Primary Endometrial High Grade Neuroendocrine Carcinoma: A Case Report with Cytological, Histopathological and Immunohistochemical Features

Kazuhiro Kobayashi¹, Masashi Matsuyama², Fumimasa Etori², Naomi Kawaguchi², Kyoko Nambu², Asuka Sekiya², Yuka Hiraku³, Kazushige Yamamoto³, Naoki Watanabe², Tetsuya Yamada⁴, Takuji Tanaka^1,2*

¹Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu City, Japan.
²Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospial, Gifu City, Japan.
³Department of Obstetrics & Gynecology, Gifu Municipal Hospial, Gifu City, Japan.
⁴Department of Diagnostic Pathology, Kizawa Memory Hospital, Minokamo City, Japan.

DOI: 10.4236/ojpathology.2015.51001                

Abstract

An 84-year-old woman suffered from post-menopausal genital bleeding for 3 months. Based on the endometrial cytological findings (suggestive of high grade neuroendocrine carcinoma) showing that there were rosette-like and cord-like structures consisting of small rounded tumor cells with oval nuclei and scanty cytoplasm, radical hysterectomy was performed. Histopathological and immunohistochemical examinations on the operated specimens revealed primary high grade neuroendocrine carcinoma of the endometrium. Despite the extensive treatment against the malignancy, the patient died due to widespread metastases after 5 months after the surgery and autopsied.

Keywords

Endometrium, High Grade Neuroendocrine Carcinoma, Undifferentiated Carcinoma, Neuroendocrine Cells

Conflicts of Interest

The authors declare no conflicts of interest.

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