Entropy Approach to the Study of Biological Activity of Chemical Compounds. The Other Side of Radioprotectors
Vladimir K. Mukhomorov
DOI: 10.4236/abc.2011.11001   PDF   HTML     6,223 Downloads   13,528 Views   Citations


An attempt made to construct a model of relationship of the radioprotective and carcinogenic properties of biologically active compounds with their electron and information factors. We discovered a simple quantitative structure – activity relationships between the radioprotective effectiveness of chemicals and their molecular structure. It is established that carcinogenic properties of chemical compounds and effective radioprotectors are overlapping with each other. Within the framework of an information approach a systemic factor is proposed for distinguish highly radio protective agents among a series of drug. It was shown that the correlation obtained relating the structure of the compounds of the radio protective effect may be applied to studies of the mechanism of action of the preparations and for the purposeful synthesis of new chemicals.

Share and Cite:

Mukhomorov, V. (2011) Entropy Approach to the Study of Biological Activity of Chemical Compounds. The Other Side of Radioprotectors. Advances in Biological Chemistry, 1, 1-5. doi: 10.4236/abc.2011.11001.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Mukhomorov, V.K. (1984) Intermolecular interactions and biological activity of chlorine-containing molecules. Khimiko-Farmacevticheskii Zhurnal, Moscow, 18, 17-25.
[2] Mukhomorov, V.K. (1987) Statistical aspects of linkage of radioprotective action of derivatives mercaptoethylamine and its analogues with their electronic parameters. Khimiko-Farmacevticheskii Zhurnal, 21, 1210-1215.
[3] Bonchev, D. and Trinajsti?, N. (1977) Information theory, distace matrix, and molecular branching. Journal of Chemical Physics, 2, 392-397.
[4] Veljkovi?, V., Lalovi?, D. (1973) General model pseudopotential for positive ions. Physical Letters A, 45, 59-62.
[5] F?rster, E. and R?nz, B. (1979) Methoden der Korrelations und Regressionsanalyse. Verlag Die Wirtshaft.
[6] Mukhomorov, V.K. (1988) Entropy function and radioprotective efficacy of N-substituted S-2-aminoethylthio sulfates. Radiobiology, 28, 407-411.
[7] Sweeney T.R. (1979) Survey of compounds from the antiradiation drug development programm. Washington.
[8] Leo, A. Hansh, C. and Etkins, D. (1971) Partition coefficients and their uses. Chemical Review. 71, 525-674.
[9] Quastler, H. (1953) The alphabet of the information. Information Theory in Biology. H. Quasler Ed., Pergamon Press, London - New York – Paris - Los Angeles, 46, 3-35.
[10] Alexeyev, V.L. and Levich, A.P. (1997) A search for maximum species abundances in ecological communities under conditional diversity optimization. Bulletin of Mathemati Biology. 59, 649-677.
[11] Kolmogorov, A.N. (1987) Theory of information and theory of algorithms. Nauka, Moscow, (in Russian).
[12] Romantzev, E.F. (1968) Radiation and chemical protection. Nauka, Moscow, 1968 (in Russian).
[13] Turusov, V.S. (1964) Cancerogenic substances. Hand- book. Nauka, Moscow, (in Russian).

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.