Embryonal Rhabdomyosarcoma of the Uterine Cervix: Two Cases Report and Literature Review

Khlifi Abdeljalil^*, Boukadida Asma, Mouna Kouira, Hachani Faten, Meddeb Sawssen, Hidar Samir, Bibi Mohamed, Essaidi Habib, Khairi Hedi

Department of Gynecology and Obstetrics, University Teaching Hospital Farhat Hached, Sousse, Tunisia.

DOI: 10.4236/ojog.2014.414122                

Abstract

Introduction: Embryonal rhabdomyosarcoma (RMS) of the uterine cervix is a rare and extremely aggressive malignant entity. However, prognosis seems to be improved with the use of multimodality approach treatment. Cases: We report the cases of 50- and 51-year-old women, presenting with vaginal bleeding and mass. The two patients underwent radical surgery. Histological examination revealed RMS of uterine cervix. Treatment was effective in the first case but despite the chemotherapy, the second patient died two months later. Discussion and Conclusions: The prognosis of the cervical embryonal RMS depends on clinical and histological features. The current treatment protocols are based on trials done on pediatric patients. Studies on embryonal RMS treatment and outcomes are limited in women over forty years. In patients with unfavorable prognosis characteristics, the multimodality approach including surgery, adjuvant chemo and radiotherapy can be effective. Otherwise, surgery alone can effectively be proposed.

Keywords

Embryonal Rhabdomyosarcoma, Uterine Cervix, Radiation Therapy, Chemotherapy, Surgery

Conflicts of Interest

The authors declare no conflicts of interest.

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