Computational Analysis of Physicochemical, Pharmacokinetic and Toxicological Properties of Deoxyhypusine Synthase Inhibitors with Antimalarial Activity

Nayara S. R. Silva¹, Luana K. S. Gonçalves¹, Jonatas L. Duarte¹, Juliane S. Silva¹, César F. Santos¹, Francinaldo S. Braga¹, Raí C. Silva¹, Josivan S. Costa¹, Lorane I. S. Hage-Melim^1,2, Cleydson B. R. dos Santos^1,2*

¹Laboratory of Modeling and Computational Chemistry, Federal University of Amapá, Campus Universitário Marco Zero, Macapá, Brazil.
²Postgraduate Program in Pharmaceutical Sciences, Federal University of Amapá, Macapá, Brazil.

DOI: 10.4236/cmb.2014.44006                

Abstract

Malaria is a parasitic disease which has as etiological agents protozoa of the genus Plasmodium prevalent in tropical countries. The appearance of Plasmodium strains resistant to artemisinin has become necessary the development of new drugs using computational tools to combat this epidemic. Diverse transporter proteins can act as antimalarials targets, thereby being the enzyme deoxyhypusine synthase a promising antimalarial target. The present study aimed to investigate 15 most active inhibitors of deoxyhypusine synthase target, deposited in databases Binding DB, in order to trace a pattern of physicochemical, pharmacokinetic and toxicological properties of the inhibitors for this enzyme and propose new inhibitors of deoxyhypusine synthase target. The physicochemical properties were obtained according to the Lipinski parameters to evaluate oral absorption. Based on the certain properties were proposed three new inhibitors (A, B and C). The ADME/Tox properties were calculated for new inhibitors compared with results of the selected compounds. The fifteen inhibitors for oral administration showed satisfactory results, because they have adapted to the Lipinski parameters. In relation to the penetration of the blood-brain barrier the inhibitors analyzed showed penetration values less than 1, and ranged from 0.0411815 to 0.481764, being that the compound 1 showed value of C_Brain/C_Blood = 0.135467. Compound B showed a higher strength in plasma protein binding in relation to the compound 1, having a variation be-tween them of ±1.489344. Therefore, the compound B would present a longer halflife compared with compound 1. The proposed compounds showed positive and satisfactory results, being able to reach less adverse effects related to the central nervous system depending of administered dose.

Keywords

Antimalarial Activity, Deoxyhypusine Synthase Inhibitors, Physicochemical Property, Pharmacokinetic and Toxicological Properties

Conflicts of Interest

The authors declare no conflicts of interest.

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