An Efficient and Rapid Synthesis of 2-amino-4-arylthiazoles Employing Microwave Irradiation in Water

Kishor S. Jain, Jitender B. Bariwal, Muthu K. Kathiravan, Vikas K. Raskar, Gajanan S. Wankhede, Nitin A. Londhe, Satish N. Dighe

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DOI: 10.4236/gsc.2011.12007                

Abstract

A facile, high yielding green chemical synthetic protocol adaptable to the parallel synthesis of a library of potentially bioactive 2-amino-4-arylthiazoles is reported herein. The methodology involves the condensation of various aracyl bromides with N-arylthioureas under MWI using water as solvent, to yield pure products (81%-97%) in very short reaction times (1-20 min).

Keywords

Green Chemical Synthesis, MWI, Water, 2-amino-4-arylthiazoles

Conflicts of Interest

The authors declare no conflicts of interest.

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