The Association of Night Shift Work with the Development of Breast Cancer in Women

P. I. J. Moukangoe; M. S. Jansen van Rensburg

doi:10.4236/ojepi.2015.51003

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Open Journal of Epidemiology > Vol.5 No.1, February 2015

The Association of Night Shift Work with the Development of Breast Cancer in Women ()

P. I. J. Moukangoe, M. S. Jansen van Rensburg

Independent Consultants, Johannesburg, South Africa.

DOI: 10.4236/ojepi.2015.51003 PDF HTML XML 2,903 Downloads 3,663 Views Citations

Abstract

Breast cancer is a serious public health concern in South Africa and globally. It is estimated that one in seven South Africans will develop cancer in their lifetime. According to a case-controlled study, 80% of cancer cases are thought to be due to external, non-inherited factors, which could potentially have been prevented. The objectives of the current case-control study were: 1) to determine the relationship between night shift work and the development of breast cancer; 2) to explore the relationship between night shift work and other types of cancer; 3) to explore any difference between night shift work and breast cancer, and night shift work and other types of cancer. A total of 106 research participants were selected using non-probability, convenience sampling methods and interviewed using a structured questionnaire. Seventy-two (68%) of the women who were interviewed were black, while 32% (n = 35) were white. Of the 106 research participants, 82% (n = 87) had a history of being employed, while 18% (n = 19) had never been employed. Analysed data showed that 29% (n = 31) of the women had a history of working night shift. Of the 31 research participants who reported having worked night shift, 90% (n = 28) had actually done rotating shift work, rather than regular night shift work. The odds ratio of working night shift was found to be 1.24 (OR = 1.24, p = 0.615) higher in breast cancer research participants compared to research participants diagnosed with other types of cancer—odds ratio of 0.80 (p = 0.610). For rotational work, the OR was 1.445, indicating a higher risk than for shift work. It is recommended that the relationship between working night shift and breast cancer risk be explored further through cross-sectional and cohort studies.

Keywords

Breast Cancer, Cancer, Night Shift, Rotating Shift, Regular Night Shift, Parity, Genetic Predisposition

Share and Cite:

Moukangoe, P. and Jansen van Rensburg, M. (2015) The Association of Night Shift Work with the Development of Breast Cancer in Women. Open Journal of Epidemiology, 5, 14-21. doi: 10.4236/ojepi.2015.51003.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Fan, L., Zheng, Y., Yu, K.D., Liu, G.Y., Wu, J., Lu, J.S., Shen, K.W., Shen, Z.Z. and Shao, Z.M. (2009) Breast Cancer in a Transitional Society over 18 Years: Trends and Present Status in Shanghai, China. Breast Cancer Research and Treatment Journal, 117, 409-416. http://dx.doi.org/10.1007/s10549-008-0303-z
[2]	Key, T.J., Verkasalo, P.K. and Banks, E. (2001) Epidemiology of Breast Cancer. Lancet Oncology, 2, 133-140. http://dx.doi.org/10.1016/S1470-2045(00)00254-0
[3]	South African Medical Research Council (2013) What Are the Top Causes of Death Due to Cancer in South Africa? Burden of Disease Research Unit. http://www.mrc.ac.za/bod/faqcancer.htm
[4]	Urban, M., Banks, E., Egger, S., Canfell, K., O’Connell, D., Beral, V. and Sitas, F. (2012) Injectable and Oral Contraceptive Use and Cancers of the Breast, Cervix, Ovary, and Endometrium in Black South African Women: Case-Control Study. PLOS Medicine, 9, 1-11.
[5]	Cancer Association of South Africa (2010) Overview of the Latest National Cancer Registry Statistics. Leading Five Female Cancers in South Africa. http://www.cansa.org.za/womens-health/
[6]	Straif, K., Baan, R., Grosse, Y., Secretan, B., Ghissassi, F., Bouvard, V., Altieri, A., Benbrahim-Tallal, L. and Cogliano, V. (2007) Carcinogenicity of Shift-Work, Painting, and Fire-Fighting. Lancet Oncology, 8, 1065-1066. http://dx.doi.org/10.1016/S1470-2045(07)70373-X
[7]	Stevens, R.G. (2009) Light-at-Night, Circadian Disruption and Breast Cancer: Assessment of Existing Evidence. International Journal of Epidemiology, 38, 963-970. http://dx.doi.org/10.1093/ije/dyp178
[8]	Wise, J. (2009) Danish Night Shift Workers with Breast Cancer Awarded Compensation. British Medical Journal, 338, 1152.
[9]	Hansen, J. (2006) Risk of Breast Cancer after Night- and Shift Work: Current Evidence and Ongoing Studies in Denmark. Cancer Causes Control, 17, 531-537. http://dx.doi.org/10.1007/s10552-005-9006-5
[10]	Scheer, F.A., Hilton, M.F., Mantzoros, C.S. and Shea, S.A. (2009) Adverse Metabolic and Cardiovascular Consequences of Circardian Misalignment. Proceedings of the National Academy of Science United States of America, 106, 4453-4458. http://dx.doi.org/10.1073/pnas.0808180106
[11]	Costa, G. (2001) Shift-Work Health Consequences. In: Karwowski, W., Eds., International Encyclopedia of Ergonomics and Human Factors, Volume 2, Taylor Francis, London, 1359-1360.
[12]	Megdal, S.P., Kroenke, C.H., Laden, F., Pukkala, E. and Schernhammer, E.S. (2005) Night Work and Breast Cancer Risk: A Systematic Review and Meta-Analysis. European Journal of Cancer, 41, 2023-2032. http://dx.doi.org/10.1016/j.ejca.2005.05.010
[13]	Grundy, A., Richardson, H., Burstyn, I., Lohrisch, C., SenGupta, S.K., Lai, A.S., Lee, D., Spinelli, J.J. and Aroson, K.J. (2013) Increased Risk of Breast Cancer Associated with Long-Term Shift Work in CANADA. Occupational and Environmental Medicine, 70, 831-838.
[14]	Lie, J.A., Roessink, J. and Kjaerheim, K. (2006) Breast Cancer and Night Work among Norwegian Nurses. Cancer Causes Control, 17, 39-44. http://dx.doi.org/10.1007/s10552-005-3639-2
[15]	Schernhammer, E.S., Laden, F., Speizer, F.E., Willet, W.C., Hunter, D.J., Kawachi, I. and Colditz, G.A. (2001) Rotating Night Shifts and Risk of Breast Cancer in Women Participating in the Nurses’ Health Study. Journal of National Cancer Institute, 93, 1563-1568. http://dx.doi.org/10.1093/jnci/93.20.1563
[16]	Schernhammer, E.S., Kroenke, C.H., Laden, F. and Hankinson, S.E. (2006) Night Work and Risk of Breast Cancer. Epidemiology, 17, 108-111. http://dx.doi.org/10.1097/01.ede.0000190539.03500.c1
[17]	Pesch, B., Harth, V., Rabstein, S., Baish, C., Schiffermann, M., Bonberg, N., Heinze, E., Spickenheuer, A., Justenhoven, C., Brauch, H., Hamann, U., Ko, Y., Straif, K. and Bruning, T. (2010) Night Work and Breast Cancer—Results from the German GENICA Study. Scandanavian Journal of Work, Environment and Health, 36, 134-141.
[18]	Anjoeka, P., Bu-Tian, J., Xiao-Ou, S., Shouzheng, X., Gong, Y., Hong-Lan, L., Nathaniel, R., Yu-Tang, G., Wei, Z. and Wong-Ho, Chow. (2010) Night Shift Work and Breast Cancer Risk in a Cohort of Chinese Women. American Journal of Epidemiology, 171, 953-959. http://dx.doi.org/10.1093/aje/kwq029
[19]	Groot, M.T., Baltussen, R., Uyl-de Groot, C.A., Anderson, B.O. and Hortobagyi, G.N. (2005) Costs and Health Effects of Breast Cancer Interventions in Epidemiologically Different Regions of Africa, North America, and Asia. 2nd Biennial Global Summit Consensus Conference on International Breast Health Care, Bethesda, 12-15 January 2005, 581-590.