Bilateral Mixed Germ Cell Tumour in an Adolescent Girl with Premature Ovarian Failure


Germ cell tumours (GCTs) of the ovary are rare, comprising approximately 20% of all ovarian tumors with the malignant variant accounting for less than 5% of all ovarian neoplasms. Malignant mixed germ cell tumours are rarer still with dysgerminoma & yolk sac tumour being the most common components with three component variants being categorised in the rarest of rare varieties. Bilateral dysgerminomas occur in 15% of germ cell neoplasms but rarely present with premature ovarian failure. We present the case of an adolescent girl with a short history of abdominal pain and distension with amenorrhoea for a year. Clinical and radio ogical examination revealed a pelvic/adnexal mass with elevation of tumour markers and she had to undergo a staging laparotomy with bilateral salpingo-oophorectomy. Histopatholgy examination was reported as malignant mixed germ cell tumour of left ovary, predominantly with immature teratoma and minor components of yolk-sac tumour and dysgerminoma and right ovary with dysgerminoma. In view of mixed germ cell disease, she was planned for adjuvant chemotherapy.

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Roy, P. , Biswas, B. , Paul, S. , Choudhrie, L. and Jose, R. (2014) Bilateral Mixed Germ Cell Tumour in an Adolescent Girl with Premature Ovarian Failure. Open Journal of Obstetrics and Gynecology, 4, 805-808. doi: 10.4236/ojog.2014.413111.

Conflicts of Interest

The authors declare no conflicts of interest.


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