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Efficacy of Cognitive Remediation in Schizophrenia: A Short Review of Its Variable Effects According to Cognitive Domain

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DOI: 10.4236/ojpsych.2015.52019    3,627 Downloads   4,334 Views   Citations


Cognitive impairment is a symptom of schizophrenia and strongly associated with impaired social function. In recent years, cognitive interventions (cognitive remediation therapies) have been implemented and their results have also been reported. Intervention studies have been conducted using a variety of methods that differ in terms of terminology, approach, and targeted cognitive domains. In this study, we examined trends in recent cognitive remediation research conducted subsequent to the meta-analyses of McGurk et al. (2007) and Wykes et al. (2011). We identified studies conducted between 2009 and 2013 to examine computer-assisted cognitive remediation and collated and analyzed the literature describing their major results and trends. Our results indicated improved cognitive performance subsequent to cognitive remediation therapy using computer programs. We found promising outcomes, particularly in reasoning and problem solving, verbal learning and memory, verbal working memory, and attention and vigilance, which replicated the findings of Wykes et al. (2011).

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The authors declare no conflicts of interest.

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Katsumi, A. , Hoshino, H. , Fujimoto, S. and Niwa, S. (2015) Efficacy of Cognitive Remediation in Schizophrenia: A Short Review of Its Variable Effects According to Cognitive Domain. Open Journal of Psychiatry, 5, 170-176. doi: 10.4236/ojpsych.2015.52019.


[1] Heinrichs, R.W. (2004) Meta-Analysis and the Science of Schizophrenia: Variant Evidence or Evidence of Variants? Neuroscience & Biobehavioral Review, 28, 379-394.
[2] Hodge, M.A., Siciliano, D., Witney, P., Moss, B., Moore, C., Judd, G., et al. (2010) A Randomized Controlled Trial of Cognitive Remediation in Schizophrenia. Schizophrenia Bulletin, 36, 419-427.
[3] d’Amato, T., Bation, R., Cochet, A., Jalenques, I., Galland, F., Giraud-Baro, E., et al. (2011) A Randomized, Controlled Trial of Computer-Assisted Cognitive Remediation for Schizophrenia. Schizophrenia Research, 125, 284-290.
[4] Benedict. R.H., Harris, A.E., Markow, T., McCormick, J.A., Nuechteriein, K.H. and Asarnow, R.F. (1994) Effects of Attention Training on Information Processing in Schizophrenia. Schizophrenia Bulletin, 20, 537-546.
[5] Lopez-Luengo, B. and Vazquez, C. (2003) Effects of Attention Process Training on Cognitive Functioning of Schizophrenic Patients. Psychiatry Research, 119, 41-53.
[6] Wykes, T., Reeder, C., Corner, J., Williams, C. and Everitt, B. (1999) The Effects of Neurocognitive Remediation on Executive Processing in Patients with Schizophrenia. Schizophrenia Bulletin, 25, 291-307.
[7] Bellucci, D.M., Glaberman, K. and Hasiam, N. (2003) Computer-Assisted Cognitive Rehabilitation Reduces Negative Symptoms in The Severely Mentally Ill. Schizophrenia Research, 59, 225-232.
[8] van der Gaag, M., Kern, R.S., van den Bosch, R.J. and Liberman, R.P. (2002) A Controlled Trial of Cognitive Remediation in Schizophrenia. Schizophrenia Bulletin, 28, 167-176.
[9] Wolwer, W., Frommann, N., Halfmann, S., Piaszek, A., Streit, M. and Gaebel, W. (2005) Remediation of Impairments in Facial Affect Recognition in Schizophrenia: Efficacy and Specificity of A New Training Program. Schizophrenia Research, 80, 295-303.
[10] Medalia, A., Revheim, N. and Casey, M. (2001) The Remediation of Problem-Solving Skills in Schizophrenia. Schizophrenia Bulletin, 27, 259-267.
[11] McGurk, S.R., Twamley, E.W., Sitzer, D.I., McHugo, G.J. and Mueser, K.T. (2007) A Meta-Analysis of Cognitive Remediation in Schizophrenia. American Journal of Psychiatry, 164, 1791-1802.
[12] Wykes, T., Huddy, V., Cellard, C., McGurk, S.R. and Czobor, P.A. (2011) A Meta-Analysis of Cognitive Remediation for Schizophrenia: Methodology and Effect Sizes. American Journal of Psychiatry, 168, 472-485.
[13] Bell, M.D., Zito, W. and Greig, T. (2008) Neurocognitive Enhancement Therapy with Vocational Services: Work Outcomes at Two-Year Follow-Up. Schizophrenia Research, 105, 18-29.
[14] McGurk, S.R., Mueser, K.T. and Pascaris, A. (2005) Cognitive Training and Supported Employment for Persons with Severe Mental Illness: One Year Results from a Randomized Controlled Trial. Schizophrenia Bulletin, 31, 898-909.
[15] Vauth, R., Corrigan, P.W., Clauss, M., Dietl, M., Dreher-Rudolph, M., Stieglitz, R.-D., et al. (2005) Cognitive Strategies versus Self-Management Skills as Adjunct to Vocational Rehabilitation. Schizophrenia Bulletin, 31, 55-66.
[16] Medalia, A. and Saperstein, A.M. (2013) Does Cognitive Remediation for Schizophrenia Improve Functional Outcomes? Current Opinion in Psychiatry, 26, 151-157.
[17] Cavallaro, R., Anselmetti, S., Poletti, S., Dietl, M., Dreher-Rudolph, M., Stieglitz, R.-D. and Vater, R. (2009) Computer-Aided Neurocognitive Remediation as an Enhancing Strategy for Schizophrenia Rehabilitation. Psychiatry Research, 169, 191-196.
[18] Eack, S.M., Greenwald, D.P., Hogarty, S.S., Cooley, S.J., DiBarry, A.L., Montrose, D.M. and Keshavan, M.S. (2009) Cognitive Enhancement Therapy for Early-Course Schizophrenia: Effects of a Two-Year Randomized Controlled Trial. Psychiatric Services, 60, 1468-1476.
[19] Fisher, M., Holland, C., Merzenich, M.M. and Vinogradov, S. (2009) Using Neuroplasticity-Based Auditory Training to Improve Verbal Memory in Schizophrenia. American Journal of Psychiatry, 166, 805-811.
[20] Dickinson, D., Tenhula, W., Morris, S., Brown, C., Peer, J., Spencer, K., et al. (2010) A Randomized, Controlled Trial of Computer-Assisted Cognitive Remediation for Schizophrenia. American Journal of Psychiatry, 167, 170-180.
[21] Fisher, M., Holland, C., Subramaniam, K. and Vinogradov, S. (2010) Neuroplasticity-Based Cognitive Training in Schizophrenia: An Interim Report on the Effects 6 Months Later. Schizophrenia Bulletin, 36, 869-879.
[22] Vita, A., De Peri, L., Barlati, S., Cacciani, P., Deste, G., Poli, R., et al. (2011) Effectiveness of Different Modalities of Cognitive Remediation on Symptomatological, Neuropsychological, and Functional Outcome Domains in Schizophrenia: A Prospective Study in a Real-World Setting. Schizophrenia Research, 133, 223-231.
[23] Gharaeipour, M. and Scott, B.J. (2012) Effects of Cognitive Remediation on Neurocognitive Functions and Psychiatric Symptoms in Schizophrenia Inpatients. Schizophrenia Research, 142, 165-170.
[24] Ikezawa, S., Mogami, T., Hayami, Y., Sato, I., Kato, T., Kimura, I., et al. (2012) The Pilot Study of A Neuropsychological Educational Approach to Cognitive Remediation for Patients with Schizophrenia in Japan. Psychiatry Research, 195, 107-110.
[25] Rass, O., Forsyth, J.K., Bolbecker, A.R., Hetrick, W.P., Breier, A., Lysaker, P.H., O’Donnell, B.F., et al. (2012) Computer-Assisted Cognitive Remediation for Schizophrenia: A Randomized Single-Blind Pilot Study. Schizophrenia Research, 139, 92-98.
[26] D’Souza, D.C., Radhakrishnan, R., Perry, E., Bhakta, S., Singh, N.M., Yadav, R., et al. (2013) Feasibility, Safety, and Efficacy of the Combination of D-serine and Computerized Cognitive Retraining in Schizophrenia: An International Collaborative Pilot Study. Neuropsychopharmacology, 38, 492-503.
[27] Franck, N., Duboc, C., Sundby, C., Amado, I., Wykes, T., Demily, C., et al. (2013) Specific vs. General Cognitive Remediation for Executive Functioning in Schizophrenia: A Multicenter Randomized Trial. Schizophrenia Research, 147, 68-74.
[28] Garrido, G., Barrios, M., Penadés, R., Enríquez, M., Garolera, M., Aragay, N., et al. (2013) Computer-Assisted Cognitive Remediation Therapy: Cognition, Self-Esteem and Quality of Life in Schizophrenia. Schizophrenia Research, 150, 563-569.
[29] Hubacher, M., Weiland, M., Calabrese, P., Stoppe, G., St?cklin, M., Fischer-Barnicol, D., et al. (2013) Working Memory Training in Patients with Chronic Schizophrenia: A Pilot Study. Psychiatry Journal, 2013, Article ID: 154867.
[30] Tan, B.L. and King, R. (2013) The Effects of Cognitive Remediation on Functional Outcomes Among People with Schizophrenia: A Randomised Controlled Study. Australian & New Zealand Journal of Psychiatry, 47, 1068-1080.
[31] Trapp, W., Landgrebe, M., Hoesl, K., Lautenbacher, S., Gallhofer, B., Günther, W. and Hajak, G. (2013) Cognitive Remediation Improves Cognition and Good Cognitive Performance Increases Time to Relapse—Results of a 5 Year Catamnestic Study in Schizophrenia Patients. BMC Psychiatry, 13, 184.

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