Correlation of Blood Lactate and Mixed Venous Oxygen Saturation in Off-Pump CABG

Ganapathy Sambandam Kamalakkannan, Ranjith Karthekeyan, Mahesh Vakamudi, Sandeep Bangale, Rajeshkumar Kodali, Hemanand Nayagam, Sushma Nandipati

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Department of Anesthesiology, Sri Ramachandra Medical College and Research Institute, Chennai, India.

DOI: 10.4236/wjcs.2014.47020                

Abstract

Aim: To evaluate the correlation of blood lactate and mixed venous oxygen saturation to predict outcome in off-pump coronary artery bypass grafting. Method: This is a randomized study including 30 patients. Blood lactate and mixed venous oxygen saturation were measured in 4 groups of patients—number of grafts, presence or absence of left main coronary artery disease, ejection fraction and serum creatinine. Blood samples were taken before induction, after grafting, on intensive care unit admission, 24 hours and 48 hours after surgery. The measured blood lactate and mixed venous oxygen saturation are compared to assess the outcomes in terms of duration of ventilation and intensive care unit stay. Results: The blood lactate and mixed venous oxygen saturation values increased post operatively but no statistically significant difference in three groups— number of grafts, left main coronary artery disease and ejection fraction. In serum creatinine group, the blood lactate value was found to be statistically significant after grafting in patients with creatinine <1.5 mg/dl, however, there was a significant disparity in numbers. Conclusion: Mixed venous oxygen saturation is a better predictor of morbidity than blood lactate in terms of intensive care unit stay in patients undergoing off pump coronary artery bypass grafting.

Keywords

Off-Pump Coronary Artery Bypass Grafting, Blood Lactate, Mixed Venous Oxygen Saturation, Ejection Fraction, Duration of Ventilation, Duration of Intensive Care Unit Stay

Conflicts of Interest

The authors declare no conflicts of interest.

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