Formulation and In-Vitro Release Pattern Study of Gliclazide Matrix Tablet
Tanbir Ahammad1, Marium Begum2, A. F. M. Towheedur Rahman3, Moynul Hasan4, Saikat Ranjan Paul5, Shaila Eamen6, Md. Iftekhar Hussain2, Md. Hazrat Ali7, Md. Ashraful Islam8, Mohammad Mizanur Rahman2, Mamunur Rashid9*
1Department of Pharmacy, BRAC University, Dhaka, Bangladesh.
2Department of Pharmacy, Primeasia University, Dhaka, Bangladesh.
3Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
4Department of Pharmacy, Dhaka International University, Dhaka, Bangladesh.
5Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
6Department of Pharmacy, Jahangirnagar University, Dhaka, Bangladesh.
7Department of Pharmacy, International Islamic University of Chittagong, Chittagong, Bang-ladesh.
8Department of Biomedical Imaging, Faculty of Bioscience, Abo Akademi University, Turku, Finland.
9Department of Pharmacy, University of Rajshshi, Rajshahi, Bangladesh.
DOI: 10.4236/pp.2015.63015   PDF   HTML   XML   4,914 Downloads   6,044 Views   Citations


In current decade, pharmaceutical industries of Bangladesh are giving much emphasize on the formulation of time release preparation to treat various chronic diseases in order to decrease the frequency of administration and to improve patient compliance. Objectives: The objective of this investigation is to design and evaluate sustained release matrix tablet of Gliclazide by direct compression method employing polymers of hydroxypropylmethyl cellulose (HPMC) derivatives (K15M CR and K4M CR) and to select the optimized formulations and compression process by performing a comparative release kinetic study with a reference product, Diamicron MR (one of the worldwide brand of Gliclazide sustain released tablet manufactured by Servier one of the French pharmaceutical company) tablet. Methods: Release kinetics of Gliclazide matrix tablets were determined using USP paddle method at Phosphate buffer (pH 7.4). The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer model. Result: It is found that formulation with lower polymeric concentration follows Higuchi release kinetics and that the formulation with higher concentration best fits with zero order release kinetics. Among the formulations, F1 and F6 show almost similar dissolution profile with Diamicron MR Tablet, which can be suitable candidates for further in-vivo bioequivalence study. Conclusion: Findings of this investigation suggest that F1 and F6 formulations are potential candidates for further bioequivalence study among other formulations.

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Ahammad, T. , Begum, M. , Towheedur Rahman, A. , Hasan, M. , Paul, S. , Eamen, S. , Hussain, M. , Ali, M. , Islam, M. , Rahman, M. and Rashid, M. (2015) Formulation and In-Vitro Release Pattern Study of Gliclazide Matrix Tablet. Pharmacology & Pharmacy, 6, 125-131. doi: 10.4236/pp.2015.63015.

Conflicts of Interest

The authors declare no conflicts of interest.


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