A Study of Mallory-Weiss Syndrome Secondary to Upper Gastrointestinal Bleeding


Background: In Mallory-Weiss Syndrome (MWS), vomiting causes the mucous membrane and submucosa near the esophagogastric mucosal junction to tear and bleed. Thus, MWS can arise after heavy drinking and as a complication of endoscopic upper gastrointestinal examinations or procedures. However, there has been no report of MWS secondary to upper gastrointestinal bleeding thus far. Case Subjects: Of 79 MWS cases over a 10-year period from 2002 to 2011, we identified and studied 6 cases, in which MWS was probably caused by another lesion causing upper gastrointestinal bleeding. Results: There were 2 cases, each of gastric ulcers, duodenal ulcers, and varicose veins. In 3 cases, MWS was discovered during treatment of the primary lesion and was simultaneously treated. In the other 3 cases, patients were treated for MWS according to endoscopic diagnosis, and the primary lesion was overlooked; in these cases, the primary lesion was identified and treated after the bleeding recurred. One patient with cirrhosis died of hepatic failure. Conclusion: Care should be taken when dealing with MWS because it can occur as a result of vomiting caused by hematemesis or as a complication of endoscopic examination and treatment. When assessing MWS, other hemorrhagic lesions may be overlooked.

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Inoue, Y. , Fujino, Y. , Onodera, M. , Kikuchi, S. , Sato, M. , Sato, H. , Noda, H. , Kojika, M. , Suzuki, Y. and Endo, S. (2014) A Study of Mallory-Weiss Syndrome Secondary to Upper Gastrointestinal Bleeding. Open Journal of Clinical Diagnostics, 4, 130-136. doi: 10.4236/ojcd.2014.43021.

Conflicts of Interest

The authors declare no conflicts of interest.


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