Inflammatory Pseudotumor of the Anterior Mediastinum Appearing as a Thymic Malignancy: Report of a Case


We treated a patient with inflammatory pseudotumor of the mediastinum that exhibited high uptake of fluorodeoxyglucose on positron emission tomography. A 69-year-old male patient was diagnosed with a mass measuring 70 mm in diameter in the anterior mediastinum as revealed by computed tomography. The lesion showed strong uptake of 18-fluorine fluorodeoxyglucose with a maximum standardized uptake value of 10.24 on positron emission tomography, which was suggestive of a thymic malignancy. Complete resection of the mass was achieved, and the postoperative pathological examination confirmed an inflammatory pseudotumor of the mediastinum arising in a perithymic lymph node. Despite its rarity, inflammatory pseudotumor should be taken into consideration when diagnosing a mass lesion with characteristics suggestive of thymic neoplasm on fluorodeoxyglucose positron emission tomography-computed tomography.

Share and Cite:

Kanazawa, G. , Sakamaki, Y. and Oda, T. (2014) Inflammatory Pseudotumor of the Anterior Mediastinum Appearing as a Thymic Malignancy: Report of a Case. Case Reports in Clinical Medicine, 3, 357-360. doi: 10.4236/crcm.2014.36079.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Mountney, J., Suvarna, S.K., Brown, P.W.G. and Thorpe, J.A.C. (1997) Inflammatory Pseudotumor of the Lung Mimicking Thymoma. European Journal of Cardio-Thoracic Surgery, 12, 801-803.
[2] Chen, C.H., Lin, R.L., Liu, H.C., Chen, C.H., Hung, T.T. and Huang, W.C. (2008) Inflammatory Myofibroblastic Tumor Mimicking Anterior Mediastinal Malignancy. The Annals of Thoracic Surgery, 86, 1362-1364.
[3] Tomiyama, N., Müller, N.L., Ellis, S.J., Cleverley, J.R., Okumura, M., Miyoshi, S., Miyoshi, S., Kusumoto, M., et al. (2001) Invasive and Noninvasive Thymoma: Distinctive CT Features. Journal of Computer Assisted Tomography, 25, 388-393.
[4] Umiker, W.O. and Lverson, L. (1954) Postinflammatory Tumors of the Lung; Report of Four Cases Simulating Xanthoma, Fibroma, or Plasma Cell Tumor. Journal of Thoracic Surgery, 28, 55-63.
[5] Addis, B.J. and Corrin, B. (1990) Inflammatory Pseudorumors. Systemic Pathology. The Lungs. Churchill Livingstone, London, 333-339.
[6] Fabre, D.O., Fadel, E.I., Singhal, S.U., Montpreville, V.I., Mussot, S.A., Mercier, O.L., Mercier, O., Dartevelle, P.G., et al. (2009) Complete Resection of Pulmonary Inflammatory Pseudotumor Has Excellent Long-Term Prognosis. The Journal of Thoracic and Cardiovascular Surgery, 137, 435-440.
[7] Imperato, J.P., Folkman, J., Sagerman, R.H. and Cassady, J.R. (1986) Treatment of Plasma Cell Granuloma of the Lung with Radiation Therapy. A Report of Two Cases and a Review of the Literature. Cancer, 57, 2127-2129.<2127::AID-CNCR2820571107>3.0.CO;2-O
[8] Lawrence, B., Perez-Atayde, A., Hibbard, M.K., Rubin, B., Cin, P. and Pinkus, J. (2000) TPM3-ALK and TPM4-ALK Oncogenes in Inflammatory Myofibroblastic Tumors. The American Journal of Pathology, 157, 377-384.
[9] Matsumoto, I., Oda, M., Takizawa, M., Waseda, R., Nakajima, K., Kawano, M., Mochizuki, T., Ikeda, H., et al. (2013) Usefulness of Fluorine-18 Fluorodeoxyglucose-Positron Emission Tomography in Management Strategy for Thymic Epithelial Tumors. The Annals of Thoracic Surgery, 95, 305-311.
[10] Otsuka, H. (2012) The Utility of FDG-PET in the Diagnosis of Thymic Epithelial Tumors. The Journal of Medical Investigation, 59, 225-234.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.