Non Small-Cell Lung Cancer Metastatic to the Mitral Valve: Case Report and Review of the Literature


In 2008, 1.6 million new cases of lung cancer were diagnosed worldwide, representing 13% of all cancer cases for the year, and in 2010, 19% of cancer deaths were attributed to lung cancer. Though lung cancer frequently metastasizes to the adrenal glands, bone, brain, liver, and other lung, it infrequently metastasizes to the heart. Here, we report a case of lung cancer metastatic to the mitral valve.

Share and Cite:

Axelson, D. , Kreitzer, N. and Fermann, G. (2014) Non Small-Cell Lung Cancer Metastatic to the Mitral Valve: Case Report and Review of the Literature. Case Reports in Clinical Medicine, 3, 424-428. doi: 10.4236/crcm.2014.37094.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E. and Forman, D. (2011) Global Cancer Statistics. CA: A Cancer Journal for Clinicians, 61, 69-90.
[2] Lozano, R., Naghavi, M. and Foreman, K., et al. (2012) Global and Regional Mortality from 235 Causes of Death for 20 Age Groups in 1990 and 2010: A Systematic Analysis for the Global Burden of Disease Study 2010. Lancet, 380, 2095-2128.–2128
[3] Devesa, S.S., Bray, F., Vizcaino, A.P. and Parkin, D.M. (2005) International Lung Cancer Trends by Histiologic Type: Male:Female Differences Diminishing and Adenocarcinoma Rates Rising. International Journal of Cancer, 117, 294-299.–299
[4] Morgensztern, D., Ng, S.H., Gao, F. and Govindan, R. (2010) Trends in Stage Distribution for Patients with Non-Small Cell Lung Cancer: A National Cancer Database Survey. Journal of Thoracic Oncology, 5, 29-33.–33
[5] Lenihan, D.J. and Cardinale, D.M. (2012) Late Cardiac Effects of Cancer Treatment. Journal of Clinical Oncology, 30, 3657-3664.
[6] Sadat, U., Noor, N., See, T.C. and Varty, K. (2007) Peripheral Arterial Ischemia by a Primary Lung Tumour Invading Left Atrium. Lung Cancer, 57, 237-239.
[7] Kim, J.H., Jung, J.Y., Park, Y.I., Hwang, S.I., Jung, C.S., Lee, S.H. and Yoo, C.W. (2005) Non-Small Cell Lung Cancer Initially Presenting with Intracardiac Metastasis. Korean Journal of Internal Medicine, 20, 86-89.
[8] Klatt, E.C. and Heitz, D.R. (1990) Cardiac Metastases. Cancer, 65, 1456-1459.<1456::AID-CNCR2820650634>3.0.CO;2-5
[9] Lee, P. and Kishan, A.U. (2012) Radiotherapy Is Effective for Primary Lung Cancer Invading the Left Atrium. BMJ Case Reports.
[10] Liang, Y.H., Kuo, S.W., Lin, Y.L. and Chang, Y.L. (2011) Disseminated Microvascular Pulmonary Tumor Embolism from Non-Small Cell Lung Cancer Leading to Pulmonary Hypertension Followed by Sudden Cardiac Arrest. Lung Cancer, 72, 132-135.
[11] Leeies, M. and Weldon, E. (2011) STEMI Stymie: Metastatic Cancer and Cardiac Tamponade Presenting as Inferior STEMI. Annals of Emergency Medicine, 57, 221-224.
[12] Reynen, K., Kockeritz, U. and Strasser, R.H. (2004) Metastases to the Heart. Annals of Oncology, 15, 375-381.–381%2C+2004
[13] Ratto, G.B., Costa, R., Vassallo, G., Alloisio, A., Maineri, P. and Bruzzi, P. (2004) Twelve-Year Experience with Left Atrial Resection in the Treatment of Non-Small Cell Lung Cancer. Annals of Thoracic Surgery, 78, 234-237.
[14] Spaggiari, L., D’Aiuto, M., Veronesi, G., Pelosi, G., de Pas, T., Catalano, G. and de Braud, F. (2005) Extended Pneumonectomy with Partial Resection of the Left Atrium, without Cardiopulmonary Bypass, for Lung Cancer. Annals of Thoracic Surgery, 79, 234-240.

Copyright © 2022 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.