved Their Peripherals Antioxidants Markers after the Application of a High Antioxidant Diet. Reproductive Biology and Endocrinology, 7, 54-65. http://dx.doi.org/10.1186/1477-7827-7-54
[19] Mier-Cabrera, J., Genera-Garcia, M., De la Jara-Diaz, J., Perichart-Perera, O., Vadillo-Ortega, F. and Hernandez-Guerrero, C. (2008) Effect of Vitamins C and E Supplementation on Peripheral Oxidative Stress Markers and Pregnancy Rate in Women with Endometriosis. International Journal of Gynecology and Obstetrics, 100, 252-256. http://dx.doi.org/10.1016/j.ijgo.2007.08.018
[20] Murphy, M.P. (2014) Antioxidants as Therapies: Can We Improve on Nature? Free Radical Biology and Medicine, 66, 20-23. http://dx.doi.org/10.1016/j.freeradbiomed.2013.04.010
[21] Burton, G.J., Hempstock, J. and Jauniaux, E. (2003) Oxygen, Early Embryonic Metabolism and Free Radical-Mediated Embryopathies. Reproductive BioMedicine Online, 6, 84-96.
http://dx.doi.org/10.1016/S1472-6483(10)62060-3
[22] Jauniaux, E., Poston, L. and Burton, G.J. (2006) Placental-Related Diseases of Pregnancy: Involvement of Oxidative Stress and Implications in Human Evolution. Human Reproduction Update, 12, 747-755.
http://dx.doi.org/10.1093/humupd/dml016
[23] Sugino, N. (2007) The Role of Oxygen Radical-Mediated Signaling Pathways in Endometrial Function. Placenta, 28, S133-S136. http://dx.doi.org/10.1016/j.placenta.2006.12.002
[24] Velthut, A., Zilmer, M., Zilmer, K., Kaart, T., Karro, H. and Salumets, A. (2013) Elevated Blood Plasma Antioxidant Status Is Favorable for Achieving IVF/ICSI Pregnancy. Reproductive BioMedicine Online, 26, 345-352. http://dx.doi.org/10.1016/j.rbmo.2012.12.012
[25] Jenkins, C., Wilson, R., Roberts, J., Miller, H., McKillop, J. and Walker, J. (2000) Antioxidants: Their Role in Pregnancy and Miscarriage. Antioxidants & Redox Signaling, 2, 623-628.
http://dx.doi.org/10.1089/15230860050192369
[26] Mistry, H.D., Broughton Pipkin, F., Redman, C.W.G. and Poston, L. (2012) Selenium in Reproductive Health. American Journal of Obstetrics and Gynecology, 206, 21-30.
http://dx.doi.org/10.1016/j.ajog.2011.07.034
[27] Abdulah, R., Noerjasin, H., Septiani, L., Mutakin, Defi, I.R., Suradji, E.W., Puspitasari, I.M., Barliana, M.I., Yamazaki, C., Nakazawa, M. and Koyama, H. (2013) Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects. Biological Trace Element Research, 154, 1-6.
http://dx.doi.org/10.1007/s12011-013-9701-0
[28] Perkins, A.V. (2006) Endogenous Anti-Oxidants in Pregnancy and Preeclampsia. Australian and New Zealand Journal of Obstetrics and Gynaecology, 46, 77-83.
http://dx.doi.org/10.1111/j.1479-828X.2006.00532.x
[29] Rumbold, A., Middleton, P., Pan, N. and Crowther, C.A. (2011) Vitamin Supplementation for Preventing Miscarriage. Cochrane Database of Systematic Reviews, 1, Article ID: CD004073.
http://dx.doi.org/10.1002/14651858.CD004073.pub3
[30] Haggarty, P., McCallum, H., McBain, H., Andrews, K., Duthie, S., McNeill, G., Templeton, A., Haites, N., Campbell, D. and Bhattacharya, S. (2006) Effect of B Vitamins and Genetics on Success of in-Vitro Fertilisation: Prospective Cohort Study. The Lancet, 367, 1513-1519. http://dx.doi.org/10.1016/S0140-6736(06)68651-0
[31] Cicek, N., Eryilmaz, O.G., Sarikaya, E., Gulerman, C. and Genc, Y. (2012) Vitamin E: Effect on Controlled Ovarian Stimulation of Unexplained Infertile Women. Journal of Assisted Reproduction and Genetics, 29, 325-328. http://dx.doi.org/10.1007/s10815-012-9714-1
[32] Crha, I., Hruba, D., Ventruba, P., Fiala, J., Totusek, J., Henmi, H., Endo, T., Kitajima, Y., Manase, K., Hata, H. and Kudo, R. (2003) Effects of Ascorbic Acid Supplementation on Serum Progesterone Levels in Patients with a Luteal Phase Defect. Fertility and Sterility, 80, 459-461. http://dx.doi.org/10.1016/S0015-0282(03)00657-5
[33] Westphal, L.M., Polan, M.L., Trant, A.S. and Mooney, S.B. (2004) A Nutritional Supplement for Improving Fertility in Women: A Pilot Study. Journal of Reproductive Medicine, 49, 289-293.
[34] Agrawal, R., Burt, E., Gallagher, A.M., Butler, L., Venkatakrishnan, R. and Peitsidis, P. (2012) Prospective Randomized Trial of Multiple Micronutrients in Subfertile Women Undergoing Ovulation Induction: A Pilot Study. Reproductive BioMedicine Online, 24, 54-60. http://dx.doi.org/10.1016/j.rbmo.2011.10.004
[35] Ruder, E.H., Hartman, T.J., Reindollar, R.H. and Goldman, M.B. (2014) Female Dietary Antioxidant Intake and Time to Pregnancy among Couples Treated for Unexplained Infertility. Fertility and Sterility, 101, 759-766. http://dx.doi.org/10.1016/j.fertnstert.2013.11.008
[36] Youssef, M.A., Abdelmoty, H.I., Elashmwi, H.A., Abduljawad, E.M., Elghamary, N., Magdy, A., Mohesen, M.N., Abdella, R.M., Bar, M.A., Gouda, H.M., Ali, A.M., Raslan, A.N., Youssef, D., Sherif, N.A. and Ismail, A.I. (2014) Oral Antioxidants Supplementation for Women with Unexplained Infertility Undergoing ICSI/IVF: Randomized Controlled Trial.. Human Fertility, 18, 38-42.
[37] Agarwal, A. and Allamaneni, S.S. (2004) Role of Free Radicals in Female Reproductive Diseases and Assisted Reproduction. Reproductive BioMedicine Online, 9, 338-347.
http://dx.doi.org/10.1016/S1472-6483(10)62151-7
[38] Kehila, M., Ben Hmid, R., Ben Khedher, S., Mahjoub, S. and Channoufi, M.B. (2014) Concordance and Contributions of Hysterosalpingography and Laparoscopy in Exploration of Pelvic and Tubal Infertility. The Pan African Medical Journal, 17, 126-130.
[39] Luttjeboer, F., Harada, T., Hughes, E., Johnson, N., Lilford, R. and Mol, B.W. (2007) Tubal Flushing for Subfertility. Cochrane Database of Systematic Reviews, 3, Article ID: CD003718.

  
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