Safety and Tolerability of Transdermal Rotigotine in a Clinical Practice Cohort for 2 Years

Iria Rodriguez Constenla; Antonio Pato Pato; Icíar Cimas Hernando; José Ramón Lorenzo Gonzalez

doi:10.4236/wjns.2014.45050

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World Journal of Neuroscience > Vol.4 No.5, November 2014

Safety and Tolerability of Transdermal Rotigotine in a Clinical Practice Cohort for 2 Years ()

Iria Rodriguez Constenla^*, Antonio Pato Pato, Icíar Cimas Hernando, José Ramón Lorenzo Gonzalez

Servicio de Neurología, Hospital Povisa, Vigo, Spain.

DOI: 10.4236/wjns.2014.45050 PDF HTML XML 3,443 Downloads 3,920 Views

Abstract

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disease that occurs as a result of loss of dopaminergic neurons from the substantia nigra. Rotigotine is a non-ergolinic dopamine agonist available as a silicone-based transdermal patch for the treatment of PD. In the European Union, rotigotine transdermal patch is indicated for use as monotherapy in early idiopathic PD, or in combination with levodopa through the disease course to the late stages where motor complications with levodopa become an issue. Objective: To investigate the safety and tolerability of transdermal rotigotine, in patients with PD being treated during routine clinical practice for 2 years. Results: 114 patients were enrolled, and evaluated for adverse events over a 24-month period. Adverse events occurred in 39 patients (34.21%). 23 patients (20.17%) reported application site reactions (dermatitis, erythema, itching), and 16 (14.03%) had systemic adverse events. Sleep disorders were the most common problem; the others were hallucinations, depression, dizziness, and syncope. No patient experienced dyskinesia. Adverse events necessitated the discontinuation of rotigotine for application site reactions in fourteen patients (12.28%) and 11 patients (9.64%); reasons for discontinuation were systemic adverse events. Conclusion: Rotigotine is safe and well tolerated when used to treat PD in routine clinical practice.

Keywords

Rotigotine, Parkinson’s Disease, Tolerability, Safety, Clinical Practice

Share and Cite:

Constenla, I. , Pato, A. , Hernando, I. and Gonzalez, J. (2014) Safety and Tolerability of Transdermal Rotigotine in a Clinical Practice Cohort for 2 Years. World Journal of Neuroscience, 4, 443-449. doi: 10.4236/wjns.2014.45050.

Conflicts of Interest

The authors declare no conflicts of interest.

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