Influence of Antirisk Factors of Cardiovascular Diseases on Intracellular Metabolism of Neutrophils in Men with Obesity


Background: The factor promoting development of oxidative stress at obesity can be the neutro-phils. Objective: To study the influence antirisk factors of cardiovascular diseases on intracellular metabolism of neutrophils in men with peripheral obesity. Methods: In 103 male patients aged 23 to 64 years without coronary heart disease, we studied the presence obesity, antirisk factors of cardiovascular diseases, and the metabolic activity of neutrophils. Results: It is identified that obesity in men associates with more rare use of crude vegetables or fruits every day, and also low physical activity. The daily uses of crude vegetables or fruits, and also the increase of physical activity in obese men promote increase intracellular activity of antioxidative protection at neutrophils. Conclusion: The antirisk factors of cardiovascular diseases increase activity antioxidative protection of neutrophils in men with peripheral obesity, reducing the probability of development of oxidative stress.

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Kratnov, A. and Timganova, E. (2015) Influence of Antirisk Factors of Cardiovascular Diseases on Intracellular Metabolism of Neutrophils in Men with Obesity. World Journal of Cardiovascular Surgery, 5, 25-29. doi: 10.4236/wjcs.2015.53005.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Go, A.S., Mozaffarian, D., Roger, V.L., et al. (2013) Heart Disease and Stroke Statistics—2013 Update: A Report from the American Heart Association. Circulation, 127, e6-e245.
[2] Malnick, S.D.H. and Knobler, H. (2006) The Medical Complications of Obesity. QJM: An International Journal of Medicine, 99, 565-579.
[3] Heitzer, T., Schlinzig, T., Krohn, K., et al. (2001) Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients with Coronary Artery Disease. Circulation, 104, 2673-2678.
[4] Kratnov, A.E. (2014) Activity of Intracellular Metabolism at Neutrophils in Patients with Metabolic Syndrome. Research in Endocrinology, 2014, Article ID: 963868.
[5] Yusuf, S., Hawken, S., Ounpuu, S., et al. (2004) Effect of Potentially Modifiable Risk Factors Associated with Myocardial Infarction in 52 Countries (the INTERHEART Study): Case-Control Study. Lancet, 364, 937-952.
[6] Gentle, Т.А. and Thompson, R.А. (1990) Neutrophil Function Tests in Clinical Immunology. In: Gooi, Н.G. and Chapel, Н., Eds., Clinical Immunology. А Practical Approach, 2nd Edition, Oxford University Press, New York.
[7] Saidov, M.Z. and Pinegin, B.V. (1991) Spectrophotometric Analysis of Myeloperoxidase Activity in Phagocytes. Laboratornoe delo, 3, 56-59.
[8] Kratnov, A.E., Potapov, P.P., Vlasova, A.V., et al. (2005) The Activity of Glutathione Reductase in Neutrophils of Patients with Mucoviscidosis. Klinicheskaia laboratornaia diagnostika, 2, 33-36.
[9] Mamontova, N.S, Beloborodova, E.I. and Tucalova, L.I. (1994) Activity of Catalase at Chronic Dipsomania. Kliniches-kaia laboratornaia diagnostika, 1, 27-28.
[10] Strong, J.P., Malcom, G.T., McMahan, C.A., et al. (1999) Prevalence and Extent of Atherosclerosis in Adolescents and Young Adults: Implications for Prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. JAMA, 281, 727-735. on 12/12/2014
[11] Bosevski, M., Georgievska-Ismail, L.J., Tosev, S. and Borozanov, V. (2009) Risk Factors for Development of Peripheral and Carotid Artery Disease among Type 2 Diabetes Patients. Prilozi, 30, 81-90.
[12] Spagnoli, L., Bonanno, E., Sangiorgi, G. and Mauriello, A. (2007) Role of Inflammation in Atherosclerosis. Journal of Nuclear Medicine, 48, 1800-1815.
[13] Das, U.N. (2001) Is Obesity an Inflammatory Condition? Nutrition, 17, 953-966.
[14] Cave, M.C., Hurt, R.T., Frazier, T.H., Matheson, P.J., Garrison, P.N., McClain, C.J., et al. (2008) Obesity, Inflammation, and the Potential Application of Pharmaconutrition. Nutrition in Clinical Practice, 23, 16-34.
[15] Flores-Mateo, G., Carrillo-Santisteve, P., Elosua, R., Guallar, E., Marrugat, J., Bleys, J., et al. (2009) Antioxidant Enzyme Activity and Coronary Heart Disease: Meta-Analyses of Observational Studies. American Journal of Epidemiology, 170, 135-147.
[16] Ford, E.S., Ahluwalia, I.B. and Galuska, D.A. (2000) Social Relationships and Cardiovascular Disease Risk Factors: Findings from the Third National Health and Nutrition Examination Survey. Preventive Medicine, 30, 83-92.

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