A Rare Case of Adenoid Cystic Carcinoma of the Breast: Discussion and Review of the Literature

Saad Lannaz, Imane Ouziane, Youssef Bensouda, Hind Mrabti, Hassan Errihani

Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.

DOI: 10.4236/crcm.2014.37096                

Abstract

Adenoid cystic carcinoma (ACC) of the breast is a rare type of primary breast cancer with a favorable prognosis, despite its triple-negative status. There has been no consensus regarding treatments. We will report a case of Adenoid cystic carcinoma of the breast presented with localized disease and no axillary lymph node metastases. We performed a radical mastectomy with axillary lymph node dissection, with a favorable clinical course and we will describe the clinic pathologic features of ACC of the breast and review the current literature.

Keywords

Adenoid Cystic Carcinoma, Triple-Negative Breast Carcinoma

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Law, Y.M., Quek, S.T., Tan, P.H. and Wong, S.L. (2009) Adenoid Cystic Carcinoma of the Breast. Singapore Medical Journal, 50, e8-e11.
[2]	Geschickter, C.F. and Copeland, M.M. (1945) Diseases of the Breast: Diagnosis, Pathology, and Treatment. J. B. Lippincott, Philadelphia.
[3]	Li, N., Xu, L., Zhao, H., El-Naggar, A.K. and Sturgis, E.M. (2012) A Comparison of the Demographics, Clinical Features, and Survival of Patients with Adenoid Cystic Carcinoma of Major and Minor Salivary Glands versus Less Common Sites within the Surveillance, Epidemiology, and End Results Registry. Cancer, 118, 3945-3953. http://dx.doi.org/10.1002/cncr.26740
[4]	Dinkel, H.-P., Clees, M. and Gassel, A.M. (1999) Role of Sonography in Detecting Recurrence in Adenoid Cystic Carcinoma of the Breast. AJR, 173, 497-498. http://dx.doi.org/10.2214/ajr.173.2.10430162
[5]	Santamaria, G., Velasco, M., Zanon, G., Farrus, B., Molina, R., Sole, M., et al. (1998) Adenoid Cystic Carcinoma of the Breast: Mammographic Appearance and Pathologic Correlation. AJR, 171, 1679-1683.
[6]	Sperber, F., Blank, A. and Metser, U. (2002) Adenoid Cystic Carcinoma of the Breast: Mammographic, Sonographic, and Pathological Correlation. The Breast Journal, 8, 53-54. http://dx.doi.org/10.1046/j.1524-4741.2002.08012.x
[7]	Youk, J.H., Kim, M.J., Kim, E.-K., Lee, J.Y., Oh, K.K. and Park, B.W. (2006) Recurrence of Adenoid Cystic Carcinoma of the Breast after Lumpectomy and Adjuvant Therapy. Journal of Ultrasound in Medicine, 25, 921-924.
[8]	Sumpio, B.E., Jennings, T.A., Merino, M.J. and Sullivan, P.D. (1987) Adenoid Cystic Carcinoma of the Breast. Data from the Connecticut Tumor Registry and a Review of the Literature. Annals of Surgery, 205, 295-301. http://dx.doi.org/10.1097/00000658-198703000-00013
[9]	Azoulay, S., Laé, M., Fréneaux, P., Merle, S., Al Ghuslan, A., Chnecker, C., et al. (2005) KIT Is Highly Expressed in Adenoid Cystic Carcinoma of the Breast, a Basal-Like Carcinoma Associated with a Favourable Outcome. Modern Pathology, 18, 1623-1631.
[10]	Weigelt, B., Horlings, H.M., Kreike, B., Hauptmann, M., Wessels, L.F.A., de Jong, D., et al. (2008) Refinement of Breast Cancer Classification by Molecular Characterization of Histological Specila Types. The Journal of Pathology, 216, 141-150. http://dx.doi.org/10.1002/path.2407
[11]	Leeming, R., Jenkins, M. and Mendelsohn, G. (1992) Adenoid Cystic Carcinoma of the Breast. Archives of Surgery, 127, 233-235. http://dx.doi.org/10.1001/archsurg.1992.01420020127019
[12]	McClenathan, J.H. and de la Roza, G. (2002) Adenoid Cystic Breast Cancer. The American Journal of Surgery, 183, 646-649. http://dx.doi.org/10.1016/S0002-9610(02)00858-9
[13]	Boujelbene, N., Khabir, A., Boujelbene, N., Jeanneret Sozzi, W., Mirimanoff, R.O. and Khanfir, K. (2012) Clinical Review: Breast Adenoid Cystic Carcinoma. Breast, 21, 124-127. http://dx.doi.org/10.1016/j.breast.2011.11.006
[14]	Coates, J.M., Martinez, S.R., Bold, R.J. and Chen, S.L. (2010) Adjuvant Radiation Therapy Is Associated with Improved Survival for Adenoid Cystic Carcinoma of the Breast. Journal of Surgical Oncology, 102, 342-347. http://dx.doi.org/10.1002/jso.21638
[15]	Goldhirsch, A., Winer, E.P., Coates, A.S., Gelber, R.D., Piccart-Gebhart, M., Thürlimann, B. and Senn, H.-J. (2013) Personalizing the Treatment of Women with Early Breast Cancer: Highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer. Annals of Oncology, 24, 2206-2223. http://dx.doi.org/10.1093/annonc/mdt303
[16]	Senkus, E., Kyriakides, S., Penault-Llorca, F., Poortmans, P., Thompson, A., Zackrisson, S. and Cardoso, F. on Behalf of the ESMO Guidelines Working Group (2013) Primary Breast Cancer: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up. Annals of Oncology, 24, vi7-vi23. http://dx.doi.org/10.1093/annonc/mdt284
[17]	Weigelt, B., Horlings, H.M., Kreike, B., Hauptmann, M., Wessels, L.F.A., de Jong, D., et al. (2008) Refinement of Breast Cancer Classification by Molecular Characterization of Histological Specila Types. The Journal of Pathology, 216, 141-150. http://dx.doi.org/10.1002/path.2407
[18]	Arpino, G., Clark, G.M., Mohsin, S., Bardou, V.J. and Elledge, R.M. (2002) Adenoid Cystic Carcinoma of the Breast: Molecular Markers, Treatment, and Clinical Outcome. Cancer, 94, 2119-2127. http://dx.doi.org/10.1002/cncr.10455