Parathyroid Hormone: Is It Really the Cause for Increased Tooth Mobility after Orthognathic Surgery?


Introduction: Following orthognathic surgery, increased tooth mobility is observed clinically and is utilized for postsurgical orthodontic tooth movement. It was suggested that the increase may result from a surgery-associated alteration of parathyroid hormone (PTH) and calcium metabolism. Materials and Methods: 30 young adult patients were divided into a mandibular osteotomy group (Group A, n = 20) and an untreated control group (Group B, n = 10). Tooth mobility was evaluated using the Periotest device. Tooth mobility, serum PTH and calcium levels were determined repeatedly for both groups. Results: The tooth mobility was increased significantly in the Group A patients in the first 10 days post-surgery. All serum PTH and calcium mean levels were within normal ranges. No significant differences were found between the measurements of both groups. The serum calcium levels recorded at the 1st post-surgery day were slightly lower in the operated patients compared to the control group. Conclusion: It can be concluded that the increased facility of orthodontic tooth movement immediately post-surgery was confirmed by Periotest measurements, while no association was found with surgery-related altered levels of PTH and calcium. Since dietary effects can be ruled out, the increase of clinical tooth mobility may rather result from preoperative orthodontic forces and/or the post-surgical elimination of masticatory muscular influences.

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Watted, N. , Hussein, E. , Abu-Mowais, M. , Abdulgani, A. , Proff, P. and Muhamad, A. (2014) Parathyroid Hormone: Is It Really the Cause for Increased Tooth Mobility after Orthognathic Surgery?. Open Journal of Stomatology, 4, 424-433. doi: 10.4236/ojst.2014.48057.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Gianelly, A.A. and Schnur, R.M. (1969) The Use of Parathyroid Hormone to Assist Orthodontic Tooth Movement. American Journal of Orthodontics, 55, 305-312.
[2] Midgett, R.J., Shaye, R. and Fruge Jr., J.F. (1981) The Effect of Altered Bone Metabolism on Orthodontic Tooth Movement. American Journal of Orthodontics, 80, 256-262.
[3] Soma, S., Iwamoto, M., Higuchi, Y. and Kurisu, K. (1999) Effects of Continuous Infusion of PTH on Experimental Tooth Movement in Rats. Journal of Bone and Mineral Research, 14, 546-554.
[4] Chevalley, T. and Rizzoli, R. (1999) Os et hormones. Influence de l’hormone parathyroidienne sur l’os. La Presse Médicale, 28, 547-553.
[5] Boabaid, F., Berry, J.E., Koh, A.J., Somerman, M.J. and McCcauley, L.K. (2004) The Role of Parathyroid Hormone-Related Protein in the Regulation of Osteoclastogenesis by Cementoblasts. Journal of Periodontology, 75, 1247-1254.
[6] Lee, S.K. and Lorenzo, J.A. (1999) Parathyroid Hormone Stimulates TRANCE and Inhibits Osteoprotegerin Messenger Ribonucleic Acid Expression in Murine Bone Marrow Cultures: Correlation with Osteoclast-Like Cell Formation. Endocrinology, 140, 3552-3561.
[7] Lossdörfer, S., Götz, W., Rath-Deschner, B. and Jäger, A. (2006) Parathyroid Hormone (1-34) Mediates Proliferative and Apoptotic Signaling in Human Periodontal Ligament Cells in Vitro via Protein Kinase C-Dependent and Protein Kinase A-Dependent Pathways. Cell and Tissue Research, 325, 469-479.
[8] Lossdörfer, S., Yildiz, F., Götz, W., Kheralla, Y. and Jäger, A. (2010) Anabolic Effect of Intermittent PTH (1-34) on the Local Microenvironment during the Late Phase of Periodontal Repair in a Rat Model of Tooth Root Resorption. Clinical Oral Investigations, 14, 89-98.
[9] Engström, C., Jennings, J., Lundy, M. and Baylink, D.J. (1988) Effect of Bone Matrix-Derived Growth Factors on Skull and Tibia in the Growing Rat. Journal of Oral Pathology, 17, 334-340.
[10] Watted, N., Bill, J.S. and Peters, Ch. (2000) A Therapeutic Concept for the Combined Orthodontic Surgical Correction of Angle Class II Deformities with Short-Face Syndrome: Surgical Lengthening of the Lower Face. Clinical Orthodontics and Research, 3, 78-93.
[11] Hullihen, S.R. (1900) Case of Elongation of the under Jaw and Distorsion of the Face and Neck, Caused by a Burn. Dental Cosmos, Philadelphia, 42, 287-293.
[12] Obwegeser, H. and Trauner, R. (1955) Zur Operationstechnik bei der Progenie und anderen Unterkieferanomalien. Dtsch Zahn Mund Kieferheilk 23, H 1 und 2.
[13] Pont, G.D. (1959) L’osteotomia retromolare per la correzione della progenia. Minerva Chirurgica, 18, 1138-1141.
[14] Epker, B.N. (1977) Modification in the Sagittal Osteotomy of the Mandible. Journal of Oral Surgery, 34, 157-159.
[15] Nichols Institute Diagnostic (1998) The Quest Diagnostics Manual Endocrinology, Test Selection and Interpretation. 4th Edition, California.
[16] Lutwak, L., Krook, L., Henrikson, P.A., Uris, R., Whalen, J., Coulston, A. and Lesser, G. (1971) Calcium Deficiency and Human Periodontal Disease. Israel Journal of Medical Sciences, 7, 504-505.
[17] Schulte, W. and Lukas, D. (1992) The Periotest Method. International Dental Journal, 42, 433-440.
[18] Fletcher, P.D., Scopp, I.W. and Hersh, R.A. (1977) Oral Manifestations of Secondary Hyperparathyroidism Related to Long-Term Hemodialysis Therapy. Oral Surgery, Oral Medicine, Oral Pathology, 43, 218-226.
[19] Goldie, R.S. and King, G.J. (1984) Root Resorption and Tooth Movement in Orthodontically Treated, Calcium-Deficient, and Lactating Rats. American Journal of Orthodontics, 85, 424-430.

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