Efficacy of Haemocoagulase as a Topical Haemostatic Agent after Minor Oral Surgical Procedures—A Prospective Study

Kaberi Majumder, Shalender  , J. K. Dayashankara Rao, Neelima Gehlot, Varun Arya, Vijay Siwach

Department of Oral and Maxillofacial Surgery, SGT Dental College, Gurgaon, India.
Department of Orthodontics, SGT Dental College, Gurgaon, India.

DOI: 10.4236/ijcm.2014.514117                

Abstract

Purpose: Haemocoagulase is a topical haemostatic agent which provides the adequate haemostasis after minor oral surgical procedures and it has also been proved to be beneficial in promoting wound healing. The aim of this study was to check the efficacy of haemocoagulase in stopping the bleeding and its effect over wound healing after the minor oral surgical procedure. Material & Method: This study is comprised of 150 surgical sites in 75 patients. The subjects were divided into 2 groups in which Group 1 consists of 50 surgical sites in 25 patients and Group II consists of 100 surgical sites in 50 patients. Group I comprised of the group of simple extraction. In these patients one tooth socket was selected as haemocoagulase site and the other socket was the control group in which no drug was used to control haemorrhage. Group II comprised of the group of patients with bilateral impactions. 50 sockets and surgical sites were sprinkled with Haemocoagulase, and 50 sockets and surgical sites were used as control side in which no drug was used to control haemorrhage. Results: In Group I bleeding was stopped with the average time of 1.35 minutes, while at control side bleeding was stopped with the average time of 2.25 minutes. In Group II bleeding was stopped with average time for haemostasis being 1.46 minutes, while at control side the bleeding was stopped in an average time of 2.43 minutes. Conclusion: Haemocoagulase after minor oral surgery not only provides faster haemostasis but also enhances healing.

Keywords

Local Haemostatic Agents, Haemocoagulase, Botox

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Kim, S.H. and Lee, H.S. (1993) Efficacy of Intravitreal Haemocoagulase for Control of Bleeding in Rabbit Experimental Model of Vitrectomy. Japanese Journal of Ophthalmology, 37, 379-384.
[2]	Parmar, B.S. and Mansuri, S. (2006) Efficacy of Haemocoagulase as a Topical Haemostatic Agent after Third Molar Surgery (A Study of 50 Cases). Journal of Maxillofacial Surgery, 5, 5-9.
[3]	Borea, G. and Capuzz, I.P. (1993) Tranexamic Acid as a Mouthwash in Anticoagulant Treated Patients Undergoing Oral Surgery. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 75, 29-31. http://dx.doi.org/10.1016/0030-4220(93)90401-O
[4]	Zwischenberger, J.B., Brunston Jr., R.L., Swann, J.R. and Conti, V.R. (1999) Comparison of Two Topical Collagen-Based Hemostatic Sponges during Cardiothoracic Procedures. Journal of Investigative Surgery, 12, 101-106. http://dx.doi.org/10.1080/089419399272656
[5]	Tan, S.R. and Tope, W.D. (2004) Effectiveness of Microporous Polysaccharide Hemospheres for Achieving Hemostasis in Mohs Micrographic Surgery. Dermatologic Surgery, 30, 908-914. http://dx.doi.org/10.1111/j.1524-4725.2004.30261.x
[6]	Levy, J.H. (2004) Hemostatic Agents. Transfusion, 44, 58S-62S. http://dx.doi.org/10.1111/j.0041-1132.2004.04173.x
[7]	Szpalski, M., Gunzburg, R. and Sztern, B. (2004) An Overview of Blood-Sparing Techniques Used in Spine Surgery during the Perioperative Period. European Spine Journal, 13, S18-S27. http://dx.doi.org/10.1007/s00586-004-0752-y
[8]	Kanko, M., Liman, T. and Topcu, S. (2006) A Low-Cost and Simple Method to Stop Intraoperative Leakage-Type Bleeding: Use of the Vancomycin-Oxidized Regenerated Cellulose (ORC) Sandwich. Journal of Investigative Surgery, 19, 323-327. http://dx.doi.org/10.1080/08941930600889425
[9]	Henry, M.C.W., Tashjian, D.B., Kasowski, H., Duncan, C. and Moss, R.L. (2005) Postoperative Paraplegia Secondary to the Use of Oxidized Cellulose (Surgicel). Journal of Pediatric Surgery, 40, E9-E11. http://dx.doi.org/10.1016/j.jpedsurg.2005.01.032
[10]	Favuzza, J. and Hechtman, H.B. (2004) Hemostasis in the Absence of Clotting Factors. Journal of Trauma, 57, S42-S44. http://dx.doi.org/10.1097/01.TA.0000136745.89568.D9
[11]	Galownia, J., Martin, J. and Davis, M.E. (2006) Aluminophosphate-Based, Microporous Materials for Blood Clotting. Microporous and Mesoporous Materials, 92, 61-63. http://dx.doi.org/10.1016/j.micromeso.2005.12.020
[12]	Hunt, K.E. and Crookston, K.P. (2003) Hemostatic Agent QuikClot™ Activates Coagulation Directly via the Contact Pathway. Transfusion, 43, 6A.
[13]	Gabay, M.L. (2006) Absorbable Haemostatic Agents. American Journal of Health System Pharmacy, 63, 1244-1253. http://dx.doi.org/10.2146/ajhp060003
[14]	Allison, R.T. (1994) Foreign Body Reaction and an Associated Histological Artifact Due to Bone Wax. British Journal of Biomedical Science, 51, 14-17.
[15]	Zaganelli, G.L. and Magalhaes, A. (1996) Purification and Characterization of a Fibrinogen Clotting Enzyme from the Venom of Jararacussu (Bothrops jararacussu). Toxicon, 34, 807-819. http://dx.doi.org/10.1016/0041-0101(96)00006-2
[16]	Serrano, S.M. and Mentele, R. (1995) Purification, Characterization, and Amino Acid Sequence of a Serine Proteinase, PA-BJ, with Platelet Aggregating Activity from the Venom of Bothrops jararaca. Biochemistry, 34, 7186-7193. http://dx.doi.org/10.1021/bi00021a033
[17]	Ramesh, K.V. and Ramanarayan, K. (1990) Effect of Botropase on Wound Healing. Indian Journal of Surgery, 52, 218-221.