Primary Liver Large B-Cell Lymphoma: A Rare Diagnosis

Joana de Castro Rocha¹, Raquel Lopes², Ana Rita Cruz¹, Cristina Gonçalves², João Araújo Correia¹, Jorge Coutinho²

¹Internal Medicine Department, Centro Hospitalar do Porto, Porto, Portugal.
²Hematology Department, Centro Hospitalar do Porto, Porto, Portugal.

DOI: 10.4236/ojbd.2015.51002                

Abstract

Primary liver lymphoma is extremely rare, in most of cases it is a B cell lymphoma. Usually the diagnosis is made in middle-aged individuals and most of them have a relatively short life expectancy. In this article, the authors present a case report of a 75-year-old woman with symptoms of three weeks of evolution of diffuse abdominal pain, asthenia and anorexia. The analysis showed cyto cholestasis and the radiological image with lush hepatomegaly because of a large hepatic mass. The patient started chemotherapy and actually is well twenty months after the end of the chemotherapy.

Keywords

Large B Cell Lymphoma, Liver, Rarity

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Mouna, B., Wafae, A., Hind, M. and Hassan, E. (2011) Primary Liver Lymphoma: A Case Report and Literature Review. Journal of Cancer Therapy, 2, 725-727. http://dx.doi.org/10.4236/jct.2011.25098
[2]	Leung, V., Lin, S.Y., Loke, T., Chau, T.N., Leung, C.Y., Fung, T.P. and Lam, S.H. (2009) Primary Hepatic Peripheral T-Cell Lymphoma in a Patient with Chronic Hepatitis B Infection. Hong Kong Medical Journal, 15, 288-290.
[3]	Zafar, M.H., Aggarwal, S. and Bhalla, S. (2012) Complete Response to Chemotherapy in Primary Hepatic Lymphoma. Journal of Cancer Research and Therapeutics, 8, 114-116. http://dx.doi.org/10.4103/0973-1482.95187
[4]	Stancu, M., Jones, D., Veja, F. and Medeiros, L.J. (2012) Peripheral T-Cell Lymphoma Arising in the Liver. American Journal of Clinical Pathology, 118, 574-581.
[5]	Varshney, P., Arya, R. and Songra, B. (2014) Primary Non Hodgkin Lymphoma of Liver: A Rare Diagnosis. Journal of Medical Science and Clinical Research, 2, 398-401.
[6]	Ma, Y.J., Chen, E.Q., Chen, X.B., Wang, J. and Tang, H. (2011) Primary Hepatic Diffuse Large B Cell Lymphoma: A Case Report. Hepatitis Monthly, 11, 203-205.
[7]	Mishra, S., Shukla, A., Tripathi, A.K. and Kumar, A. (2012) Primary T-Cell Lymphoma of Liver. BMJ Case Reports, 2013. http://dx.doi.org/10.1136/bcr-2012-008467
[8]	Haider, F.S., Smith, R. and Khan, S. (2008) Primary Hepatic Lymphoma Presenting as Fulminant Hepatic Failure with Hyperferritinemia: A Case Report. Journal of Medical Case Reports, 2, 279. http://dx.doi.org/10.1186/1752-1947-2-279
[9]	Emile, J.F., Azoulay, D., Gornet, J.M., Lopes, G., Delvart, V., Samuel, D., Reynes, M., Bismuth, H. and Goldwasser, F. (2001) Primary Non-Hodgkin’s Lymphomas of the Liver with Nodular Diffuse Infiltration Patterns Have Different Prognoses. Annals of Oncology, 12, 1005-1010. http://dx.doi.org/10.1023/A:1011131930409
[10]	Ehsan, N., Badr, M.T., El-Refaie, A. and Attar, I.E. (2010) Diffuse Large B Cell Lymphoma of the Liver: Immunophe-notypic Profile, Biological Properties and Association with Hepatitis C Virus Infection. Nile Liver Journal, 1, 43-48.
[11]	Bouliaris, K., Christodoulidis, G., Koukoulis, G., Mamaloudis, I., Ioannou, M., Bouronikou, E., Palassopoulou, M. and Tepetes, K. (2014) A Primary Hepatic Lymphoma Treated with Liver Resection and Chemotherapy. Case Reports in Surgery, 2014, Article ID: 749509.
[12]	Resende, V., Oliveira, T.S., Gomes, R.T., Laboissiére, R.S., Tavares Jr., W.C. and Couto, O.F.M. (2013) Primary Hepatic Lymphoma: A Case Report. International Journal of Surgery Case Reports, 4, 1165-1168. http://dx.doi.org/10.1016/j.ijscr.2013.10.003
[13]	Sousa, M.H. and Albuquerque, A. (1999) Linfoma primário do fígado. Relato de um caso clínico e revisão da literatura. Revista da Sociedade Portuguesa de Medicina Interna, 6, 122-127.