11C-Labeled Capsaicin and Its in Vivo Molecular Imaging in Rats by Positron Emission Tomography

Abstract

Synthesis of 11C-labeled capsaicin ([11C]-2) was accomplished by O-[11C]methylation with [11C]-methyl iodide to a corresponding catechol precursor (1). In Vivo whole-body distribution of [11C]-2 in rats was investigated by positron emission tomography after intravenous injection. The results showed that [11C]-2 accumulated in the brain and body surface, which was closely associated with the expression of transient receptor potential vanilloid 1.

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Goto, M. , Mizuma, H. , Wada, Y. , Suzuki, M. , Watanabe, Y. , Onoe, H. and Doi, H. (2015) 11C-Labeled Capsaicin and Its in Vivo Molecular Imaging in Rats by Positron Emission Tomography. Food and Nutrition Sciences, 6, 216-220. doi: 10.4236/fns.2015.62022.

Conflicts of Interest

The authors declare no conflicts of interest.

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